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P41438

- S19A1_MOUSE

UniProt

P41438 - S19A1_MOUSE

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Protein

Folate transporter 1

Gene

Slc19a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transporter for the intake of folate, reduced folates and methotrexate.

GO - Molecular functioni

  1. folic acid binding Source: UniProtKB-KW
  2. folic acid transporter activity Source: InterPro
  3. methotrexate transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Folate-binding

Enzyme and pathway databases

ReactomeiREACT_220137. Metabolism of folate and pterines.

Names & Taxonomyi

Protein namesi
Recommended name:
Folate transporter 1
Alternative name(s):
Intestinal folate carrier 1
Short name:
IFC-1
Reduced folate carrier 1
Short name:
RFC-1
Short name:
RFC1
Solute carrier family 19 member 1
Gene namesi
Name:Slc19a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:103182. Slc19a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence AnalysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence AnalysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Folate transporter 1PRO_0000178661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
Modified residuei467 – 4671Phosphoserine1 Publication
Modified residuei477 – 4771Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP41438.
PRIDEiP41438.

PTM databases

PhosphoSiteiP41438.

Expressioni

Gene expression databases

BgeeiP41438.
ExpressionAtlasiP41438. baseline and differential.
GenevestigatoriP41438.

Structurei

3D structure databases

ProteinModelPortaliP41438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241030.
HOGENOMiHOG000001583.
HOVERGENiHBG054198.
InParanoidiP41438.
KOiK14609.
PhylomeDBiP41438.
TreeFamiTF313684.

Family and domain databases

InterProiIPR002666. Folate_carrier.
IPR016196. MFS_dom_general_subst_transpt.
IPR028339. RFC.
[Graphical view]
PANTHERiPTHR10686. PTHR10686. 1 hit.
PfamiPF01770. Folate_carrier. 1 hit.
[Graphical view]
PIRSFiPIRSF028739. Folate_carrier. 1 hit.
PIRSF500793. Folate_transporter_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00806. rfc. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P41438-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPTGQVAEK QAYEEPRQDH ELKSWRCLVF YLCFFGFMAQ LRPGESFITP
60 70 80 90 100
FLLERKFTKE QVTNEIIPML PYSHLAVLVP VFLLTDYLRY KPVLVLQCLS
110 120 130 140 150
FVCVWLLLLL GTSVVHMQLM EVFYSVTMAA RIAYSSYIFS LVHPSRYQRM
160 170 180 190 200
ASYSRAAVLL GVFISSVLGQ ALVTVGHIST YTLNCVSLGF ILFSLVLSLF
210 220 230 240 250
LKRPKRSLFF NRSTLARGAL PCELDQMHPG PDRPETRKLD RMLGTCRDSF
260 270 280 290 300
LVRMLSELVE NARQPQLRLW CLWWVFNSSG YYLITYYVHV LWRSTDSSLS
310 320 330 340 350
YNGAVDAAST LLSAITSFSA GFLSIRWTLW SKLVIAGVIA IQASLVFCMF
360 370 380 390 400
QIRDIWVCYV TFVLFRGAYQ FLVPIATFQI ASSLSKELCA LVFGINTFLA
410 420 430 440 450
TALKTCITLV VSDKRGLGLQ VRDQFRIYFI YFLMLSITCF AWAGLDGLRY
460 470 480 490 500
CQRGRHQPLA QAQELRSPLE TSVQAISLQD GDLRGPQPSA PQLLSEDGME
510
DDRGDLRVEA KA
Length:512
Mass (Da):58,150
Last modified:November 1, 1995 - v1
Checksum:i640CB7AD2624BF67
GO
Isoform 2 (identifier: P41438-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-313: WWVFNSSGYYLITYYVHVLWRSTDSSLSYNGAVDAASTLLS → C

Show »
Length:472
Mass (Da):53,577
Checksum:i4BBD933AD971CE1D
GO
Isoform 3 (identifier: P41438-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-379: FQ → PS
     380-512: Missing.

Show »
Length:379
Mass (Da):43,371
Checksum:i898147C34EB427B5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei273 – 31341WWVFN…STLLS → C in isoform 2. 1 PublicationVSP_006125Add
BLAST
Alternative sequencei378 – 3792FQ → PS in isoform 3. 1 PublicationVSP_006126
Alternative sequencei380 – 512133Missing in isoform 3. 1 PublicationVSP_006127Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36539 mRNA. Translation: AAB38483.1.
L23755 mRNA. Translation: AAA39738.1.
U32469 mRNA. Translation: AAC52258.1.
U66103 mRNA. Translation: AAC53287.1.
U57784
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53288.1.
U57785
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53289.1.
U57785
, U57781, U57782, U57783, U57784 Genomic DNA. Translation: AAC53290.1.
U57785
, U57781, U57782, U57783 Genomic DNA. Translation: AAC53291.1.
BC015263 mRNA. Translation: AAH15263.1.
CCDSiCCDS35947.1. [P41438-1]
PIRiA53092.
RefSeqiNP_001186200.1. NM_001199271.1. [P41438-1]
NP_112473.1. NM_031196.3. [P41438-1]
XP_006513477.1. XM_006513414.1. [P41438-1]
XP_006513478.1. XM_006513415.1. [P41438-1]
XP_006513479.1. XM_006513416.1. [P41438-1]
XP_006513480.1. XM_006513417.1. [P41438-1]
XP_006513481.1. XM_006513418.1. [P41438-3]
UniGeneiMm.265060.

