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P41361 (ANT3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Antithrombin-III

Short name=ATIII
Alternative name(s):
Serpin C1
Gene names
Name:SERPINC1
Synonyms:AT3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin By similarity.

Subunit structure

Forms protease inhibiting heterodimer with TMPRSS7 By similarity.

Subcellular location

Secretedextracellular space By similarity.

Tissue specificity

Plasma.

Post-translational modification

Phosphorylation sites are present in the extracellular medium By similarity.

Sequence similarities

Belongs to the serpin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Ref.2
Chain33 – 465433Antithrombin-III
PRO_0000094123

Sites

Binding site821Heparin By similarity
Binding site1621Heparin By similarity
Binding site1781Heparin By similarity
Site426 – 4272Reactive bond

Amino acid modifications

Glycosylation1291N-linked (GlcNAc...)
Glycosylation1681N-linked (GlcNAc...)
Glycosylation1881N-linked (GlcNAc...)
Glycosylation2251N-linked (GlcNAc...)
Disulfide bond41 ↔ 161
Disulfide bond54 ↔ 128
Disulfide bond280 ↔ 463

Experimental info

Sequence conflict1291N → D in AAI02748. Ref.1
Sequence conflict1331K → T AA sequence Ref.2
Sequence conflict1821G → D AA sequence Ref.2
Sequence conflict4411I → F AA sequence Ref.2

Secondary structure

............................................................ 465
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P41361 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: B674E579154F291F

FASTA46552,347
        10         20         30         40         50         60 
MISNGIGTVT AGKRSICLLP LLLIGLWGCV TCHRSPVEDV CTAKPRDIPV NPMCIYRSSE 

        70         80         90        100        110        120 
KKATEGQGSE QKIPGATNRR VWELSKANSH FATAFYQHLA DSKNNNDNIF LSPLSISTAF 

       130        140        150        160        170        180 
AMTKLGACNN TLKQLMEVFK FDTISEKTSD QIHFFFAKLN CRLYRKANKS SELVSANRLF 

       190        200        210        220        230        240 
GGKSITFNET YQDISEVVYG AKLQPLDFKG NAEQSRLTIN QWISNKTEGR ITDVIPPQAI 

       250        260        270        280        290        300 
NEFTVLVLVN TIYFKGLWKS KFSPENTRKE LFYKADGESC SVLMMYQESK FRYRRVAEST 

       310        320        330        340        350        360 
QVLELPFKGD DITMVLILPK LEKTLAKVEQ ELTPDMLQEW LDELTETLLV VHMPRFRIED 

       370        380        390        400        410        420 
SFSVKEQLQD MGLEDLFSPE KSRLPGIVAE GRSDLYVSDA FHKAFLEVNE EGSEAAASTV 

       430        440        450        460 
ISIAGRSLNS DRVTFKANRP ILVLIREVAL NTIIFMGRVA NPCVD 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.
[2]"The complete amino acid sequence of bovine antithrombin (ATIII)."
Mejdoub H., le Ret M., Boulanger Y., Maman M., Choay J., Reinbolt J.
J. Protein Chem. 10:205-212(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 33-465.
[3]"Crystal structure of cleaved bovine antithrombin III at 3.2-A resolution."
Mourey L., Samama J.-P., Delarue M., Petitou M., Choay J., Moras D.
J. Mol. Biol. 232:223-241(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 33-465.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102747 mRNA. Translation: AAI02748.1.
PIRA61435.
RefSeqNP_001029870.1. NM_001034698.2.
UniGeneBt.11574.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ATTX-ray3.20A/B37-465[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000005713.

Chemistry

ChEMBLCHEMBL2150842.

Protein family/group databases

MEROPSI04.018.

Proteomic databases

PaxDbP41361.
PRIDEP41361.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID540261.
KEGGbta:540261.

Organism-specific databases

CTD462.

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238519.
HOVERGENHBG005957.
InParanoidP41361.
KOK03911.

Family and domain databases

InterProIPR015555. AT-III.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP41361.
NextBio20878526.

Entry information

Entry nameANT3_BOVIN
AccessionPrimary (citable) accession number: P41361
Secondary accession number(s): Q3SZQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 27, 2006
Last modified: February 19, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references