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P41273

- TNFL9_HUMAN

UniProt

P41273 - TNFL9_HUMAN

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Protein

Tumor necrosis factor ligand superfamily member 9

Gene

TNFSF9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.1 Publication

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: ProtInc
  2. cell-cell signaling Source: ProtInc
  3. cell proliferation Source: ProtInc
  4. immune response Source: InterPro
  5. myeloid dendritic cell differentiation Source: Ensembl
  6. positive regulation of activated T cell proliferation Source: Ensembl
  7. positive regulation of cytotoxic T cell differentiation Source: Ensembl
  8. positive regulation of interferon-gamma production Source: Ensembl
  9. positive regulation of interleukin-12 production Source: Ensembl
  10. positive regulation of interleukin-6 production Source: Ensembl
  11. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 9
Alternative name(s):
4-1BB ligand
Short name:
4-1BBL
Gene namesi
Name:TNFSF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11939. TNFSF9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei29 – 4921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini50 – 254205ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Tumor necrosis factor ligand superfamily member 9PRO_0000185501Add
BLAST

Proteomic databases

MaxQBiP41273.
PaxDbiP41273.
PRIDEiP41273.

PTM databases

PhosphoSiteiP41273.

Expressioni

Tissue specificityi

Expressed in brain, placenta, lung, skeletal muscle and kidney.

Gene expression databases

BgeeiP41273.
CleanExiHS_TNFSF9.
GenevestigatoriP41273.

Organism-specific databases

HPAiHPA041376.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi114281. 14 interactions.
DIPiDIP-3020N.
STRINGi9606.ENSP00000245817.

Structurei

Secondary structure

1
254
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi83 – 853Combined sources
Beta strandi92 – 976Combined sources
Beta strandi104 – 1063Combined sources
Beta strandi115 – 1173Combined sources
Beta strandi121 – 1233Combined sources
Beta strandi133 – 1353Combined sources
Beta strandi139 – 15113Combined sources
Beta strandi159 – 16810Combined sources
Beta strandi178 – 1858Combined sources
Beta strandi195 – 20612Combined sources
Beta strandi210 – 2178Combined sources
Helixi220 – 2234Combined sources
Beta strandi226 – 2283Combined sources
Beta strandi234 – 2396Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X29X-ray2.30A80-246[»]
ProteinModelPortaliP41273.
SMRiP41273. Positions 80-246.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41273.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 417Poly-Leu

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41045.
GeneTreeiENSGT00390000006244.
HOGENOMiHOG000154658.
HOVERGENiHBG079273.
InParanoidiP41273.
KOiK05472.
OMAiWQLTQGA.
OrthoDBiEOG7HQNB2.
PhylomeDBiP41273.
TreeFamiTF338523.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41273-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYASDASLD PEAPWPPAPR ARACRVLPWA LVAGLLLLLL LAAACAVFLA
60 70 80 90 100
CPWAVSGARA SPGSAASPRL REGPELSPDD PAGLLDLRQG MFAQLVAQNV
110 120 130 140 150
LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR
160 170 180 190 200
RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ
210 220 230 240 250
GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS

PRSE
Length:254
Mass (Da):26,625
Last modified:February 1, 1995 - v1
Checksum:i827551F34563E508
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171P → A.
Corresponds to variant rs442511 [ dbSNP | Ensembl ].
VAR_011928

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03398 mRNA. Translation: AAA53134.1.
BC104805 mRNA. Translation: AAI04806.1.
BC104807 mRNA. Translation: AAI04808.1.
CCDSiCCDS12169.1.
PIRiI38427.
RefSeqiNP_003802.1. NM_003811.3.
XP_006722994.1. XM_006722931.1.
UniGeneiHs.1524.

Genome annotation databases

EnsembliENST00000245817; ENSP00000245817; ENSG00000125657.
GeneIDi8744.
KEGGihsa:8744.
UCSCiuc002mfh.2. human.

Polymorphism databases

DMDMi728739.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03398 mRNA. Translation: AAA53134.1 .
BC104805 mRNA. Translation: AAI04806.1 .
BC104807 mRNA. Translation: AAI04808.1 .
CCDSi CCDS12169.1.
PIRi I38427.
RefSeqi NP_003802.1. NM_003811.3.
XP_006722994.1. XM_006722931.1.
UniGenei Hs.1524.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2X29 X-ray 2.30 A 80-246 [» ]
ProteinModelPortali P41273.
SMRi P41273. Positions 80-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114281. 14 interactions.
DIPi DIP-3020N.
STRINGi 9606.ENSP00000245817.

PTM databases

PhosphoSitei P41273.

Polymorphism databases

DMDMi 728739.

Proteomic databases

MaxQBi P41273.
PaxDbi P41273.
PRIDEi P41273.

Protocols and materials databases

DNASUi 8744.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245817 ; ENSP00000245817 ; ENSG00000125657 .
GeneIDi 8744.
KEGGi hsa:8744.
UCSCi uc002mfh.2. human.

Organism-specific databases

CTDi 8744.
GeneCardsi GC19P006531.
HGNCi HGNC:11939. TNFSF9.
HPAi HPA041376.
MIMi 606182. gene.
neXtProti NX_P41273.
PharmGKBi PA36629.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41045.
GeneTreei ENSGT00390000006244.
HOGENOMi HOG000154658.
HOVERGENi HBG079273.
InParanoidi P41273.
KOi K05472.
OMAi WQLTQGA.
OrthoDBi EOG7HQNB2.
PhylomeDBi P41273.
TreeFami TF338523.

Miscellaneous databases

ChiTaRSi TNFSF9. human.
EvolutionaryTracei P41273.
GenomeRNAii 8744.
NextBioi 32809.
PROi P41273.
SOURCEi Search...

Gene expression databases

Bgeei P41273.
CleanExi HS_TNFSF9.
Genevestigatori P41273.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily."
    Won E.Y., Cha K., Byun J.S., Kim D.U., Shin S., Ahn B., Kim Y.H., Rice A.J., Walz T., Kwon B.S., Cho H.S.
    J. Biol. Chem. 285:9202-9210(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 80-246, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiTNFL9_HUMAN
AccessioniPrimary (citable) accession number: P41273
Secondary accession number(s): Q2M3S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3