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P41440

- S19A1_HUMAN

UniProt

P41440 - S19A1_HUMAN

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Protein

Folate transporter 1

Gene

SLC19A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H+-pump.

GO - Molecular functioni

  1. folic acid binding Source: UniProtKB-KW
  2. folic acid transporter activity Source: ProtInc
  3. methotrexate transporter activity Source: ProtInc

GO - Biological processi

  1. folic acid metabolic process Source: Reactome
  2. folic acid transport Source: ProtInc
  3. small molecule metabolic process Source: Reactome
  4. vitamin metabolic process Source: Reactome
  5. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Folate-binding

Enzyme and pathway databases

ReactomeiREACT_11167. Metabolism of folate and pterines.

Protein family/group databases

TCDBi2.A.48.1.1. the reduced folate carrier (rfc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Folate transporter 1
Short name:
FOLT
Alternative name(s):
Intestinal folate carrier 1
Short name:
IFC-1
Placental folate transporter
Reduced folate carrier protein
Short name:
RFC
Solute carrier family 19 member 1
Gene namesi
Name:SLC19A1
Synonyms:FLOT1, RFC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:10937. SLC19A1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti306574. Methotrexate dose selection.
PharmGKBiPA327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Folate transporter 1PRO_0000178660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Modified residuei474 – 4741PhosphoserineBy similarity
Modified residuei485 – 4851PhosphoserineBy similarity
Modified residuei499 – 4991Phosphoserine1 Publication
Modified residuei503 – 5031Phosphoserine1 Publication

Post-translational modificationi

Heavily glycosylated.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP41440.
PaxDbiP41440.
PRIDEiP41440.

PTM databases

PhosphoSiteiP41440.

Expressioni

Tissue specificityi

Placenta, liver, and to a much smaller extent, in lung.

Gene expression databases

BgeeiP41440.
CleanExiHS_FLOT1.
HS_RFC1.
HS_SLC19A1.
ExpressionAtlasiP41440. baseline and differential.
GenevestigatoriP41440.

Organism-specific databases

HPAiHPA024802.

Interactioni

Protein-protein interaction databases

BioGridi112461. 2 interactions.
STRINGi9606.ENSP00000308895.

Structurei

3D structure databases

ProteinModelPortaliP41440.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Cytoplasmic1 PublicationAdd
BLAST
Topological domaini45 – 7026Extracellular1 PublicationAdd
BLAST
Topological domaini90 – 956Cytoplasmic1 Publication
Topological domaini117 – 1237Extracellular1 Publication
Topological domaini145 – 15915Cytoplasmic1 PublicationAdd
BLAST
Topological domaini178 – 1869Extracellular1 Publication
Topological domaini204 – 25956Cytoplasmic1 PublicationAdd
BLAST
Topological domaini288 – 30922Extracellular1 PublicationAdd
BLAST
Topological domaini328 – 3336Cytoplasmic1 Publication
Topological domaini355 – 3606Extracellular1 Publication
Topological domaini379 – 39416Cytoplasmic1 PublicationAdd
BLAST
Topological domaini420 – 43314Extracellular1 PublicationAdd
BLAST
Topological domaini455 – 591137Cytoplasmic1 PublicationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalCuratedAdd
BLAST
Transmembranei71 – 8919HelicalCuratedAdd
BLAST
Transmembranei96 – 11621HelicalCuratedAdd
BLAST
Transmembranei124 – 14421HelicalCuratedAdd
BLAST
Transmembranei160 – 17718HelicalCuratedAdd
BLAST
Transmembranei187 – 20317HelicalCuratedAdd
BLAST
Transmembranei260 – 28728HelicalCuratedAdd
BLAST
Transmembranei310 – 32718HelicalCuratedAdd
BLAST
Transmembranei334 – 35421HelicalCuratedAdd
BLAST
Transmembranei361 – 37818HelicalCuratedAdd
BLAST
Transmembranei395 – 41925HelicalCuratedAdd
BLAST
Transmembranei434 – 45421HelicalCuratedAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241030.
GeneTreeiENSGT00510000046382.
HOVERGENiHBG054198.
InParanoidiP41440.
KOiK14609.
OMAiFAYLAIM.
PhylomeDBiP41440.
TreeFamiTF313684.

