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P41361

- ANT3_BOVIN

UniProt

P41361 - ANT3_BOVIN

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Protein

Antithrombin-III

Gene

SERPINC1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821HeparinBy similarity
Binding sitei162 – 1621HeparinBy similarity
Binding sitei178 – 1781HeparinBy similarity
Sitei426 – 4272Reactive bond

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of blood coagulation, intrinsic pathway Source: InterPro
  4. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Antithrombin-III
Short name:
ATIII
Alternative name(s):
Serpin C1
Gene namesi
Name:SERPINC1
Synonyms:AT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secretedextracellular space By similarity

GO - Cellular componenti

  1. extracellular region Source: RefGenome
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 PublicationAdd
BLAST
Chaini33 – 465433Antithrombin-IIIPRO_0000094123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 161
Disulfide bondi54 ↔ 128
Glycosylationi129 – 1291N-linked (GlcNAc...)
Glycosylationi168 – 1681N-linked (GlcNAc...)
Glycosylationi188 – 1881N-linked (GlcNAc...)
Glycosylationi225 – 2251N-linked (GlcNAc...)
Disulfide bondi280 ↔ 463

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP41361.
PRIDEiP41361.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005713.

Structurei

Secondary structure

1
465
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni39 – 424Combined sources
Turni77 – 804Combined sources
Helixi81 – 10222Combined sources
Beta strandi109 – 1113Combined sources
Helixi113 – 12311Combined sources
Turni124 – 1263Combined sources
Helixi129 – 13810Combined sources
Helixi141 – 1433Combined sources
Helixi149 – 16113Combined sources
Turni168 – 1703Combined sources
Beta strandi178 – 1825Combined sources
Helixi189 – 19911Combined sources
Beta strandi202 – 2065Combined sources
Helixi208 – 22619Combined sources
Turni227 – 2293Combined sources
Beta strandi244 – 26017Combined sources
Beta strandi266 – 2738Combined sources
Beta strandi279 – 29618Combined sources
Turni297 – 2993Combined sources
Beta strandi300 – 3078Combined sources
Beta strandi310 – 31910Combined sources
Helixi325 – 3306Combined sources
Helixi337 – 3426Combined sources
Beta strandi345 – 36319Combined sources
Helixi364 – 3718Combined sources
Helixi375 – 3773Combined sources
Turni379 – 3813Combined sources
Beta strandi387 – 3915Combined sources
Beta strandi396 – 40914Combined sources
Beta strandi412 – 42514Combined sources
Beta strandi441 – 4477Combined sources
Turni448 – 4503Combined sources
Beta strandi453 – 4597Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ATTX-ray3.20A/B37-465[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41361.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP41361.
KOiK03911.

Family and domain databases

InterProiIPR015555. AT-III.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41361-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISNGIGTVT AGKRSICLLP LLLIGLWGCV TCHRSPVEDV CTAKPRDIPV
60 70 80 90 100
NPMCIYRSSE KKATEGQGSE QKIPGATNRR VWELSKANSH FATAFYQHLA
110 120 130 140 150
DSKNNNDNIF LSPLSISTAF AMTKLGACNN TLKQLMEVFK FDTISEKTSD
160 170 180 190 200
QIHFFFAKLN CRLYRKANKS SELVSANRLF GGKSITFNET YQDISEVVYG
210 220 230 240 250
AKLQPLDFKG NAEQSRLTIN QWISNKTEGR ITDVIPPQAI NEFTVLVLVN
260 270 280 290 300
TIYFKGLWKS KFSPENTRKE LFYKADGESC SVLMMYQESK FRYRRVAEST
310 320 330 340 350
QVLELPFKGD DITMVLILPK LEKTLAKVEQ ELTPDMLQEW LDELTETLLV
360 370 380 390 400
VHMPRFRIED SFSVKEQLQD MGLEDLFSPE KSRLPGIVAE GRSDLYVSDA
410 420 430 440 450
FHKAFLEVNE EGSEAAASTV ISIAGRSLNS DRVTFKANRP ILVLIREVAL
460
NTIIFMGRVA NPCVD
Length:465
Mass (Da):52,347
Last modified:June 27, 2006 - v2
Checksum:iB674E579154F291F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1291N → D in AAI02748. 1 PublicationCurated
Sequence conflicti133 – 1331K → T AA sequence (PubMed:1930634)Curated
Sequence conflicti182 – 1821G → D AA sequence (PubMed:1930634)Curated
Sequence conflicti441 – 4411I → F AA sequence (PubMed:1930634)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102747 mRNA. Translation: AAI02748.1.
PIRiA61435.
RefSeqiNP_001029870.1. NM_001034698.2.
UniGeneiBt.11574.

Genome annotation databases

GeneIDi540261.
KEGGibta:540261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102747 mRNA. Translation: AAI02748.1 .
PIRi A61435.
RefSeqi NP_001029870.1. NM_001034698.2.
UniGenei Bt.11574.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ATT X-ray 3.20 A/B 37-465 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000005713.

Chemistry

ChEMBLi CHEMBL2150842.

Protein family/group databases

MEROPSi I04.018.

Proteomic databases

PaxDbi P41361.
PRIDEi P41361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 540261.
KEGGi bta:540261.

Organism-specific databases

CTDi 462.

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi P41361.
KOi K03911.

Miscellaneous databases

EvolutionaryTracei P41361.
NextBioi 20878526.

Family and domain databases

InterProi IPR015555. AT-III.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.
  2. "The complete amino acid sequence of bovine antithrombin (ATIII)."
    Mejdoub H., le Ret M., Boulanger Y., Maman M., Choay J., Reinbolt J.
    J. Protein Chem. 10:205-212(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-465.
  3. "Crystal structure of cleaved bovine antithrombin III at 3.2-A resolution."
    Mourey L., Samama J.-P., Delarue M., Petitou M., Choay J., Moras D.
    J. Mol. Biol. 232:223-241(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 33-465.

Entry informationi

Entry nameiANT3_BOVIN
AccessioniPrimary (citable) accession number: P41361
Secondary accession number(s): Q3SZQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 27, 2006
Last modified: November 26, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3