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P41438

- S19A1_MOUSE

UniProt

P41438 - S19A1_MOUSE

Protein

Folate transporter 1

Gene

Slc19a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Transporter for the intake of folate, reduced folates and methotrexate.

    GO - Molecular functioni

    1. folic acid binding Source: UniProtKB-KW
    2. folic acid transporter activity Source: InterPro
    3. methotrexate transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Folate-binding

    Enzyme and pathway databases

    ReactomeiREACT_220137. Metabolism of folate and pterines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Folate transporter 1
    Alternative name(s):
    Intestinal folate carrier 1
    Short name:
    IFC-1
    Reduced folate carrier 1
    Short name:
    RFC-1
    Short name:
    RFC1
    Solute carrier family 19 member 1
    Gene namesi
    Name:Slc19a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:103182. Slc19a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Folate transporter 1PRO_0000178661Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
    Modified residuei467 – 4671Phosphoserine1 Publication
    Modified residuei477 – 4771Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP41438.

    PTM databases

    PhosphoSiteiP41438.

    Expressioni

    Gene expression databases

    ArrayExpressiP41438.
    BgeeiP41438.
    GenevestigatoriP41438.

    Structurei

    3D structure databases

    ProteinModelPortaliP41438.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei427 – 44721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241030.
    HOGENOMiHOG000001583.
    HOVERGENiHBG054198.
    InParanoidiP41438.
    KOiK14609.
    PhylomeDBiP41438.
    TreeFamiTF313684.

    Family and domain databases

    InterProiIPR002666. Folate_carrier.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR028339. RFC.
    [Graphical view]
    PANTHERiPTHR10686. PTHR10686. 1 hit.
    PfamiPF01770. Folate_carrier. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028739. Folate_carrier. 1 hit.
    PIRSF500793. Folate_transporter_1. 1 hit.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00806. rfc. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P41438-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPTGQVAEK QAYEEPRQDH ELKSWRCLVF YLCFFGFMAQ LRPGESFITP    50
    FLLERKFTKE QVTNEIIPML PYSHLAVLVP VFLLTDYLRY KPVLVLQCLS 100
    FVCVWLLLLL GTSVVHMQLM EVFYSVTMAA RIAYSSYIFS LVHPSRYQRM 150
    ASYSRAAVLL GVFISSVLGQ ALVTVGHIST YTLNCVSLGF ILFSLVLSLF 200
    LKRPKRSLFF NRSTLARGAL PCELDQMHPG PDRPETRKLD RMLGTCRDSF 250
    LVRMLSELVE NARQPQLRLW CLWWVFNSSG YYLITYYVHV LWRSTDSSLS 300
    YNGAVDAAST LLSAITSFSA GFLSIRWTLW SKLVIAGVIA IQASLVFCMF 350
    QIRDIWVCYV TFVLFRGAYQ FLVPIATFQI ASSLSKELCA LVFGINTFLA 400
    TALKTCITLV VSDKRGLGLQ VRDQFRIYFI YFLMLSITCF AWAGLDGLRY 450
    CQRGRHQPLA QAQELRSPLE TSVQAISLQD GDLRGPQPSA PQLLSEDGME 500
    DDRGDLRVEA KA 512
    Length:512
    Mass (Da):58,150
    Last modified:November 1, 1995 - v1
    Checksum:i640CB7AD2624BF67
    GO
    Isoform 2 (identifier: P41438-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         273-313: WWVFNSSGYYLITYYVHVLWRSTDSSLSYNGAVDAASTLLS → C

    Show »
    Length:472
    Mass (Da):53,577
    Checksum:i4BBD933AD971CE1D
    GO
    Isoform 3 (identifier: P41438-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         378-379: FQ → PS
         380-512: Missing.

    Show »
    Length:379
    Mass (Da):43,371
    Checksum:i898147C34EB427B5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei273 – 31341WWVFN…STLLS → C in isoform 2. 1 PublicationVSP_006125Add
    BLAST
    Alternative sequencei378 – 3792FQ → PS in isoform 3. 1 PublicationVSP_006126
    Alternative sequencei380 – 512133Missing in isoform 3. 1 PublicationVSP_006127Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36539 mRNA. Translation: AAB38483.1.
    L23755 mRNA. Translation: AAA39738.1.
    U32469 mRNA. Translation: AAC52258.1.
    U66103 mRNA. Translation: AAC53287.1.
    U57784
    , U57781, U57782, U57783 Genomic DNA. Translation: AAC53288.1.
    U57785
    , U57781, U57782, U57783 Genomic DNA. Translation: AAC53289.1.
    U57785
    , U57781, U57782, U57783, U57784 Genomic DNA. Translation: AAC53290.1.
    U57785
    , U57781, U57782, U57783 Genomic DNA. Translation: AAC53291.1.
    BC015263 mRNA. Translation: AAH15263.1.
    CCDSiCCDS35947.1. [P41438-1]
    PIRiA53092.
    RefSeqiNP_001186200.1. NM_001199271.1. [P41438-1]
    NP_112473.1. NM_031196.3. [P41438-1]
    XP_006513477.1. XM_006513414.1. [P41438-1]
    XP_006513478.1. XM_006513415.1. [P41438-1]
    XP_006513479.1. XM_006513416.1. [P41438-1]
    XP_006513480.1. XM_006513417.1. [P41438-1]
    XP_006513481.1. XM_006513418.1. [P41438-3]
    UniGeneiMm.265060.

