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Protein

CD27 antigen

Gene

Cd27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

GO - Molecular functioni

GO - Biological processi

  • B cell proliferation Source: UniProtKB
  • extrinsic apoptotic signaling pathway Source: MGI
  • immunoglobulin secretion Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • negative regulation of T cell apoptotic process Source: MGI
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • positive regulation of JNK cascade Source: UniProtKB
  • positive regulation of T cell differentiation Source: UniProtKB
  • response to ethanol Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
CD27 antigen
Alternative name(s):
CD27L receptor
T-cell activation antigen CD27
Tumor necrosis factor receptor superfamily member 7
CD_antigen: CD27
Gene namesi
Name:Cd27
Synonyms:Tnfrsf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:88326. Cd27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 182159ExtracellularSequence analysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence analysisAdd
BLAST
Topological domaini204 – 25047CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 250227CD27 antigenPRO_0000034572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
Disulfide bondi40 ↔ 53PROSITE-ProRule annotation
Disulfide bondi43 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi87 ↔ 104PROSITE-ProRule annotation
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 117PROSITE-ProRule annotation
Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP41272.
PaxDbiP41272.
PRIDEiP41272.

PTM databases

PhosphoSiteiP41272.

Expressioni

Tissue specificityi

In thymus and spleen, but not in non-lymphoid tissues.

Gene expression databases

BgeeiP41272.
CleanExiMM_CD27.
ExpressionAtlasiP41272. baseline and differential.
GenevisibleiP41272. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with SIVA1 and TRAF2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204252. 2 interactions.
IntActiP41272. 1 interaction.
STRINGi10090.ENSMUSP00000032486.

Structurei

3D structure databases

ProteinModelPortaliP41272.
SMRiP41272. Positions 36-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 6338TNFR-Cys 1Add
BLAST
Repeati64 – 10441TNFR-Cys 2Add
BLAST
Repeati105 – 14137TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUP. Eukaryota.
ENOG410ZDEA. LUCA.
HOGENOMiHOG000082545.
HOVERGENiHBG018200.
InParanoidiP41272.
KOiK05144.
OMAiYSCPREE.
OrthoDBiEOG7W41CQ.
PhylomeDBiP41272.
TreeFamiTF336960.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022328. TNFR_7.
[Graphical view]
PRINTSiPR01960. TNFACTORR7.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWPPPYWLC MLGTLVGLSA TLAPNSCPDK HYWTGGGLCC RMCEPGTFFV
60 70 80 90 100
KDCEQDRTAA QCDPCIPGTS FSPDYHTRPH CESCRHCNSG FLIRNCTVTA
110 120 130 140 150
NAECSCSKNW QCRDQECTEC DPPLNPALTR QPSETPSPQP PPTHLPHGTE
160 170 180 190 200
KPSWPLHRQL PNSTVYSQRS SHRPLCSSDC IRIFVTFSSM FLIFVLGAIL
210 220 230 240 250
FFHQRRNHGP NEDRQAVPEE PCPYSCPREE EGSAIPIQED YRKPEPAFYP
Length:250
Mass (Da):28,164
Last modified:February 1, 1995 - v1
Checksum:i48477C2E0C244697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24495 mRNA. No translation available.
CCDSiCCDS39639.1.
PIRiA49053.
RefSeqiNP_001028298.1. NM_001033126.2.
UniGeneiMm.367714.

Genome annotation databases

EnsembliENSMUST00000032486; ENSMUSP00000032486; ENSMUSG00000030336.
GeneIDi21940.
KEGGimmu:21940.
UCSCiuc009duc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24495 mRNA. No translation available.
CCDSiCCDS39639.1.
PIRiA49053.
RefSeqiNP_001028298.1. NM_001033126.2.
UniGeneiMm.367714.

3D structure databases

ProteinModelPortaliP41272.
SMRiP41272. Positions 36-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204252. 2 interactions.
IntActiP41272. 1 interaction.
STRINGi10090.ENSMUSP00000032486.

PTM databases

PhosphoSiteiP41272.

Proteomic databases

EPDiP41272.
PaxDbiP41272.
PRIDEiP41272.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032486; ENSMUSP00000032486; ENSMUSG00000030336.
GeneIDi21940.
KEGGimmu:21940.
UCSCiuc009duc.1. mouse.

Organism-specific databases

CTDi939.
MGIiMGI:88326. Cd27.

Phylogenomic databases

eggNOGiENOG410IZUP. Eukaryota.
ENOG410ZDEA. LUCA.
HOGENOMiHOG000082545.
HOVERGENiHBG018200.
InParanoidiP41272.
KOiK05144.
OMAiYSCPREE.
OrthoDBiEOG7W41CQ.
PhylomeDBiP41272.
TreeFamiTF336960.

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

PROiP41272.
SOURCEiSearch...

Gene expression databases

BgeeiP41272.
CleanExiMM_CD27.
ExpressionAtlasiP41272. baseline and differential.
GenevisibleiP41272. MM.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022328. TNFR_7.
[Graphical view]
PRINTSiPR01960. TNFACTORR7.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family."
    Gravestein L.A., Blom B., Nolten L.A., de Vries E., van der Horst G., Ossendorp F., Borst J., Loenen W.A.
    Eur. J. Immunol. 23:943-950(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Thymus.

Entry informationi

Entry nameiCD27_MOUSE
AccessioniPrimary (citable) accession number: P41272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.