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Protein

Cell division control protein 18

Gene

cdc18

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Plays a key role in coupling S phase to start and mitosis. Acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orp1, involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 206ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA clamp loader activity Source: PomBase
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA replication initiation Source: InterPro
  • mitotic DNA replication checkpoint Source: PomBase
  • mitotic pre-replicative complex assembly Source: PomBase
  • positive regulation of DNA replication initiation Source: PomBase
  • positive regulation of protein phosphorylation Source: PomBase
  • regulation of protein localization to chromatin Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, DNA replication, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-68689 CDC6 association with the ORC:origin complex
R-SPO-68962 Activation of the pre-replicative complex
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 18
Gene namesi
Name:cdc18
ORF Names:SPBC14C8.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC14C8.07c
PomBaseiSPBC14C8.07c cdc18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509781 – 577Cell division control protein 18Add BLAST577

Post-translational modificationi

Ubiquitinated by pop1 and pop2 and targeted to the 26S proteasome for degradation.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP41411
PRIDEiP41411

PTM databases

iPTMnetiP41411

Interactioni

Subunit structurei

Interacts with the origin recognition complex (ORC) and is recruited to the ars1 origin of replication. Interacts with cdt1, pop1 and pop2.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi276557, 52 interactors
IntActiP41411, 3 interactors
STRINGi4896.SPBC14C8.07c.1

Structurei

3D structure databases

ProteinModelPortaliP41411
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC6/cdc18 family.Curated

Phylogenomic databases

InParanoidiP41411
KOiK02213
OMAiRKAFEIC
OrthoDBiEOG092C0XFO
PhylomeDBiP41411

Family and domain databases

CDDicd08768 Cdc6_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR016314 Cdc6/18
IPR015163 Cdc6_C
IPR027417 P-loop_NTPase
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF09079 Cdc6_C, 1 hit
PIRSFiPIRSF001767 Cdc6, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01074 Cdc6_C, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

P41411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCETPIGCHT PRRCNRFIDS AALIDCTNKT NQREHSPSFS IEIPTTPSRK
60 70 80 90 100
RTLASSHFQT PTKRIKYELG ELQEEKTDLY PNFPAQLKEN KKPKLPTTPQ
110 120 130 140 150
TPKTPKRTIQ IVTPKSLNRT CNPVPFATRL LQSTPHRQLF PPTPSTPSTP
160 170 180 190 200
SYNSTAKLSL RKSYRSAGVV GRENEKSIVE SFFRQHLDAN AGGALYVSGA
210 220 230 240 250
PGTGKTVLLH NVLDHVVSDY PKVNVCYINC MTINEPKAIF EKIHSKIVKE
260 270 280 290 300
EILENEDHHI NFQCELESHF TQSANELYNP VIIVLDEMDH LIAREQQVLY
310 320 330 340 350
TLFEWPSRPT SRLILVGIAN ALDMTDRFLP RLRTKHITPK LLSFTPYTAQ
360 370 380 390 400
EISTIIKARL KTAATTSEKN NPFTPIKSIS EVSDDSINVV SQHADETPFI
410 420 430 440 450
HPAAIELCAR KVAASSGDLR KALDICRHAI ELAEREWKAQ HDNTLSSVDI
460 470 480 490 500
PRASIAHVVR ATSAMSQSAS ARLKNLGLQQ KAILCTLVVC EKTSLSVADV
510 520 530 540 550
FEKYSSLCLR DRLIYPLTSS EFCDVANSLE TLAIIRLRTK QRNGKPQDRI
560 570
ISLLVPEMDV ITAVGDIGTL KRFFDRR
Length:577
Mass (Da):64,753
Last modified:November 1, 1995 - v1
Checksum:i74DBE9D5CF23504D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16793 Genomic DNA Translation: AAA02871.1
CU329671 Genomic DNA Translation: CAA18425.1
PIRiA40726
RefSeqiNP_595910.1, NM_001021818.2

Genome annotation databases

EnsemblFungiiSPBC14C8.07c.1; SPBC14C8.07c.1:pep; SPBC14C8.07c
GeneIDi2540013
KEGGispo:SPBC14C8.07c

Similar proteinsi

Entry informationi

Entry nameiCDC18_SCHPO
AccessioniPrimary (citable) accession number: P41411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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