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P41350 (CAV1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caveolin-1
Gene names
Name:Cav1
Synonyms:Cav
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway By similarity.

Subunit structure

Homooligomer By similarity. Interacts (via the N-terminus) with DPP4; the interaction is direct By similarity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP and NOSTRIN By similarity. Interacts with SNAP25 and STX1A. Interacts with SLC7A9. Ref.2 Ref.3

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein By similarity. Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein By similarity. Membrane raft By similarity. Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Ref.3

Tissue specificity

Cortex and inner medulla of kidney (at protein level). Expressed in the hippocampus. Ref.2 Ref.3

Post-translational modification

Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress By similarity.

Sequence similarities

Belongs to the caveolin family.

Sequence caution

The sequence CAA86587.1 differs from that shown. Reason: Frameshift at position 161.

Ontologies

Keywords
   Cellular componentCell membrane
Golgi apparatus
Membrane
   Coding sequence diversityAlternative initiation
   PTMAcetylation
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell costimulation

Inferred from sequence or structural similarity. Source: UniProtKB

cellular calcium ion homeostasis

Inferred from mutant phenotype PubMed 17337601. Source: RGD

cellular response to mechanical stimulus

Inferred from direct assay PubMed 20172952. Source: RGD

cholesterol efflux

Inferred from mutant phenotype PubMed 17499231. Source: RGD

cholesterol transport

Traceable author statement Ref.2. Source: RGD

maintenance of protein location in cell

Inferred from mutant phenotype PubMed 18162583. Source: BHF-UCL

microtubule polymerization

Inferred from mutant phenotype PubMed 16480946. Source: RGD

negative regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 20172952. Source: RGD

negative regulation of canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cation channel activity

Inferred from direct assay PubMed 20624795. Source: RGD

negative regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 16051704. Source: RGD

negative regulation of muscle cell apoptotic process

Inferred from mutant phenotype PubMed 18039791. Source: RGD

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 21826216. Source: RGD

negative regulation of smooth muscle cell proliferation

Inferred from mutant phenotype PubMed 20828553. Source: RGD

negative regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

organ regeneration

Inferred from expression pattern PubMed 22431231. Source: RGD

oxidation-reduction process

Inferred from physical interaction PubMed 12566108. Source: GOC

positive regulation of endocytosis

Inferred from mutant phenotype PubMed 17715130. Source: RGD

positive regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 20828553. Source: RGD

positive regulation of microtubule polymerization

Inferred from mutant phenotype PubMed 16480946. Source: RGD

positive regulation of signal transduction

Inferred from mutant phenotype PubMed 18039791. Source: RGD

positive regulation of vasoconstriction

Inferred from mutant phenotype PubMed 21098487. Source: RGD

response to drug

Inferred from expression pattern PubMed 17331262. Source: RGD

response to gamma radiation

Inferred from expression pattern PubMed 17993744. Source: RGD

response to glucocorticoid

Inferred from expression pattern PubMed 17537407. Source: RGD

response to mechanical stimulus

Inferred from mutant phenotype PubMed 17446044. Source: RGD

response to nutrient

Inferred from expression pattern PubMed 16335790. Source: RGD

transcytosis

Traceable author statement Ref.2. Source: RGD

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 18162583. Source: BHF-UCL

Golgi membrane

Inferred from sequence or structural similarity. Source: HGNC

basal plasma membrane

Inferred from direct assay PubMed 16904002. Source: RGD

caveola

Inferred from direct assay PubMed 19931615. Source: UniProtKB

cell surface

Inferred from direct assay PubMed 10887965. Source: RGD

cytoplasm

Inferred from direct assay PubMed 10887965. Source: RGD

cytoplasmic vesicle

Inferred from direct assay PubMed 17499231. Source: RGD

cytosol

Inferred from direct assay PubMed 16352305. Source: RGD

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: HGNC

endosome

Inferred from sequence or structural similarity. Source: UniProtKB

focal adhesion

Inferred from direct assay PubMed 15731459PubMed 16618703. Source: RGD

integral component of membrane

Traceable author statement PubMed 12388423. Source: RGD

lipid particle

Inferred from direct assay PubMed 14528016. Source: RGD

membrane raft

Inferred from direct assay PubMed 18162583. Source: BHF-UCL

mitochondrion

Inferred from direct assay PubMed 16352305. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 19931615. Source: UniProtKB

