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Protein

Folate transporter 1

Gene

Slc19a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transporter for the intake of folate, reduced folates and methotrexate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Folate-binding

Enzyme and pathway databases

ReactomeiR-MMU-196757. Metabolism of folate and pterines.

Names & Taxonomyi

Protein namesi
Recommended name:
Folate transporter 1
Alternative name(s):
Intestinal folate carrier 1
Short name:
IFC-1
Reduced folate carrier 1
Short name:
RFC-1
Short name:
RFC1
Solute carrier family 19 member 1
Gene namesi
Name:Slc19a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103182. Slc19a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001786611 – 512Folate transporter 1Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1
Modified residuei467PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP41438.
PeptideAtlasiP41438.
PRIDEiP41438.

PTM databases

iPTMnetiP41438.
PhosphoSitePlusiP41438.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001436.
ExpressionAtlasiP41438. baseline and differential.
GenevisibleiP41438. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101050.

Structurei

3D structure databases

ProteinModelPortaliP41438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3810. Eukaryota.
ENOG410XT34. LUCA.
GeneTreeiENSGT00510000046382.
HOGENOMiHOG000001583.
HOVERGENiHBG054198.
InParanoidiP41438.
KOiK14609.
OrthoDBiEOG091G0BSJ.
PhylomeDBiP41438.
TreeFamiTF313684.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002666. Folate_carrier.
IPR020846. MFS_dom.
IPR028339. RFC.
[Graphical view]
PANTHERiPTHR10686. PTHR10686. 1 hit.
PTHR10686:SF12. PTHR10686:SF12. 1 hit.
PfamiPF01770. Folate_carrier. 1 hit.
[Graphical view]
PIRSFiPIRSF028739. Folate_carrier. 1 hit.
PIRSF500793. Folate_transporter_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00806. rfc. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41438-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPTGQVAEK QAYEEPRQDH ELKSWRCLVF YLCFFGFMAQ LRPGESFITP
60 70 80 90 100
FLLERKFTKE QVTNEIIPML PYSHLAVLVP VFLLTDYLRY KPVLVLQCLS
110 120 130 140 150
FVCVWLLLLL GTSVVHMQLM EVFYSVTMAA RIAYSSYIFS LVHPSRYQRM
160 170 180 190 200
ASYSRAAVLL GVFISSVLGQ ALVTVGHIST YTLNCVSLGF ILFSLVLSLF
210 220 230 240 250
LKRPKRSLFF NRSTLARGAL PCELDQMHPG PDRPETRKLD RMLGTCRDSF
260 270 280 290 300
LVRMLSELVE NARQPQLRLW CLWWVFNSSG YYLITYYVHV LWRSTDSSLS
310 320 330 340 350
YNGAVDAAST LLSAITSFSA GFLSIRWTLW SKLVIAGVIA IQASLVFCMF
360 370 380 390 400
QIRDIWVCYV TFVLFRGAYQ FLVPIATFQI ASSLSKELCA LVFGINTFLA
410 420 430 440 450
TALKTCITLV VSDKRGLGLQ VRDQFRIYFI YFLMLSITCF AWAGLDGLRY
460 470 480 490 500
CQRGRHQPLA QAQELRSPLE TSVQAISLQD GDLRGPQPSA PQLLSEDGME
510
DDRGDLRVEA KA
Length:512
Mass (Da):58,150
Last modified:November 1, 1995 - v1
Checksum:i640CB7AD2624BF67
GO
Isoform 2 (identifier: P41438-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-313: WWVFNSSGYYLITYYVHVLWRSTDSSLSYNGAVDAASTLLS → C

Show »
Length:472
Mass (Da):53,577
Checksum:i4BBD933AD971CE1D
GO
Isoform 3 (identifier: P41438-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-379: FQ → PS
     380-512: Missing.

