Reviewed, UniProtKB/Swiss-Prot P41392 (AMPM_KLEOX)

Names and origin

Protein names

Recommended name:
    Methionine aminopeptidase
      Short name=MAP
    EC=3.4.11.18
Alternative name(s):
    Peptidase M

Gene names

Name:

map

Organism

Klebsiella oxytoca

Taxonomic identifier

571 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	43 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Removes the amino-terminal methionine from nascent proteins.
Catalytic activity	Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Cofactor	Binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. The enzyme is also active with zinc, manganese or divalent iron ions By similarity.
Sequence similarities	Belongs to the peptidase M24A family.

Ontologies

Keywords
Ligand	Cobalt Metal-binding
Molecular function	Aminopeptidase Hydrolase Protease
Gene Ontology (GO)
Biological process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW cobalt ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 43	›43	Methionine aminopeptidase		PRO_0000148943
Sites
	Metal binding	14	1	Cobalt 1 By similarity
	Metal binding	14	1	Cobalt 2 By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P41392-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5E030E6D4A3049E1	FASTA	43	4,826
	10 20 30 40 TVKTKDRSLS AQYEHTIVVT DNGCEILTLR KDDTIPAIIS HNE

References

[1]	"The role of uridylyltransferase in the control of Klebsiella pneumoniae nif gene regulation." Edwards R.A., Merrick M.J. Mol. Gen. Genet. 247:189-198(1995) [PubMed: 7753028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M5a1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X78685 Genomic DNA. Translation: CAA55352.1.
PIR	S43195. S54755.
3D structure databases
HSSP	HSSP built from PDB template 3MAT based on UniProtKB P07906.
ModBase	Search...
Protein family/group databases
MEROPS	M24.001.
Enzyme and pathway databases
BRENDA	3.4.11.18. 81705.
Family and domain databases
InterPro	IPR000994. Pept_M24_structural-domain. IPR002467. Pept_M24A_MAP1. [Graphical view]
Gene3D	G3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
PANTHER	PTHR10804:SF13. Pept_M24A_MAP1. 1 hit. PTHR10804. Peptidase_M24_cat_core. 1 hit.
Pfam	PF00557. Peptidase_M24. 1 hit. [Graphical view]
PROSITE	PS00680. MAP_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPM_KLEOX

Accession

Primary (citable) accession number: P41392

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)