P41442 (GSPG_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative type II secretion system protein G
Short name=T2SS protein G

Alternative name(s):
Protein transport protein HofG
Putative general secretion pathway protein G

Gene names

Name:	gspG
Synonyms:	hofG, hopG
Ordered Locus Names:	b3328, JW3290

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins Potential.
Induction	Silenced by the DNA-binding protein H-NS under standard growth conditions. Ref.5
Miscellaneous	Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.
Sequence similarities	Belongs to the GSP G family.

Ontologies

Keywords
Biological process	Protein transport Transport
PTM	Methylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein secretion by the type II secretion system Inferred from electronic annotation. Source: InterPro
Cellular_component	type II protein secretion system complex Inferred from electronic annotation. Source: InterPro
Molecular_function	protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 9	9	By similarity		PRO_0000024200
	Chain	10 – 145	136	Putative type II secretion system protein G		PRO_0000024201
Amino acid modifications
	Modified residue	10	1	N-methylphenylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41442 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: CBCD67D743810072	FASTA	145	15,905
	10 20 30 40 50 60 MRATDKQRGF TLLEIMVVIV IIGVLASLVV PNLMGNKEKA DKQKAVSDIV ALENALDMYK 70 80 90 100 110 120 LDNHHYPTTN QGLESLVEAP TLPPLAANYN KEGYIKRLPA DPWGNDYVLV NPGEHGAYDL 130 140 LSAGPDGEMG TEDDITNWGL SKKKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the hopG gene, a component of Escherichia coli K-12 type II export system, and its conservation among different pathogenic Escherichia coli and Shigella isolates." Stojiljkovic I., Schoenherr R., Kusters J.G. J. Bacteriol. 177:1892-1895(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"The cryptic general secretory pathway (gsp) operon of Escherichia coli K-12 encodes functional proteins." Francetic O., Pugsley A.P. J. Bacteriol. 178:3544-3549(1996) [PubMed] [Europe PMC] [Abstract] Cited for: LACK OF EXPRESSION, GENE NAME. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
[5]	"Expression of the endogenous type II secretion pathway in Escherichia coli leads to chitinase secretion." Francetic O., Belin D., Badaut C., Pugsley A.P. EMBO J. 19:6697-6703(2000) [PubMed] [Europe PMC] [Abstract] Cited for: LACK OF EXPRESSION, TRANSCRIPTIONAL REGULATION. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20786 Genomic DNA. Translation: AAA69031.1. U18997 Genomic DNA. Translation: AAA58125.1. U00096 Genomic DNA. Translation: AAC76353.1. AP009048 Genomic DNA. Translation: BAE77963.1.
PIR	B56150.
RefSeq	NP_417787.1. NC_000913.2. YP_492104.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P41442.
SMR	P41442. Positions 35-138.
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b3328.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76353; AAC76353; b3328. BAE77963; BAE77963; BAE77963.
GeneID	12933173. 947827.
KEGG	ecj:Y75_p3848. eco:b3328.
PATRIC	32122088. VBIEscCol129921_3421.
Organism-specific databases
EchoBASE	EB2723.
EcoGene	EG12886. gspG.
Phylogenomic databases
eggNOG	COG2165.
HOGENOM	HOG000008196.
KO	K02456.
OMA	EIMVVIF.
ProtClustDB	CLSK891805.
Enzyme and pathway databases
BioCyc	EcoCyc:G7706-MONOMER. ECOL316407:JW3290-MONOMER.
Gene expression databases
Genevestigator	P41442.
Family and domain databases
InterPro	IPR000983. Bac_GSPG. IPR012902. N_methyl_site. IPR013545. T2SS_protein-G. IPR010054. Type2_sec_GspG. [Graphical view]
Pfam	PF13544. N_methyl_2. 1 hit. PF08334. T2SG. 1 hit. [Graphical view]
PRINTS	PR00813. BCTERIALGSPG.
TIGRFAMs	TIGR02532. IV_pilin_GFxxxE. 1 hit. TIGR01710. typeII_sec_gspG. 1 hit.
PROSITE	PS00409. PROKAR_NTER_METHYL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSPG_ECOLI

Accession

Primary (citable) accession number: P41442
Secondary accession number(s): Q2M6Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program