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Protein

Ran GTPase-activating protein 1

Gene

rna1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory protein spi1 (Ran), converting it to the putatively inactive GDP-bound state.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei74Critical residue for GTP hydrolysis1

GO - Molecular functioni

  • GTPase activator activity Source: PomBase

GO - Biological processi

  • chromatin silencing at centromere Source: PomBase
  • kinetochore organization Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • nucleocytoplasmic transport Source: PomBase
  • positive regulation of protein export from nucleus Source: PomBase
  • regulation of GTPase activity Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ran GTPase-activating protein 1
Short name:
Protein rna1
Gene namesi
Name:rna1
ORF Names:SPAC22E12.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22E12.07.
PomBaseiSPAC22E12.07. rna1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: GOC
  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nuclear membrane Source: PomBase
  • nucleus Source: PomBase
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567411 – 386Ran GTPase-activating protein 1Add BLAST386

Proteomic databases

MaxQBiP41391.
PRIDEiP41391.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi278353. 16 interactors.
IntActiP41391. 1 interactor.
MINTiMINT-4690066.

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi12 – 15Combined sources4
Helixi19 – 22Combined sources4
Helixi23 – 25Combined sources3
Helixi26 – 30Combined sources5
Beta strandi36 – 38Combined sources3
Beta strandi42 – 44Combined sources3
Helixi46 – 54Combined sources9
Turni55 – 58Combined sources4
Beta strandi64 – 66Combined sources3
Helixi76 – 78Combined sources3
Helixi80 – 90Combined sources11
Beta strandi98 – 100Combined sources3
Turni108 – 110Combined sources3
Helixi111 – 120Combined sources10
Beta strandi126 – 128Combined sources3
Helixi135 – 156Combined sources22
Beta strandi163 – 165Combined sources3
Helixi173 – 175Combined sources3
Helixi176 – 185Combined sources10
Beta strandi191 – 193Combined sources3
Helixi201 – 209Combined sources9
Helixi212 – 214Combined sources3
Beta strandi220 – 222Combined sources3
Helixi229 – 239Combined sources11
Helixi240 – 242Combined sources3
Beta strandi248 – 250Combined sources3
Helixi258 – 269Combined sources12
Beta strandi278 – 280Combined sources3
Helixi288 – 301Combined sources14
Beta strandi307 – 309Combined sources3
Beta strandi313 – 315Combined sources3
Helixi320 – 332Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5DX-ray2.70C/F/I/L1-386[»]
1K5GX-ray3.10C/F/I/L1-386[»]
1YRGX-ray2.66A/B2-386[»]
2CA6X-ray2.20A/B1-386[»]
ProteinModelPortaliP41391.
SMRiP41391.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 48LRR 1Add BLAST26
Repeati85 – 112LRR 2Add BLAST28
Repeati113 – 141LRR 3Add BLAST29
Repeati179 – 206LRR 4Add BLAST28
Repeati207 – 235LRR 5Add BLAST29
Repeati236 – 264LRR 6Add BLAST29
Repeati265 – 293LRR 7Add BLAST29
Repeati294 – 322LRR 8Add BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi323 – 374Asp/Glu-rich (acidic)Add BLAST52

Sequence similaritiesi

Belongs to the RNA1 family.Curated
Contains 8 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000195026.
InParanoidiP41391.
KOiK14319.
OMAiNTHFQIF.
OrthoDBiEOG092C0KYA.
PhylomeDBiP41391.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR027038. RanGap.
[Graphical view]
PANTHERiPTHR24113. PTHR24113. 1 hit.

Sequencei

Sequence statusi: Complete.

P41391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFSIEGKS LKLDAITTED EKSVFAVLLE DDSVKEIVLS GNTIGTEAAR
60 70 80 90 100
WLSENIASKK DLEIAEFSDI FTGRVKDEIP EALRLLLQAL LKCPKLHTVR
110 120 130 140 150
LSDNAFGPTA QEPLIDFLSK HTPLEHLYLH NNGLGPQAGA KIARALQELA
160 170 180 190 200
VNKKAKNAPP LRSIICGRNR LENGSMKEWA KTFQSHRLLH TVKMVQNGIR
210 220 230 240 250
PEGIEHLLLE GLAYCQELKV LDLQDNTFTH LGSSALAIAL KSWPNLRELG
260 270 280 290 300
LNDCLLSARG AAAVVDAFSK LENIGLQTLR LQYNEIELDA VRTLKTVIDE
310 320 330 340 350
KMPDLLFLEL NGNRFSEEDD VVDEIREVFS TRGRGELDEL DDMEELTDEE
360 370 380
EEDEEEEAES QSPEPETSEE EKEDKELADE LSKAHI
Length:386
Mass (Da):43,236
Last modified:November 1, 1995 - v1
Checksum:i8E1C9C506988A7F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69882 Genomic DNA. Translation: CAA49509.1.
CU329670 Genomic DNA. Translation: CAA93894.1.
PIRiS37691.
RefSeqiNP_594833.1. NM_001020262.2.

Genome annotation databases

EnsemblFungiiSPAC22E12.07.1; SPAC22E12.07.1:pep; SPAC22E12.07.
GeneIDi2541863.
KEGGispo:SPAC22E12.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69882 Genomic DNA. Translation: CAA49509.1.
CU329670 Genomic DNA. Translation: CAA93894.1.
PIRiS37691.
RefSeqiNP_594833.1. NM_001020262.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5DX-ray2.70C/F/I/L1-386[»]
1K5GX-ray3.10C/F/I/L1-386[»]
1YRGX-ray2.66A/B2-386[»]
2CA6X-ray2.20A/B1-386[»]
ProteinModelPortaliP41391.
SMRiP41391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278353. 16 interactors.
IntActiP41391. 1 interactor.
MINTiMINT-4690066.

Proteomic databases

MaxQBiP41391.
PRIDEiP41391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC22E12.07.1; SPAC22E12.07.1:pep; SPAC22E12.07.
GeneIDi2541863.
KEGGispo:SPAC22E12.07.

Organism-specific databases

EuPathDBiFungiDB:SPAC22E12.07.
PomBaseiSPAC22E12.07. rna1.

Phylogenomic databases

HOGENOMiHOG000195026.
InParanoidiP41391.
KOiK14319.
OMAiNTHFQIF.
OrthoDBiEOG092C0KYA.
PhylomeDBiP41391.

Miscellaneous databases

EvolutionaryTraceiP41391.
PROiP41391.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR027038. RanGap.
[Graphical view]
PANTHERiPTHR24113. PTHR24113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNA1_SCHPO
AccessioniPrimary (citable) accession number: P41391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.