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P41500

- ACYP1_BOVIN

UniProt

P41500 - ACYP1_BOVIN

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Protein

Acylphosphatase-1

Gene

ACYP1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei26 – 261PROSITE-ProRule annotation
Active sitei44 – 441PROSITE-ProRule annotation

GO - Molecular functioni

  1. acylphosphatase activity Source: RefGenome

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SABIO-RKP41500.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-1 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, erythrocyte/testis isozyme
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1
Gene namesi
Name:ACYP1
Synonyms:ACYPE
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed; in isoform ACY21 Publication
Chaini2 – 101100Acylphosphatase-1PRO_0000158534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine; in isoform ACY21 Publication

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Organ-common type isozyme is found in many different tissues.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018595.

Structurei

Secondary structure

1
101
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 1911
Beta strandi21 – 244
Helixi25 – 3511
Beta strandi39 – 446
Beta strandi50 – 578
Helixi58 – 7013
Beta strandi77 – 8812
Beta strandi95 – 1006

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ACYX-ray1.80A4-101[»]
ProteinModelPortaliP41500.
SMRiP41500. Positions 4-101.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41500.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 10191Acylphosphatase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated
Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG289322.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP41500.
KOiK01512.
OMAiAEFRNEK.
OrthoDBiEOG7ZGX55.
TreeFamiTF300288.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Note: It is uncertain whether isoform ACY1 is produced by alternative initiation or another biological event.

Isoform ACY2 (identifier: P41500-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMAEGDTLI SVDYEIFGKV QGVFFRKYTQ AEGKKLGLVG WVQNTDQGTV
60 70 80 90 100
QGQLQGPASK VRHMQEWLET KGSPKSHIDR ASFHNEKVIV KLDYTDFQIV

K
Length:101
Mass (Da):11,432
Last modified:January 23, 2007 - v2
Checksum:i92DC05E7BF0D86B7
GO
Isoform ACY1 (identifier: P41500-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.

Show »
Length:99
Mass (Da):11,214
Checksum:i73DBBF3C27569C06
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 22Missing in isoform ACY1. CuratedVSP_026023

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114901 mRNA. Translation: AAI14902.1.
PIRiA61449.
RefSeqiNP_001039447.1. NM_001045982.2. [P41500-1]
XP_005212005.1. XM_005211948.1. [P41500-1]
UniGeneiBt.33942.

Genome annotation databases

EnsembliENSBTAT00000018595; ENSBTAP00000018595; ENSBTAG00000013992. [P41500-1]
GeneIDi507844.
KEGGibta:507844.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC114901 mRNA. Translation: AAI14902.1 .
PIRi A61449.
RefSeqi NP_001039447.1. NM_001045982.2. [P41500-1 ]
XP_005212005.1. XM_005211948.1. [P41500-1 ]
UniGenei Bt.33942.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ACY X-ray 1.80 A 4-101 [» ]
ProteinModelPortali P41500.
SMRi P41500. Positions 4-101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000018595.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018595 ; ENSBTAP00000018595 ; ENSBTAG00000013992 . [P41500-1 ]
GeneIDi 507844.
KEGGi bta:507844.

Organism-specific databases

CTDi 97.

Phylogenomic databases

eggNOGi NOG289322.
GeneTreei ENSGT00390000011103.
HOGENOMi HOG000292688.
HOVERGENi HBG050454.
InParanoidi P41500.
KOi K01512.
OMAi AEFRNEK.
OrthoDBi EOG7ZGX55.
TreeFami TF300288.

Enzyme and pathway databases

SABIO-RK P41500.

Miscellaneous databases

EvolutionaryTracei P41500.
NextBioi 20868244.

Family and domain databases

InterProi IPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view ]
Pfami PF00708. Acylphosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00112. ACYLPHPHTASE.
SUPFAMi SSF54975. SSF54975. 1 hit.
PROSITEi PS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ACY2).
    Strain: Hereford.
    Tissue: Fetal pons.
  2. "Purification, kinetic properties and primary structure of bovine erythrocyte acylphosphatase."
    Pazzagli L., Ikram U.K., Liguri G., Taddei N., Gentilini A., Cecchi C., Manao G., Cappugi G.
    Ital. J. Biochem. 42:233-245(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-101 (ISOFORM ACY2), ACETYLATION AT SER-2.
    Tissue: Erythrocyte.
  3. "Bovine testis acylphosphatase: purification and amino acid sequence."
    Pazzagli L., Cappugi G., Camici G., Manao G., Ramponi G.
    J. Protein Chem. 12:593-601(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-101 (ISOFORM ACY2), PROTEIN SEQUENCE OF 4-101 (ISOFORM ACY1), ACETYLATION OF N-TERMINUS.
    Tissue: Testis.
  4. "Crystal structure of common type acylphosphatase from bovine testis."
    Thunnissen M.M.G.M., Taddei N., Liguri G., Ramponi G., Nordlund P.
    Structure 5:69-79(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 4-101 (ISOFORM ACY1).
    Tissue: Testis.

Entry informationi

Entry nameiACYP1_BOVIN
AccessioniPrimary (citable) accession number: P41500
Secondary accession number(s): Q1RMH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3