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P41412 (RES2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division cycle-related protein res2/pct1
Gene names
Name:res2
Synonyms:pct1
ORF Names:SPAC22F3.09c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the initiation of mitotic and premeiotic DNA synthesis. Has an additional role in meiotic division.

Subunit structure

Interacts with cdc10 and cdk9. Ref.4

Induction

During conjugation and nitrogen starvation.

Sequence similarities

Contains 2 ANK repeats.

Contains 1 HTH APSES-type DNA-binding domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

cig2P366303EBI-1149177,EBI-1149212
res1P335202EBI-1149177,EBI-1149288

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 657657Cell division cycle-related protein res2/pct1
PRO_0000067073

Regions

Domain8 – 115108HTH APSES-type
Repeat247 – 27630ANK 1
Repeat368 – 39730ANK 2
DNA binding39 – 6022H-T-H motif By similarity

Experimental info

Sequence conflict4821A → R in CAA83678. Ref.2
Sequence conflict4821A → R in AAB32253. Ref.2
Sequence conflict639 – 6413Missing in AAB32253. Ref.2
Sequence conflict6571K → DLEK in AAB32253. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P41412 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 1159312B63E475E4

FASTA65773,702
        10         20         30         40         50         60 
MAPRSSAVHV AVYSGVEVYE CFIKGVSVMR RRRDSWLNAT QILKVADFDK PQRTRVLERQ 

        70         80         90        100        110        120 
VQIGAHEKVQ GGYGKYQGTW VPFQRGVDLA TKYKVDGIMS PILSLDIDEG KAIAPKKKQT 

       130        140        150        160        170        180 
KQKKPSVRGR RGRKPSSLSS STLHSVNEKQ PNSSISPTIE SSMNKVNLPG AEEQVSATPL 

       190        200        210        220        230        240 
PASPNALLSP NDNTIKPVEE LGMLEAPLDK YEESLLDFFL HPEEGRIPSF LYSPPPDFQV 

       250        260        270        280        290        300 
NSVIDDDGHT SLHWACSMGH IEMIKLLLRA NADIGVCNRL SQTPLMRSVI FTNNYDCQTF 

       310        320        330        340        350        360 
GQVLELLQST IYAVDTNGQS IFHHIVQSTS TPSKVAAAKY YLDCILEKLI SIQPFENVVR 

       370        380        390        400        410        420 
LVNLQDSNGD TSLLIAARNG AMDCVNSLLS YNANPSIPNR QRRTASEYLL EADKKPHSLL 

       430        440        450        460        470        480 
QSNSNASHSA FSFSGISPAI ISPSCSSHAF VKAIPSISSK FSQLAEEYES QLREKEEDLI 

       490        500        510        520        530        540 
RANRLKQDTL NEISRTYQEL TFLQKNNPTY SQSMENLIRE AQETYQQLSK RLLIWLEARQ 

       550        560        570        580        590        600 
IFDLERSLKP HTSLSISFPS DFLKKEDGLS LNNDFKKPAC NNVTNSDEYE QLINKLTSLQ 

       610        620        630        640        650 
ASRKKDTLYI RKLYEELGID DTVNSYRRLI AMSCGINPED LSLEILDAVE EALTREK

« Hide

References

« Hide 'large scale' references
[1]"res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast."
Miyamoto M., Tanaka K., Okayama H.
EMBO J. 13:1873-1880(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 38364 / 968.
[2]"pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for meiosis in the fission yeast Schizosaccharomyces pombe."
Zhu Y., Takeda T., Nasmyth K., Jones N.
Genes Dev. 8:885-898(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[4]"Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control."
Pei Y., Schwer B., Shuman S.
J. Biol. Chem. 278:7180-7188(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CDK9.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D17761 Genomic DNA. Translation: BAA04608.1.
Z32838 mRNA. Translation: CAA83678.1.
S73870 mRNA. Translation: AAB32253.1.
CU329670 Genomic DNA. Translation: CAA91074.1.
PIRA54278.
RefSeqNP_593032.1. NM_001018431.2.

3D structure databases

ProteinModelPortalP41412.
SMRP41412. Positions 8-104.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-35569N.
IntActP41412. 3 interactions.
STRING4896.SPAC22F3.09c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC22F3.09c.1; SPAC22F3.09c.1:pep; SPAC22F3.09c.
GeneID2541871.
KEGGspo:SPAC22F3.09c.

Organism-specific databases

PomBaseSPAC22F3.09c.

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000138334.
KOK06867.
OMAKPQRTRV.
OrthoDBEOG4PRWZZ.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PfamPF00023. Ank. 2 hits.
PF04383. KilA-N. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMSSF48403. ANK. 1 hit.
SSF54616. Mlu1-box-bd_prot_DNA-bd. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS51299. HTH_APSES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802958.

Entry information

Entry nameRES2_SCHPO
AccessionPrimary (citable) accession number: P41412
Secondary accession number(s): Q02300
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents