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P41440

- S19A1_HUMAN

UniProt

P41440 - S19A1_HUMAN

Protein

Folate transporter 1

Gene

SLC19A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H+-pump.

    GO - Molecular functioni

    1. folic acid binding Source: UniProtKB-KW
    2. folic acid transporter activity Source: ProtInc
    3. methotrexate transporter activity Source: ProtInc

    GO - Biological processi

    1. folic acid metabolic process Source: Reactome
    2. folic acid transport Source: ProtInc
    3. small molecule metabolic process Source: Reactome
    4. vitamin metabolic process Source: Reactome
    5. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Folate-binding

    Enzyme and pathway databases

    ReactomeiREACT_11167. Metabolism of folate and pterines.

    Protein family/group databases

    TCDBi2.A.48.1.1. the reduced folate carrier (rfc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Folate transporter 1
    Short name:
    FOLT
    Alternative name(s):
    Intestinal folate carrier 1
    Short name:
    IFC-1
    Placental folate transporter
    Reduced folate carrier protein
    Short name:
    RFC
    Solute carrier family 19 member 1
    Gene namesi
    Name:SLC19A1
    Synonyms:FLOT1, RFC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:10937. SLC19A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti306574. Methotrexate dose selection.
    PharmGKBiPA327.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Folate transporter 1PRO_0000178660Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Modified residuei474 – 4741PhosphoserineBy similarity
    Modified residuei485 – 4851PhosphoserineBy similarity
    Modified residuei499 – 4991Phosphoserine1 Publication
    Modified residuei503 – 5031Phosphoserine1 Publication

    Post-translational modificationi

    Heavily glycosylated.

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP41440.
    PaxDbiP41440.
    PRIDEiP41440.

    PTM databases

    PhosphoSiteiP41440.

    Expressioni

    Tissue specificityi

    Placenta, liver, and to a much smaller extent, in lung.

    Gene expression databases

    ArrayExpressiP41440.
    BgeeiP41440.
    CleanExiHS_FLOT1.
    HS_RFC1.
    HS_SLC19A1.
    GenevestigatoriP41440.

    Organism-specific databases

    HPAiHPA024802.

    Interactioni

    Protein-protein interaction databases

    BioGridi112461. 1 interaction.
    STRINGi9606.ENSP00000308895.

    Structurei

    3D structure databases

    ProteinModelPortaliP41440.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini45 – 7026Extracellular1 PublicationAdd
    BLAST
    Topological domaini90 – 956Cytoplasmic1 Publication
    Topological domaini117 – 1237Extracellular1 Publication
    Topological domaini145 – 15915Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini178 – 1869Extracellular1 Publication
    Topological domaini204 – 25956Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini288 – 30922Extracellular1 PublicationAdd
    BLAST
    Topological domaini328 – 3336Cytoplasmic1 Publication
    Topological domaini355 – 3606Extracellular1 Publication
    Topological domaini379 – 39416Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini420 – 43314Extracellular1 PublicationAdd
    BLAST
    Topological domaini455 – 591137Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalCuratedAdd
    BLAST
    Transmembranei71 – 8919HelicalCuratedAdd
    BLAST
    Transmembranei96 – 11621HelicalCuratedAdd
    BLAST
    Transmembranei124 – 14421HelicalCuratedAdd
    BLAST
    Transmembranei160 – 17718HelicalCuratedAdd
    BLAST
    Transmembranei187 – 20317HelicalCuratedAdd
    BLAST
    Transmembranei260 – 28728HelicalCuratedAdd
    BLAST
    Transmembranei310 – 32718HelicalCuratedAdd
    BLAST
    Transmembranei334 – 35421HelicalCuratedAdd
    BLAST
    Transmembranei361 – 37818HelicalCuratedAdd
    BLAST
    Transmembranei395 – 41925HelicalCuratedAdd
    BLAST
    Transmembranei434 – 45421HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241030.
    HOVERGENiHBG054198.
    InParanoidiP41440.
    KOiK14609.
    OMAiFAYLAIM.
    PhylomeDBiP41440.
    TreeFamiTF313684.

