Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caveolin-1

Gene

Cav1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).By similarity

GO - Molecular functioni

  1. ion channel binding Source: BHF-UCL
  2. kinase binding Source: RGD
  3. MDM2/MDM4 family protein binding Source: RGD
  4. nitric-oxide synthase binding Source: RGD
  5. RNA polymerase I transcription factor binding Source: RGD
  6. SNARE binding Source: RGD
  7. structural molecule activity Source: HGNC
  8. syntaxin binding Source: RGD

GO - Biological processi

  1. cellular calcium ion homeostasis Source: RGD
  2. cellular response to mechanical stimulus Source: RGD
  3. cellular senescence Source: RGD
  4. cholesterol efflux Source: RGD
  5. maintenance of protein location in cell Source: BHF-UCL
  6. microtubule polymerization Source: RGD
  7. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  8. negative regulation of cation channel activity Source: RGD
  9. negative regulation of endothelial cell proliferation Source: RGD
  10. negative regulation of ERK1 and ERK2 cascade Source: RGD
  11. negative regulation of muscle cell apoptotic process Source: RGD
  12. negative regulation of neuron differentiation Source: RGD
  13. negative regulation of smooth muscle cell proliferation Source: RGD
  14. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  15. organ regeneration Source: RGD
  16. positive regulation of endocytosis Source: RGD
  17. positive regulation of endothelial cell proliferation Source: RGD
  18. positive regulation of microtubule polymerization Source: RGD
  19. positive regulation of signal transduction Source: RGD
  20. positive regulation of vasoconstriction Source: RGD
  21. response to drug Source: RGD
  22. response to gamma radiation Source: RGD
  23. response to glucocorticoid Source: RGD
  24. response to mechanical stimulus Source: RGD
  25. response to nutrient Source: RGD
  26. T cell costimulation Source: UniProtKB
  27. wound healing Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_236244. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:Cav1
Synonyms:Cav
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2280. Cav1.

Subcellular locationi

Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Membranecaveola By similarity; Peripheral membrane protein By similarity. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 104103CytoplasmicSequence AnalysisAdd
BLAST
Intramembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 17853CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basal plasma membrane Source: RGD
  2. caveola Source: UniProtKB
  3. cell surface Source: RGD
  4. cytoplasm Source: RGD
  5. cytoplasmic vesicle Source: RGD
  6. cytosol Source: RGD
  7. endoplasmic reticulum Source: HGNC
  8. endosome Source: UniProtKB
  9. focal adhesion Source: RGD
  10. Golgi apparatus Source: BHF-UCL
  11. Golgi membrane Source: HGNC
  12. integral component of membrane Source: RGD
  13. lipid particle Source: RGD
  14. membrane raft Source: BHF-UCL
  15. mitochondrion Source: RGD
  16. perinuclear region of cytoplasm Source: UniProtKB
  17. peroxisomal membrane Source: RGD
  18. plasma membrane Source: UniProtKB
  19. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 178177Caveolin-1PRO_0000004768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei5 – 51N6-acetyllysineBy similarity
Modified residuei6 – 61PhosphotyrosineBy similarity
Modified residuei14 – 141Phosphotyrosine; by ABL1By similarity
Modified residuei25 – 251PhosphotyrosineBy similarity
Modified residuei42 – 421PhosphotyrosineBy similarity
Lipidationi133 – 1331S-palmitoyl cysteineBy similarity
Lipidationi143 – 1431S-palmitoyl cysteineBy similarity
Lipidationi156 – 1561S-palmitoyl cysteineBy similarity

Post-translational modificationi

Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP41350.
PRIDEiP41350.

PTM databases

PhosphoSiteiP41350.

Expressioni

Tissue specificityi

Cortex and inner medulla of kidney (at protein level). Expressed in the hippocampus.2 Publications

Gene expression databases

GenevestigatoriP41350.

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP and NOSTRIN (By similarity). Interacts with SNAP25 and STX1A. Interacts with SLC7A9.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc22a5O705942EBI-1161014,EBI-9846085

Protein-protein interaction databases

IntActiP41350. 7 interactions.
MINTiMINT-202594.

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiNOG86001.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP41350.
PhylomeDBiP41350.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P41350-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPLF EAIGKIFSNI RISTQEEI
Length:178
Mass (Da):20,553
Last modified:August 16, 2004 - v3
Checksum:i55E8F6ABC7514FD2
GO
Isoform 2 (identifier: P41350-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:147
Mass (Da):17,104
Checksum:i6BB1A8538BC34440
GO

Sequence cautioni

The sequence CAA86587.1 differs from that shown. Reason: Frameshift at position 161. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201A → G in CAA86587 (Ref. 1) Curated
Sequence conflicti154 – 1541T → N in CAA86587 (Ref. 1) Curated
Sequence conflicti162 – 1621A → G in CAA86587 (Ref. 1) Curated
Sequence conflicti171 – 1711R → P in CAA86587 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131Missing in isoform 2. 1 PublicationVSP_018694Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46614 mRNA. Translation: CAA86587.1. Frameshift.
AF439778 mRNA. Translation: AAL33579.1.
AF439779 mRNA. Translation: AAL33580.1.
UniGeneiRn.22518.

Genome annotation databases

UCSCiRGD:2280. rat. [P41350-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46614 mRNA. Translation: CAA86587.1. Frameshift.
AF439778 mRNA. Translation: AAL33579.1.
AF439779 mRNA. Translation: AAL33580.1.
UniGeneiRn.22518.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP41350. 7 interactions.
MINTiMINT-202594.

PTM databases

PhosphoSiteiP41350.

Proteomic databases

PaxDbiP41350.
PRIDEiP41350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2280. rat. [P41350-1]

Organism-specific databases

RGDi2280. Cav1.

Phylogenomic databases

eggNOGiNOG86001.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP41350.
PhylomeDBiP41350.

Enzyme and pathway databases

ReactomeiREACT_236244. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

PROiP41350.

Gene expression databases

GenevestigatoriP41350.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Immuno-electronmicroscopical identification of caveolin in rat adipocyte plasma membranes."
    Vinten J., Voldstedlund M., Carlsen J., Christiansen K., Clausen H., Tranum-Jensen J.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Adipose tissue.
  2. "ATP dependence of the SNARE/caveolin 1 interaction in the hippocampus."
    Magga J.M., Kay J.G., Davy A., Poulton N.P., Robbins S.M., Braun J.E.A.
    Biochem. Biophys. Res. Commun. 291:1232-1238(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH SNAP25 AND SYNTAXIN.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney."
    Kwak J.O., Kim H.W., Jung S.M., Song J.H., Hong S.B., Oh K.J., Ko C.B., Cha S.H.
    J. Nephrol. 18:681-689(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SLC7A9.

Entry informationi

Entry nameiCAV1_RAT
AccessioniPrimary (citable) accession number: P41350
Secondary accession number(s): Q8VIK8, Q8VIK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 16, 2004
Last modified: March 4, 2015
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.