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P41394

- DHAS_LEPIN

UniProt

P41394 - DHAS_LEPIN

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Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

Catalytic activityi

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei113 – 1131PhosphateUniRule annotation
Active sitei148 – 1481Acyl-thioester intermediateUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei204 – 2041PhosphateUniRule annotation
Binding sitei234 – 2341SubstrateUniRule annotation
Active sitei241 – 2411Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADPUniRule annotation
Nucleotide bindingi39 – 402NADPUniRule annotation
Nucleotide bindingi178 – 1792NADPUniRule annotation
Nucleotide bindingi326 – 3272NADPUniRule annotation

GO - Molecular functioni

  1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
  3. NAD binding Source: InterPro
  4. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
  2. aspartate metabolic process Source: InterPro
  3. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  4. isoleucine biosynthetic process Source: InterPro
  5. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
  6. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis, Methionine biosynthesis, Threonine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciLINT189518:GJBB-3740-MONOMER.
UniPathwayiUPA00034; UER00016.
UPA00050; UER00463.
UPA00051; UER00464.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
Short name:
ASA dehydrogenaseUniRule annotation
Short name:
ASADHUniRule annotation
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:asdUniRule annotation
Ordered Locus Names:LB_355
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001408: Chromosome II

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Aspartate-semialdehyde dehydrogenasePRO_0000141380Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LB355.

Structurei

3D structure databases

ProteinModelPortaliP41394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0136.
HOGENOMiHOG000013358.
InParanoidiP41394.
KOiK00133.
OMAiMSIVVGR.
OrthoDBiEOG6JB158.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_02121. ASADH.
InterProiIPR000319. Asp-semialdehyde_DH_CS.
IPR005676. Asp_semi-ald_DH_pep-lack.
IPR012080. Asp_semialdehyde_DH.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
PIRSFiPIRSF000148. ASA_dh. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00978. asd_EA. 1 hit.
PROSITEiPS01103. ASD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41394-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRVKVAVLG ATGSVGQRFI QLLDHHPFFE VTHLCASENS AGKTYGEVMK
60 70 80 90 100
TRWKISSDIP AYAKNLVITT PDPAKTKDVV LAFSGLDSNV AGEVEKNYAN
110 120 130 140 150
AGIHIISNSK NHRMDPTVPI LSAEVNSSHL EVLTSQKTKG KIITNSNCTI
160 170 180 190 200
MGVTISLKPL LDRFGIESVM LFSMQAISGA GYPGVPTMDI LGNVIPHIGG
210 220 230 240 250
EEEKAEIEPL KCLGKVENGK ILHADFSISA HCNRVPVFDG HTVCVSVKFK
260 270 280 290 300
KKPSREEIIS SWKDFSGEPQ TLGLPLAPNP VILFREEEDR PQPRLDLDTG
310 320 330 340
KGMTTVIGRL RPDPILDWKY VVLSHNTIRG AAGAALLNAE LLYKKKFLG
Length:349
Mass (Da):38,018
Last modified:December 6, 2002 - v2
Checksum:i1DB092D05CE66254
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311V → I in AAB21985. (PubMed:1348268)Curated
Sequence conflicti31 – 311V → I in AAA25262. (PubMed:1348268)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S92223 Genomic DNA. Translation: AAB21985.1.
M77500 Genomic DNA. Translation: AAA25262.1.
AE010301 Genomic DNA. Translation: AAN51914.1.
PIRiA44846.
RefSeqiNP_714899.1. NC_004343.2.

Genome annotation databases

EnsemblBacteriaiAAN51914; AAN51914; LB_355.
GeneIDi1153914.
KEGGilil:LB_355.
PATRICi22390238. VBILepInt91350_4670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S92223 Genomic DNA. Translation: AAB21985.1 .
M77500 Genomic DNA. Translation: AAA25262.1 .
AE010301 Genomic DNA. Translation: AAN51914.1 .
PIRi A44846.
RefSeqi NP_714899.1. NC_004343.2.

3D structure databases

ProteinModelPortali P41394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189518.LB355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN51914 ; AAN51914 ; LB_355 .
GeneIDi 1153914.
KEGGi lil:LB_355.
PATRICi 22390238. VBILepInt91350_4670.

Phylogenomic databases

eggNOGi COG0136.
HOGENOMi HOG000013358.
InParanoidi P41394.
KOi K00133.
OMAi MSIVVGR.
OrthoDBi EOG6JB158.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00016 .
UPA00050 ; UER00463 .
UPA00051 ; UER00464 .
BioCyci LINT189518:GJBB-3740-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_02121. ASADH.
InterProi IPR000319. Asp-semialdehyde_DH_CS.
IPR005676. Asp_semi-ald_DH_pep-lack.
IPR012080. Asp_semialdehyde_DH.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view ]
Pfami PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view ]
PIRSFi PIRSF000148. ASA_dh. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00978. asd_EA. 1 hit.
PROSITEi PS01103. ASD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of dapD, aroD and asd of Leptospira interrogans serovar icterohaemorrhagiae, and nucleotide sequence of the asd gene."
    Baril C., Richaud C., Fourni E., Baranton G., Saint-Girons I.
    J. Gen. Microbiol. 138:47-53(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Serogroup Icterohaemorrhagiae.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56601.

Entry informationi

Entry nameiDHAS_LEPIN
AccessioniPrimary (citable) accession number: P41394
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 6, 2002
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3