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P41350

- CAV1_RAT

UniProt

P41350 - CAV1_RAT

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Protein
Caveolin-1
Gene
Cav1, Cav
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway By similarity.

GO - Molecular functioni

  1. SNARE binding Source: RGD
  2. kinase binding Source: RGD
  3. nitric-oxide synthase activity Source: RGD
  4. nitric-oxide synthase binding Source: RGD
  5. protein binding Source: IntAct
  6. structural molecule activity Source: HGNC
  7. syntaxin binding Source: RGD

GO - Biological processi

  1. T cell costimulation Source: UniProtKB
  2. cellular calcium ion homeostasis Source: RGD
  3. cellular response to mechanical stimulus Source: RGD
  4. cholesterol efflux Source: RGD
  5. cholesterol transport Source: RGD
  6. maintenance of protein location in cell Source: BHF-UCL
  7. microtubule polymerization Source: RGD
  8. negative regulation of ERK1 and ERK2 cascade Source: RGD
  9. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  10. negative regulation of cation channel activity Source: RGD
  11. negative regulation of endothelial cell proliferation Source: RGD
  12. negative regulation of muscle cell apoptotic process Source: RGD
  13. negative regulation of neuron differentiation Source: RGD
  14. negative regulation of smooth muscle cell proliferation Source: RGD
  15. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  16. organ regeneration Source: RGD
  17. oxidation-reduction process Source: GOC
  18. positive regulation of endocytosis Source: RGD
  19. positive regulation of endothelial cell proliferation Source: RGD
  20. positive regulation of microtubule polymerization Source: RGD
  21. positive regulation of signal transduction Source: RGD
  22. positive regulation of vasoconstriction Source: RGD
  23. response to drug Source: RGD
  24. response to gamma radiation Source: RGD
  25. response to glucocorticoid Source: RGD
  26. response to mechanical stimulus Source: RGD
  27. response to nutrient Source: RGD
  28. transcytosis Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:Cav1
Synonyms:Cav
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2280. Cav1.

Subcellular locationi

Golgi apparatus membrane; Peripheral membrane protein By similarity. Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein By similarity. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 104103Cytoplasmic Reviewed prediction
Add
BLAST
Intramembranei105 – 12521Helical; Reviewed prediction
Add
BLAST
Topological domaini126 – 17853Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: BHF-UCL
  2. Golgi membrane Source: HGNC
  3. basal plasma membrane Source: RGD
  4. caveola Source: UniProtKB
  5. cell surface Source: RGD
  6. cytoplasm Source: RGD
  7. cytoplasmic vesicle Source: RGD
  8. cytosol Source: RGD
  9. endoplasmic reticulum Source: HGNC
  10. endosome Source: UniProtKB
  11. focal adhesion Source: RGD
  12. integral component of membrane Source: RGD
  13. lipid particle Source: RGD
  14. membrane raft Source: BHF-UCL
  15. mitochondrion Source: RGD
  16. perinuclear region of cytoplasm Source: UniProtKB
  17. peroxisomal membrane Source: RGD
  18. plasma membrane Source: UniProtKB
  19. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 178177Caveolin-1
PRO_0000004768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei5 – 51N6-acetyllysine By similarity
Modified residuei6 – 61Phosphotyrosine By similarity
Modified residuei14 – 141Phosphotyrosine; by ABL1 By similarity
Modified residuei25 – 251Phosphotyrosine By similarity
Modified residuei42 – 421Phosphotyrosine By similarity
Lipidationi133 – 1331S-palmitoyl cysteine By similarity
Lipidationi143 – 1431S-palmitoyl cysteine By similarity
Lipidationi156 – 1561S-palmitoyl cysteine By similarity

Post-translational modificationi

Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress By similarity.

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP41350.
PRIDEiP41350.

PTM databases

PhosphoSiteiP41350.

Expressioni

Tissue specificityi

Cortex and inner medulla of kidney (at protein level). Expressed in the hippocampus.2 Publications

Gene expression databases

GenevestigatoriP41350.

Interactioni

Subunit structurei

Homooligomer By similarity. Interacts (via the N-terminus) with DPP4; the interaction is direct By similarity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP and NOSTRIN By similarity. Interacts with SNAP25 and STX1A. Interacts with SLC7A9.2 Publications

Protein-protein interaction databases

IntActiP41350. 5 interactions.
MINTiMINT-202594.

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.

Phylogenomic databases

eggNOGiNOG86001.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP41350.
PhylomeDBiP41350.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: P41350-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID    50
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY 100
RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI 150
YVHTFCDPLF EAIGKIFSNI RISTQEEI 178
Length:178
Mass (Da):20,553
Last modified:August 16, 2004 - v3
Checksum:i55E8F6ABC7514FD2
GO
Isoform 2 (identifier: P41350-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-31: Missing.

Show »
Length:148
Mass (Da):17,235
Checksum:i6BF87CF9EE10F570
GO

Sequence cautioni

The sequence CAA86587.1 differs from that shown. Reason: Frameshift at position 161.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 3130Missing in isoform 2.
VSP_018694Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201A → G in CAA86587. 1 Publication
Sequence conflicti154 – 1541T → N in CAA86587. 1 Publication
Sequence conflicti162 – 1621A → G in CAA86587. 1 Publication
Sequence conflicti171 – 1711R → P in CAA86587. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46614 mRNA. Translation: CAA86587.1. Frameshift.
AF439778 mRNA. Translation: AAL33579.1.
AF439779 mRNA. Translation: AAL33580.1.
UniGeneiRn.22518.

Genome annotation databases

UCSCiRGD:2280. rat. [P41350-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46614 mRNA. Translation: CAA86587.1 . Frameshift.
AF439778 mRNA. Translation: AAL33579.1 .
AF439779 mRNA. Translation: AAL33580.1 .
UniGenei Rn.22518.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P41350. 5 interactions.
MINTi MINT-202594.

PTM databases

PhosphoSitei P41350.

Proteomic databases

PaxDbi P41350.
PRIDEi P41350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2280. rat. [P41350-1 ]

Organism-specific databases

RGDi 2280. Cav1.

Phylogenomic databases

eggNOGi NOG86001.
HOGENOMi HOG000036550.
HOVERGENi HBG003422.
InParanoidi P41350.
PhylomeDBi P41350.

Miscellaneous databases

PROi P41350.

Gene expression databases

Genevestigatori P41350.

Family and domain databases

InterProi IPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view ]
PANTHERi PTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
Pfami PF01146. Caveolin. 1 hit.
[Graphical view ]
PROSITEi PS01210. CAVEOLIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Immuno-electronmicroscopical identification of caveolin in rat adipocyte plasma membranes."
    Vinten J., Voldstedlund M., Carlsen J., Christiansen K., Clausen H., Tranum-Jensen J.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Adipose tissue.
  2. "ATP dependence of the SNARE/caveolin 1 interaction in the hippocampus."
    Magga J.M., Kay J.G., Davy A., Poulton N.P., Robbins S.M., Braun J.E.A.
    Biochem. Biophys. Res. Commun. 291:1232-1238(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH SNAP25 AND SYNTAXIN.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney."
    Kwak J.O., Kim H.W., Jung S.M., Song J.H., Hong S.B., Oh K.J., Ko C.B., Cha S.H.
    J. Nephrol. 18:681-689(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SLC7A9.

Entry informationi

Entry nameiCAV1_RAT
AccessioniPrimary (citable) accession number: P41350
Secondary accession number(s): Q8VIK8, Q8VIK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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