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P41394

- DHAS_LEPIN

UniProt

P41394 - DHAS_LEPIN

Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (06 Dec 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

    Catalytic activityi

    L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei113 – 1131PhosphateUniRule annotation
    Active sitei148 – 1481Acyl-thioester intermediateUniRule annotation
    Binding sitei175 – 1751SubstrateUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation
    Binding sitei204 – 2041PhosphateUniRule annotation
    Binding sitei234 – 2341SubstrateUniRule annotation
    Active sitei241 – 2411Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADPUniRule annotation
    Nucleotide bindingi39 – 402NADPUniRule annotation
    Nucleotide bindingi178 – 1792NADPUniRule annotation
    Nucleotide bindingi326 – 3272NADPUniRule annotation

    GO - Molecular functioni

    1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
    3. NAD binding Source: InterPro
    4. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
    2. aspartate metabolic process Source: InterPro
    3. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    4. isoleucine biosynthetic process Source: InterPro
    5. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
    6. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis, Methionine biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciLINT189518:GJBB-3740-MONOMER.
    UniPathwayiUPA00034; UER00016.
    UPA00050; UER00463.
    UPA00051; UER00464.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
    Short name:
    ASA dehydrogenaseUniRule annotation
    Short name:
    ASADHUniRule annotation
    Alternative name(s):
    Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:asdUniRule annotation
    Ordered Locus Names:LB_355
    OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
    Taxonomic identifieri189518 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000001408: Chromosome II

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Aspartate-semialdehyde dehydrogenasePRO_0000141380Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi189518.LB355.

    Structurei

    3D structure databases

    ProteinModelPortaliP41394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0136.
    HOGENOMiHOG000013358.
    KOiK00133.
    OMAiMSIVVGR.
    OrthoDBiEOG6JB158.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_02121. ASADH.
    InterProiIPR000319. Asp-semialdehyde_DH_CS.
    IPR005676. Asp_semi-ald_DH_pep-lack.
    IPR012080. Asp_semialdehyde_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view]
    PfamiPF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000148. ASA_dh. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00978. asd_EA. 1 hit.
    PROSITEiPS01103. ASD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41394-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRVKVAVLG ATGSVGQRFI QLLDHHPFFE VTHLCASENS AGKTYGEVMK    50
    TRWKISSDIP AYAKNLVITT PDPAKTKDVV LAFSGLDSNV AGEVEKNYAN 100
    AGIHIISNSK NHRMDPTVPI LSAEVNSSHL EVLTSQKTKG KIITNSNCTI 150
    MGVTISLKPL LDRFGIESVM LFSMQAISGA GYPGVPTMDI LGNVIPHIGG 200
    EEEKAEIEPL KCLGKVENGK ILHADFSISA HCNRVPVFDG HTVCVSVKFK 250
    KKPSREEIIS SWKDFSGEPQ TLGLPLAPNP VILFREEEDR PQPRLDLDTG 300
    KGMTTVIGRL RPDPILDWKY VVLSHNTIRG AAGAALLNAE LLYKKKFLG 349
    Length:349
    Mass (Da):38,018
    Last modified:December 6, 2002 - v2
    Checksum:i1DB092D05CE66254
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311V → I in AAB21985. (PubMed:1348268)Curated
    Sequence conflicti31 – 311V → I in AAA25262. (PubMed:1348268)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S92223 Genomic DNA. Translation: AAB21985.1.
    M77500 Genomic DNA. Translation: AAA25262.1.
    AE010301 Genomic DNA. Translation: AAN51914.1.
    PIRiA44846.
    RefSeqiNP_714899.1. NC_004343.2.

    Genome annotation databases

    EnsemblBacteriaiAAN51914; AAN51914; LB_355.
    GeneIDi1153914.
    KEGGilil:LB_355.
    PATRICi22390238. VBILepInt91350_4670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S92223 Genomic DNA. Translation: AAB21985.1 .
    M77500 Genomic DNA. Translation: AAA25262.1 .
    AE010301 Genomic DNA. Translation: AAN51914.1 .
    PIRi A44846.
    RefSeqi NP_714899.1. NC_004343.2.

    3D structure databases

    ProteinModelPortali P41394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 189518.LB355.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN51914 ; AAN51914 ; LB_355 .
    GeneIDi 1153914.
    KEGGi lil:LB_355.
    PATRICi 22390238. VBILepInt91350_4670.

    Phylogenomic databases

    eggNOGi COG0136.
    HOGENOMi HOG000013358.
    KOi K00133.
    OMAi MSIVVGR.
    OrthoDBi EOG6JB158.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00016 .
    UPA00050 ; UER00463 .
    UPA00051 ; UER00464 .
    BioCyci LINT189518:GJBB-3740-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_02121. ASADH.
    InterProi IPR000319. Asp-semialdehyde_DH_CS.
    IPR005676. Asp_semi-ald_DH_pep-lack.
    IPR012080. Asp_semialdehyde_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view ]
    Pfami PF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000148. ASA_dh. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00978. asd_EA. 1 hit.
    PROSITEi PS01103. ASD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of dapD, aroD and asd of Leptospira interrogans serovar icterohaemorrhagiae, and nucleotide sequence of the asd gene."
      Baril C., Richaud C., Fourni E., Baranton G., Saint-Girons I.
      J. Gen. Microbiol. 138:47-53(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Serogroup Icterohaemorrhagiae.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 56601.

    Entry informationi

    Entry nameiDHAS_LEPIN
    AccessioniPrimary (citable) accession number: P41394
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: December 6, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3