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P41317 (MBL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannose-binding protein C

Short name=MBP-C
Alternative name(s):
Mannan-binding protein
RA-reactive factor P28A subunit
Short name=RARF/P28A
Gene names
Name:Mbl2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages By similarity.

Subunit structure

Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 By similarity. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity By similarity.

Subcellular location

Secreted By similarity.

Post-translational modification

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity.

Sequence similarities

Contains 1 C-type lectin domain.

Contains 1 collagen-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 244226Mannose-binding protein C
PRO_0000017405

Regions

Domain38 – 9659Collagen-like
Domain129 – 241113C-type lectin

Amino acid modifications

Modified residue4314-hydroxyproline Potential
Modified residue5814-hydroxyproline Potential
Modified residue6914-hydroxyproline Potential
Modified residue7814-hydroxyproline Potential
Modified residue8114-hydroxyproline Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Disulfide bond29Interchain By similarity
Disulfide bond34Interchain By similarity
Disulfide bond151 ↔ 240 By similarity
Disulfide bond218 ↔ 232 By similarity

Experimental info

Sequence conflict31I → L in AAB19343. Ref.1
Sequence conflict151V → A in AAB19343. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P41317 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 49AE84E2290DEB0A

FASTA24425,957
        10         20         30         40         50         60 
MSIFTSFLLL CVVTVVYAET LTEGVQNSCP VVTCSSPGLN GFPGKDGRDG AKGEKGEPGQ 

        70         80         90        100        110        120 
GLRGLQGPPG KVGPTGPPGN PGLKGAVGPK GDRGDRAEFD TSEIDSEIAA LRSELRALRN 

       130        140        150        160        170        180 
WVLFSLSEKV GKKYFVSSVK KMSLDRVKAL CSEFQGSVAT PRNAEENSAI QKVAKDIAYL 

       190        200        210        220        230        240 
GITDVRVEGS FEDLTGNRVR YTNWNDGEPN NTGDGEDCVV ILGNGKWNDV PCSDSFLAIC 


EFSD 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant."
Sastry K., Zahedi K., Lelias J.M., Whitehead A.S., Ezekowitz R.A.
J. Immunol. 147:692-697(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CBA/J.
Tissue: Liver.
[2]"Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes."
Sastry R., Wang J.S., Brown D.C., Ezekowitz R.A., Tauber A.I., Sastry K.N.
Mamm. Genome 6:103-110(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/c.
[3]Kuge S., Ihara S., Watanabe E., Watanabe M., Takishima K., Suga T., Mamaiya G., Kawakami M.
Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S42294 mRNA. Translation: AAB19343.1.
U09016 expand/collapse EMBL AC list , U09013, U09014, U09015 Genomic DNA. Translation: AAA82010.1.
D11440 mRNA. Translation: BAA02005.1.
BC010760 mRNA. Translation: AAH10760.1.
PIRLNMSMC. I48651.
RefSeqNP_034906.1. NM_010776.1.
XP_006526793.1. XM_006526730.1.
UniGeneMm.30045.

3D structure databases

ProteinModelPortalP41317.
SMRP41317. Positions 34-91, 106-243.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025797.

Proteomic databases

PaxDbP41317.
PRIDEP41317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025797; ENSMUSP00000025797; ENSMUSG00000024863.
GeneID17195.
KEGGmmu:17195.
UCSCuc008hel.1. mouse.

Organism-specific databases

CTD4153.
MGIMGI:96924. Mbl2.

Phylogenomic databases

eggNOGNOG265984.
HOGENOMHOG000085660.
HOVERGENHBG108270.
InParanoidP41317.
KOK03991.
OMAALCTHFQ.
OrthoDBEOG7VTDPW.
PhylomeDBP41317.
TreeFamTF330481.

Gene expression databases

BgeeP41317.
CleanExMM_MBL2.
GenevestigatorP41317.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291550.
PROP41317.
SOURCESearch...

Entry information

Entry nameMBL2_MOUSE
AccessionPrimary (citable) accession number: P41317
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot