P41274 (TNFL9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor ligand superfamily member 9

Alternative name(s):
4-1BB ligand
Short name=4-1BBL

Gene names

Name:	Tnfsf9
Synonyms:	Cd137l, Cd157l, Ly63l

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Subunit structure	Homotrimer Potential.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the tumor necrosis factor family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Cytokine
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	immune response Inferred from electronic annotation. Source: InterPro regulation of cell proliferation Inferred from direct assay Ref.1. Source: MGI
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.1. Source: MGI
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW tumor necrosis factor receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Tumor necrosis factor ligand superfamily member 9		PRO_0000185502
Regions
	Topological domain	1 – 82	82	Cytoplasmic Potential
	Transmembrane	83 – 103	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	104 – 309	206	Extracellular Potential
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	293	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P41274 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 2A425829AD6B89C0	FASTA	309	33,853
	10 20 30 40 50 60 MDQHTLDVED TADARHPAGT SCPSDAALLR DTGLLADAAL LSDTVRPTNA ALPTDAAYPA 70 80 90 100 110 120 VNVRDREAAW PPALNFCSRH PKLYGLVALV LLLLIAACVP IFTRTEPRPA LTITTSPNLG 130 140 150 160 170 180 TRENNADQVT PVSHIGCPNT TQQGSPVFAK LLAKNQASLC NTTLNWHSQD GAGSSYLSQG 190 200 210 220 230 240 LRYEEDKKEL VVDSPGLYYV FLELKLSPTF TNTGHKVQGW VSLVLQAKPQ VDDFDNLALT 250 260 270 280 290 300 VELFPCSMEN KLVDRSWSQL LLLKAGHRLS VGLRAYLHGA QDAYRDWELS YPNTTSFGLF LVKPDNPWE

References

[1]

"Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor." Goodwin R.G., Din W.S., Davis-Smith T., Anderson D.M., Gimpel S.D., Sato T.A., Maliszewski C.R., Brannan C.I., Copeland N.G., Jenkins N.A., Farrah T., Armitage R.J., Fanslow W.C., Smith C.A. Eur. J. Immunol. 23:2631-2641(1993) [PubMed: 8405064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: T-cell.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L15435 Genomic DNA. Translation: AAA39435.1.
IPI	IPI00112755.
PIR	I53384.
RefSeq	NP_033430.1. NM_009404.3.
UniGene	Mm.41171.
3D structure databases
ProteinModelPortal	P41274.
SMR	P41274. Positions 133-307.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1153N.
STRING	P41274.
PTM databases
PhosphoSite	P41274.
Proteomic databases
PRIDE	P41274.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039490; ENSMUSP00000040412; ENSMUSG00000035678.
GeneID	21950.
KEGG	mmu:21950.
Organism-specific databases
CTD	8744.
MGI	MGI:1101058. Tnfsf9.
Phylogenomic databases
eggNOG	maNOG20270.
HOVERGEN	HBG067183.
InParanoid	P41274.
OrthoDB	EOG4MGS8J.
PhylomeDB	P41274.
Gene expression databases
ArrayExpress	P41274.
Bgee	P41274.
Genevestigator	P41274.
GermOnline	ENSMUSG00000035678. Mus musculus.
Family and domain databases
InterPro	IPR006052. TNF. IPR021184. TNF_CS. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
KO	K05472.
Pfam	PF00229. TNF. 1 hit. [Graphical view]
SMART	SM00207. TNF. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	301612.
SOURCE	Search...

Entry information

Entry name

TNFL9_MOUSE

Accession

Primary (citable) accession number: P41274

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program