Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P41350

- CAV1_RAT

UniProt

P41350 - CAV1_RAT

Protein

Caveolin-1

Gene

Cav1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway By similarity.By similarity

    GO - Molecular functioni

    1. kinase binding Source: RGD
    2. nitric-oxide synthase binding Source: RGD
    3. protein binding Source: IntAct
    4. SNARE binding Source: RGD
    5. structural molecule activity Source: HGNC
    6. syntaxin binding Source: RGD

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: RGD
    2. cellular response to mechanical stimulus Source: RGD
    3. cholesterol efflux Source: RGD
    4. maintenance of protein location in cell Source: BHF-UCL
    5. microtubule polymerization Source: RGD
    6. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    7. negative regulation of cation channel activity Source: RGD
    8. negative regulation of endothelial cell proliferation Source: RGD
    9. negative regulation of ERK1 and ERK2 cascade Source: RGD
    10. negative regulation of muscle cell apoptotic process Source: RGD
    11. negative regulation of neuron differentiation Source: RGD
    12. negative regulation of smooth muscle cell proliferation Source: RGD
    13. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    14. organ regeneration Source: RGD
    15. positive regulation of endocytosis Source: RGD
    16. positive regulation of endothelial cell proliferation Source: RGD
    17. positive regulation of microtubule polymerization Source: RGD
    18. positive regulation of signal transduction Source: RGD
    19. positive regulation of vasoconstriction Source: RGD
    20. response to drug Source: RGD
    21. response to gamma radiation Source: RGD
    22. response to glucocorticoid Source: RGD
    23. response to mechanical stimulus Source: RGD
    24. response to nutrient Source: RGD
    25. T cell costimulation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caveolin-1
    Gene namesi
    Name:Cav1
    Synonyms:Cav
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2280. Cav1.

    Subcellular locationi

    Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Membranecaveola By similarity; Peripheral membrane protein By similarity. Membrane raft By similarity
    Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

    GO - Cellular componenti

    1. basal plasma membrane Source: RGD
    2. caveola Source: UniProtKB
    3. cell surface Source: RGD
    4. cytoplasm Source: RGD
    5. cytoplasmic vesicle Source: RGD
    6. cytosol Source: RGD
    7. endoplasmic reticulum Source: HGNC
    8. endosome Source: UniProtKB
    9. focal adhesion Source: RGD
    10. Golgi apparatus Source: BHF-UCL
    11. Golgi membrane Source: HGNC
    12. integral component of membrane Source: RGD
    13. lipid particle Source: RGD
    14. membrane raft Source: BHF-UCL
    15. mitochondrion Source: RGD
    16. perinuclear region of cytoplasm Source: UniProtKB
    17. peroxisomal membrane Source: RGD
    18. plasma membrane Source: UniProtKB
    19. protein complex Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 178177Caveolin-1PRO_0000004768Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei5 – 51N6-acetyllysineBy similarity
    Modified residuei6 – 61PhosphotyrosineBy similarity
    Modified residuei14 – 141Phosphotyrosine; by ABL1By similarity
    Modified residuei25 – 251PhosphotyrosineBy similarity
    Modified residuei42 – 421PhosphotyrosineBy similarity
    Lipidationi133 – 1331S-palmitoyl cysteineBy similarity
    Lipidationi143 – 1431S-palmitoyl cysteineBy similarity
    Lipidationi156 – 1561S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.By similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP41350.
    PRIDEiP41350.

    PTM databases

    PhosphoSiteiP41350.

    Expressioni

    Tissue specificityi

    Cortex and inner medulla of kidney (at protein level). Expressed in the hippocampus.2 Publications

    Gene expression databases

    GenevestigatoriP41350.

    Interactioni

    Subunit structurei

    Homooligomer By similarity. Interacts (via the N-terminus) with DPP4; the interaction is direct By similarity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP and NOSTRIN By similarity. Interacts with SNAP25 and STX1A. Interacts with SLC7A9.By similarity2 Publications

    Protein-protein interaction databases

    IntActiP41350. 5 interactions.
    MINTiMINT-202594.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 104103CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini126 – 17853CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the caveolin family.Curated

    Phylogenomic databases

    eggNOGiNOG86001.
    HOGENOMiHOG000036550.
    HOVERGENiHBG003422.
    InParanoidiP41350.
    PhylomeDBiP41350.

