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Protein

Tumor necrosis factor ligand superfamily member 9

Gene

TNFSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.1 Publication

GO - Molecular functioni

  • receptor binding Source: ProtInc
  • tumor necrosis factor receptor superfamily binding Source: GO_Central

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • immune response Source: InterPro
  • positive regulation of activated T cell proliferation Source: GO_Central
  • positive regulation of cytotoxic T cell differentiation Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125657-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 9
Alternative name(s):
4-1BB ligand
Short name:
4-1BBL
Gene namesi
Name:TNFSF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:11939. TNFSF9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini50 – 254ExtracellularSequence analysisAdd BLAST205

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8744.
OpenTargetsiENSG00000125657.
PharmGKBiPA36629.

Polymorphism and mutation databases

BioMutaiTNFSF9.
DMDMi728739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855011 – 254Tumor necrosis factor ligand superfamily member 9Add BLAST254

Proteomic databases

EPDiP41273.
MaxQBiP41273.
PaxDbiP41273.
PeptideAtlasiP41273.
PRIDEiP41273.

PTM databases

iPTMnetiP41273.
PhosphoSitePlusiP41273.

Expressioni

Tissue specificityi

Expressed in brain, placenta, lung, skeletal muscle and kidney.

Gene expression databases

BgeeiENSG00000125657.
CleanExiHS_TNFSF9.
ExpressionAtlasiP41273. baseline and differential.
GenevisibleiP41273. HS.

Organism-specific databases

HPAiHPA041376.
HPA059857.

Interactioni

Subunit structurei

Homotrimer.1 Publication

GO - Molecular functioni

  • receptor binding Source: ProtInc
  • tumor necrosis factor receptor superfamily binding Source: GO_Central

Protein-protein interaction databases

BioGridi114281. 32 interactors.
DIPiDIP-3020N.
STRINGi9606.ENSP00000245817.

Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi83 – 85Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi104 – 106Combined sources3
Beta strandi115 – 117Combined sources3
Beta strandi121 – 123Combined sources3
Beta strandi133 – 135Combined sources3
Beta strandi139 – 151Combined sources13
Beta strandi159 – 168Combined sources10
Beta strandi178 – 185Combined sources8
Beta strandi195 – 206Combined sources12
Beta strandi210 – 217Combined sources8
Helixi220 – 223Combined sources4
Beta strandi226 – 228Combined sources3
Beta strandi234 – 239Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X29X-ray2.30A80-246[»]
ProteinModelPortaliP41273.
SMRiP41273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41273.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 41Poly-Leu7

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4ZC. Eukaryota.
ENOG4111EDT. LUCA.
GeneTreeiENSGT00390000006244.
HOGENOMiHOG000154658.
HOVERGENiHBG079273.
InParanoidiP41273.
KOiK05472.
OMAiWQLTQGA.
OrthoDBiEOG091G0GL6.
PhylomeDBiP41273.
TreeFamiTF338523.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYASDASLD PEAPWPPAPR ARACRVLPWA LVAGLLLLLL LAAACAVFLA
60 70 80 90 100
CPWAVSGARA SPGSAASPRL REGPELSPDD PAGLLDLRQG MFAQLVAQNV
110 120 130 140 150
LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR
160 170 180 190 200
RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ
210 220 230 240 250
GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS

PRSE
Length:254
Mass (Da):26,625
Last modified:February 1, 1995 - v1
Checksum:i827551F34563E508
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01192817P → A.Corresponds to variant rs442511dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03398 mRNA. Translation: AAA53134.1.
BC104805 mRNA. Translation: AAI04806.1.
BC104807 mRNA. Translation: AAI04808.1.
CCDSiCCDS12169.1.
PIRiI38427.
RefSeqiNP_003802.1. NM_003811.3.
UniGeneiHs.1524.

Genome annotation databases

EnsembliENST00000245817; ENSP00000245817; ENSG00000125657.
GeneIDi8744.
KEGGihsa:8744.
UCSCiuc002mfh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03398 mRNA. Translation: AAA53134.1.
BC104805 mRNA. Translation: AAI04806.1.
BC104807 mRNA. Translation: AAI04808.1.
CCDSiCCDS12169.1.
PIRiI38427.
RefSeqiNP_003802.1. NM_003811.3.
UniGeneiHs.1524.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X29X-ray2.30A80-246[»]
ProteinModelPortaliP41273.
SMRiP41273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114281. 32 interactors.
DIPiDIP-3020N.
STRINGi9606.ENSP00000245817.

PTM databases

iPTMnetiP41273.
PhosphoSitePlusiP41273.

Polymorphism and mutation databases

BioMutaiTNFSF9.
DMDMi728739.

Proteomic databases

EPDiP41273.
MaxQBiP41273.
PaxDbiP41273.
PeptideAtlasiP41273.
PRIDEiP41273.

Protocols and materials databases

DNASUi8744.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245817; ENSP00000245817; ENSG00000125657.
GeneIDi8744.
KEGGihsa:8744.
UCSCiuc002mfh.2. human.

Organism-specific databases

CTDi8744.
DisGeNETi8744.
GeneCardsiTNFSF9.
HGNCiHGNC:11939. TNFSF9.
HPAiHPA041376.
HPA059857.
MIMi606182. gene.
neXtProtiNX_P41273.
OpenTargetsiENSG00000125657.
PharmGKBiPA36629.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4ZC. Eukaryota.
ENOG4111EDT. LUCA.
GeneTreeiENSGT00390000006244.
HOGENOMiHOG000154658.
HOVERGENiHBG079273.
InParanoidiP41273.
KOiK05472.
OMAiWQLTQGA.
OrthoDBiEOG091G0GL6.
PhylomeDBiP41273.
TreeFamiTF338523.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125657-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

ChiTaRSiTNFSF9. human.
EvolutionaryTraceiP41273.
GenomeRNAii8744.
PROiP41273.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125657.
CleanExiHS_TNFSF9.
ExpressionAtlasiP41273. baseline and differential.
GenevisibleiP41273. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNFL9_HUMAN
AccessioniPrimary (citable) accession number: P41273
Secondary accession number(s): Q2M3S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.