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P41273

- TNFL9_HUMAN

UniProt

P41273 - TNFL9_HUMAN

Protein

Tumor necrosis factor ligand superfamily member 9

Gene

TNFSF9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.1 Publication

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell-cell signaling Source: ProtInc
    3. cell proliferation Source: ProtInc
    4. immune response Source: InterPro
    5. myeloid dendritic cell differentiation Source: Ensembl
    6. positive regulation of activated T cell proliferation Source: Ensembl
    7. positive regulation of cytotoxic T cell differentiation Source: Ensembl
    8. positive regulation of interferon-gamma production Source: Ensembl
    9. positive regulation of interleukin-12 production Source: Ensembl
    10. positive regulation of interleukin-6 production Source: Ensembl
    11. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 9
    Alternative name(s):
    4-1BB ligand
    Short name:
    4-1BBL
    Gene namesi
    Name:TNFSF9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11939. TNFSF9.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36629.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Tumor necrosis factor ligand superfamily member 9PRO_0000185501Add
    BLAST

    Proteomic databases

    MaxQBiP41273.
    PaxDbiP41273.
    PRIDEiP41273.

    PTM databases

    PhosphoSiteiP41273.

    Expressioni

    Tissue specificityi

    Expressed in brain, placenta, lung, skeletal muscle and kidney.

    Gene expression databases

    BgeeiP41273.
    CleanExiHS_TNFSF9.
    GenevestigatoriP41273.

    Organism-specific databases

    HPAiHPA041376.

    Interactioni

    Subunit structurei

    Homotrimer.1 Publication

    Protein-protein interaction databases

    BioGridi114281. 6 interactions.
    DIPiDIP-3020N.
    STRINGi9606.ENSP00000245817.

    Structurei

    Secondary structure

    1
    254
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi83 – 853
    Beta strandi92 – 976
    Beta strandi104 – 1063
    Beta strandi115 – 1173
    Beta strandi121 – 1233
    Beta strandi133 – 1353
    Beta strandi139 – 15113
    Beta strandi159 – 16810
    Beta strandi178 – 1858
    Beta strandi195 – 20612
    Beta strandi210 – 2178
    Helixi220 – 2234
    Beta strandi226 – 2283
    Beta strandi234 – 2396

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2X29X-ray2.30A80-246[»]
    ProteinModelPortaliP41273.
    SMRiP41273. Positions 80-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP41273.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini50 – 254205ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 417Poly-Leu

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41045.
    HOGENOMiHOG000154658.
    HOVERGENiHBG079273.
    InParanoidiP41273.
    KOiK05472.
    OMAiWQLTQGA.
    OrthoDBiEOG7HQNB2.
    PhylomeDBiP41273.
    TreeFamiTF338523.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYASDASLD PEAPWPPAPR ARACRVLPWA LVAGLLLLLL LAAACAVFLA    50
    CPWAVSGARA SPGSAASPRL REGPELSPDD PAGLLDLRQG MFAQLVAQNV 100
    LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR 150
    RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ 200
    GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS 250
    PRSE 254
    Length:254
    Mass (Da):26,625
    Last modified:February 1, 1995 - v1
    Checksum:i827551F34563E508
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171P → A.
    Corresponds to variant rs442511 [ dbSNP | Ensembl ].
    VAR_011928

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03398 mRNA. Translation: AAA53134.1.
    BC104805 mRNA. Translation: AAI04806.1.
    BC104807 mRNA. Translation: AAI04808.1.
    CCDSiCCDS12169.1.
    PIRiI38427.
    RefSeqiNP_003802.1. NM_003811.3.
    XP_006722994.1. XM_006722931.1.
    UniGeneiHs.1524.

    Genome annotation databases

    EnsembliENST00000245817; ENSP00000245817; ENSG00000125657.
    GeneIDi8744.
    KEGGihsa:8744.
    UCSCiuc002mfh.2. human.

    Polymorphism databases

    DMDMi728739.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03398 mRNA. Translation: AAA53134.1 .
    BC104805 mRNA. Translation: AAI04806.1 .
    BC104807 mRNA. Translation: AAI04808.1 .
    CCDSi CCDS12169.1.
    PIRi I38427.
    RefSeqi NP_003802.1. NM_003811.3.
    XP_006722994.1. XM_006722931.1.
    UniGenei Hs.1524.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2X29 X-ray 2.30 A 80-246 [» ]
    ProteinModelPortali P41273.
    SMRi P41273. Positions 80-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114281. 6 interactions.
    DIPi DIP-3020N.
    STRINGi 9606.ENSP00000245817.

    PTM databases

    PhosphoSitei P41273.

    Polymorphism databases

    DMDMi 728739.

    Proteomic databases

    MaxQBi P41273.
    PaxDbi P41273.
    PRIDEi P41273.

    Protocols and materials databases

    DNASUi 8744.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245817 ; ENSP00000245817 ; ENSG00000125657 .
    GeneIDi 8744.
    KEGGi hsa:8744.
    UCSCi uc002mfh.2. human.

    Organism-specific databases

    CTDi 8744.
    GeneCardsi GC19P006531.
    HGNCi HGNC:11939. TNFSF9.
    HPAi HPA041376.
    MIMi 606182. gene.
    neXtProti NX_P41273.
    PharmGKBi PA36629.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41045.
    HOGENOMi HOG000154658.
    HOVERGENi HBG079273.
    InParanoidi P41273.
    KOi K05472.
    OMAi WQLTQGA.
    OrthoDBi EOG7HQNB2.
    PhylomeDBi P41273.
    TreeFami TF338523.

    Miscellaneous databases

    ChiTaRSi TNFSF9. human.
    EvolutionaryTracei P41273.
    GenomeRNAii 8744.
    NextBioi 32809.
    PROi P41273.
    SOURCEi Search...

    Gene expression databases

    Bgeei P41273.
    CleanExi HS_TNFSF9.
    Genevestigatori P41273.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily."
      Won E.Y., Cha K., Byun J.S., Kim D.U., Shin S., Ahn B., Kim Y.H., Rice A.J., Walz T., Kwon B.S., Cho H.S.
      J. Biol. Chem. 285:9202-9210(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 80-246, FUNCTION, SUBUNIT.

    Entry informationi

    Entry nameiTNFL9_HUMAN
    AccessioniPrimary (citable) accession number: P41273
    Secondary accession number(s): Q2M3S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3