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P41411 (CDC18_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 18
Gene names
Name:cdc18
ORF Names:SPBC14C8.07c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Plays a key role in coupling S phase to start and mitosis. Acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orp1, involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint. Ref.1 Ref.3 Ref.4 Ref.7 Ref.9

Subunit structure

Interacts with the origin recognition complex (ORC) and is recruited to the ars1 origin of replication. Interacts with cdt1, pop1 and pop2. Ref.4 Ref.5 Ref.6 Ref.7 Ref.8

Post-translational modification

Ubiquitinated by pop1 and pop2 and targeted to the 26S proteasome for degradation.

Sequence similarities

Belongs to the CDC6/cdc18 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 577577Cell division control protein 18
PRO_0000150978

Regions

Nucleotide binding199 – 2068ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P41411 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 74DBE9D5CF23504D

FASTA57764,753
        10         20         30         40         50         60 
MCETPIGCHT PRRCNRFIDS AALIDCTNKT NQREHSPSFS IEIPTTPSRK RTLASSHFQT 

        70         80         90        100        110        120 
PTKRIKYELG ELQEEKTDLY PNFPAQLKEN KKPKLPTTPQ TPKTPKRTIQ IVTPKSLNRT 

       130        140        150        160        170        180 
CNPVPFATRL LQSTPHRQLF PPTPSTPSTP SYNSTAKLSL RKSYRSAGVV GRENEKSIVE 

       190        200        210        220        230        240 
SFFRQHLDAN AGGALYVSGA PGTGKTVLLH NVLDHVVSDY PKVNVCYINC MTINEPKAIF 

       250        260        270        280        290        300 
EKIHSKIVKE EILENEDHHI NFQCELESHF TQSANELYNP VIIVLDEMDH LIAREQQVLY 

       310        320        330        340        350        360 
TLFEWPSRPT SRLILVGIAN ALDMTDRFLP RLRTKHITPK LLSFTPYTAQ EISTIIKARL 

       370        380        390        400        410        420 
KTAATTSEKN NPFTPIKSIS EVSDDSINVV SQHADETPFI HPAAIELCAR KVAASSGDLR 

       430        440        450        460        470        480 
KALDICRHAI ELAEREWKAQ HDNTLSSVDI PRASIAHVVR ATSAMSQSAS ARLKNLGLQQ 

       490        500        510        520        530        540 
KAILCTLVVC EKTSLSVADV FEKYSSLCLR DRLIYPLTSS EFCDVANSLE TLAIIRLRTK 

       550        560        570 
QRNGKPQDRI ISLLVPEMDV ITAVGDIGTL KRFFDRR 

« Hide

References

« Hide 'large scale' references
[1]"The fission yeast cdc18+ gene product couples S phase to START and mitosis."
Kelly T.J., Martin G.S., Forsburg S.L., Stephen R.J., Russo A., Nurse P.
Cell 74:371-382(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast."
Nishitani H., Nurse P.
Cell 83:397-405(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18."
Kominami K., Toda T.
Genes Dev. 11:1548-1560(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH POP1.
[5]"sud1+ targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast."
Jallepalli P.V., Tien D., Kelly T.J.
Proc. Natl. Acad. Sci. U.S.A. 95:8159-8164(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH POP2.
[6]"F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p."
Wolf D.A., McKeon F., Jackson P.K.
Curr. Biol. 9:373-376(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH POP1 AND POP2.
[7]"The Cdt1 protein is required to license DNA for replication in fission yeast."
Nishitani H., Lygerou Z., Nishimoto T., Nurse P.
Nature 404:625-628(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CDT1.
[8]"Purification and characterization of the Schizosaccharomyces pombe origin recognition complex: interaction with origin DNA and Cdc18 protein."
Chuang R.-Y., Chretien L., Dai J., Kelly T.J.
J. Biol. Chem. 277:16920-16927(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ORC.
[9]"Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p."
Murakami H., Yanow S.K., Griffiths D., Nakanishi M., Nurse P.
Nat. Cell Biol. 4:384-388(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L16793 Genomic DNA. Translation: AAA02871.1.
CU329671 Genomic DNA. Translation: CAA18425.1.
PIRA40726.
RefSeqNP_595910.1. NM_001021818.2.

3D structure databases

ProteinModelPortalP41411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276557. 51 interactions.
IntActP41411. 3 interactions.
STRING4896.SPBC14C8.07c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC14C8.07c.1; SPBC14C8.07c.1:pep; SPBC14C8.07c.
GeneID2540013.
KEGGspo:SPBC14C8.07c.

Organism-specific databases

PomBaseSPBC14C8.07c.

Phylogenomic databases

eggNOGCOG1474.
KOK02213.
OMAPRELNFH.
OrthoDBEOG7ZWD9N.
PhylomeDBP41411.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR015163. Cdc6_C_dom.
IPR016314. Cell_div_Cdc6/18.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
PIRSFPIRSF001767. Cdc6. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
ProtoNetSearch...

Other

NextBio20801156.

Entry information

Entry nameCDC18_SCHPO
AccessionPrimary (citable) accession number: P41411
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names