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P41265

- GP_PUUMK

UniProt

P41265 - GP_PUUMK

Protein

Envelope glycoprotein

Gene

GP

Organism
Puumala virus (strain K27)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei658 – 6592Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. signal transduction Source: InterPro
    3. suppression by virus of host innate immune response Source: UniProtKB-KW
    4. suppression by virus of host TRAF activity Source: UniProtKB-KW
    5. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiPuumala virus (strain K27)
    Taxonomic identifieri39000 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 11481125Envelope glycoproteinPRO_0000036825Add
    BLAST
    Chaini24 – 658635Glycoprotein G1By similarityPRO_0000036826Add
    BLAST
    Chaini659 – 1148490Glycoprotein G2By similarityPRO_0000036827Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi142 – 1421N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi357 – 3571N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi409 – 4091N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi898 – 8981N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi937 – 9371N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 495472LumenalSequence AnalysisAdd
    BLAST
    Topological domaini517 – 658142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini659 – 1114456LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1136 – 114813CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei496 – 51621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1115 – 113521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini621 – 64424ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view]
    PfamiPF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
    ProDomiPD001813. Hanta_G2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS51056. ITAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41265-1 [UniParc]FASTAAdd to Basket

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    MGELSPVCLY LLLQGLLLCN TGAARNLNEL KMECPHTIRL GQGLVVGSVE     50
    LPSLPIQQVE TLKLESSCNF DLHTSTAGQQ SFTKWTWEIK GDLAENTQAS 100
    STSFQTKSSE VNLRGLCLIP TLVVETAARM RKTIACYDLS CNQTVCQPTV 150
    YLMGPIQTCI TTKSCLLSLG DQRIQVNYEK TYCVSGQLVE GICFNPIHTM 200
    ALSQPSHTYD IMTMMVRCFL VIKKVTSGDS MKIEKNFETL VQKNGCTANN 250
    FQGYYICLIG SSSEPLYVPA LDDYRSAEVL SRMAFAPHGE DHDIEKNAVS 300
    AMRIAGKVTG KAPSTESSDT VQGIAFSGSP LYTSTGVLTS KDDPVYIWAP 350
    GIIMEGNHSI CEKKTLPLTW TGFISLPGEI EKTTQCTVFC TLAGPGADCE 400
    AYSETGIFNI SSPTCSINRV QRFRGSEQQI KFVCQRVDMD ITVYCNGMKK 450
    VILTKTLVIG QCIYTFTSIF SLIPGVAHSL AVELCVPGLH GWATMLLLLT 500
    LCFGWVLIPT ITMILLKILI AFAYLCSKYN TDSKFRILIE KVKREYQKTM 550
    GSMVCEVCQY ECETAKELES HRKSCSIGSC PYCLNPSEAT TSALQAHFKV 600
    CKLTSRFQEN LRKSLTVYEP MQGCYRTLSL FRYRSRFFVG LVWCVLLVLE 650
    LIVWAASAET QNLNAGWTDT AHGSGIIPMK TDLELDFSLP SSASYTYRRQ 700
    LQNPANEQEK IPFHLQLSKQ VIHAEIQHLG HWMDATFNLK TAFHCYGSCE 750
    KYAYPWQTAG CFIEKDYEYE TGWGCNPPDC PGVGTGCTAC GVYLDKLKSV 800
    GKVFKIVSLR YTRKVCIQLG TEQTCKTVDS NDCLITTSVK VCLIGTISKF 850
    QPSDTLLFLG PLQQGGLIFK QWCTTTCQFG DPGDIMSTPT GMKCPELNGS 900
    FRKKCAFATT PVCQFDGNTI SGYKRMIATK DSFQSFNVTE PHISTSALEW 950
    IDPDSSLRDH INVIVSRDLS FQDLSETPCQ IDLATASIDG AWGSGVGFNL 1000
    VCTVSLTECS AFLTSIKACD AAMCYGSTTA NLVRGQNTIH IVGKGGHSGS 1050
    KFMCCHDTKC SSTGLVAAAP HLDRVTGYNQ ADSDKIFDDG APECGMSCWF 1100
    KKSGEWILGV LNGNWMVVAV LVVLLILSIL LFTLCCPRRP SYRKEHKP 1148
    Length:1,148
    Mass (Da):126,574
    Last modified:February 1, 1995 - v1
    Checksum:i0AB1A245F502D265
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08754 Unassigned DNA. Translation: AAC37847.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08754 Unassigned DNA. Translation: AAC37847.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view ]
    Pfami PF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
    ProDomi PD001813. Hanta_G2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS51056. ITAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide and deduced amino acid sequences of the M and S genome segments of two Puumala virus isolates from Russia."
      Xiao S.Y., Spik K.W., Li D., Schmaljohn C.S.
      Virus Res. 30:97-103(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiGP_PUUMK
    AccessioniPrimary (citable) accession number: P41265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3