Show »
Length:379
Mass (Da):43,371
Checksum:i898147C34EB427B5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006125273 – 313WWVFN…STLLS → C in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_006126378 – 379FQ → PS in isoform 3. 1 Publication2
Alternative sequenceiVSP_006127380 – 512Missing in isoform 3. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36539 mRNA. Translation: AAB38483.1.
L23755 mRNA. Translation: AAA39738.1.
U32469 mRNA. Translation: AAC52258.1.
U66103 mRNA. Translation: AAC53287.1.
U57784
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53288.1.
U57785
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53289.1.
U57785
, U57781, U57782, U57783, U57784 Genomic DNA. Translation: AAC53290.1.
U57785
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53291.1.
BC015263 mRNA. Translation: AAH15263.1.
CCDSiCCDS35947.1. [P41438-1]
PIRiA53092.
RefSeqiNP_001186200.1. NM_001199271.1. [P41438-1]
NP_112473.1. NM_031196.3. [P41438-1]
XP_006513477.1. XM_006513414.3. [P41438-1]
XP_006513478.1. XM_006513415.3. [P41438-1]
XP_006513479.1. XM_006513416.2. [P41438-1]
XP_006513480.1. XM_006513417.2. [P41438-1]
XP_006513481.1. XM_006513418.3. [P41438-3]
UniGeneiMm.265060.

Genome annotation databases

EnsembliENSMUST00000105410; ENSMUSP00000101050; ENSMUSG00000001436. [P41438-1]
ENSMUST00000144234; ENSMUSP00000116784; ENSMUSG00000001436. [P41438-1]
GeneIDi20509.
KEGGimmu:20509.
UCSCiuc007fvc.2. mouse. [P41438-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36539 mRNA. Translation: AAB38483.1.
L23755 mRNA. Translation: AAA39738.1.
U32469 mRNA. Translation: AAC52258.1.
U66103 mRNA. Translation: AAC53287.1.
U57784
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53288.1.
U57785
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53289.1.
U57785
, U57781, U57782, U57783, U57784 Genomic DNA. Translation: AAC53290.1.
U57785
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53291.1.
BC015263 mRNA. Translation: AAH15263.1.
CCDSiCCDS35947.1. [P41438-1]
PIRiA53092.
RefSeqiNP_001186200.1. NM_001199271.1. [P41438-1]
NP_112473.1. NM_031196.3. [P41438-1]
XP_006513477.1. XM_006513414.3. [P41438-1]
XP_006513478.1. XM_006513415.3. [P41438-1]
XP_006513479.1. XM_006513416.2. [P41438-1]
XP_006513480.1. XM_006513417.2. [P41438-1]
XP_006513481.1. XM_006513418.3. [P41438-3]
UniGeneiMm.265060.

3D structure databases

ProteinModelPortaliP41438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101050.

PTM databases

iPTMnetiP41438.
PhosphoSitePlusiP41438.

Proteomic databases

PaxDbiP41438.
PeptideAtlasiP41438.
PRIDEiP41438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105410; ENSMUSP00000101050; ENSMUSG00000001436. [P41438-1]
ENSMUST00000144234; ENSMUSP00000116784; ENSMUSG00000001436. [P41438-1]
GeneIDi20509.
KEGGimmu:20509.
UCSCiuc007fvc.2. mouse. [P41438-1]

Organism-specific databases

CTDi6573.
MGIiMGI:103182. Slc19a1.

Phylogenomic databases

eggNOGiKOG3810. Eukaryota.
ENOG410XT34. LUCA.
GeneTreeiENSGT00510000046382.
HOGENOMiHOG000001583.
HOVERGENiHBG054198.
InParanoidiP41438.
KOiK14609.
OrthoDBiEOG091G0BSJ.
PhylomeDBiP41438.
TreeFamiTF313684.

Enzyme and pathway databases

ReactomeiR-MMU-196757. Metabolism of folate and pterines.

Miscellaneous databases

PROiP41438.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001436.
ExpressionAtlasiP41438. baseline and differential.
GenevisibleiP41438. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002666. Folate_carrier.
IPR020846. MFS_dom.
IPR028339. RFC.
[Graphical view]
PANTHERiPTHR10686. PTHR10686. 1 hit.
PTHR10686:SF12. PTHR10686:SF12. 1 hit.
PfamiPF01770. Folate_carrier. 1 hit.
[Graphical view]
PIRSFiPIRSF028739. Folate_carrier. 1 hit.
PIRSF500793. Folate_transporter_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00806. rfc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS19A1_MOUSE
AccessioniPrimary (citable) accession number: P41438
Secondary accession number(s): Q62450, Q62451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.