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Protein

Pancreatic hormone

Gene

PPY

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic hormone
Short name:
PH
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
Gene namesi
Name:PPY
OrganismiErinaceus europaeus (Western European hedgehog)
Taxonomic identifieri9365 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000447991 – 36Pancreatic hormoneAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36Tyrosine amide1 Publication1

Keywords - PTMi

Amidation

Structurei

3D structure databases

ProteinModelPortaliP41335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Phylogenomic databases

HOGENOMiHOG000252942.
HOVERGENiHBG096195.
OrthoDBiEOG091G15HI.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
VPLEPVYPGD NATPEQMAHY AAELRRYINM LTRPRY
Length:36
Mass (Da):4,234
Last modified:February 1, 1995 - v1
Checksum:i7609C6989148208F
GO

Cross-referencesi

3D structure databases

ProteinModelPortaliP41335.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000252942.
HOVERGENiHBG096195.
OrthoDBiEOG091G15HI.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAHO_ERIEU
AccessioniPrimary (citable) accession number: P41335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.