Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 9

Gene

TNFSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.1 Publication

GO - Molecular functioni

  • receptor binding Source: ProtInc
  • tumor necrosis factor receptor superfamily binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 9
Alternative name(s):
4-1BB ligand
Short name:
4-1BBL
Gene namesi
Name:TNFSF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:11939. TNFSF9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei29 – 4921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini50 – 254205ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36629.

Polymorphism and mutation databases

BioMutaiTNFSF9.
DMDMi728739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Tumor necrosis factor ligand superfamily member 9PRO_0000185501Add
BLAST

Proteomic databases

MaxQBiP41273.
PaxDbiP41273.
PRIDEiP41273.

PTM databases

PhosphoSiteiP41273.

Expressioni

Tissue specificityi

Expressed in brain, placenta, lung, skeletal muscle and kidney.

Gene expression databases

BgeeiP41273.
CleanExiHS_TNFSF9.
GenevisibleiP41273. HS.

Organism-specific databases

HPAiHPA041376.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi114281. 26 interactions.
DIPiDIP-3020N.
STRINGi9606.ENSP00000245817.

Structurei

Secondary structure

1
254
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi83 – 853Combined sources
Beta strandi92 – 976Combined sources
Beta strandi104 – 1063Combined sources
Beta strandi115 – 1173Combined sources
Beta strandi121 – 1233Combined sources
Beta strandi133 – 1353Combined sources
Beta strandi139 – 15113Combined sources
Beta strandi159 – 16810Combined sources
Beta strandi178 – 1858Combined sources
Beta strandi195 – 20612Combined sources
Beta strandi210 – 2178Combined sources
Helixi220 – 2234Combined sources
Beta strandi226 – 2283Combined sources
Beta strandi234 – 2396Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X29X-ray2.30A80-246[»]
ProteinModelPortaliP41273.
SMRiP41273. Positions 80-246.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41273.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 417Poly-Leu

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41045.
GeneTreeiENSGT00390000006244.
HOGENOMiHOG000154658.
HOVERGENiHBG079273.
InParanoidiP41273.
KOiK05472.
OMAiYYVFLEL.
OrthoDBiEOG7HQNB2.
PhylomeDBiP41273.
TreeFamiTF338523.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYASDASLD PEAPWPPAPR ARACRVLPWA LVAGLLLLLL LAAACAVFLA
60 70 80 90 100
CPWAVSGARA SPGSAASPRL REGPELSPDD PAGLLDLRQG MFAQLVAQNV
110 120 130 140 150
LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR
160 170 180 190 200
RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ
210 220 230 240 250
GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS

PRSE
Length:254
Mass (Da):26,625
Last modified:February 1, 1995 - v1
Checksum:i827551F34563E508
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171P → A.
Corresponds to variant rs442511 [ dbSNP | Ensembl ].
VAR_011928

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03398 mRNA. Translation: AAA53134.1.
BC104805 mRNA. Translation: AAI04806.1.
BC104807 mRNA. Translation: AAI04808.1.
CCDSiCCDS12169.1.
PIRiI38427.
RefSeqiNP_003802.1. NM_003811.3.
XP_006722994.1. XM_006722931.1.
UniGeneiHs.1524.

Genome annotation databases

EnsembliENST00000245817; ENSP00000245817; ENSG00000125657.
GeneIDi8744.
KEGGihsa:8744.
UCSCiuc002mfh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03398 mRNA. Translation: AAA53134.1.
BC104805 mRNA. Translation: AAI04806.1.
BC104807 mRNA. Translation: AAI04808.1.
CCDSiCCDS12169.1.
PIRiI38427.
RefSeqiNP_003802.1. NM_003811.3.
XP_006722994.1. XM_006722931.1.
UniGeneiHs.1524.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X29X-ray2.30A80-246[»]
ProteinModelPortaliP41273.
SMRiP41273. Positions 80-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114281. 26 interactions.
DIPiDIP-3020N.
STRINGi9606.ENSP00000245817.

PTM databases

PhosphoSiteiP41273.

Polymorphism and mutation databases

BioMutaiTNFSF9.
DMDMi728739.

Proteomic databases

MaxQBiP41273.
PaxDbiP41273.
PRIDEiP41273.

Protocols and materials databases

DNASUi8744.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245817; ENSP00000245817; ENSG00000125657.
GeneIDi8744.
KEGGihsa:8744.
UCSCiuc002mfh.2. human.

Organism-specific databases

CTDi8744.
GeneCardsiGC19P006531.
HGNCiHGNC:11939. TNFSF9.
HPAiHPA041376.
MIMi606182. gene.
neXtProtiNX_P41273.
PharmGKBiPA36629.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41045.
GeneTreeiENSGT00390000006244.
HOGENOMiHOG000154658.
HOVERGENiHBG079273.
InParanoidiP41273.
KOiK05472.
OMAiYYVFLEL.
OrthoDBiEOG7HQNB2.
PhylomeDBiP41273.
TreeFamiTF338523.

Miscellaneous databases

ChiTaRSiTNFSF9. human.
EvolutionaryTraceiP41273.
GenomeRNAii8744.
NextBioi32809.
PROiP41273.
SOURCEiSearch...

Gene expression databases

BgeeiP41273.
CleanExiHS_TNFSF9.
GenevisibleiP41273. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily."
    Won E.Y., Cha K., Byun J.S., Kim D.U., Shin S., Ahn B., Kim Y.H., Rice A.J., Walz T., Kwon B.S., Cho H.S.
    J. Biol. Chem. 285:9202-9210(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 80-246, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiTNFL9_HUMAN
AccessioniPrimary (citable) accession number: P41273
Secondary accession number(s): Q2M3S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 24, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.