Family and domain databases

InterProiIPR002666. Folate_carrier.
IPR016196. MFS_dom_general_subst_transpt.
IPR028339. RFC.
[Graphical view]
PANTHERiPTHR10686. PTHR10686. 1 hit.
PfamiPF01770. Folate_carrier. 1 hit.
[Graphical view]
PIRSFiPIRSF028739. Folate_carrier. 1 hit.
PIRSF500793. Folate_transporter_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00806. rfc. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P41440) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP
60 70 80 90 100
YLLGPDKNFT REQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG
110 120 130 140 150
LSFVSVWLLL LLGHSVAHMQ LMELFYSVTM AARIAYSSYI FSLVRPARYQ
160 170 180 190 200
RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV SFSTLNYISL AFLTFSVVLA
210 220 230 240 250
LFLKRPKRSL FFNRDDRGRC ETSASELERM NPGPGGKLGH ALRVACGDSV
260 270 280 290 300
LARMLRELGD SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN
310 320 330 340 350
SARVYNGAAD AASTLLGAIT SFAAGFVKIR WARWSKLLIA GVTATQAGLV
360 370 380 390 400
FLLAHTRHPS SIWLCYAAFV LFRGSYQFLV PIATFQIASS LSKELCALVF
410 420 430 440 450
GVNTFFATIV KTIITFIVSD VRGLGLPVRK QFQLYSVYFL ILSIIYFLGA
460 470 480 490 500
MLDGLRHCQR GHHPRQPPAQ GLRSAAEEKA AQALSVQDKG LGGLQPAQSP
510 520 530 540 550
PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV TTPSPCTLCS
560 570 580 590
AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNVN Q
Length:591
Mass (Da):64,868
Last modified:December 1, 2000 - v3
Checksum:i0437B1615F5517EB
GO
Isoform 2 (identifier: P41440-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: MVPSSPAVEK...GPDKNFTREQ → MRPQPAEPAPGGRGNEACSIHSE

Note: No experimental confirmation available.

Show »
Length:551
Mass (Da):60,034
Checksum:i491A0402C6E9A05F
GO
Isoform 3 (identifier: P41440-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     432-591: FQLYSVYFLI...PSDGVQNVNQ → NEELHVASLS...PVCPSEVCPS

Note: No experimental confirmation available.

Show »
Length:489
Mass (Da):54,262
Checksum:i64D568ECA8030F70
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 632EQ → DE(PubMed:7826387)Curated
Sequence conflicti62 – 632EQ → DE(PubMed:7641195)Curated
Sequence conflicti268 – 2681R → P in AAA98442. (PubMed:7826387)Curated
Sequence conflicti457 – 4571H → D in AAB35058. (PubMed:7641195)Curated
Sequence conflicti483 – 4831A → R in AAB35058. (PubMed:7641195)Curated
Sequence conflicti549 – 5491C → S(PubMed:7826387)Curated
Sequence conflicti549 – 5491C → S(PubMed:7641195)Curated
Sequence conflicti549 – 5491C → S(PubMed:7852378)Curated
Sequence conflicti549 – 5491C → S1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271H → R.5 Publications
Corresponds to variant rs1051266 [ dbSNP | Ensembl ].
VAR_020210
Natural varianti558 – 5581A → V.
Corresponds to variant rs35786590 [ dbSNP | Ensembl ].
VAR_052404

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363MVPSS…FTREQ → MRPQPAEPAPGGRGNEACSI HSE in isoform 2. 1 PublicationVSP_042891Add
BLAST
Alternative sequencei432 – 591160FQLYS…QNVNQ → NEELHVASLSLWKSHLRLAA DTLSSEGSSGSGPRSWFLSP TLRAALHGPVCPSEVCPS in isoform 3. 1 PublicationVSP_044497Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15939 mRNA. Translation: AAA98442.1.
U19720 mRNA. Translation: AAC50180.1.
S78996 mRNA. Translation: AAB35058.1.
U17566 mRNA. Translation: AAA74914.1.
U92873
, U92869, U92870, U92871, U92872 Genomic DNA. Translation: AAC26162.1.
AF004354 mRNA. Translation: AAB61417.1.
AK303168 mRNA. Translation: BAH13909.1.
AK313125 mRNA. Translation: BAG35945.1.
AL163302 Genomic DNA. Translation: CAB90483.1. Sequence problems.
BX322561 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09331.1.
BC003068 mRNA. Translation: AAH03068.1.
CCDSiCCDS13725.1. [P41440-1]
CCDS56217.1. [P41440-2]
CCDS56218.1. [P41440-3]
PIRiI38924.
I52728.
RefSeqiNP_001192135.1. NM_001205206.1. [P41440-3]
NP_001192136.1. NM_001205207.1. [P41440-2]
NP_919231.1. NM_194255.2. [P41440-1]
UniGeneiHs.736903.
Hs.84190.

Genome annotation databases

EnsembliENST00000311124; ENSP00000308895; ENSG00000173638. [P41440-1]
ENST00000380010; ENSP00000369347; ENSG00000173638. [P41440-3]
ENST00000485649; ENSP00000441772; ENSG00000173638. [P41440-2]
GeneIDi6573.
KEGGihsa:6573.
UCSCiuc002zhl.2. human. [P41440-1]
uc002zhm.2. human. [P41440-3]
uc011aft.2. human. [P41440-2]

Polymorphism databases

DMDMi12643280.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15939 mRNA. Translation: AAA98442.1 .
U19720 mRNA. Translation: AAC50180.1 .
S78996 mRNA. Translation: AAB35058.1 .
U17566 mRNA. Translation: AAA74914.1 .
U92873
, U92869 , U92870 , U92871 , U92872 Genomic DNA. Translation: AAC26162.1 .
AF004354 mRNA. Translation: AAB61417.1 .
AK303168 mRNA. Translation: BAH13909.1 .
AK313125 mRNA. Translation: BAG35945.1 .
AL163302 Genomic DNA. Translation: CAB90483.1 . Sequence problems.
BX322561 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09331.1 .
BC003068 mRNA. Translation: AAH03068.1 .
CCDSi CCDS13725.1. [P41440-1 ]
CCDS56217.1. [P41440-2 ]
CCDS56218.1. [P41440-3 ]
PIRi I38924.
I52728.
RefSeqi NP_001192135.1. NM_001205206.1. [P41440-3 ]
NP_001192136.1. NM_001205207.1. [P41440-2 ]
NP_919231.1. NM_194255.2. [P41440-1 ]
UniGenei Hs.736903.
Hs.84190.

