Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P41317

- MBL2_MOUSE

UniProt

P41317 - MBL2_MOUSE

Protein

Mannose-binding protein C

Gene

Mbl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages By similarity.By similarity

    GO - Molecular functioni

    1. mannose binding Source: UniProtKB-KW

    GO - Biological processi

    1. complement activation, classical pathway Source: UniProtKB-KW
    2. complement activation, lectin pathway Source: MGI
    3. defense response to Gram-positive bacterium Source: MGI
    4. killing by host of symbiont cells Source: MGI
    5. negative regulation of growth of symbiont in host Source: MGI
    6. positive regulation of phagocytosis Source: MGI

    Keywords - Biological processi

    Complement activation lectin pathway, Complement pathway, Immunity, Innate immunity

    Keywords - Ligandi

    Calcium, Lectin, Mannose-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-binding protein C
    Short name:
    MBP-C
    Alternative name(s):
    Mannan-binding protein
    RA-reactive factor P28A subunit
    Short name:
    RARF/P28A
    Gene namesi
    Name:Mbl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:96924. Mbl2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 244226Mannose-binding protein CPRO_0000017405Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 – 29InterchainPROSITE-ProRule annotation
    Disulfide bondi34 – 34InterchainPROSITE-ProRule annotation
    Modified residuei43 – 4314-hydroxyprolineSequence Analysis
    Modified residuei58 – 5814-hydroxyprolineSequence Analysis
    Modified residuei69 – 6914-hydroxyprolineSequence Analysis
    Modified residuei78 – 7814-hydroxyprolineSequence Analysis
    Modified residuei81 – 8114-hydroxyprolineSequence Analysis
    Disulfide bondi151 ↔ 240PROSITE-ProRule annotation
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi218 ↔ 232PROSITE-ProRule annotation

    Post-translational modificationi

    Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    MaxQBiP41317.
    PaxDbiP41317.
    PRIDEiP41317.

    Expressioni

    Gene expression databases

    BgeeiP41317.
    CleanExiMM_MBL2.
    GenevestigatoriP41317.

    Interactioni

    Subunit structurei

    Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 By similarity. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000025797.

    Structurei

    3D structure databases

    ProteinModelPortaliP41317.
    SMRiP41317. Positions 106-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 9659Collagen-likeAdd
    BLAST
    Domaini129 – 241113C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili108 – 12619By similarityAdd
    BLAST

    Domaini

    The coiled-coil domain mediates trimerization.By similarity

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Coiled coil, Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG265984.
    HOGENOMiHOG000085660.
    HOVERGENiHBG108270.
    InParanoidiP41317.
    KOiK03991.
    OMAiAICEFSD.
    OrthoDBiEOG7VTDPW.
    PhylomeDBiP41317.
    TreeFamiTF330481.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    [Graphical view]
    PfamiPF01391. Collagen. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41317-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIFTSFLLL CVVTVVYAET LTEGVQNSCP VVTCSSPGLN GFPGKDGRDG    50
    AKGEKGEPGQ GLRGLQGPPG KVGPTGPPGN PGLKGAVGPK GDRGDRAEFD 100
    TSEIDSEIAA LRSELRALRN WVLFSLSEKV GKKYFVSSVK KMSLDRVKAL 150
    CSEFQGSVAT PRNAEENSAI QKVAKDIAYL GITDVRVEGS FEDLTGNRVR 200
    YTNWNDGEPN NTGDGEDCVV ILGNGKWNDV PCSDSFLAIC EFSD 244
    Length:244
    Mass (Da):25,957
    Last modified:February 1, 1996 - v2
    Checksum:i49AE84E2290DEB0A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31I → L in AAB19343. (PubMed:1712818)Curated
    Sequence conflicti15 – 151V → A in AAB19343. (PubMed:1712818)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S42294 mRNA. Translation: AAB19343.1.
    U09016
    , U09013, U09014, U09015 Genomic DNA. Translation: AAA82010.1.
    D11440 mRNA. Translation: BAA02005.1.
    BC010760 mRNA. Translation: AAH10760.1.
    CCDSiCCDS29742.1.
    PIRiI48651. LNMSMC.
    RefSeqiNP_034906.1. NM_010776.1.
    XP_006526793.1. XM_006526730.1.
    UniGeneiMm.30045.

    Genome annotation databases

    EnsembliENSMUST00000025797; ENSMUSP00000025797; ENSMUSG00000024863.
    GeneIDi17195.
    KEGGimmu:17195.
    UCSCiuc008hel.1. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Mannose-binding protein C

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S42294 mRNA. Translation: AAB19343.1 .
    U09016
    , U09013 , U09014 , U09015 Genomic DNA. Translation: AAA82010.1 .
    D11440 mRNA. Translation: BAA02005.1 .
    BC010760 mRNA. Translation: AAH10760.1 .
    CCDSi CCDS29742.1.
    PIRi I48651. LNMSMC.
    RefSeqi NP_034906.1. NM_010776.1.
    XP_006526793.1. XM_006526730.1.
    UniGenei Mm.30045.

    3D structure databases

    ProteinModelPortali P41317.
    SMRi P41317. Positions 106-243.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000025797.

    Proteomic databases

    MaxQBi P41317.
    PaxDbi P41317.
    PRIDEi P41317.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025797 ; ENSMUSP00000025797 ; ENSMUSG00000024863 .
    GeneIDi 17195.
    KEGGi mmu:17195.
    UCSCi uc008hel.1. mouse.

    Organism-specific databases

    CTDi 4153.
    MGIi MGI:96924. Mbl2.

    Phylogenomic databases

    eggNOGi NOG265984.
    HOGENOMi HOG000085660.
    HOVERGENi HBG108270.
    InParanoidi P41317.
    KOi K03991.
    OMAi AICEFSD.
    OrthoDBi EOG7VTDPW.
    PhylomeDBi P41317.
    TreeFami TF330481.

    Miscellaneous databases

    NextBioi 291550.
    PROi P41317.
    SOURCEi Search...

    Gene expression databases

    Bgeei P41317.
    CleanExi MM_MBL2.
    Genevestigatori P41317.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    [Graphical view ]
    Pfami PF01391. Collagen. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant."
      Sastry K., Zahedi K., Lelias J.M., Whitehead A.S., Ezekowitz R.A.
      J. Immunol. 147:692-697(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CBA/J.
      Tissue: Liver.
    2. "Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes."
      Sastry R., Wang J.S., Brown D.C., Ezekowitz R.A., Tauber A.I., Sastry K.N.
      Mamm. Genome 6:103-110(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
    3. Kuge S., Ihara S., Watanabe E., Watanabe M., Takishima K., Suga T., Mamaiya G., Kawakami M.
      Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiMBL2_MOUSE
    AccessioniPrimary (citable) accession number: P41317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3