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Protein

Antithrombin-III

Gene

SERPINC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82HeparinBy similarity1
Binding sitei162HeparinBy similarity1
Binding sitei178HeparinBy similarity1
Sitei426 – 427Reactive bond2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Antithrombin-III
Short name:
ATIII
Alternative name(s):
Serpin C1
Gene namesi
Name:SERPINC1
Synonyms:AT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2150842.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000009412333 – 465Antithrombin-IIIAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 161
Disulfide bondi54 ↔ 128
Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Glycosylationi129N-linked (GlcNAc...)1
Glycosylationi168N-linked (GlcNAc...)1
Glycosylationi188N-linked (GlcNAc...)1
Glycosylationi225N-linked (GlcNAc...)1
Disulfide bondi280 ↔ 463

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP41361.
PeptideAtlasiP41361.
PRIDEiP41361.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005713.

Structurei

Secondary structure

1465
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni39 – 42Combined sources4
Turni77 – 80Combined sources4
Helixi81 – 102Combined sources22
Beta strandi109 – 111Combined sources3
Helixi113 – 123Combined sources11
Turni124 – 126Combined sources3
Helixi129 – 138Combined sources10
Helixi141 – 143Combined sources3
Helixi149 – 161Combined sources13
Turni168 – 170Combined sources3
Beta strandi178 – 182Combined sources5
Helixi189 – 199Combined sources11
Beta strandi202 – 206Combined sources5
Helixi208 – 226Combined sources19
Turni227 – 229Combined sources3
Beta strandi244 – 260Combined sources17
Beta strandi266 – 273Combined sources8
Beta strandi279 – 296Combined sources18
Turni297 – 299Combined sources3
Beta strandi300 – 307Combined sources8
Beta strandi310 – 319Combined sources10
Helixi325 – 330Combined sources6
Helixi337 – 342Combined sources6
Beta strandi345 – 363Combined sources19
Helixi364 – 371Combined sources8
Helixi375 – 377Combined sources3
Turni379 – 381Combined sources3
Beta strandi387 – 391Combined sources5
Beta strandi396 – 409Combined sources14
Beta strandi412 – 425Combined sources14
Beta strandi441 – 447Combined sources7
Turni448 – 450Combined sources3
Beta strandi453 – 459Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ATTX-ray3.20A/B37-465[»]
SMRiP41361.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41361.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP41361.
KOiK03911.

Family and domain databases

CDDicd02045. antithrombin-III_like. 1 hit.
InterProiIPR033829. Antithrombin_domain.
IPR015555. AT-III.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISNGIGTVT AGKRSICLLP LLLIGLWGCV TCHRSPVEDV CTAKPRDIPV
60 70 80 90 100
NPMCIYRSSE KKATEGQGSE QKIPGATNRR VWELSKANSH FATAFYQHLA
110 120 130 140 150
DSKNNNDNIF LSPLSISTAF AMTKLGACNN TLKQLMEVFK FDTISEKTSD
160 170 180 190 200
QIHFFFAKLN CRLYRKANKS SELVSANRLF GGKSITFNET YQDISEVVYG
210 220 230 240 250
AKLQPLDFKG NAEQSRLTIN QWISNKTEGR ITDVIPPQAI NEFTVLVLVN
260 270 280 290 300
TIYFKGLWKS KFSPENTRKE LFYKADGESC SVLMMYQESK FRYRRVAEST
310 320 330 340 350
QVLELPFKGD DITMVLILPK LEKTLAKVEQ ELTPDMLQEW LDELTETLLV
360 370 380 390 400
VHMPRFRIED SFSVKEQLQD MGLEDLFSPE KSRLPGIVAE GRSDLYVSDA
410 420 430 440 450
FHKAFLEVNE EGSEAAASTV ISIAGRSLNS DRVTFKANRP ILVLIREVAL
460
NTIIFMGRVA NPCVD
Length:465
Mass (Da):52,347
Last modified:June 27, 2006 - v2
Checksum:iB674E579154F291F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129N → D in AAI02748 (Ref. 1) Curated1
Sequence conflicti133K → T AA sequence (PubMed:1930634).Curated1
Sequence conflicti182G → D AA sequence (PubMed:1930634).Curated1
Sequence conflicti441I → F AA sequence (PubMed:1930634).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102747 mRNA. Translation: AAI02748.1.
PIRiA61435.
RefSeqiNP_001029870.1. NM_001034698.2.
UniGeneiBt.11574.

Genome annotation databases

GeneIDi540261.
KEGGibta:540261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102747 mRNA. Translation: AAI02748.1.
PIRiA61435.
RefSeqiNP_001029870.1. NM_001034698.2.
UniGeneiBt.11574.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ATTX-ray3.20A/B37-465[»]
SMRiP41361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005713.

Chemistry databases

ChEMBLiCHEMBL2150842.

Protein family/group databases

MEROPSiI04.018.

Proteomic databases

PaxDbiP41361.
PeptideAtlasiP41361.
PRIDEiP41361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi540261.
KEGGibta:540261.

Organism-specific databases

CTDi462.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP41361.
KOiK03911.

Miscellaneous databases

EvolutionaryTraceiP41361.
PROiP41361.

Family and domain databases

CDDicd02045. antithrombin-III_like. 1 hit.
InterProiIPR033829. Antithrombin_domain.
IPR015555. AT-III.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiANT3_BOVIN
AccessioniPrimary (citable) accession number: P41361
Secondary accession number(s): Q3SZQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.