3D structure databases

ProteinModelPortali P41440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112461. 2 interactions.
STRINGi 9606.ENSP00000308895.

Chemistry

BindingDBi P41440.
ChEMBLi CHEMBL4833.
DrugBanki DB00563. Methotrexate.
DB06813. Pralatrexate.
GuidetoPHARMACOLOGYi 1014.

Protein family/group databases

TCDBi 2.A.48.1.1. the reduced folate carrier (rfc) family.

PTM databases

PhosphoSitei P41440.

Polymorphism databases

DMDMi 12643280.

Proteomic databases

MaxQBi P41440.
PaxDbi P41440.
PRIDEi P41440.

Protocols and materials databases

DNASUi 6573.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311124 ; ENSP00000308895 ; ENSG00000173638 . [P41440-1 ]
ENST00000380010 ; ENSP00000369347 ; ENSG00000173638 . [P41440-3 ]
ENST00000485649 ; ENSP00000441772 ; ENSG00000173638 . [P41440-2 ]
GeneIDi 6573.
KEGGi hsa:6573.
UCSCi uc002zhl.2. human. [P41440-1 ]
uc002zhm.2. human. [P41440-3 ]
uc011aft.2. human. [P41440-2 ]

Organism-specific databases

CTDi 6573.
GeneCardsi GC21M046913.
HGNCi HGNC:10937. SLC19A1.
HPAi HPA024802.
MIMi 600424. gene.
neXtProti NX_P41440.
Orphaneti 306574. Methotrexate dose selection.
PharmGKBi PA327.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241030.
GeneTreei ENSGT00510000046382.
HOVERGENi HBG054198.
InParanoidi P41440.
KOi K14609.
OMAi FAYLAIM.
PhylomeDBi P41440.
TreeFami TF313684.

Enzyme and pathway databases

Reactomei REACT_11167. Metabolism of folate and pterines.

Miscellaneous databases

GeneWikii SLC19A1.
GenomeRNAii 6573.
NextBioi 25575.
PROi P41440.
SOURCEi Search...

Gene expression databases

Bgeei P41440.
CleanExi HS_FLOT1.
HS_RFC1.
HS_SLC19A1.
ExpressionAtlasi P41440. baseline and differential.
Genevestigatori P41440.

Family and domain databases

InterProi IPR002666. Folate_carrier.
IPR016196. MFS_dom_general_subst_transpt.
IPR028339. RFC.
[Graphical view ]
PANTHERi PTHR10686. PTHR10686. 1 hit.
Pfami PF01770. Folate_carrier. 1 hit.
[Graphical view ]
PIRSFi PIRSF028739. Folate_carrier. 1 hit.
PIRSF500793. Folate_transporter_1. 1 hit.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00806. rfc. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-27.
    Tissue: Placenta.
  2. Prasad P.D.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 490-527.
  3. "Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells."
    Wong S.C., Proefke A., Bhushan A., Matherly L.H.
    J. Biol. Chem. 270:17468-17475(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-27.
  4. "Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells."
    Moscow J.A., Gong M., He R., Sgagias M.K., Dixon K.H., Anzick S.L., Meltzer P.S., Cowan K.H.
    Cancer Res. 55:3790-3794(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-27.
    Tissue: Testis.
  5. "Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake."
    Williams F.M., Flintoff W.F.
    J. Biol. Chem. 270:2987-2992(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphoma.
  6. "Structural analysis of the human RFC1 gene encoding a folate transporter and alternatively spliced transcripts with 5' end heterogeneity."
    Tolner B.M., Roy K., Sirotnak F.M.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-27.
    Tissue: Liver.
  7. "Human intestinal folate transport: cloning, expression, and distribution of complementary RNA."
    Nguyen T.T., Dyer D.L., Dunning D.D., Rubin S.A., Grant K.E., Said H.M.
    Gastroenterology 112:783-791(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thymus and Tongue.
  9. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-27.
    Tissue: Brain.
  12. "Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion."
    Ferguson P.L., Flintoff W.F.
    J. Biol. Chem. 274:16269-16278(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499 AND SER-503, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS19A1_HUMAN
AccessioniPrimary (citable) accession number: P41440
Secondary accession number(s): B2R7U8
, B7Z8C3, E9PFY4, O00553, O60227, Q13026, Q9BTX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3