    Family and domain databases

    InterProiIPR002666. Folate_carrier.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR028339. RFC.
    [Graphical view]
    PANTHERiPTHR10686. PTHR10686. 1 hit.
    PfamiPF01770. Folate_carrier. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028739. Folate_carrier. 1 hit.
    PIRSF500793. Folate_transporter_1. 1 hit.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00806. rfc. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P41440-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP    50
    YLLGPDKNFT REQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG 100
    LSFVSVWLLL LLGHSVAHMQ LMELFYSVTM AARIAYSSYI FSLVRPARYQ 150
    RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV SFSTLNYISL AFLTFSVVLA 200
    LFLKRPKRSL FFNRDDRGRC ETSASELERM NPGPGGKLGH ALRVACGDSV 250
    LARMLRELGD SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN 300
    SARVYNGAAD AASTLLGAIT SFAAGFVKIR WARWSKLLIA GVTATQAGLV 350
    FLLAHTRHPS SIWLCYAAFV LFRGSYQFLV PIATFQIASS LSKELCALVF 400
    GVNTFFATIV KTIITFIVSD VRGLGLPVRK QFQLYSVYFL ILSIIYFLGA 450
    MLDGLRHCQR GHHPRQPPAQ GLRSAAEEKA AQALSVQDKG LGGLQPAQSP 500
    PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV TTPSPCTLCS 550
    AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNVN Q 591
    Length:591
    Mass (Da):64,868
    Last modified:December 1, 2000 - v3
    Checksum:i0437B1615F5517EB
    GO
    Isoform 2 (identifier: P41440-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-63: MVPSSPAVEK...GPDKNFTREQ → MRPQPAEPAPGGRGNEACSIHSE

    Note: No experimental confirmation available.

    Show »
    Length:551
    Mass (Da):60,034
    Checksum:i491A0402C6E9A05F
    GO
    Isoform 3 (identifier: P41440-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         432-591: FQLYSVYFLI...PSDGVQNVNQ → NEELHVASLS...PVCPSEVCPS

    Note: No experimental confirmation available.

    Show »
    Length:489
    Mass (Da):54,262
    Checksum:i64D568ECA8030F70
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 632EQ → DE(PubMed:7826387)Curated
    Sequence conflicti62 – 632EQ → DE(PubMed:7641195)Curated
    Sequence conflicti268 – 2681R → P in AAA98442. (PubMed:7826387)Curated
    Sequence conflicti457 – 4571H → D in AAB35058. (PubMed:7641195)Curated
    Sequence conflicti483 – 4831A → R in AAB35058. (PubMed:7641195)Curated
    Sequence conflicti549 – 5491C → S(PubMed:7826387)Curated
    Sequence conflicti549 – 5491C → S(PubMed:7641195)Curated
    Sequence conflicti549 – 5491C → S(PubMed:7852378)Curated
    Sequence conflicti549 – 5491C → S1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271H → R.5 Publications
    Corresponds to variant rs1051266 [ dbSNP | Ensembl ].
    VAR_020210
    Natural varianti558 – 5581A → V.
    Corresponds to variant rs35786590 [ dbSNP | Ensembl ].
    VAR_052404

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6363MVPSS…FTREQ → MRPQPAEPAPGGRGNEACSI HSE in isoform 2. 1 PublicationVSP_042891Add
    BLAST
    Alternative sequencei432 – 591160FQLYS…QNVNQ → NEELHVASLSLWKSHLRLAA DTLSSEGSSGSGPRSWFLSP TLRAALHGPVCPSEVCPS in isoform 3. 1 PublicationVSP_044497Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15939 mRNA. Translation: AAA98442.1.
    U19720 mRNA. Translation: AAC50180.1.
    S78996 mRNA. Translation: AAB35058.1.
    U17566 mRNA. Translation: AAA74914.1.
    U92873
    , U92869, U92870, U92871, U92872 Genomic DNA. Translation: AAC26162.1.
    AF004354 mRNA. Translation: AAB61417.1.
    AK303168 mRNA. Translation: BAH13909.1.
    AK313125 mRNA. Translation: BAG35945.1.
    AL163302 Genomic DNA. Translation: CAB90483.1. Sequence problems.
    BX322561 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09331.1.
    BC003068 mRNA. Translation: AAH03068.1.
    CCDSiCCDS13725.1. [P41440-1]
    CCDS56217.1. [P41440-2]
    CCDS56218.1. [P41440-3]
    PIRiI38924.
    I52728.
    RefSeqiNP_001192135.1. NM_001205206.1. [P41440-3]
    NP_001192136.1. NM_001205207.1. [P41440-2]
    NP_919231.1. NM_194255.2. [P41440-1]
    UniGeneiHs.736903.
    Hs.84190.

    Genome annotation databases

    EnsembliENST00000311124; ENSP00000308895; ENSG00000173638. [P41440-1]
    ENST00000380010; ENSP00000369347; ENSG00000173638. [P41440-3]
    ENST00000485649; ENSP00000441772; ENSG00000173638. [P41440-2]
    GeneIDi6573.
    KEGGihsa:6573.
    UCSCiuc002zhl.2. human. [P41440-1]
    uc002zhm.2. human. [P41440-3]
    uc011aft.2. human. [P41440-2]