    Genome annotation databases

    EnsembliENSMUST00000105410; ENSMUSP00000101050; ENSMUSG00000001436. [P41438-1]
    ENSMUST00000144234; ENSMUSP00000116784; ENSMUSG00000001436. [P41438-1]
    GeneIDi20509.
    KEGGimmu:20509.
    UCSCiuc007fvc.2. mouse. [P41438-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36539 mRNA. Translation: AAB38483.1 .
    L23755 mRNA. Translation: AAA39738.1 .
    U32469 mRNA. Translation: AAC52258.1 .
    U66103 mRNA. Translation: AAC53287.1 .
    U57784
    , U57781 , U57782 , U57783 Genomic DNA. Translation: AAC53288.1 .
    U57785
    , U57781 , U57782 , U57783 Genomic DNA. Translation: AAC53289.1 .
    U57785
    , U57781 , U57782 , U57783 , U57784 Genomic DNA. Translation: AAC53290.1 .
    U57785
    , U57781 , U57782 , U57783 Genomic DNA. Translation: AAC53291.1 .
    BC015263 mRNA. Translation: AAH15263.1 .
    CCDSi CCDS35947.1. [P41438-1 ]
    PIRi A53092.
    RefSeqi NP_001186200.1. NM_001199271.1. [P41438-1 ]
    NP_112473.1. NM_031196.3. [P41438-1 ]
    XP_006513477.1. XM_006513414.1. [P41438-1 ]
    XP_006513478.1. XM_006513415.1. [P41438-1 ]
    XP_006513479.1. XM_006513416.1. [P41438-1 ]
    XP_006513480.1. XM_006513417.1. [P41438-1 ]
    XP_006513481.1. XM_006513418.1. [P41438-3 ]
    UniGenei Mm.265060.

    3D structure databases

    ProteinModelPortali P41438.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P41438.

    Proteomic databases

    PRIDEi P41438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105410 ; ENSMUSP00000101050 ; ENSMUSG00000001436 . [P41438-1 ]
    ENSMUST00000144234 ; ENSMUSP00000116784 ; ENSMUSG00000001436 . [P41438-1 ]
    GeneIDi 20509.
    KEGGi mmu:20509.
    UCSCi uc007fvc.2. mouse. [P41438-1 ]

    Organism-specific databases

    CTDi 6573.
    MGIi MGI:103182. Slc19a1.

    Phylogenomic databases

    eggNOGi NOG241030.
    HOGENOMi HOG000001583.
    HOVERGENi HBG054198.
    InParanoidi P41438.
    KOi K14609.
    PhylomeDBi P41438.
    TreeFami TF313684.

    Enzyme and pathway databases

    Reactomei REACT_220137. Metabolism of folate and pterines.

    Miscellaneous databases

    NextBioi 298695.
    PROi P41438.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41438.
    Bgeei P41438.
    Genevestigatori P41438.

    Family and domain databases

    InterProi IPR002666. Folate_carrier.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR028339. RFC.
    [Graphical view ]
    PANTHERi PTHR10686. PTHR10686. 1 hit.
    Pfami PF01770. Folate_carrier. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028739. Folate_carrier. 1 hit.
    PIRSF500793. Folate_transporter_1. 1 hit.
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00806. rfc. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells."
      Dixon K.H., Lanpher B.C., Chiu J., Kelly K., Cowan K.H.
      J. Biol. Chem. 269:17-20(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA.
    2. "Intestinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA."
      Said H.M., Nguyen T.T., Dyer D.L., Cowan K.H., Rubin S.A.
      Biochim. Biophys. Acta 1281:164-172(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
      Tissue: Intestine.
    3. "Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line."
      Brigle K.E., Spinella M.J., Sierra E.E., Goldman I.D.
      J. Biol. Chem. 270:22974-22979(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
    4. "Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter."
      Tolner B.M., Roy K., Sirotnak F.M.
      Gene 189:1-7(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Kidney.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467 AND SER-477, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS19A1_MOUSE
    AccessioniPrimary (citable) accession number: P41438
    Secondary accession number(s): Q62450, Q62451
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3