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Protein

Tumor necrosis factor ligand superfamily member 9

Gene

Tnfsf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

GO - Molecular functioni

  • receptor binding Source: MGI
  • tumor necrosis factor receptor superfamily binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 9
Alternative name(s):
4-1BB ligand
Short name:
4-1BBL
Gene namesi
Name:Tnfsf9
Synonyms:Cd137l, Cd157l, Ly63l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1101058. Tnfsf9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8282CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini104 – 309206ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Tumor necrosis factor ligand superfamily member 9PRO_0000185502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP41274.
PRIDEiP41274.

PTM databases

PhosphoSiteiP41274.

Expressioni

Gene expression databases

BgeeiP41274.
ExpressionAtlasiP41274. baseline and differential.
GenevisibleiP41274. MM.

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

  • receptor binding Source: MGI
  • tumor necrosis factor receptor superfamily binding Source: MGI

Protein-protein interaction databases

BioGridi204262. 1 interaction.
DIPiDIP-1153N.
STRINGi10090.ENSMUSP00000040412.

Structurei

3D structure databases

ProteinModelPortaliP41274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4ZC. Eukaryota.
ENOG4111EDT. LUCA.
HOVERGENiHBG067183.
InParanoidiP41274.
KOiK05472.
OMAiYYVFLEL.
OrthoDBiEOG7HQNB2.
PhylomeDBiP41274.
TreeFamiTF338523.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQHTLDVED TADARHPAGT SCPSDAALLR DTGLLADAAL LSDTVRPTNA
60 70 80 90 100
ALPTDAAYPA VNVRDREAAW PPALNFCSRH PKLYGLVALV LLLLIAACVP
110 120 130 140 150
IFTRTEPRPA LTITTSPNLG TRENNADQVT PVSHIGCPNT TQQGSPVFAK
160 170 180 190 200
LLAKNQASLC NTTLNWHSQD GAGSSYLSQG LRYEEDKKEL VVDSPGLYYV
210 220 230 240 250
FLELKLSPTF TNTGHKVQGW VSLVLQAKPQ VDDFDNLALT VELFPCSMEN
260 270 280 290 300
KLVDRSWSQL LLLKAGHRLS VGLRAYLHGA QDAYRDWELS YPNTTSFGLF

LVKPDNPWE
Length:309
Mass (Da):33,853
Last modified:February 1, 1995 - v1
Checksum:i2A425829AD6B89C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15435 Genomic DNA. Translation: AAA39435.1.
CCDSiCCDS28926.1.
PIRiI53384.
RefSeqiNP_033430.1. NM_009404.3.
UniGeneiMm.41171.

Genome annotation databases

EnsembliENSMUST00000039490; ENSMUSP00000040412; ENSMUSG00000035678.
GeneIDi21950.
KEGGimmu:21950.
UCSCiuc008ded.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15435 Genomic DNA. Translation: AAA39435.1.
CCDSiCCDS28926.1.
PIRiI53384.
RefSeqiNP_033430.1. NM_009404.3.
UniGeneiMm.41171.

3D structure databases

ProteinModelPortaliP41274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204262. 1 interaction.
DIPiDIP-1153N.
STRINGi10090.ENSMUSP00000040412.

PTM databases

PhosphoSiteiP41274.

Proteomic databases

PaxDbiP41274.
PRIDEiP41274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039490; ENSMUSP00000040412; ENSMUSG00000035678.
GeneIDi21950.
KEGGimmu:21950.
UCSCiuc008ded.1. mouse.

Organism-specific databases

CTDi8744.
MGIiMGI:1101058. Tnfsf9.

Phylogenomic databases

eggNOGiENOG410J4ZC. Eukaryota.
ENOG4111EDT. LUCA.
HOVERGENiHBG067183.
InParanoidiP41274.
KOiK05472.
OMAiYYVFLEL.
OrthoDBiEOG7HQNB2.
PhylomeDBiP41274.
TreeFamiTF338523.

Miscellaneous databases

NextBioi301612.
PROiP41274.
SOURCEiSearch...

Gene expression databases

BgeeiP41274.
ExpressionAtlasiP41274. baseline and differential.
GenevisibleiP41274. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor."
    Goodwin R.G., Din W.S., Davis-Smith T., Anderson D.M., Gimpel S.D., Sato T.A., Maliszewski C.R., Brannan C.I., Copeland N.G., Jenkins N.A., Farrah T., Armitage R.J., Fanslow W.C., Smith C.A.
    Eur. J. Immunol. 23:2631-2641(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: T-cell.

Entry informationi

Entry nameiTNFL9_MOUSE
AccessioniPrimary (citable) accession number: P41274
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.