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P41500

- ACYP1_BOVIN

UniProt

P41500 - ACYP1_BOVIN

Protein

Acylphosphatase-1

Gene

ACYP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    An acylphosphate + H2O = a carboxylate + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei26 – 261PROSITE-ProRule annotation
    Active sitei44 – 441PROSITE-ProRule annotation

    GO - Molecular functioni

    1. acylphosphatase activity Source: RefGenome

    GO - Biological processi

    1. metabolic process Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    SABIO-RKP41500.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylphosphatase-1 (EC:3.6.1.7)
    Alternative name(s):
    Acylphosphatase, erythrocyte/testis isozyme
    Acylphosphatase, organ-common type isozyme
    Acylphosphate phosphohydrolase 1
    Gene namesi
    Name:ACYP1
    Synonyms:ACYPE
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 10

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed; in isoform ACY21 Publication
    Chaini2 – 101100Acylphosphatase-1PRO_0000158534Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine; in isoform ACY22 Publications

    Keywords - PTMi

    Acetylation

    Expressioni

    Tissue specificityi

    Organ-common type isozyme is found in many different tissues.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000018595.

    Structurei

    Secondary structure

    1
    101
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 1911
    Beta strandi21 – 244
    Helixi25 – 3511
    Beta strandi39 – 446
    Beta strandi50 – 578
    Helixi58 – 7013
    Beta strandi77 – 8812
    Beta strandi95 – 1006

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ACYX-ray1.80A4-101[»]
    ProteinModelPortaliP41500.
    SMRiP41500. Positions 4-101.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41500.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 10191Acylphosphatase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the acylphosphatase family.Curated
    Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG289322.
    GeneTreeiENSGT00390000011103.
    HOGENOMiHOG000292688.
    HOVERGENiHBG050454.
    InParanoidiP41500.
    KOiK01512.
    OMAiAEFRNEK.
    OrthoDBiEOG7ZGX55.
    TreeFamiTF300288.

    Family and domain databases

    InterProiIPR020456. Acylphosphatase.
    IPR001792. Acylphosphatase-like_dom.
    IPR017968. Acylphosphatase_CS.
    [Graphical view]
    PfamiPF00708. Acylphosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00112. ACYLPHPHTASE.
    SUPFAMiSSF54975. SSF54975. 1 hit.
    PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
    PS00151. ACYLPHOSPHATASE_2. 1 hit.
    PS51160. ACYLPHOSPHATASE_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Note: It is uncertain whether isoform ACY1 is produced by alternative initiation or another biological event.

    Isoform ACY2 (identifier: P41500-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSMAEGDTLI SVDYEIFGKV QGVFFRKYTQ AEGKKLGLVG WVQNTDQGTV    50
    QGQLQGPASK VRHMQEWLET KGSPKSHIDR ASFHNEKVIV KLDYTDFQIV 100
    K 101
    Length:101
    Mass (Da):11,432
    Last modified:January 23, 2007 - v2
    Checksum:i92DC05E7BF0D86B7
    GO
    Isoform ACY1 (identifier: P41500-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2: Missing.

    Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.

    Show »
    Length:99
    Mass (Da):11,214
    Checksum:i73DBBF3C27569C06
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 22Missing in isoform ACY1. CuratedVSP_026023

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114901 mRNA. Translation: AAI14902.1.
    PIRiA61449.
    RefSeqiNP_001039447.1. NM_001045982.2. [P41500-1]
    XP_005212005.1. XM_005211948.1. [P41500-1]
    UniGeneiBt.33942.

    Genome annotation databases

    EnsembliENSBTAT00000018595; ENSBTAP00000018595; ENSBTAG00000013992. [P41500-1]
    GeneIDi507844.
    KEGGibta:507844.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114901 mRNA. Translation: AAI14902.1 .
    PIRi A61449.
    RefSeqi NP_001039447.1. NM_001045982.2. [P41500-1 ]
    XP_005212005.1. XM_005211948.1. [P41500-1 ]
    UniGenei Bt.33942.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ACY X-ray 1.80 A 4-101 [» ]
    ProteinModelPortali P41500.
    SMRi P41500. Positions 4-101.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000018595.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000018595 ; ENSBTAP00000018595 ; ENSBTAG00000013992 . [P41500-1 ]
    GeneIDi 507844.
    KEGGi bta:507844.

    Organism-specific databases

    CTDi 97.

    Phylogenomic databases

    eggNOGi NOG289322.
    GeneTreei ENSGT00390000011103.
    HOGENOMi HOG000292688.
    HOVERGENi HBG050454.
    InParanoidi P41500.
    KOi K01512.
    OMAi AEFRNEK.
    OrthoDBi EOG7ZGX55.
    TreeFami TF300288.

    Enzyme and pathway databases

    SABIO-RK P41500.

    Miscellaneous databases

    EvolutionaryTracei P41500.
    NextBioi 20868244.

    Family and domain databases

    InterProi IPR020456. Acylphosphatase.
    IPR001792. Acylphosphatase-like_dom.
    IPR017968. Acylphosphatase_CS.
    [Graphical view ]
    Pfami PF00708. Acylphosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00112. ACYLPHPHTASE.
    SUPFAMi SSF54975. SSF54975. 1 hit.
    PROSITEi PS00150. ACYLPHOSPHATASE_1. 1 hit.
    PS00151. ACYLPHOSPHATASE_2. 1 hit.
    PS51160. ACYLPHOSPHATASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ACY2).
      Strain: Hereford.
      Tissue: Fetal pons.
    2. "Purification, kinetic properties and primary structure of bovine erythrocyte acylphosphatase."
      Pazzagli L., Ikram U.K., Liguri G., Taddei N., Gentilini A., Cecchi C., Manao G., Cappugi G.
      Ital. J. Biochem. 42:233-245(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-101 (ISOFORM ACY2), ACETYLATION AT SER-2.
      Tissue: Erythrocyte.
    3. "Bovine testis acylphosphatase: purification and amino acid sequence."
      Pazzagli L., Cappugi G., Camici G., Manao G., Ramponi G.
      J. Protein Chem. 12:593-601(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-101 (ISOFORM ACY2), PROTEIN SEQUENCE OF 4-101 (ISOFORM ACY1), ACETYLATION OF N-TERMINUS.
      Tissue: Testis.
    4. "Crystal structure of common type acylphosphatase from bovine testis."
      Thunnissen M.M.G.M., Taddei N., Liguri G., Ramponi G., Nordlund P.
      Structure 5:69-79(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 4-101 (ISOFORM ACY1).
      Tissue: Testis.

    Entry informationi

    Entry nameiACYP1_BOVIN
    AccessioniPrimary (citable) accession number: P41500
    Secondary accession number(s): Q1RMH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3