Genome annotation databases

EnsembliENSMUST00000105410; ENSMUSP00000101050; ENSMUSG00000001436. [P41438-1]
ENSMUST00000144234; ENSMUSP00000116784; ENSMUSG00000001436. [P41438-1]
GeneIDi20509.
KEGGimmu:20509.
UCSCiuc007fvc.2. mouse. [P41438-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36539 mRNA. Translation: AAB38483.1 .
L23755 mRNA. Translation: AAA39738.1 .
U32469 mRNA. Translation: AAC52258.1 .
U66103 mRNA. Translation: AAC53287.1 .
U57784
, U57781 , U57782 , U57783 Genomic DNA. Translation: AAC53288.1 .
U57785
, U57781 , U57782 , U57783 Genomic DNA. Translation: AAC53289.1 .
U57785
, U57781 , U57782 , U57783 , U57784 Genomic DNA. Translation: AAC53290.1 .
U57785
, U57781 , U57782 , U57783 Genomic DNA. Translation: AAC53291.1 .
BC015263 mRNA. Translation: AAH15263.1 .
CCDSi CCDS35947.1. [P41438-1 ]
PIRi A53092.
RefSeqi NP_001186200.1. NM_001199271.1. [P41438-1 ]
NP_112473.1. NM_031196.3. [P41438-1 ]
XP_006513477.1. XM_006513414.1. [P41438-1 ]
XP_006513478.1. XM_006513415.1. [P41438-1 ]
XP_006513479.1. XM_006513416.1. [P41438-1 ]
XP_006513480.1. XM_006513417.1. [P41438-1 ]
XP_006513481.1. XM_006513418.1. [P41438-3 ]
UniGenei Mm.265060.

3D structure databases

ProteinModelPortali P41438.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P41438.

Proteomic databases

MaxQBi P41438.
PRIDEi P41438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105410 ; ENSMUSP00000101050 ; ENSMUSG00000001436 . [P41438-1 ]
ENSMUST00000144234 ; ENSMUSP00000116784 ; ENSMUSG00000001436 . [P41438-1 ]
GeneIDi 20509.
KEGGi mmu:20509.
UCSCi uc007fvc.2. mouse. [P41438-1 ]

Organism-specific databases

CTDi 6573.
MGIi MGI:103182. Slc19a1.

Phylogenomic databases

eggNOGi NOG241030.
HOGENOMi HOG000001583.
HOVERGENi HBG054198.
InParanoidi P41438.
KOi K14609.
PhylomeDBi P41438.
TreeFami TF313684.

Enzyme and pathway databases

Reactomei REACT_220137. Metabolism of folate and pterines.

Miscellaneous databases

NextBioi 298695.
PROi P41438.
SOURCEi Search...

Gene expression databases

Bgeei P41438.
ExpressionAtlasi P41438. baseline and differential.
Genevestigatori P41438.

Family and domain databases

InterProi IPR002666. Folate_carrier.
IPR016196. MFS_dom_general_subst_transpt.
IPR028339. RFC.
[Graphical view ]
PANTHERi PTHR10686. PTHR10686. 1 hit.
Pfami PF01770. Folate_carrier. 1 hit.
[Graphical view ]
PIRSFi PIRSF028739. Folate_carrier. 1 hit.
PIRSF500793. Folate_transporter_1. 1 hit.
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00806. rfc. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells."
    Dixon K.H., Lanpher B.C., Chiu J., Kelly K., Cowan K.H.
    J. Biol. Chem. 269:17-20(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA.
  2. "Intestinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA."
    Said H.M., Nguyen T.T., Dyer D.L., Cowan K.H., Rubin S.A.
    Biochim. Biophys. Acta 1281:164-172(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
    Tissue: Intestine.
  3. "Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line."
    Brigle K.E., Spinella M.J., Sierra E.E., Goldman I.D.
    J. Biol. Chem. 270:22974-22979(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
  4. "Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter."
    Tolner B.M., Roy K., Sirotnak F.M.
    Gene 189:1-7(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Kidney.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467 AND SER-477, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS19A1_MOUSE
AccessioniPrimary (citable) accession number: P41438
Secondary accession number(s): Q62450, Q62451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3