ID   TNFL9_MOUSE             Reviewed;         309 AA.
AC   P41274;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   13-OCT-2009, entry version 59.
DE   RecName: Full=Tumor necrosis factor ligand superfamily member 9;
DE   AltName: Full=4-1BB ligand;
DE            Short=4-1BBL;
GN   Name=Tnfsf9; Synonyms=Cd137l, Cd157l, Ly63l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=T-cell;
RX   MEDLINE=94009225; PubMed=8405064; DOI=10.1002/eji.1830231037;
RA   Goodwin R.G., Din W.S., Davis-Smith T., Anderson D.M., Gimpel S.D.,
RA   Sato T.A., Maliszewski C.R., Brannan C.I., Copeland N.G.,
RA   Jenkins N.A., Farrah T., Armitage R.J., Fanslow W.C., Smith C.A.;
RT   "Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a
RT   member of an emerging family of cytokines with homology to tumor
RT   necrosis factor.";
RL   Eur. J. Immunol. 23:2631-2641(1993).
CC   -!- FUNCTION: Cytokine that binds to TNFRSF9. Induces the
CC       proliferation of activated peripheral blood T-cells. May have a
CC       role in activation-induced cell death (AICD). May play a role in
CC       cognate interactions between T-cells and B-cells/macrophages.
CC   -!- SUBUNIT: Homotrimer (Potential).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family.
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DR   EMBL; L15435; AAA39435.1; -; Genomic_DNA.
DR   IPI; IPI00112755; -.
DR   PIR; I53384; I53384.
DR   RefSeq; NP_033430.1; -.
DR   UniGene; Mm.41171; -.
DR   DIP; DIP:1153N; -.
DR   STRING; P41274; -.
DR   PRIDE; P41274; -.
DR   Ensembl; ENSMUST00000039490; ENSMUSP00000040412; ENSMUSG00000035678; Mus musculus.
DR   GeneID; 21950; -.
DR   KEGG; mmu:21950; -.
DR   UCSC; uc008ded.1; mouse.
DR   CTD; 21950; -.
DR   MGI; MGI:1101058; Tnfsf9.
DR   HOVERGEN; P41274; -.
DR   NextBio; 301612; -.
DR   ArrayExpress; P41274; -.
DR   Bgee; P41274; -.
DR   Genevestigator; P41274; -.
DR   GermOnline; ENSMUSG00000035678; Mus musculus.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR006052; TNF_family.
DR   Pfam; PF00229; TNF; 1.
DR   SMART; SM00207; TNF; 1.
DR   PROSITE; PS00251; TNF_1; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Glycoprotein; Membrane; Signal-anchor; Transmembrane.
FT   CHAIN         1    309       Tumor necrosis factor ligand superfamily
FT                                member 9.
FT                                /FTId=PRO_0000185502.
FT   TOPO_DOM      1     82       Cytoplasmic (Potential).
FT   TRANSMEM     83    103       Signal-anchor for type II membrane
FT                                protein (Potential).
FT   TOPO_DOM    104    309       Extracellular (Potential).
FT   CARBOHYD    139    139       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    161    161       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    293    293       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   309 AA;  33853 MW;  2A425829AD6B89C0 CRC64;
     MDQHTLDVED TADARHPAGT SCPSDAALLR DTGLLADAAL LSDTVRPTNA ALPTDAAYPA
     VNVRDREAAW PPALNFCSRH PKLYGLVALV LLLLIAACVP IFTRTEPRPA LTITTSPNLG
     TRENNADQVT PVSHIGCPNT TQQGSPVFAK LLAKNQASLC NTTLNWHSQD GAGSSYLSQG
     LRYEEDKKEL VVDSPGLYYV FLELKLSPTF TNTGHKVQGW VSLVLQAKPQ VDDFDNLALT
     VELFPCSMEN KLVDRSWSQL LLLKAGHRLS VGLRAYLHGA QDAYRDWELS YPNTTSFGLF
     LVKPDNPWE
//