P41350 (CAV1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Caveolin-1

Gene names

Name:	Cav1
Synonyms:	Cav

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway By similarity.
Subunit structure	Homooligomer By similarity. Interacts (via the N-terminus) with DPP4; the interaction is direct By similarity. Interacts with SNAP25 and STX1A. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP and NOSTRIN By similarity. Ref.2
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein By similarity. Cell membrane; Peripheral membrane protein By similarity. Membrane › caveola; Peripheral membrane protein By similarity. Membrane raft By similarity. Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae By similarity.
Tissue specificity	Expressed in the hyppocampus. Ref.2
Post-translational modification	Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress By similarity.
Sequence similarities	Belongs to the caveolin family.
Sequence caution	The sequence CAA86587.1 differs from that shown. Reason: Frameshift at position 161.

Ontologies

Keywords
Cellular component	Cell membrane Golgi apparatus Membrane
Coding sequence diversity	Alternative initiation
PTM	Acetylation Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Inferred from sequence or structural similarity. Source: UniProtKB cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 17337601. Source: RGD cellular response to mechanical stimulus Inferred from direct assay PubMed 20172952. Source: RGD cholesterol efflux Inferred from mutant phenotype PubMed 17499231. Source: RGD maintenance of protein location in cell Inferred from mutant phenotype PubMed 18162583. Source: BHF-UCL microtubule polymerization Inferred from mutant phenotype PubMed 16480946. Source: RGD negative regulation of ERK1 and ERK2 cascade Inferred from direct assay PubMed 20172952. Source: RGD negative regulation of canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cation channel activity Inferred from direct assay PubMed 20624795. Source: RGD negative regulation of endothelial cell proliferation Inferred from mutant phenotype PubMed 16051704. Source: RGD negative regulation of muscle cell apoptotic process Inferred from mutant phenotype PubMed 18039791. Source: RGD negative regulation of neuron differentiation Inferred from mutant phenotype PubMed 21826216. Source: RGD negative regulation of smooth muscle cell proliferation Inferred from mutant phenotype PubMed 20828553. Source: RGD negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB organ regeneration Inferred from expression pattern PubMed 22431231. Source: RGD positive regulation of endocytosis Inferred from mutant phenotype PubMed 17715130. Source: RGD positive regulation of endothelial cell proliferation Inferred from mutant phenotype PubMed 20828553. Source: RGD positive regulation of microtubule polymerization Inferred from mutant phenotype PubMed 16480946. Source: RGD positive regulation of signal transduction Inferred from mutant phenotype PubMed 18039791. Source: RGD positive regulation of vasoconstriction Inferred from mutant phenotype PubMed 21098487. Source: RGD response to drug Inferred from expression pattern PubMed 17331262. Source: RGD response to gamma radiation Inferred from expression pattern PubMed 17993744. Source: RGD response to glucocorticoid stimulus Inferred from expression pattern PubMed 17537407. Source: RGD response to nutrient Inferred from expression pattern PubMed 16335790. Source: RGD transcytosis Traceable author statement Ref.2. Source: RGD
Cellular_component	Golgi membrane Inferred from sequence or structural similarity. Source: HGNC basal plasma membrane Inferred from direct assay PubMed 16904002. Source: RGD caveola Inferred from direct assay PubMed 19931615. Source: UniProtKB cell surface Inferred from direct assay PubMed 10887965. Source: RGD cytoplasmic vesicle Inferred from direct assay PubMed 17499231. Source: RGD cytosol Inferred from direct assay PubMed 16352305. Source: RGD endoplasmic reticulum Inferred from sequence or structural similarity. Source: HGNC endosome Inferred from sequence or structural similarity. Source: UniProtKB focal adhesion Inferred from direct assay PubMed 15731459PubMed 16618703. Source: RGD integral to membrane Traceable author statement PubMed 12388423. Source: RGD lipid particle Inferred from direct assay PubMed 14528016. Source: RGD mitochondrion Inferred from direct assay PubMed 16352305. Source: RGD perinuclear region of cytoplasm Inferred from direct assay PubMed 19931615. Source: UniProtKB peroxisomal membrane Inferred from direct assay PubMed 20146263. Source: RGD protein complex Inferred from direct assay PubMed 22492718. Source: RGD
Molecular_function	structural molecule activity Inferred from sequence or structural similarity. Source: HGNC syntaxin binding Inferred from mutant phenotype Ref.2. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform Alpha (identifier: P41350-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: P41350-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 178	177	Caveolin-1		PRO_0000004768
Regions
	Topological domain	2 – 104	103	Cytoplasmic Potential
	Intramembrane	105 – 125	21	Helical; Potential
	Topological domain	126 – 178	53	Cytoplasmic Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	5	1	N6-acetyllysine By similarity
	Modified residue	6	1	Phosphotyrosine By similarity
	Modified residue	14	1	Phosphotyrosine; by ABL1 By similarity
	Modified residue	25	1	Phosphotyrosine By similarity
	Modified residue	42	1	Phosphotyrosine By similarity
	Lipidation	133	1	S-palmitoyl cysteine By similarity
	Lipidation	143	1	S-palmitoyl cysteine By similarity
	Lipidation	156	1	S-palmitoyl cysteine By similarity
Natural variations
	Alternative sequence	1 – 31	31	Missing in isoform Beta.		VSP_018694
Experimental info
	Sequence conflict	120	1	A → G in CAA86587. Ref.1
	Sequence conflict	154	1	T → N in CAA86587. Ref.1
	Sequence conflict	162	1	A → G in CAA86587. Ref.1
	Sequence conflict	171	1	R → P in CAA86587. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified August 16, 2004. Version 3. Checksum: 55E8F6ABC7514FD2	FASTA	178	20,553
	10 20 30 40 50 60 MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID LVNRDPKHLN 70 80 90 100 110 120 DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSTIFGIP MALIWGIYFA 130 140 150 160 170 ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RISTQEEI
	Isoform Beta [UniParc]. Checksum: 6BB1A8538BC34440	FASTA	147	17,104
	10 20 30 40 50 60 MADEVNEKQV YDAHTKEIDL VNRDPKHLND DVVKIDFEDV IAEPEGTHSF DGIWKASFTT 70 80 90 100 110 120 FTVTKYWFYR LLSTIFGIPM ALIWGIYFAI LSFLHIWAVV PCIKSFLIEI QCISRVYSIY 130 140 VHTFCDPLFE AIGKIFSNIR ISTQEEI

