##gff-version 3
P41438	UniProtKB	Chain	1	512	.	.	.	ID=PRO_0000178661;Note=Reduced folate transporter	
P41438	UniProtKB	Topological domain	1	27	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	28	48	.	.	.	Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	49	64	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	65	85	.	.	.	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	86	91	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	92	112	.	.	.	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	113	121	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	122	142	.	.	.	Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	143	155	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	156	176	.	.	.	Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	177	180	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	181	201	.	.	.	Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	202	271	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	272	292	.	.	.	Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	293	304	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	305	325	.	.	.	Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	326	329	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	330	350	.	.	.	Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	351	354	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	355	375	.	.	.	Note=Helical%3B Name%3D10;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	376	390	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	391	411	.	.	.	Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	412	426	.	.	.	Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Transmembrane	427	447	.	.	.	Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P41438	UniProtKB	Topological domain	448	512	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Region	400	412	.	.	.	Note=Required for substrate-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Region	478	512	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41438	UniProtKB	Compositional bias	496	512	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P41438	UniProtKB	Modified residue	1	1	.	.	.	Note=N-acetylmethionine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P41440	
P41438	UniProtKB	Modified residue	467	467	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19144319;Dbxref=PMID:19144319	
P41438	UniProtKB	Modified residue	472	472	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
P41438	UniProtKB	Modified residue	477	477	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19144319,ECO:0007744|PubMed:21183079;Dbxref=PMID:19144319,PMID:21183079	
P41438	UniProtKB	Alternative sequence	273	313	.	.	.	ID=VSP_006125;Note=In isoform 2. WWVFNSSGYYLITYYVHVLWRSTDSSLSYNGAVDAASTLLS->C;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9161403;Dbxref=PMID:9161403	
P41438	UniProtKB	Alternative sequence	378	379	.	.	.	ID=VSP_006126;Note=In isoform 3. FQ->PS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9161403;Dbxref=PMID:9161403	
P41438	UniProtKB	Alternative sequence	380	512	.	.	.	ID=VSP_006127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9161403;Dbxref=PMID:9161403	
P41438	UniProtKB	Mutagenesis	48	48	.	.	.	Note=Induces resistance to 5%2C10-dideazatetrahydrofolate%3B when associated with G-105. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9748272;Dbxref=PMID:9748272	
P41438	UniProtKB	Mutagenesis	105	105	.	.	.	Note=Induces resistance to 5%2C10-dideazatetrahydrofolate%3B when associated with F-48. W->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9748272;Dbxref=PMID:9748272