Reviewed, UniProtKB/Swiss-Prot P41274 (TNFL9_MOUSE)

Names and origin

Protein names

Recommended name:
    Tumor necrosis factor ligand superfamily member 9
Alternative name(s):
    4-1BB ligand
      Short name=4-1BBL

Gene names

Name:	Tnfsf9
Synonyms:	Cd137l, Cd157l, Ly63l

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Subunit structure	Homotrimer Potential.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the tumor necrosis factor family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Cytokine
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	immune response Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	tumor necrosis factor receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Tumor necrosis factor ligand superfamily member 9		PRO_0000185502
Regions
	Topological domain	1 – 82	82	Cytoplasmic Potential
	Transmembrane	83 – 103	21	Signal-anchor for type II membrane protein Potential
	Topological domain	104 – 309	206	Extracellular Potential
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	293	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P41274-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 2A425829AD6B89C0	FASTA	309	33,853
	10 20 30 40 50 60 MDQHTLDVED TADARHPAGT SCPSDAALLR DTGLLADAAL LSDTVRPTNA ALPTDAAYPA 70 80 90 100 110 120 VNVRDREAAW PPALNFCSRH PKLYGLVALV LLLLIAACVP IFTRTEPRPA LTITTSPNLG 130 140 150 160 170 180 TRENNADQVT PVSHIGCPNT TQQGSPVFAK LLAKNQASLC NTTLNWHSQD GAGSSYLSQG 190 200 210 220 230 240 LRYEEDKKEL VVDSPGLYYV FLELKLSPTF TNTGHKVQGW VSLVLQAKPQ VDDFDNLALT 250 260 270 280 290 300 VELFPCSMEN KLVDRSWSQL LLLKAGHRLS VGLRAYLHGA QDAYRDWELS YPNTTSFGLF LVKPDNPWE

References

[1]

"Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor." Goodwin R.G., Din W.S., Davis-Smith T., Anderson D.M., Gimpel S.D., Sato T.A., Maliszewski C.R., Brannan C.I., Copeland N.G., Jenkins N.A., Farrah T., Armitage R.J., Fanslow W.C., Smith C.A. Eur. J. Immunol. 23:2631-2641(1993) [PubMed: 8405064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: T-cell.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L15435 Genomic DNA. Translation: AAA39435.1.
PIR	I53384.
RefSeq	NP_033430.1.
UniGene	Mm.41171
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1153N.
Genome annotation databases
Ensembl	ENSMUSG00000035678. Mus musculus. [Contig view]
GeneID	21950.
KEGG	mmu:21950.
Organism-specific databases
MGI	MGI:1101058. Tnfsf9.
Phylogenomic databases
HOGENOM	P41274.
HOVERGEN	P41274.
Gene expression databases
ArrayExpress	P41274.
GermOnline	ENSMUSG00000035678. Mus musculus.
Family and domain databases
InterPro	IPR006052. TNF_family. [Graphical view]
Pfam	PF00229. TNF. 1 hit. [Graphical view]
SMART	SM00207. TNF. 1 hit. [Graphical view]
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	301612.
SOURCE	Search...

Entry information

Entry name

TNFL9_MOUSE

Accession

Primary (citable) accession number: P41274

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 25, 2008
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)