References

[1]	"Immuno-electronmicroscopical identification of caveolin in rat adipocyte plasma membranes." Vinten J., Voldstedlund M., Carlsen J., Christiansen K., Clausen H., Tranum-Jensen J. Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA). Tissue: Adipose tissue.
[2]	"ATP dependence of the SNARE/caveolin 1 interaction in the hippocampus." Magga J.M., Kay J.G., Davy A., Poulton N.P., Robbins S.M., Braun J.E.A. Biochem. Biophys. Res. Commun. 291:1232-1238(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), TISSUE SPECIFICITY, INTERACTION WITH SNAP25 AND SYNTAXIN. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46614 mRNA. Translation: CAA86587.1. Frameshift. AF439778 mRNA. Translation: AAL33579.1. AF439779 mRNA. Translation: AAL33580.1.
IPI	IPI00192313. IPI00896144.
UniGene	Rn.22518.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P41350. 5 interactions.
MINT	MINT-202594.
PTM databases
PhosphoSite	P41350.
Proteomic databases
PaxDb	P41350.
PRIDE	P41350.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:2280. rat.
Organism-specific databases
RGD	2280. Cav1.
Phylogenomic databases
eggNOG	NOG86001.
HOGENOM	HOG000036550.
HOVERGEN	HBG003422.
InParanoid	P41350.
OrthoDB	EOG4JQ3ZP.
Gene expression databases
ArrayExpress	P41350.
Genevestigator	P41350.
GermOnline	ENSRNOG00000006694. Rattus norvegicus.
Family and domain databases
InterPro	IPR001612. Caveolin. IPR015504. Caveolin_1. IPR018361. Caveolin_CS. [Graphical view]
PANTHER	PTHR10844. PTHR10844. 1 hit. PTHR10844:SF5. PTHR10844:SF5. 1 hit.
Pfam	PF01146. Caveolin. 1 hit. [Graphical view]
PROSITE	PS01210. CAVEOLIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAV1_RAT

Accession

Primary (citable) accession number: P41350
Secondary accession number(s): Q8VIK8, Q8VIK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	August 16, 2004
Last modified:	April 3, 2013
This is version 119 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program