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Protein

Acylphosphatase-1

Gene

ACYP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei26PROSITE-ProRule annotation1
Active sitei44PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SABIO-RKP41500.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-1 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, erythrocyte/testis isozyme
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1
Gene namesi
Name:ACYP1
Synonyms:ACYPE
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; in isoform ACY21 Publication
ChainiPRO_00001585342 – 101Acylphosphatase-1Add BLAST100
Isoform ACY1 (identifier: P41500-2)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine; in isoform ACY21 Publication1
Isoform ACY1 (identifier: P41500-2)
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP41500.
PRIDEiP41500.

Expressioni

Tissue specificityi

Organ-common type isozyme is found in many different tissues.

Gene expression databases

BgeeiENSBTAG00000013992.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018595.

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 19Combined sources11
Beta strandi21 – 24Combined sources4
Helixi25 – 35Combined sources11
Beta strandi39 – 44Combined sources6
Beta strandi50 – 57Combined sources8
Helixi58 – 70Combined sources13
Beta strandi77 – 88Combined sources12
Beta strandi95 – 100Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ACYX-ray1.80A4-101[»]
ProteinModelPortaliP41500.
SMRiP41500.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41500.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 101Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated
Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP41500.
KOiK01512.
OMAiVIVKLDY.
OrthoDBiEOG091G0XR1.
TreeFamiTF300288.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Note: It is uncertain whether isoform ACY1 is produced by alternative initiation or another biological event.
Isoform ACY2 (identifier: P41500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMAEGDTLI SVDYEIFGKV QGVFFRKYTQ AEGKKLGLVG WVQNTDQGTV
60 70 80 90 100
QGQLQGPASK VRHMQEWLET KGSPKSHIDR ASFHNEKVIV KLDYTDFQIV

K
Length:101
Mass (Da):11,432
Last modified:January 23, 2007 - v2
Checksum:i92DC05E7BF0D86B7
GO
Isoform ACY1 (identifier: P41500-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Show »
Length:99
Mass (Da):11,214
Checksum:i73DBBF3C27569C06
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0260231 – 2Missing in isoform ACY1. Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114901 mRNA. Translation: AAI14902.1.
PIRiA61449.
RefSeqiNP_001039447.1. NM_001045982.2. [P41500-1]
XP_005212005.1. XM_005211948.3. [P41500-1]
UniGeneiBt.33942.

Genome annotation databases

EnsembliENSBTAT00000018595; ENSBTAP00000018595; ENSBTAG00000013992. [P41500-1]
GeneIDi507844.
KEGGibta:507844.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114901 mRNA. Translation: AAI14902.1.
PIRiA61449.
RefSeqiNP_001039447.1. NM_001045982.2. [P41500-1]
XP_005212005.1. XM_005211948.3. [P41500-1]
UniGeneiBt.33942.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ACYX-ray1.80A4-101[»]
ProteinModelPortaliP41500.
SMRiP41500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018595.

Proteomic databases

PaxDbiP41500.
PRIDEiP41500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018595; ENSBTAP00000018595; ENSBTAG00000013992. [P41500-1]
GeneIDi507844.
KEGGibta:507844.

Organism-specific databases

CTDi97.

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP41500.
KOiK01512.
OMAiVIVKLDY.
OrthoDBiEOG091G0XR1.
TreeFamiTF300288.

Enzyme and pathway databases

SABIO-RKP41500.

Miscellaneous databases

EvolutionaryTraceiP41500.

Gene expression databases

BgeeiENSBTAG00000013992.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACYP1_BOVIN
AccessioniPrimary (citable) accession number: P41500
Secondary accession number(s): Q1RMH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.