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Protein

Caveolin-1

Gene

Cav1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae.By similarity

GO - Molecular functioni

  • ATPase binding Source: RGD
  • enzyme binding Source: RGD
  • identical protein binding Source: RGD
  • inward rectifier potassium channel inhibitor activity Source: RGD
  • ion channel binding Source: BHF-UCL
  • kinase binding Source: RGD
  • MDM2/MDM4 family protein binding Source: RGD
  • nitric-oxide synthase binding Source: RGD
  • peptidase activator activity Source: RGD
  • protein binding, bridging Source: RGD
  • protein complex scaffold activity Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • Rac GTPase binding Source: RGD
  • receptor binding Source: RGD
  • RNA polymerase I transcription factor binding Source: RGD
  • SNARE binding Source: RGD
  • structural molecule activity Source: HGNC
  • syntaxin binding Source: RGD

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:Cav1
Synonyms:Cav
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2280. Cav1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 104CytoplasmicSequence analysisAdd BLAST103
Intramembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 178CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000047682 – 178Caveolin-1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei5N6-acetyllysine; alternateBy similarity1
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei14Phosphotyrosine; by ABL1By similarity1
Modified residuei25PhosphotyrosineBy similarity1
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki30Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki47Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Lipidationi133S-palmitoyl cysteineBy similarity1
Lipidationi143S-palmitoyl cysteineBy similarity1
Lipidationi156S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.By similarity
Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP41350.
PRIDEiP41350.

PTM databases

iPTMnetiP41350.
PhosphoSitePlusiP41350.

Expressioni

Tissue specificityi

Cortex and inner medulla of kidney (at protein level). Expressed in the hippocampus.2 Publications

Interactioni

Subunit structurei

Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP and NOSTRIN (By similarity). Interacts with SNAP25 and STX1A (PubMed:11883949). Interacts with SLC7A9 (PubMed:16358225). Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner (By similarity). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc22a5O705942EBI-1161014,EBI-9846085

GO - Molecular functioni

  • ATPase binding Source: RGD
  • enzyme binding Source: RGD
  • identical protein binding Source: RGD
  • ion channel binding Source: BHF-UCL
  • kinase binding Source: RGD
  • MDM2/MDM4 family protein binding Source: RGD
  • nitric-oxide synthase binding Source: RGD
  • protein binding, bridging Source: RGD
  • protein complex scaffold activity Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • Rac GTPase binding Source: RGD
  • receptor binding Source: RGD
  • RNA polymerase I transcription factor binding Source: RGD
  • SNARE binding Source: RGD
  • syntaxin binding Source: RGD

Protein-protein interaction databases

CORUMiP41350.
IntActiP41350. 7 interactors.
MINTiMINT-202594.
STRINGi10116.ENSRNOP00000009253.

Structurei

3D structure databases

SMRiP41350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 94Required for homooligomerizationBy similarityAdd BLAST93
Regioni82 – 94Interaction with CAVIN3By similarityAdd BLAST13

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IV7A. Eukaryota.
ENOG4111HJR. LUCA.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP41350.
PhylomeDBiP41350.

Family and domain databases

InterProiView protein in InterPro
IPR015504. CAV-1.
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF18. PTHR10844:SF18. 1 hit.
PfamiView protein in Pfam
PF01146. Caveolin. 1 hit.
PROSITEiView protein in PROSITE
PS01210. CAVEOLIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P41350-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSTIFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI
160 170
YVHTFCDPLF EAIGKIFSNI RISTQEEI
Length:178
Mass (Da):20,553
Last modified:August 16, 2004 - v3
Checksum:i55E8F6ABC7514FD2
GO
Isoform 2 (identifier: P41350-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:147
Mass (Da):17,104
Checksum:i6BB1A8538BC34440
GO

Sequence cautioni

The sequence CAA86587 differs from that shown. Reason: Frameshift at position 161.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120A → G in CAA86587 (Ref. 1) Curated1
Sequence conflicti154T → N in CAA86587 (Ref. 1) Curated1
Sequence conflicti162A → G in CAA86587 (Ref. 1) Curated1
Sequence conflicti171R → P in CAA86587 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186941 – 31Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46614 mRNA. Translation: CAA86587.1. Frameshift.
AF439778 mRNA. Translation: AAL33579.1.
AF439779 mRNA. Translation: AAL33580.1.
UniGeneiRn.22518.

Genome annotation databases

UCSCiRGD:2280. rat. [P41350-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiCAV1_RAT
AccessioniPrimary (citable) accession number: P41350
Secondary accession number(s): Q8VIK8, Q8VIK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families