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P41500 (ACYP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acylphosphatase-1

EC=3.6.1.7
Alternative name(s):
Acylphosphatase, erythrocyte/testis isozyme
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1
Gene names
Name:ACYP1
Synonyms:ACYPE
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

An acylphosphate + H2O = a carboxylate + phosphate.

Tissue specificity

Organ-common type isozyme is found in many different tissues.

Sequence similarities

Belongs to the acylphosphatase family.

Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
   Coding sequence diversityAlternative initiation
   Molecular functionHydrolase
   PTMAcetylation
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processmetabolic process

Inferred from Biological aspect of Ancestor. Source: GOC

   Molecular_functionacylphosphatase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Note: It is uncertain whether isoform ACY1 is produced by alternative initiation or another biological event.
Isoform ACY2 (identifier: P41500-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform ACY1 (identifier: P41500-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.
Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; in isoform ACY2 Ref.2 Ref.3
Chain2 – 101100Acylphosphatase-1
PRO_0000158534

Regions

Domain11 – 10191Acylphosphatase-like

Sites

Active site261 Potential
Active site441 Potential

Amino acid modifications

Modified residue21N-acetylserine; in isoform ACY2 Ref.2

Natural variations

Alternative sequence1 – 22Missing in isoform ACY1.
VSP_026023

Secondary structure

............... 101
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform ACY2 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 92DC05E7BF0D86B7

FASTA10111,432
        10         20         30         40         50         60 
MSMAEGDTLI SVDYEIFGKV QGVFFRKYTQ AEGKKLGLVG WVQNTDQGTV QGQLQGPASK 

        70         80         90        100 
VRHMQEWLET KGSPKSHIDR ASFHNEKVIV KLDYTDFQIV K 

« Hide

Isoform ACY1 [UniParc].

Checksum: 73DBBF3C27569C06
Show »

FASTA9911,214

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ACY2).
Strain: Hereford.
Tissue: Fetal pons.
[2]"Purification, kinetic properties and primary structure of bovine erythrocyte acylphosphatase."
Pazzagli L., Ikram U.K., Liguri G., Taddei N., Gentilini A., Cecchi C., Manao G., Cappugi G.
Ital. J. Biochem. 42:233-245(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-101 (ISOFORM ACY2), ACETYLATION AT SER-2.
Tissue: Erythrocyte.
[3]"Bovine testis acylphosphatase: purification and amino acid sequence."
Pazzagli L., Cappugi G., Camici G., Manao G., Ramponi G.
J. Protein Chem. 12:593-601(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-101 (ISOFORM ACY2), PROTEIN SEQUENCE OF 4-101 (ISOFORM ACY1), ACETYLATION OF N-TERMINUS.
Tissue: Testis.
[4]"Crystal structure of common type acylphosphatase from bovine testis."
Thunnissen M.M.G.M., Taddei N., Liguri G., Ramponi G., Nordlund P.
Structure 5:69-79(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 4-101 (ISOFORM ACY1).
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC114901 mRNA. Translation: AAI14902.1.
PIRA61449.
RefSeqNP_001039447.1. NM_001045982.2. [P41500-1]
XP_005212005.1. XM_005211948.1. [P41500-1]
UniGeneBt.33942.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ACYX-ray1.80A4-101[»]
ProteinModelPortalP41500.
SMRP41500. Positions 4-101.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000018595.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000018595; ENSBTAP00000018595; ENSBTAG00000013992. [P41500-1]
GeneID507844.
KEGGbta:507844.

Organism-specific databases

CTD97.

Phylogenomic databases

eggNOGNOG289322.
GeneTreeENSGT00390000011103.
HOGENOMHOG000292688.
HOVERGENHBG050454.
InParanoidP41500.
KOK01512.
OMAAEFRNEK.
OrthoDBEOG7ZGX55.
TreeFamTF300288.

Enzyme and pathway databases

SABIO-RKP41500.

Family and domain databases

InterProIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSPR00112. ACYLPHPHTASE.
SUPFAMSSF54975. SSF54975. 1 hit.
PROSITEPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP41500.
NextBio20868244.

Entry information

Entry nameACYP1_BOVIN
AccessionPrimary (citable) accession number: P41500
Secondary accession number(s): Q1RMH2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references