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Protein

Caveolin-1

Gene

Cav1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).By similarity

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
  • kinase binding Source: RGD
  • MDM2/MDM4 family protein binding Source: RGD
  • nitric-oxide synthase binding Source: RGD
  • RNA polymerase I transcription factor binding Source: RGD
  • SNARE binding Source: RGD
  • structural molecule activity Source: HGNC
  • syntaxin binding Source: RGD

GO - Biological processi

  • animal organ regeneration Source: RGD
  • caveola assembly Source: InterPro
  • cellular calcium ion homeostasis Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • cellular senescence Source: RGD
  • cholesterol efflux Source: RGD
  • maintenance of protein location in cell Source: BHF-UCL
  • microtubule polymerization Source: RGD
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of cation channel activity Source: RGD
  • negative regulation of endothelial cell proliferation Source: RGD
  • negative regulation of ERK1 and ERK2 cascade Source: RGD
  • negative regulation of muscle cell apoptotic process Source: RGD
  • negative regulation of neuron differentiation Source: RGD
  • negative regulation of smooth muscle cell proliferation Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • positive regulation of endocytosis Source: RGD
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of microtubule polymerization Source: RGD
  • positive regulation of signal transduction Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • receptor internalization Source: UniProtKB
  • response to drug Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nutrient Source: RGD
  • T cell costimulation Source: UniProtKB
  • wound healing Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:Cav1
Synonyms:Cav
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2280. Cav1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 104CytoplasmicSequence analysisAdd BLAST103
Intramembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 178CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • basal plasma membrane Source: RGD
  • caveola Source: UniProtKB
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • cytoplasmic vesicle Source: RGD
  • cytosol Source: RGD
  • endoplasmic reticulum Source: HGNC
  • endosome Source: UniProtKB
  • focal adhesion Source: RGD
  • Golgi apparatus Source: BHF-UCL
  • Golgi membrane Source: HGNC
  • lipid particle Source: RGD
  • membrane raft Source: BHF-UCL
  • mitochondrion Source: RGD
  • perinuclear region of cytoplasm Source: UniProtKB
  • peroxisomal membrane Source: RGD
  • plasma membrane Source: UniProtKB
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000047682 – 178Caveolin-1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei5N6-acetyllysineBy similarity1
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei14Phosphotyrosine; by ABL1By similarity1
Modified residuei25PhosphotyrosineBy similarity1
Lipidationi133S-palmitoyl cysteineBy similarity1
Lipidationi143S-palmitoyl cysteineBy similarity1
Lipidationi156S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP41350.
PRIDEiP41350.

PTM databases

iPTMnetiP41350.
PhosphoSitePlusiP41350.

Expressioni

Tissue specificityi

Cortex and inner medulla of kidney (at protein level). Expressed in the hippocampus.2 Publications

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP and NOSTRIN (By similarity). Interacts with SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc22a5O705942EBI-1161014,EBI-9846085

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
  • kinase binding Source: RGD
  • MDM2/MDM4 family protein binding Source: RGD
  • nitric-oxide synthase binding Source: RGD
  • RNA polymerase I transcription factor binding Source: RGD
  • SNARE binding Source: RGD
  • syntaxin binding Source: RGD

Protein-protein interaction databases

IntActiP41350. 7 interactors.
MINTiMINT-202594.
STRINGi10116.ENSRNOP00000009253.

Structurei

3D structure databases

ProteinModelPortaliP41350.
SMRiP41350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IV7A. Eukaryota.
ENOG4111HJR. LUCA.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP41350.
PhylomeDBiP41350.

Family and domain databases

InterProiIPR015504. CAV-1.
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF18. PTHR10844:SF18. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P41350-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPLF EAIGKIFSNI RISTQEEI
Length:178
Mass (Da):20,553
Last modified:August 16, 2004 - v3
Checksum:i55E8F6ABC7514FD2
GO
Isoform 2 (identifier: P41350-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:147
Mass (Da):17,104
Checksum:i6BB1A8538BC34440
GO

Sequence cautioni

The sequence CAA86587 differs from that shown. Reason: Frameshift at position 161.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120A → G in CAA86587 (Ref. 1) Curated1
Sequence conflicti154T → N in CAA86587 (Ref. 1) Curated1
Sequence conflicti162A → G in CAA86587 (Ref. 1) Curated1
Sequence conflicti171R → P in CAA86587 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186941 – 31Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46614 mRNA. Translation: CAA86587.1. Frameshift.
AF439778 mRNA. Translation: AAL33579.1.
AF439779 mRNA. Translation: AAL33580.1.
UniGeneiRn.22518.

Genome annotation databases

UCSCiRGD:2280. rat. [P41350-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46614 mRNA. Translation: CAA86587.1. Frameshift.
AF439778 mRNA. Translation: AAL33579.1.
AF439779 mRNA. Translation: AAL33580.1.
UniGeneiRn.22518.

3D structure databases

ProteinModelPortaliP41350.
SMRiP41350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP41350. 7 interactors.
MINTiMINT-202594.
STRINGi10116.ENSRNOP00000009253.

PTM databases

iPTMnetiP41350.
PhosphoSitePlusiP41350.

Proteomic databases

PaxDbiP41350.
PRIDEiP41350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2280. rat. [P41350-1]

Organism-specific databases

RGDi2280. Cav1.

Phylogenomic databases

eggNOGiENOG410IV7A. Eukaryota.
ENOG4111HJR. LUCA.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP41350.
PhylomeDBiP41350.

Enzyme and pathway databases

ReactomeiR-RNO-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

PROiP41350.

Family and domain databases

InterProiIPR015504. CAV-1.
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF18. PTHR10844:SF18. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAV1_RAT
AccessioniPrimary (citable) accession number: P41350
Secondary accession number(s): Q8VIK8, Q8VIK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.