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P41361

- ANT3_BOVIN

UniProt

P41361 - ANT3_BOVIN

Protein

Antithrombin-III

Gene

SERPINC1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821HeparinBy similarity
    Binding sitei162 – 1621HeparinBy similarity
    Binding sitei178 – 1781HeparinBy similarity
    Sitei426 – 4272Reactive bond

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of blood coagulation, intrinsic pathway Source: InterPro
    4. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiI04.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Antithrombin-III
    Short name:
    ATIII
    Alternative name(s):
    Serpin C1
    Gene namesi
    Name:SERPINC1
    Synonyms:AT3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Secretedextracellular space By similarity

    GO - Cellular componenti

    1. extracellular region Source: RefGenome
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 32321 PublicationAdd
    BLAST
    Chaini33 – 465433Antithrombin-IIIPRO_0000094123Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 161
    Disulfide bondi54 ↔ 128
    Glycosylationi129 – 1291N-linked (GlcNAc...)
    Glycosylationi168 – 1681N-linked (GlcNAc...)
    Glycosylationi188 – 1881N-linked (GlcNAc...)
    Glycosylationi225 – 2251N-linked (GlcNAc...)
    Disulfide bondi280 ↔ 463

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP41361.
    PRIDEiP41361.

    Expressioni

    Tissue specificityi

    Plasma.

    Interactioni

    Subunit structurei

    Forms protease inhibiting heterodimer with TMPRSS7.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000005713.

    Structurei

    Secondary structure

    1
    465
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni39 – 424
    Turni77 – 804
    Helixi81 – 10222
    Beta strandi109 – 1113
    Helixi113 – 12311
    Turni124 – 1263
    Helixi129 – 13810
    Helixi141 – 1433
    Helixi149 – 16113
    Turni168 – 1703
    Beta strandi178 – 1825
    Helixi189 – 19911
    Beta strandi202 – 2065
    Helixi208 – 22619
    Turni227 – 2293
    Beta strandi244 – 26017
    Beta strandi266 – 2738
    Beta strandi279 – 29618
    Turni297 – 2993
    Beta strandi300 – 3078
    Beta strandi310 – 31910
    Helixi325 – 3306
    Helixi337 – 3426
    Beta strandi345 – 36319
    Helixi364 – 3718
    Helixi375 – 3773
    Turni379 – 3813
    Beta strandi387 – 3915
    Beta strandi396 – 40914
    Beta strandi412 – 42514
    Beta strandi441 – 4477
    Turni448 – 4503
    Beta strandi453 – 4597

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ATTX-ray3.20A/B37-465[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41361.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiP41361.
    KOiK03911.

    Family and domain databases

    InterProiIPR015555. AT-III.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF53. PTHR11461:SF53. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41361-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISNGIGTVT AGKRSICLLP LLLIGLWGCV TCHRSPVEDV CTAKPRDIPV    50
    NPMCIYRSSE KKATEGQGSE QKIPGATNRR VWELSKANSH FATAFYQHLA 100
    DSKNNNDNIF LSPLSISTAF AMTKLGACNN TLKQLMEVFK FDTISEKTSD 150
    QIHFFFAKLN CRLYRKANKS SELVSANRLF GGKSITFNET YQDISEVVYG 200
    AKLQPLDFKG NAEQSRLTIN QWISNKTEGR ITDVIPPQAI NEFTVLVLVN 250
    TIYFKGLWKS KFSPENTRKE LFYKADGESC SVLMMYQESK FRYRRVAEST 300
    QVLELPFKGD DITMVLILPK LEKTLAKVEQ ELTPDMLQEW LDELTETLLV 350
    VHMPRFRIED SFSVKEQLQD MGLEDLFSPE KSRLPGIVAE GRSDLYVSDA 400
    FHKAFLEVNE EGSEAAASTV ISIAGRSLNS DRVTFKANRP ILVLIREVAL 450
    NTIIFMGRVA NPCVD 465
    Length:465
    Mass (Da):52,347
    Last modified:June 27, 2006 - v2
    Checksum:iB674E579154F291F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti129 – 1291N → D in AAI02748. 1 PublicationCurated
    Sequence conflicti133 – 1331K → T AA sequence (PubMed:1930634)Curated
    Sequence conflicti182 – 1821G → D AA sequence (PubMed:1930634)Curated
    Sequence conflicti441 – 4411I → F AA sequence (PubMed:1930634)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102747 mRNA. Translation: AAI02748.1.
    PIRiA61435.
    RefSeqiNP_001029870.1. NM_001034698.2.
    UniGeneiBt.11574.

    Genome annotation databases

    GeneIDi540261.
    KEGGibta:540261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102747 mRNA. Translation: AAI02748.1 .
    PIRi A61435.
    RefSeqi NP_001029870.1. NM_001034698.2.
    UniGenei Bt.11574.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ATT X-ray 3.20 A/B 37-465 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000005713.

    Chemistry

    ChEMBLi CHEMBL2150842.

    Protein family/group databases

    MEROPSi I04.018.

    Proteomic databases

    PaxDbi P41361.
    PRIDEi P41361.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 540261.
    KEGGi bta:540261.

    Organism-specific databases

    CTDi 462.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi P41361.
    KOi K03911.

    Miscellaneous databases

    EvolutionaryTracei P41361.
    NextBioi 20878526.

    Family and domain databases

    InterProi IPR015555. AT-III.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF53. PTHR11461:SF53. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Testis.
    2. "The complete amino acid sequence of bovine antithrombin (ATIII)."
      Mejdoub H., le Ret M., Boulanger Y., Maman M., Choay J., Reinbolt J.
      J. Protein Chem. 10:205-212(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 33-465.
    3. "Crystal structure of cleaved bovine antithrombin III at 3.2-A resolution."
      Mourey L., Samama J.-P., Delarue M., Petitou M., Choay J., Moras D.
      J. Mol. Biol. 232:223-241(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 33-465.

    Entry informationi

    Entry nameiANT3_BOVIN
    AccessioniPrimary (citable) accession number: P41361
    Secondary accession number(s): Q3SZQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3