    Family and domain databases

    InterProiIPR001612. Caveolin.
    IPR015504. Caveolin_1.
    IPR018361. Caveolin_CS.
    [Graphical view]
    PANTHERiPTHR10844. PTHR10844. 1 hit.
    PTHR10844:SF5. PTHR10844:SF5. 1 hit.
    PfamiPF01146. Caveolin. 1 hit.
    [Graphical view]
    PROSITEiPS01210. CAVEOLIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform 1 (identifier: P41350-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID    50
    LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY 100
    RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI 150
    YVHTFCDPLF EAIGKIFSNI RISTQEEI 178
    Length:178
    Mass (Da):20,553
    Last modified:August 16, 2004 - v3
    Checksum:i55E8F6ABC7514FD2
    GO
    Isoform 2 (identifier: P41350-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-31: Missing.

    Show »
    Length:148
    Mass (Da):17,235
    Checksum:i6BF87CF9EE10F570
    GO

    Sequence cautioni

    The sequence CAA86587.1 differs from that shown. Reason: Frameshift at position 161.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 1201A → G in CAA86587. 1 PublicationCurated
    Sequence conflicti154 – 1541T → N in CAA86587. 1 PublicationCurated
    Sequence conflicti162 – 1621A → G in CAA86587. 1 PublicationCurated
    Sequence conflicti171 – 1711R → P in CAA86587. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 3130Missing in isoform 2. 1 PublicationVSP_018694Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46614 mRNA. Translation: CAA86587.1. Frameshift.
    AF439778 mRNA. Translation: AAL33579.1.
    AF439779 mRNA. Translation: AAL33580.1.
    UniGeneiRn.22518.

    Genome annotation databases

    UCSCiRGD:2280. rat. [P41350-1]

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46614 mRNA. Translation: CAA86587.1 . Frameshift.
    AF439778 mRNA. Translation: AAL33579.1 .
    AF439779 mRNA. Translation: AAL33580.1 .
    UniGenei Rn.22518.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P41350. 5 interactions.
    MINTi MINT-202594.

    PTM databases

    PhosphoSitei P41350.

    Proteomic databases

    PaxDbi P41350.
    PRIDEi P41350.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2280. rat. [P41350-1 ]

    Organism-specific databases

    RGDi 2280. Cav1.

    Phylogenomic databases

    eggNOGi NOG86001.
    HOGENOMi HOG000036550.
    HOVERGENi HBG003422.
    InParanoidi P41350.
    PhylomeDBi P41350.

    Miscellaneous databases

    PROi P41350.

    Gene expression databases

    Genevestigatori P41350.

    Family and domain databases

    InterProi IPR001612. Caveolin.
    IPR015504. Caveolin_1.
    IPR018361. Caveolin_CS.
    [Graphical view ]
    PANTHERi PTHR10844. PTHR10844. 1 hit.
    PTHR10844:SF5. PTHR10844:SF5. 1 hit.
    Pfami PF01146. Caveolin. 1 hit.
    [Graphical view ]
    PROSITEi PS01210. CAVEOLIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immuno-electronmicroscopical identification of caveolin in rat adipocyte plasma membranes."
      Vinten J., Voldstedlund M., Carlsen J., Christiansen K., Clausen H., Tranum-Jensen J.
      Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Adipose tissue.
    2. "ATP dependence of the SNARE/caveolin 1 interaction in the hippocampus."
      Magga J.M., Kay J.G., Davy A., Poulton N.P., Robbins S.M., Braun J.E.A.
      Biochem. Biophys. Res. Commun. 291:1232-1238(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH SNAP25 AND SYNTAXIN.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    3. "Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney."
      Kwak J.O., Kim H.W., Jung S.M., Song J.H., Hong S.B., Oh K.J., Ko C.B., Cha S.H.
      J. Nephrol. 18:681-689(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SLC7A9.

    Entry informationi

    Entry nameiCAV1_RAT
    AccessioniPrimary (citable) accession number: P41350
    Secondary accession number(s): Q8VIK8, Q8VIK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3