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P41412

- RES2_SCHPO

UniProt

P41412 - RES2_SCHPO

Protein

Cell division cycle-related protein res2/pct1

Gene

res2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Required for the initiation of mitotic and premeiotic DNA synthesis. Has an additional role in meiotic division.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi39 – 6022H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: PomBase
    2. DNA binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. meiotic nuclear division Source: UniProtKB-KW
    2. positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
    3. regulation of transcription, DNA-templated Source: PomBase

    Keywords - Biological processi

    Cell cycle, Meiosis

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division cycle-related protein res2/pct1
    Gene namesi
    Name:res2
    Synonyms:pct1
    ORF Names:SPAC22F3.09c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC22F3.09c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. MBF transcription complex Source: PomBase
    4. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 657657Cell division cycle-related protein res2/pct1PRO_0000067073Add
    BLAST

    Proteomic databases

    MaxQBiP41412.

    Expressioni

    Inductioni

    During conjugation and nitrogen starvation.

    Interactioni

    Subunit structurei

    Interacts with cdc10 and cdk9.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    cdc10P011293EBI-1149177,EBI-1009350
    cig2P366303EBI-1149177,EBI-1149212
    res1P335202EBI-1149177,EBI-1149288

    Protein-protein interaction databases

    BioGridi278361. 196 interactions.
    DIPiDIP-35569N.
    IntActiP41412. 3 interactions.
    MINTiMINT-730815.
    STRINGi4896.SPAC22F3.09c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP41412.
    SMRiP41412. Positions 8-104.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 115108HTH APSES-typePROSITE-ProRule annotationAdd
    BLAST
    Repeati247 – 27630ANK 1Add
    BLAST
    Repeati368 – 39730ANK 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000138334.
    KOiK06867.
    OMAiVIDTESH.
    OrthoDBiEOG7ZSJ36.
    PhylomeDBiP41412.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.10.260.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view]
    PfamiPF00023. Ank. 2 hits.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF54616. SSF54616. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS51299. HTH_APSES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41412-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRSSAVHV AVYSGVEVYE CFIKGVSVMR RRRDSWLNAT QILKVADFDK    50
    PQRTRVLERQ VQIGAHEKVQ GGYGKYQGTW VPFQRGVDLA TKYKVDGIMS 100
    PILSLDIDEG KAIAPKKKQT KQKKPSVRGR RGRKPSSLSS STLHSVNEKQ 150
    PNSSISPTIE SSMNKVNLPG AEEQVSATPL PASPNALLSP NDNTIKPVEE 200
    LGMLEAPLDK YEESLLDFFL HPEEGRIPSF LYSPPPDFQV NSVIDDDGHT 250
    SLHWACSMGH IEMIKLLLRA NADIGVCNRL SQTPLMRSVI FTNNYDCQTF 300
    GQVLELLQST IYAVDTNGQS IFHHIVQSTS TPSKVAAAKY YLDCILEKLI 350
    SIQPFENVVR LVNLQDSNGD TSLLIAARNG AMDCVNSLLS YNANPSIPNR 400
    QRRTASEYLL EADKKPHSLL QSNSNASHSA FSFSGISPAI ISPSCSSHAF 450
    VKAIPSISSK FSQLAEEYES QLREKEEDLI RANRLKQDTL NEISRTYQEL 500
    TFLQKNNPTY SQSMENLIRE AQETYQQLSK RLLIWLEARQ IFDLERSLKP 550
    HTSLSISFPS DFLKKEDGLS LNNDFKKPAC NNVTNSDEYE QLINKLTSLQ 600
    ASRKKDTLYI RKLYEELGID DTVNSYRRLI AMSCGINPED LSLEILDAVE 650
    EALTREK 657
    Length:657
    Mass (Da):73,702
    Last modified:November 1, 1995 - v1
    Checksum:i1159312B63E475E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti482 – 4821A → R in CAA83678. (PubMed:7926774)Curated
    Sequence conflicti482 – 4821A → R in AAB32253. (PubMed:7926774)Curated
    Sequence conflicti639 – 6413Missing in AAB32253. (PubMed:7926774)Curated
    Sequence conflicti657 – 6571K → DLEK in AAB32253. (PubMed:7926774)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17761 Genomic DNA. Translation: BAA04608.1.
    Z32838 mRNA. Translation: CAA83678.1.
    S73870 mRNA. Translation: AAB32253.1.
    CU329670 Genomic DNA. Translation: CAA91074.1.
    PIRiA54278.
    RefSeqiNP_593032.1. NM_001018431.2.

    Genome annotation databases

    EnsemblFungiiSPAC22F3.09c.1; SPAC22F3.09c.1:pep; SPAC22F3.09c.
    GeneIDi2541871.
    KEGGispo:SPAC22F3.09c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17761 Genomic DNA. Translation: BAA04608.1 .
    Z32838 mRNA. Translation: CAA83678.1 .
    S73870 mRNA. Translation: AAB32253.1 .
    CU329670 Genomic DNA. Translation: CAA91074.1 .
    PIRi A54278.
    RefSeqi NP_593032.1. NM_001018431.2.

    3D structure databases

    ProteinModelPortali P41412.
    SMRi P41412. Positions 8-104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278361. 196 interactions.
    DIPi DIP-35569N.
    IntActi P41412. 3 interactions.
    MINTi MINT-730815.
    STRINGi 4896.SPAC22F3.09c-1.

    Proteomic databases

    MaxQBi P41412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC22F3.09c.1 ; SPAC22F3.09c.1:pep ; SPAC22F3.09c .
    GeneIDi 2541871.
    KEGGi spo:SPAC22F3.09c.

    Organism-specific databases

    PomBasei SPAC22F3.09c.

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000138334.
    KOi K06867.
    OMAi VIDTESH.
    OrthoDBi EOG7ZSJ36.
    PhylomeDBi P41412.

    Miscellaneous databases

    NextBioi 20802958.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.10.260.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view ]
    Pfami PF00023. Ank. 2 hits.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF54616. SSF54616. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS51299. HTH_APSES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast."
      Miyamoto M., Tanaka K., Okayama H.
      EMBO J. 13:1873-1880(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 38364 / 968.
    2. "pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for meiosis in the fission yeast Schizosaccharomyces pombe."
      Zhu Y., Takeda T., Nasmyth K., Jones N.
      Genes Dev. 8:885-898(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    4. "Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control."
      Pei Y., Schwer B., Shuman S.
      J. Biol. Chem. 278:7180-7188(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDK9.

    Entry informationi

    Entry nameiRES2_SCHPO
    AccessioniPrimary (citable) accession number: P41412
    Secondary accession number(s): Q02300
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3