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Protein

Putative type II secretion system protein H

Gene

gspH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7707-MONOMER.
ECOL316407:JW3291-MONOMER.
MetaCyc:G7707-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein H
Short name:
T2SS protein H
Alternative name(s):
Protein transport protein HofH
Putative general secretion pathway protein H
Gene namesi
Name:gspH
Synonyms:hofH, hopH
Ordered Locus Names:b3329, JW3291
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12887. gspH.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 66By similarityPRO_0000024216
Chaini7 – 169163Putative type II secretion system protein HPRO_0000024217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71N-methylphenylalaninePROSITE-ProRule annotation

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP41443.
PRIDEiP41443.

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
paaXP760862EBI-1129978,EBI-544692

Protein-protein interaction databases

BioGridi4262246. 206 interactions.
IntActiP41443. 4 interactions.
STRINGi511145.b3329.

Structurei

Secondary structure

1
169
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 6128Combined sources
Beta strandi65 – 695Combined sources
Beta strandi74 – 785Combined sources
Beta strandi83 – 853Combined sources
Beta strandi89 – 913Combined sources
Turni96 – 983Combined sources
Beta strandi99 – 1013Combined sources
Beta strandi105 – 11410Combined sources
Beta strandi123 – 1264Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi135 – 1417Combined sources
Turni142 – 1443Combined sources
Beta strandi147 – 15812Combined sources
Beta strandi160 – 1634Combined sources
Turni164 – 1674Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KNQNMR-A30-169[»]
ProteinModelPortaliP41443.
SMRiP41443. Positions 30-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP H family.Curated

Phylogenomic databases

eggNOGiENOG41069X0. Bacteria.
COG2165. LUCA.
HOGENOMiHOG000125353.
InParanoidiP41443.
KOiK02457.
OMAiGQFPEEM.

Family and domain databases

Gene3Di3.55.40.10. 1 hit.
InterProiIPR012902. N_methyl_site.
IPR022346. T2SS_GspH.
IPR002416. T2SS_protein-H.
[Graphical view]
PfamiPF12019. GspH. 1 hit.
PF13544. N_methyl_2. 1 hit.
[Graphical view]
PRINTSiPR00885. BCTERIALGSPH.
TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
TIGR01708. typeII_sec_gspH. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQQRGFTLL EMMLVLALVA ITASVVLFTY GREDVASTRA RETAARFTAA
60 70 80 90 100
LELAIDRATL SGQPVGIHFS DSAWRIMVPG KTPSAWRWVP LQEDAADESQ
110 120 130 140 150
NDWDEELSIH LQPFKPDDSN QPQVVILADG QITPFSLLMA NAGTGEPLLT
160
LVCSGSWPLD QTLARDTRP
Length:169
Mass (Da):18,565
Last modified:November 1, 1995 - v1
Checksum:iD42B1127FBB81A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58126.1.
U00096 Genomic DNA. Translation: AAC76354.1.
AP009048 Genomic DNA. Translation: BAE77962.1.
U20786 Genomic DNA. Translation: AAA69032.1.
PIRiD65126.
RefSeqiNP_417788.1. NC_000913.3.
WP_001076046.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76354; AAC76354; b3329.
BAE77962; BAE77962; BAE77962.
GeneIDi947834.
KEGGiecj:JW3291.
eco:b3329.
PATRICi32122090. VBIEscCol129921_3422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58126.1.
U00096 Genomic DNA. Translation: AAC76354.1.
AP009048 Genomic DNA. Translation: BAE77962.1.
U20786 Genomic DNA. Translation: AAA69032.1.
PIRiD65126.
RefSeqiNP_417788.1. NC_000913.3.
WP_001076046.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KNQNMR-A30-169[»]
ProteinModelPortaliP41443.
SMRiP41443. Positions 30-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262246. 206 interactions.
IntActiP41443. 4 interactions.
STRINGi511145.b3329.

Proteomic databases

PaxDbiP41443.
PRIDEiP41443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76354; AAC76354; b3329.
BAE77962; BAE77962; BAE77962.
GeneIDi947834.
KEGGiecj:JW3291.
eco:b3329.
PATRICi32122090. VBIEscCol129921_3422.

Organism-specific databases

EchoBASEiEB2724.
EcoGeneiEG12887. gspH.

Phylogenomic databases

eggNOGiENOG41069X0. Bacteria.
COG2165. LUCA.
HOGENOMiHOG000125353.
InParanoidiP41443.
KOiK02457.
OMAiGQFPEEM.

Enzyme and pathway databases

BioCyciEcoCyc:G7707-MONOMER.
ECOL316407:JW3291-MONOMER.
MetaCyc:G7707-MONOMER.

Miscellaneous databases

PROiP41443.

Family and domain databases

Gene3Di3.55.40.10. 1 hit.
InterProiIPR012902. N_methyl_site.
IPR022346. T2SS_GspH.
IPR002416. T2SS_protein-H.
[Graphical view]
PfamiPF12019. GspH. 1 hit.
PF13544. N_methyl_2. 1 hit.
[Graphical view]
PRINTSiPR00885. BCTERIALGSPH.
TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
TIGR01708. typeII_sec_gspH. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSPH_ECOLI
AccessioniPrimary (citable) accession number: P41443
Secondary accession number(s): Q2M6Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.