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Protein

Putative type II secretion system protein F

Gene

gspF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7705-MONOMER
MetaCyc:G7705-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein F
Short name:
T2SS protein F
Alternative name(s):
General secretion pathway protein F
Protein transport protein HofF
Gene namesi
Name:gspF
Synonyms:hofF, hopF
Ordered Locus Names:b3327, JW3289
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12885 gspF

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 163PeriplasmicSequence analysisAdd BLAST163
Transmembranei164 – 186HelicalSequence analysisAdd BLAST23
Topological domaini187 – 219CytoplasmicSequence analysisAdd BLAST33
Transmembranei220 – 236HelicalSequence analysisAdd BLAST17
Topological domaini237 – 248PeriplasmicSequence analysisAdd BLAST12
Transmembranei249 – 265HelicalSequence analysisAdd BLAST17
Topological domaini266 – 359CytoplasmicSequence analysisAdd BLAST94
Transmembranei360 – 384HelicalSequence analysisAdd BLAST25
Topological domaini385 – 398PeriplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002078311 – 398Putative type II secretion system protein FAdd BLAST398

Proteomic databases

PaxDbiP41441
PRIDEiP41441

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262168, 120 interactors
STRINGi316385.ECDH10B_3502

Structurei

3D structure databases

ProteinModelPortaliP41441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP F family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D7Q Bacteria
COG1459 LUCA
HOGENOMiHOG000253739
InParanoidiP41441
KOiK02455
OMAiSMAEFPH
PhylomeDBiP41441

Family and domain databases

InterProiView protein in InterPro
IPR011850 GspF
IPR003004 GspF/PilC
IPR018076 T2SS_F
IPR001992 Type_2_secretion_system_CS
PANTHERiPTHR30012 PTHR30012, 1 hit
PfamiView protein in Pfam
PF00482 T2SSF, 2 hits
PRINTSiPR00812 BCTERIALGSPF
TIGRFAMsiTIGR02120 GspF, 1 hit
PROSITEiView protein in PROSITE
PS00874 T2SP_F, 1 hit

Sequencei

Sequence statusi: Complete.

P41441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYRYRAMTQ DGQKLQGIID ANDERQARLR LREEGLFLLD IRPQKSSGVK
60 70 80 90 100
TRRPRISHSE LTLFTRQLAT LSAAALPLEE SLAVIGQQSS NKRLGDVLNQ
110 120 130 140 150
VRSAILEGHP LSDALQHFPT LFDSLYRTLV KAGEKSGLLA PVLEKLADYN
160 170 180 190 200
ENRQKIRSKL IQSLIYPCML TTVAIGVVII LLTAVVPKIT EQFVHMKQQL
210 220 230 240 250
PLSTRILLGL SDTLQRTGPT LLATVFIVAV GFWLWLKRGN NRHRFHAMLL
260 270 280 290 300
RVALIGPLIC AINSARYLRT LSILQSSGVP LLDGMNLSTE SLNNLEIRQR
310 320 330 340 350
LANAAENVRQ GNSIHLSLEQ TAIFPPMMLY MVASGEKSGQ LGTLMVRAAD
360 370 380 390
NQETLQQNRI ALTLSIFEPA LIITMALIVL FIVVSVLQPL LQLNSMIN
Length:398
Mass (Da):44,339
Last modified:November 1, 1995 - v1
Checksum:i8A2696AC7948BC8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270T → P in AAA69030 (PubMed:7896718).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58124.1
U00096 Genomic DNA Translation: AAC76352.1
AP009048 Genomic DNA Translation: BAE77964.1
U20786 Genomic DNA Translation: AAA69030.1
PIRiB65126
RefSeqiNP_417786.1, NC_000913.3
WP_001109573.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76352; AAC76352; b3327
BAE77964; BAE77964; BAE77964
GeneIDi947829
KEGGiecj:JW3289
eco:b3327
PATRICifig|1411691.4.peg.3404

Entry informationi

Entry nameiGSPF_ECOLI
AccessioniPrimary (citable) accession number: P41441
Secondary accession number(s): Q2M6Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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