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Protein

Nucleoprotein

Gene

N

Organism
Puumala virus (strain Evo/12CG/93)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:N
OrganismiPuumala virus (strain Evo/12CG/93)
Taxonomic identifieri38999 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Subcellular locationi

Virion
Note: Internal protein of virus particle.

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: UniProtKB-KW
  3. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433NucleoproteinPRO_0000222012Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP41268.
SMRiP41268. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR002214. Hanta_nucleocap.
[Graphical view]
PfamiPF00846. Hanta_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003949. N_HantaV. 1 hit.
ProDomiPD001501. Hanta_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P41268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLTDIQED ITRHEQQLVV ARQKLKDAER AVEVDPDDVN KNTLQARQQT
60 70 80 90 100
VSALEDKLAD YKRRMADAVS RKKMDTKPTD PTGIEPDDHL KERSSLRYGN
110 120 130 140 150
VLDVNAIDIE EPSGQTADWY TIGVYVIGFT IPIILKALYM LSTRGRQTVK
160 170 180 190 200
ENKGTRIRFK DDTSFEDING IRRPKHLYVS MPTAQSTMKA EELTPGRFRT
210 220 230 240 250
IVCGLFPTQI QVRNIMSPVM GVIGFSFFVK DWPERIREFM EKECPFIKPE
260 270 280 290 300
IKPGTPAQEM EMLKRNKIYF MQRQDVLDKN HVADIDKLID YAASGDPTSP
310 320 330 340 350
DNIDSPNAPW VFACAPDRCP PTCIYVAGMA ELGAFFSILQ DMRNTIMASK
360 370 380 390 400
TVGTAEEKLR KKSSFYQSYL RRTQSMGIQL DQRIILLFML EWGKEMVDHF
410 420 430
HLGDDMDPEL RGLAQALIDQ KVKEISNQEP LKI
Length:433
Mass (Da):49,508
Last modified:February 1, 1995 - v1
Checksum:iEF2B4DF273132F93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30703 Genomic RNA. Translation: CAA83188.1.
Z30702 Genomic RNA. Translation: CAA83187.1.
PIRiS43008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30703 Genomic RNA. Translation: CAA83188.1.
Z30702 Genomic RNA. Translation: CAA83187.1.
PIRiS43008.

3D structure databases

ProteinModelPortaliP41268.
SMRiP41268. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR002214. Hanta_nucleocap.
[Graphical view]
PfamiPF00846. Hanta_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003949. N_HantaV. 1 hit.
ProDomiPD001501. Hanta_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Genetic variation of wild Puumala viruses within the serotype, local rodent populations and individual animal."
    Plyusnin A., Vapalahti O., Lehvaeslaiho H., Apekina N., Mikhailova T., Gavilovskaya I., Laakkonen J., Niemimaa J., Henttonen H., Brummer-Korvenkontio M., Vaheri A.
    Virus Res. 38:25-41(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNCAP_PUUME
AccessioniPrimary (citable) accession number: P41268
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 4, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.