peroxisomal membrane

Inferred from direct assay PubMed 20146263. Source: RGD

plasma membrane

Inferred from direct assay Ref.3. Source: UniProtKB

protein complex

Inferred from direct assay PubMed 22492718. Source: RGD

   Molecular_functionSNARE binding

Inferred from mutant phenotype Ref.2. Source: RGD

kinase binding

Inferred from physical interaction PubMed 16419038. Source: RGD

nitric-oxide synthase activity

Inferred from physical interaction PubMed 12566108. Source: RGD

nitric-oxide synthase binding

Inferred from physical interaction PubMed 17277024. Source: RGD

protein binding

Inferred from physical interaction PubMed 15293782PubMed 15293782. Source: IntAct

structural molecule activity

Inferred from sequence or structural similarity. Source: HGNC

syntaxin binding

Inferred from mutant phenotype Ref.2. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform 1 (identifier: P41350-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P41350-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-31: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 178177Caveolin-1
PRO_0000004768

Regions

Topological domain2 – 104103Cytoplasmic Potential
Intramembrane105 – 12521Helical; Potential
Topological domain126 – 17853Cytoplasmic Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue51N6-acetyllysine By similarity
Modified residue61Phosphotyrosine By similarity
Modified residue141Phosphotyrosine; by ABL1 By similarity
Modified residue251Phosphotyrosine By similarity
Modified residue421Phosphotyrosine By similarity
Lipidation1331S-palmitoyl cysteine By similarity
Lipidation1431S-palmitoyl cysteine By similarity
Lipidation1561S-palmitoyl cysteine By similarity

Natural variations

Alternative sequence2 – 3130Missing in isoform 2.
VSP_018694

Experimental info

Sequence conflict1201A → G in CAA86587. Ref.1
Sequence conflict1541T → N in CAA86587. Ref.1
Sequence conflict1621A → G in CAA86587. Ref.1
Sequence conflict1711R → P in CAA86587. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 16, 2004. Version 3.
Checksum: 55E8F6ABC7514FD2

FASTA17820,553
        10         20         30         40         50         60 
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID LVNRDPKHLN 

        70         80         90        100        110        120 
DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSTIFGIP MALIWGIYFA 

       130        140        150        160        170 
ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RISTQEEI 

« Hide

Isoform 2 [UniParc].

Checksum: 6BF87CF9EE10F570
Show »

FASTA14817,235

References

[1]"Immuno-electronmicroscopical identification of caveolin in rat adipocyte plasma membranes."
Vinten J., Voldstedlund M., Carlsen J., Christiansen K., Clausen H., Tranum-Jensen J.
Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Adipose tissue.
[2]"ATP dependence of the SNARE/caveolin 1 interaction in the hippocampus."
Magga J.M., Kay J.G., Davy A., Poulton N.P., Robbins S.M., Braun J.E.A.
Biochem. Biophys. Res. Commun. 291:1232-1238(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH SNAP25 AND SYNTAXIN.
Strain: Sprague-Dawley.
Tissue: Brain.
[3]"Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney."
Kwak J.O., Kim H.W., Jung S.M., Song J.H., Hong S.B., Oh K.J., Ko C.B., Cha S.H.
J. Nephrol. 18:681-689(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SLC7A9.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46614 mRNA. Translation: CAA86587.1. Frameshift.
AF439778 mRNA. Translation: AAL33579.1.
AF439779 mRNA. Translation: AAL33580.1.
UniGeneRn.22518.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP41350. 5 interactions.
MINTMINT-202594.

PTM databases

PhosphoSiteP41350.

Proteomic databases

PaxDbP41350.
PRIDEP41350.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2280. rat. [P41350-1]

Organism-specific databases

RGD2280. Cav1.

Phylogenomic databases

eggNOGNOG86001.
HOGENOMHOG000036550.
HOVERGENHBG003422.
InParanoidP41350.
PhylomeDBP41350.

Gene expression databases

GenevestigatorP41350.

Family and domain databases

InterProIPR001612. Caveolin.
IPR015504. Caveolin_1.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF5. PTHR10844:SF5. 1 hit.
PfamPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP41350.

Entry information

Entry nameCAV1_RAT
AccessionPrimary (citable) accession number: P41350
Secondary accession number(s): Q8VIK8, Q8VIK9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families