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P41412

- RES2_SCHPO

UniProt

P41412 - RES2_SCHPO

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Protein

Cell division cycle-related protein res2/pct1

Gene

res2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for the initiation of mitotic and premeiotic DNA synthesis. Has an additional role in meiotic division.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi39 – 6022H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: PomBase
  2. DNA binding Source: UniProtKB-KW
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: PomBase

GO - Biological processi

  1. meiotic nuclear division Source: UniProtKB-KW
  2. positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  3. positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  4. regulation of meiotic cell cycle Source: PomBase
  5. regulation of transcription, DNA-templated Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Meiosis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-related protein res2/pct1
Gene namesi
Name:res2
Synonyms:pct1
ORF Names:SPAC22F3.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC22F3.09c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. MBF transcription complex Source: PomBase
  4. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Cell division cycle-related protein res2/pct1PRO_0000067073Add
BLAST

Proteomic databases

MaxQBiP41412.

Expressioni

Inductioni

During conjugation and nitrogen starvation.

Interactioni

Subunit structurei

Interacts with cdc10 and cdk9.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cdc10P011293EBI-1149177,EBI-1009350
cig2P366303EBI-1149177,EBI-1149212
res1P335202EBI-1149177,EBI-1149288

Protein-protein interaction databases

BioGridi278361. 196 interactions.
DIPiDIP-35569N.
IntActiP41412. 3 interactions.
MINTiMINT-730815.
STRINGi4896.SPAC22F3.09c-1.

Structurei

3D structure databases

ProteinModelPortaliP41412.
SMRiP41412. Positions 8-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 115108HTH APSES-typePROSITE-ProRule annotationAdd
BLAST
Repeati247 – 27630ANK 1Add
BLAST
Repeati368 – 39730ANK 2Add
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000138334.
InParanoidiP41412.
KOiK06867.
OMAiVIDTESH.
OrthoDBiEOG7ZSJ36.
PhylomeDBiP41412.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF54616. SSF54616. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS51299. HTH_APSES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41412-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPRSSAVHV AVYSGVEVYE CFIKGVSVMR RRRDSWLNAT QILKVADFDK
60 70 80 90 100
PQRTRVLERQ VQIGAHEKVQ GGYGKYQGTW VPFQRGVDLA TKYKVDGIMS
110 120 130 140 150
PILSLDIDEG KAIAPKKKQT KQKKPSVRGR RGRKPSSLSS STLHSVNEKQ
160 170 180 190 200
PNSSISPTIE SSMNKVNLPG AEEQVSATPL PASPNALLSP NDNTIKPVEE
210 220 230 240 250
LGMLEAPLDK YEESLLDFFL HPEEGRIPSF LYSPPPDFQV NSVIDDDGHT
260 270 280 290 300
SLHWACSMGH IEMIKLLLRA NADIGVCNRL SQTPLMRSVI FTNNYDCQTF
310 320 330 340 350
GQVLELLQST IYAVDTNGQS IFHHIVQSTS TPSKVAAAKY YLDCILEKLI
360 370 380 390 400
SIQPFENVVR LVNLQDSNGD TSLLIAARNG AMDCVNSLLS YNANPSIPNR
410 420 430 440 450
QRRTASEYLL EADKKPHSLL QSNSNASHSA FSFSGISPAI ISPSCSSHAF
460 470 480 490 500
VKAIPSISSK FSQLAEEYES QLREKEEDLI RANRLKQDTL NEISRTYQEL
510 520 530 540 550
TFLQKNNPTY SQSMENLIRE AQETYQQLSK RLLIWLEARQ IFDLERSLKP
560 570 580 590 600
HTSLSISFPS DFLKKEDGLS LNNDFKKPAC NNVTNSDEYE QLINKLTSLQ
610 620 630 640 650
ASRKKDTLYI RKLYEELGID DTVNSYRRLI AMSCGINPED LSLEILDAVE

EALTREK
Length:657
Mass (Da):73,702
Last modified:November 1, 1995 - v1
Checksum:i1159312B63E475E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti482 – 4821A → R in CAA83678. (PubMed:7926774)Curated
Sequence conflicti482 – 4821A → R in AAB32253. (PubMed:7926774)Curated
Sequence conflicti639 – 6413Missing in AAB32253. (PubMed:7926774)Curated
Sequence conflicti657 – 6571K → DLEK in AAB32253. (PubMed:7926774)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17761 Genomic DNA. Translation: BAA04608.1.
Z32838 mRNA. Translation: CAA83678.1.
S73870 mRNA. Translation: AAB32253.1.
CU329670 Genomic DNA. Translation: CAA91074.1.
PIRiA54278.
RefSeqiNP_593032.1. NM_001018431.2.

Genome annotation databases

EnsemblFungiiSPAC22F3.09c.1; SPAC22F3.09c.1:pep; SPAC22F3.09c.
GeneIDi2541871.
KEGGispo:SPAC22F3.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17761 Genomic DNA. Translation: BAA04608.1 .
Z32838 mRNA. Translation: CAA83678.1 .
S73870 mRNA. Translation: AAB32253.1 .
CU329670 Genomic DNA. Translation: CAA91074.1 .
PIRi A54278.
RefSeqi NP_593032.1. NM_001018431.2.

3D structure databases

ProteinModelPortali P41412.
SMRi P41412. Positions 8-104.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278361. 196 interactions.
DIPi DIP-35569N.
IntActi P41412. 3 interactions.
MINTi MINT-730815.
STRINGi 4896.SPAC22F3.09c-1.

Proteomic databases

MaxQBi P41412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC22F3.09c.1 ; SPAC22F3.09c.1:pep ; SPAC22F3.09c .
GeneIDi 2541871.
KEGGi spo:SPAC22F3.09c.

Organism-specific databases

PomBasei SPAC22F3.09c.

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000138334.
InParanoidi P41412.
KOi K06867.
OMAi VIDTESH.
OrthoDBi EOG7ZSJ36.
PhylomeDBi P41412.

Miscellaneous databases

NextBioi 20802958.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF54616. SSF54616. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS51299. HTH_APSES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast."
    Miyamoto M., Tanaka K., Okayama H.
    EMBO J. 13:1873-1880(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 38364 / 968.
  2. "pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for meiosis in the fission yeast Schizosaccharomyces pombe."
    Zhu Y., Takeda T., Nasmyth K., Jones N.
    Genes Dev. 8:885-898(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  4. "Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control."
    Pei Y., Schwer B., Shuman S.
    J. Biol. Chem. 278:7180-7188(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDK9.

Entry informationi

Entry nameiRES2_SCHPO
AccessioniPrimary (citable) accession number: P41412
Secondary accession number(s): Q02300
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3