Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA repair protein rhp54

Gene

rhp54

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA repair. May have a role in the processing of replication structures during late replication that is different from its role in the repair of radiation damage.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi294 – 301ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • DNA translocase activity Source: PomBase
  • helicase activity Source: UniProtKB-KW
  • protein-DNA loading ATPase activity Source: PomBase

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • double-strand break repair via homologous recombination Source: PomBase
  • heteroduplex formation Source: PomBase
  • meiotic gene conversion Source: PomBase
  • reciprocal meiotic recombination Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein rhp54 (EC:3.6.4.-)
Alternative name(s):
RAD54 homolog 1
Gene namesi
Name:rhp54
Synonyms:rad54
ORF Names:SPAC15A10.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC15A10.03c.
PomBaseiSPAC15A10.03c.

Subcellular locationi

GO - Cellular componenti

  • mitotic spindle Source: PomBase
  • nucleus Source: PomBase
  • site of double-strand break Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743431 – 852DNA repair protein rhp54Add BLAST852

Proteomic databases

MaxQBiP41410.
PRIDEiP41410.

PTM databases

SwissPalmiP41410.

Interactioni

Subunit structurei

Interacts with rhp51.1 Publication

Protein-protein interaction databases

BioGridi279199. 18 interactors.
IntActiP41410. 1 interactor.
MINTiMINT-4690088.

Structurei

3D structure databases

ProteinModelPortaliP41410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 459Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST179
Domaini614 – 767Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 51Nuclear localization signalSequence analysisAdd BLAST17
Motifi178 – 181Nuclear localization signalSequence analysis4
Motifi410 – 413DEGH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi247 – 251Poly-Pro5

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000204521.
InParanoidiP41410.
KOiK10875.
OMAiVTRPVII.
OrthoDBiEOG092C10RV.
PhylomeDBiP41410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR013967. Rad54_N.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF08658. Rad54_N. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQQPTTAKP RISTSSKLNT VLSKNKENVP GKLFKKFKCP SLVISEKRKE
60 70 80 90 100
LPLRKKPRVN YSEYGSVDGK YDSAYVSENV SGLATIKEAN RLILNHERRD
110 120 130 140 150
PSTVIKKQFS VPKPIKGHED ISKLCAHRPP PTLGMKRKVD FIPRPLYDPA
160 170 180 190 200
DEFAIVLYDP TTDADEIIPD IKEVLAEKRK KDELLKNRKG KKEISDSEPE
210 220 230 240 250
SDHDSCVSTD TVASCSTEQS LITSNTSKHR RPNKSLKDLL GIQKEKPPPP
260 270 280 290 300
PVAVVIDPKL ARILRPHQIE GVKFLYKCVT GRIDRCANGC IMADEMGLGK
310 320 330 340 350
TLQCIALLWT LLKQSPQAGK PTIEKAIITC PSSLVKNWAN ELVKWLGKDA
360 370 380 390 400
ITPFILDGKS SKQELIMALQ QWASVHGRQV TRPVLIASYE TLRSYVEHLN
410 420 430 440 450
NAEIGMLLCD EGHRLKNSDS LTFTALDKLN VQRRVILSGT PIQNDLSEYF
460 470 480 490 500
SLLNFANPGL LGSRQEFRKN YEIPILKGRD ADGTEKDKEN GDAKLAELAK
510 520 530 540 550
IVNRFIIRRT NDILSKYLPV KYEHVVFCNL SEFQLSLYKH FITSPEINKI
560 570 580 590 600
LRGTGSQPLK AIGLLKKICN HPDLLNLTED LEGCEALFPP GFIPRELRGR
610 620 630 640 650
DRNIDSSLSG KMLVLERMLY QIKQETDDKI VLISNYTSTL DLFEQLCRAR
660 670 680 690 700
GYKALRLDGT MNVNKRQRLV DTFNDPEKDA FVFLLSSKAG GCGINLIGAN
710 720 730 740 750
RLILFDPDWN PAADQQALAR VWRDGQKKDC FVYRFIATGT IEEKIFQRQS
760 770 780 790 800
HKQSLSSCVV DEAQDVERHF SLDNLRQLFQ LNDHTVCETH ETYKCKRCRD
810 820 830 840 850
GKQFIRAPAM LYGDTSTWNH FTNPTLDRIE DHLLKREAGK QQVSTVFQYK

SH
Length:852
Mass (Da):96,654
Last modified:July 15, 1998 - v2
Checksum:i9DB3A247A57B0880
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261A → T in CAA82750 (PubMed:8834792).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29640 Genomic DNA. Translation: CAA82750.1.
CU329670 Genomic DNA. Translation: CAB10100.1.
PIRiS41886.
RefSeqiNP_594290.1. NM_001019713.2.

Genome annotation databases

EnsemblFungiiSPAC15A10.03c.1; SPAC15A10.03c.1:pep; SPAC15A10.03c.
GeneIDi2542749.
KEGGispo:SPAC15A10.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29640 Genomic DNA. Translation: CAA82750.1.
CU329670 Genomic DNA. Translation: CAB10100.1.
PIRiS41886.
RefSeqiNP_594290.1. NM_001019713.2.

3D structure databases

ProteinModelPortaliP41410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279199. 18 interactors.
IntActiP41410. 1 interactor.
MINTiMINT-4690088.

PTM databases

SwissPalmiP41410.

Proteomic databases

MaxQBiP41410.
PRIDEiP41410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC15A10.03c.1; SPAC15A10.03c.1:pep; SPAC15A10.03c.
GeneIDi2542749.
KEGGispo:SPAC15A10.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC15A10.03c.
PomBaseiSPAC15A10.03c.

Phylogenomic databases

HOGENOMiHOG000204521.
InParanoidiP41410.
KOiK10875.
OMAiVTRPVII.
OrthoDBiEOG092C10RV.
PhylomeDBiP41410.

Miscellaneous databases

PROiP41410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR013967. Rad54_N.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF08658. Rad54_N. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAD54_SCHPO
AccessioniPrimary (citable) accession number: P41410
Secondary accession number(s): O13723
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.