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P41317

- MBL2_MOUSE

UniProt

P41317 - MBL2_MOUSE

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Protein

Mannose-binding protein C

Gene

Mbl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).By similarity

GO - Molecular functioni

  1. mannose binding Source: UniProtKB-KW

GO - Biological processi

  1. complement activation, classical pathway Source: UniProtKB-KW
  2. complement activation, lectin pathway Source: MGI
  3. defense response to Gram-positive bacterium Source: MGI
  4. killing by host of symbiont cells Source: MGI
  5. negative regulation of growth of symbiont in host Source: MGI
  6. negative regulation of viral process Source: Ensembl
  7. positive regulation of phagocytosis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Complement pathway, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin, Mannose-binding

Enzyme and pathway databases

ReactomeiREACT_202834. Initial triggering of complement.
REACT_247072. Lectin pathway of complement activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-binding protein C
Short name:
MBP-C
Alternative name(s):
Mannan-binding protein
RA-reactive factor P28A subunit
Short name:
RARF/P28A
Gene namesi
Name:Mbl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:96924. Mbl2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 244226Mannose-binding protein CPRO_0000017405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 – 29InterchainPROSITE-ProRule annotation
Disulfide bondi34 – 34InterchainPROSITE-ProRule annotation
Modified residuei43 – 4314-hydroxyprolineSequence Analysis
Modified residuei58 – 5814-hydroxyprolineSequence Analysis
Modified residuei69 – 6914-hydroxyprolineSequence Analysis
Modified residuei78 – 7814-hydroxyprolineSequence Analysis
Modified residuei81 – 8114-hydroxyprolineSequence Analysis
Disulfide bondi151 ↔ 240PROSITE-ProRule annotation
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi218 ↔ 232PROSITE-ProRule annotation

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiP41317.
PaxDbiP41317.
PRIDEiP41317.

Expressioni

Gene expression databases

BgeeiP41317.
CleanExiMM_MBL2.
ExpressionAtlasiP41317. baseline and differential.
GenevestigatoriP41317.

Interactioni

Subunit structurei

Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025797.

Structurei

3D structure databases

ProteinModelPortaliP41317.
SMRiP41317. Positions 50-82, 106-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 9659Collagen-likeAdd
BLAST
Domaini129 – 241113C-type lectinPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili108 – 12619By similarityAdd
BLAST

Domaini

The coiled-coil domain mediates trimerization.By similarity

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG265984.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP41317.
KOiK03991.
OMAiAICEFSD.
OrthoDBiEOG7VTDPW.
PhylomeDBiP41317.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41317-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIFTSFLLL CVVTVVYAET LTEGVQNSCP VVTCSSPGLN GFPGKDGRDG
60 70 80 90 100
AKGEKGEPGQ GLRGLQGPPG KVGPTGPPGN PGLKGAVGPK GDRGDRAEFD
110 120 130 140 150
TSEIDSEIAA LRSELRALRN WVLFSLSEKV GKKYFVSSVK KMSLDRVKAL
160 170 180 190 200
CSEFQGSVAT PRNAEENSAI QKVAKDIAYL GITDVRVEGS FEDLTGNRVR
210 220 230 240
YTNWNDGEPN NTGDGEDCVV ILGNGKWNDV PCSDSFLAIC EFSD
Length:244
Mass (Da):25,957
Last modified:February 1, 1996 - v2
Checksum:i49AE84E2290DEB0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31I → L in AAB19343. (PubMed:1712818)Curated
Sequence conflicti15 – 151V → A in AAB19343. (PubMed:1712818)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42294 mRNA. Translation: AAB19343.1.
U09016
, U09013, U09014, U09015 Genomic DNA. Translation: AAA82010.1.
D11440 mRNA. Translation: BAA02005.1.
BC010760 mRNA. Translation: AAH10760.1.
CCDSiCCDS29742.1.
PIRiI48651. LNMSMC.
RefSeqiNP_034906.1. NM_010776.1.
XP_006526793.1. XM_006526730.1.
UniGeneiMm.30045.

Genome annotation databases

EnsembliENSMUST00000025797; ENSMUSP00000025797; ENSMUSG00000024863.
GeneIDi17195.
KEGGimmu:17195.
UCSCiuc008hel.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Mannose-binding protein C

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42294 mRNA. Translation: AAB19343.1 .
U09016
, U09013 , U09014 , U09015 Genomic DNA. Translation: AAA82010.1 .
D11440 mRNA. Translation: BAA02005.1 .
BC010760 mRNA. Translation: AAH10760.1 .
CCDSi CCDS29742.1.
PIRi I48651. LNMSMC.
RefSeqi NP_034906.1. NM_010776.1.
XP_006526793.1. XM_006526730.1.
UniGenei Mm.30045.

3D structure databases

ProteinModelPortali P41317.
SMRi P41317. Positions 50-82, 106-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000025797.

Proteomic databases

MaxQBi P41317.
PaxDbi P41317.
PRIDEi P41317.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025797 ; ENSMUSP00000025797 ; ENSMUSG00000024863 .
GeneIDi 17195.
KEGGi mmu:17195.
UCSCi uc008hel.1. mouse.

Organism-specific databases

CTDi 4153.
MGIi MGI:96924. Mbl2.

Phylogenomic databases

eggNOGi NOG265984.
HOGENOMi HOG000085660.
HOVERGENi HBG108270.
InParanoidi P41317.
KOi K03991.
OMAi AICEFSD.
OrthoDBi EOG7VTDPW.
PhylomeDBi P41317.
TreeFami TF330481.

Enzyme and pathway databases

Reactomei REACT_202834. Initial triggering of complement.
REACT_247072. Lectin pathway of complement activation.

Miscellaneous databases

NextBioi 291550.
PROi P41317.
SOURCEi Search...

Gene expression databases

Bgeei P41317.
CleanExi MM_MBL2.
ExpressionAtlasi P41317. baseline and differential.
Genevestigatori P41317.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view ]
Pfami PF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant."
    Sastry K., Zahedi K., Lelias J.M., Whitehead A.S., Ezekowitz R.A.
    J. Immunol. 147:692-697(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CBA/J.
    Tissue: Liver.
  2. "Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes."
    Sastry R., Wang J.S., Brown D.C., Ezekowitz R.A., Tauber A.I., Sastry K.N.
    Mamm. Genome 6:103-110(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
  3. Kuge S., Ihara S., Watanabe E., Watanabe M., Takishima K., Suga T., Mamaiya G., Kawakami M.
    Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiMBL2_MOUSE
AccessioniPrimary (citable) accession number: P41317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3