Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell division cycle-related protein res2/pct1

Gene

res2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the initiation of mitotic and premeiotic DNA synthesis. Has an additional role in meiotic division.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi39 – 60H-T-H motifPROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: PomBase
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: PomBase

GO - Biological processi

  • meiotic cell cycle Source: UniProtKB-KW
  • positive regulation of transcription by RNA polymerase II Source: PomBase
  • positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  • regulation of meiotic cell cycle Source: PomBase
  • regulation of transcription by RNA polymerase II Source: PomBase

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-related protein res2/pct1
Gene namesi
Name:res2
Synonyms:pct1
ORF Names:SPAC22F3.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22F3.09c
PomBaseiSPAC22F3.09c res2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670731 – 657Cell division cycle-related protein res2/pct1Add BLAST657

Proteomic databases

MaxQBiP41412
PaxDbiP41412
PRIDEiP41412

Expressioni

Inductioni

During conjugation and nitrogen starvation.

Interactioni

Subunit structurei

Interacts with cdc10 and cdk9.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi278361, 200 interactors
DIPiDIP-35569N
IntActiP41412, 4 interactors
MINTiP41412
STRINGi4896.SPAC22F3.09c.1

Structurei

3D structure databases

ProteinModelPortaliP41412
SMRiP41412
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 115HTH APSES-typePROSITE-ProRule annotationAdd BLAST108
Repeati247 – 276ANK 1Add BLAST30
Repeati368 – 397ANK 2Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000138334
InParanoidiP41412
OMAiWASAMGD
OrthoDBiEOG092C16YL
PhylomeDBiP41412

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
3.10.260.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036887 HTH_APSES_sf
IPR018004 KilA_N/APSES_HTH
IPR029793 Mbp1/Res1/Res2
IPR003163 Tscrpt_reg_HTH_APSES-type
PANTHERiPTHR43828:SF1 PTHR43828:SF1, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM01252 KilA-N, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF54616 SSF54616, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS51299 HTH_APSES, 1 hit

Sequencei

Sequence statusi: Complete.

P41412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRSSAVHV AVYSGVEVYE CFIKGVSVMR RRRDSWLNAT QILKVADFDK
60 70 80 90 100
PQRTRVLERQ VQIGAHEKVQ GGYGKYQGTW VPFQRGVDLA TKYKVDGIMS
110 120 130 140 150
PILSLDIDEG KAIAPKKKQT KQKKPSVRGR RGRKPSSLSS STLHSVNEKQ
160 170 180 190 200
PNSSISPTIE SSMNKVNLPG AEEQVSATPL PASPNALLSP NDNTIKPVEE
210 220 230 240 250
LGMLEAPLDK YEESLLDFFL HPEEGRIPSF LYSPPPDFQV NSVIDDDGHT
260 270 280 290 300
SLHWACSMGH IEMIKLLLRA NADIGVCNRL SQTPLMRSVI FTNNYDCQTF
310 320 330 340 350
GQVLELLQST IYAVDTNGQS IFHHIVQSTS TPSKVAAAKY YLDCILEKLI
360 370 380 390 400
SIQPFENVVR LVNLQDSNGD TSLLIAARNG AMDCVNSLLS YNANPSIPNR
410 420 430 440 450
QRRTASEYLL EADKKPHSLL QSNSNASHSA FSFSGISPAI ISPSCSSHAF
460 470 480 490 500
VKAIPSISSK FSQLAEEYES QLREKEEDLI RANRLKQDTL NEISRTYQEL
510 520 530 540 550
TFLQKNNPTY SQSMENLIRE AQETYQQLSK RLLIWLEARQ IFDLERSLKP
560 570 580 590 600
HTSLSISFPS DFLKKEDGLS LNNDFKKPAC NNVTNSDEYE QLINKLTSLQ
610 620 630 640 650
ASRKKDTLYI RKLYEELGID DTVNSYRRLI AMSCGINPED LSLEILDAVE

EALTREK
Length:657
Mass (Da):73,702
Last modified:November 1, 1995 - v1
Checksum:i1159312B63E475E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti482A → R in CAA83678 (PubMed:7926774).Curated1
Sequence conflicti482A → R in AAB32253 (PubMed:7926774).Curated1
Sequence conflicti639 – 641Missing in AAB32253 (PubMed:7926774).Curated3
Sequence conflicti657K → DLEK in AAB32253 (PubMed:7926774).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17761 Genomic DNA Translation: BAA04608.1
Z32838 mRNA Translation: CAA83678.1
S73870 mRNA Translation: AAB32253.1
CU329670 Genomic DNA Translation: CAA91074.1
PIRiA54278
RefSeqiNP_593032.1, NM_001018431.2

Genome annotation databases

EnsemblFungiiSPAC22F3.09c.1; SPAC22F3.09c.1:pep; SPAC22F3.09c
GeneIDi2541871
KEGGispo:SPAC22F3.09c

Similar proteinsi

Entry informationi

Entry nameiRES2_SCHPO
AccessioniPrimary (citable) accession number: P41412
Secondary accession number(s): Q02300
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health