##gff-version 3
P41511	UniProtKB	Chain	1	1019	.	.	.	ID=PRO_0000145210;Note=DNA topoisomerase 1	
P41511	UniProtKB	Domain	386	860	.	.	.	Note=Topo IB-type catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01382	
P41511	UniProtKB	Region	1	160	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Region	379	380	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Region	442	447	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Region	556	558	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Region	716	737	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Region	843	890	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Region	940	1019	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Compositional bias	1	37	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Compositional bias	39	58	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Compositional bias	59	79	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Compositional bias	108	136	.	.	.	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Compositional bias	722	737	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Compositional bias	843	868	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Compositional bias	981	998	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41511	UniProtKB	Active site	822	822	.	.	.	Note=O-(3'-phospho-DNA)-tyrosine intermediate;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01382,ECO:0000255|PROSITE-ProRule:PRU10130	
P41511	UniProtKB	Site	317	317	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Site	366	366	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Site	397	397	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Site	454	454	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Site	480	480	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Site	545	545	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Site	613	613	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Site	632	632	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P41511	UniProtKB	Sequence conflict	181	181	.	.	.	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P41511	UniProtKB	Sequence conflict	197	197	.	.	.	Note=W->C;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P41511	UniProtKB	Sequence conflict	341	341	.	.	.	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P41511	UniProtKB	Sequence conflict	434	434	.	.	.	Note=W->C;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P41511	UniProtKB	Sequence conflict	452	452	.	.	.	Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P41511	UniProtKB	Sequence conflict	1011	1011	.	.	.	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P41511	UniProtKB	Sequence conflict	1017	1017	.	.	.	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305