Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Folate receptor gamma

Gene

FOLR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011FolateBy similarity
Binding sitei105 – 1051FolateBy similarity
Binding sitei194 – 1941FolateBy similarity

GO - Molecular functioni

  • folic acid binding Source: ProtInc

GO - Biological processi

  • folic acid transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Folate-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Folate receptor gamma
Short name:
FR-gamma
Alternative name(s):
Folate receptor 3
Gene namesi
Name:FOLR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3795. FOLR3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • extrinsic component of membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28211.

Chemistry

DrugBankiDB00158. Folic Acid.

Polymorphism and mutation databases

BioMutaiFOLR3.
DMDMi1169723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 243220Folate receptor gammaPRO_0000008810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 63By similarity
Disulfide bondi55 ↔ 103By similarity
Disulfide bondi64 ↔ 107By similarity
Disulfide bondi87 ↔ 173By similarity
Disulfide bondi94 ↔ 144By similarity
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi133 ↔ 207By similarity
Disulfide bondi137 ↔ 187By similarity
Disulfide bondi150 ↔ 167By similarity
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP41439.
PRIDEiP41439.

PTM databases

iPTMnetiP41439.
PhosphoSiteiP41439.

Expressioni

Tissue specificityi

Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.

Gene expression databases

BgeeiENSG00000110203.
CleanExiHS_FOLR3.
ExpressionAtlasiP41439. baseline and differential.
GenevisibleiP41439. HS.

Interactioni

Protein-protein interaction databases

BioGridi108635. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP41439.
SMRiP41439. Positions 29-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 1265Folate bindingBy similarity
Regioni155 – 1606Folate bindingBy similarity

Sequence similaritiesi

Belongs to the folate receptor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000010470.
HOGENOMiHOG000006539.
HOVERGENiHBG039612.
InParanoidiP41439.
KOiK13649.
PhylomeDBiP41439.

Family and domain databases

InterProiIPR004269. Folate_rcpt.
IPR018143. Folate_rcpt-like.
IPR032934. FR-gamma.
[Graphical view]
PANTHERiPTHR10517. PTHR10517. 1 hit.
PTHR10517:SF17. PTHR10517:SF17. 1 hit.
PfamiPF03024. Folate_rec. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P41439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWQMMQLLL LALVTAAGSA QPRSARARTD LLNVCMNAKH HKTQPSPEDE
60 70 80 90 100
LYGQCSPWKK NACCTASTSQ ELHKDTSRLY NFNWDHCGKM EPTCKRHFIQ
110 120 130 140 150
DSCLYECSPN LGPWIRQVNQ SWRKERILNV PLCKEDCERW WEDCRTSYTC
160 170 180 190 200
KSNWHKGWNW TSGINECPAG ALCSTFESYF PTPAALCEGL WSHSFKVSNY
210 220 230 240
SRGSGRCIQM WFDSAQGNPN EEVAKFYAAA MNAGAPSRGI IDS
Length:243
Mass (Da):27,638
Last modified:November 1, 1995 - v1
Checksum:iAC7636EB5355647B
GO
Isoform Short (identifier: P41439-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-243: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:104
Mass (Da):11,827
Checksum:iCA8D27D01000D88F
GO
Isoform 3 (identifier: P41439-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-105: CSPWKKNACC...RHFIQDSCLY → VGAPQGPSPG...SATLSRTAVS

Note: No experimental confirmation available.Curated
Show »
Length:285
Mass (Da):30,899
Checksum:i66EBE907349206CA
GO

Sequence cautioni

The sequence AAH30285 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431T → I in AAH30285 (PubMed:15489334).Curated
Isoform 3 (identifier: P41439-3)
Sequence conflicti76 – 761E → V in AAH30285 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 10551CSPWK…DSCLY → VGAPQGPSPGSVPLDDLPGA EEPEYGGDGCGGERLSPVSS PPSAVPGRRMPAARPAPARS CTRTPPACTTLTGITVVRWN PPASATLSRTAVS in isoform 3. 1 PublicationVSP_055089Add
BLAST
Alternative sequencei105 – 243139Missing in isoform Short. CuratedVSP_001506Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32564 mRNA. Translation: CAA83553.1.
Z32633 mRNA. Translation: CAA83566.1.
U08471 mRNA. Translation: AAA18382.1.
U08470 mRNA. Translation: AAA18381.1.
AP000812 Genomic DNA. No translation available.
BC030285 mRNA. Translation: AAH30285.1. Different initiation.
PIRiA53506.
RefSeqiNP_000795.2. NM_000804.3.
NP_001304974.1. NM_001318045.1.
UniGeneiHs.352.

Genome annotation databases

EnsembliENST00000442948; ENSP00000411161; ENSG00000110203. [P41439-2]
GeneIDi2352.
KEGGihsa:2352.
UCSCiuc058ezu.1. human. [P41439-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32564 mRNA. Translation: CAA83553.1.
Z32633 mRNA. Translation: CAA83566.1.
U08471 mRNA. Translation: AAA18382.1.
U08470 mRNA. Translation: AAA18381.1.
AP000812 Genomic DNA. No translation available.
BC030285 mRNA. Translation: AAH30285.1. Different initiation.
PIRiA53506.
RefSeqiNP_000795.2. NM_000804.3.
NP_001304974.1. NM_001318045.1.
UniGeneiHs.352.

3D structure databases

ProteinModelPortaliP41439.
SMRiP41439. Positions 29-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108635. 1 interaction.

Chemistry

DrugBankiDB00158. Folic Acid.

PTM databases

iPTMnetiP41439.
PhosphoSiteiP41439.

Polymorphism and mutation databases

BioMutaiFOLR3.
DMDMi1169723.

Proteomic databases

PeptideAtlasiP41439.
PRIDEiP41439.

Protocols and materials databases

DNASUi2352.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442948; ENSP00000411161; ENSG00000110203. [P41439-2]
GeneIDi2352.
KEGGihsa:2352.
UCSCiuc058ezu.1. human. [P41439-1]

Organism-specific databases

CTDi2352.
GeneCardsiFOLR3.
H-InvDBHIX0035971.
HGNCiHGNC:3795. FOLR3.
MIMi602469. gene.
neXtProtiNX_P41439.
PharmGKBiPA28211.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000010470.
HOGENOMiHOG000006539.
HOVERGENiHBG039612.
InParanoidiP41439.
KOiK13649.
PhylomeDBiP41439.

Miscellaneous databases

GenomeRNAii2352.
PROiP41439.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110203.
CleanExiHS_FOLR3.
ExpressionAtlasiP41439. baseline and differential.
GenevisibleiP41439. HS.

Family and domain databases

InterProiIPR004269. Folate_rcpt.
IPR018143. Folate_rcpt-like.
IPR032934. FR-gamma.
[Graphical view]
PANTHERiPTHR10517. PTHR10517. 1 hit.
PTHR10517:SF17. PTHR10517:SF17. 1 hit.
PfamiPF03024. Folate_rec. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOLR3_HUMAN
AccessioniPrimary (citable) accession number: P41439
Secondary accession number(s): J3KQ90, Q05C14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.