    Polymorphism databases

    DMDMi12643280.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15939 mRNA. Translation: AAA98442.1 .
    U19720 mRNA. Translation: AAC50180.1 .
    S78996 mRNA. Translation: AAB35058.1 .
    U17566 mRNA. Translation: AAA74914.1 .
    U92873
    , U92869 , U92870 , U92871 , U92872 Genomic DNA. Translation: AAC26162.1 .
    AF004354 mRNA. Translation: AAB61417.1 .
    AK303168 mRNA. Translation: BAH13909.1 .
    AK313125 mRNA. Translation: BAG35945.1 .
    AL163302 Genomic DNA. Translation: CAB90483.1 . Sequence problems.
    BX322561 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09331.1 .
    BC003068 mRNA. Translation: AAH03068.1 .
    CCDSi CCDS13725.1. [P41440-1 ]
    CCDS56217.1. [P41440-2 ]
    CCDS56218.1. [P41440-3 ]
    PIRi I38924.
    I52728.
    RefSeqi NP_001192135.1. NM_001205206.1. [P41440-3 ]
    NP_001192136.1. NM_001205207.1. [P41440-2 ]
    NP_919231.1. NM_194255.2. [P41440-1 ]
    UniGenei Hs.736903.
    Hs.84190.

    3D structure databases

    ProteinModelPortali P41440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112461. 1 interaction.
    STRINGi 9606.ENSP00000308895.

    Chemistry

    BindingDBi P41440.
    ChEMBLi CHEMBL4833.
    GuidetoPHARMACOLOGYi 1014.

    Protein family/group databases

    TCDBi 2.A.48.1.1. the reduced folate carrier (rfc) family.

    PTM databases

    PhosphoSitei P41440.

    Polymorphism databases

    DMDMi 12643280.

    Proteomic databases

    MaxQBi P41440.
    PaxDbi P41440.
    PRIDEi P41440.

    Protocols and materials databases

    DNASUi 6573.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311124 ; ENSP00000308895 ; ENSG00000173638 . [P41440-1 ]
    ENST00000380010 ; ENSP00000369347 ; ENSG00000173638 . [P41440-3 ]
    ENST00000485649 ; ENSP00000441772 ; ENSG00000173638 . [P41440-2 ]
    GeneIDi 6573.
    KEGGi hsa:6573.
    UCSCi uc002zhl.2. human. [P41440-1 ]
    uc002zhm.2. human. [P41440-3 ]
    uc011aft.2. human. [P41440-2 ]

    Organism-specific databases

    CTDi 6573.
    GeneCardsi GC21M046913.
    HGNCi HGNC:10937. SLC19A1.
    HPAi HPA024802.
    MIMi 600424. gene.
    neXtProti NX_P41440.
    Orphaneti 306574. Methotrexate dose selection.
    PharmGKBi PA327.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241030.
    HOVERGENi HBG054198.
    InParanoidi P41440.
    KOi K14609.
    OMAi FAYLAIM.
    PhylomeDBi P41440.
    TreeFami TF313684.

    Enzyme and pathway databases

    Reactomei REACT_11167. Metabolism of folate and pterines.

    Miscellaneous databases

    GeneWikii SLC19A1.
    GenomeRNAii 6573.
    NextBioi 25575.
    PROi P41440.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41440.
    Bgeei P41440.
    CleanExi HS_FLOT1.
    HS_RFC1.
    HS_SLC19A1.
    Genevestigatori P41440.

    Family and domain databases

    InterProi IPR002666. Folate_carrier.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR028339. RFC.
    [Graphical view ]
    PANTHERi PTHR10686. PTHR10686. 1 hit.
    Pfami PF01770. Folate_carrier. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028739. Folate_carrier. 1 hit.
    PIRSF500793. Folate_transporter_1. 1 hit.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00806. rfc. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-27.
      Tissue: Placenta.
    2. Prasad P.D.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 490-527.
    3. "Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells."
      Wong S.C., Proefke A., Bhushan A., Matherly L.H.
      J. Biol. Chem. 270:17468-17475(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-27.
    4. "Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells."
      Moscow J.A., Gong M., He R., Sgagias M.K., Dixon K.H., Anzick S.L., Meltzer P.S., Cowan K.H.
      Cancer Res. 55:3790-3794(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-27.
      Tissue: Testis.
    5. "Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake."
      Williams F.M., Flintoff W.F.
      J. Biol. Chem. 270:2987-2992(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lymphoma.
    6. "Structural analysis of the human RFC1 gene encoding a folate transporter and alternatively spliced transcripts with 5' end heterogeneity."
      Tolner B.M., Roy K., Sirotnak F.M.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-27.
      Tissue: Liver.
    7. "Human intestinal folate transport: cloning, expression, and distribution of complementary RNA."
      Nguyen T.T., Dyer D.L., Dunning D.D., Rubin S.A., Grant K.E., Said H.M.
      Gastroenterology 112:783-791(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Small intestine.
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thymus and Tongue.
    9. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-27.
      Tissue: Brain.
    12. "Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion."
      Ferguson P.L., Flintoff W.F.
      J. Biol. Chem. 274:16269-16278(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499 AND SER-503, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS19A1_HUMAN
    AccessioniPrimary (citable) accession number: P41440
    Secondary accession number(s): B2R7U8
    , B7Z8C3, E9PFY4, O00553, O60227, Q13026, Q9BTX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3