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P41251

- NRAM1_MOUSE

UniProt

P41251 - NRAM1_MOUSE

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Protein

Natural resistance-associated macrophage protein 1

Gene

Slc11a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

GO - Molecular functioni

  1. manganese ion transmembrane transporter activity Source: MGI
  2. metal ion:proton antiporter activity Source: Ensembl

GO - Biological processi

  1. activation of protein kinase activity Source: MGI
  2. antigen processing and presentation of peptide antigen Source: MGI
  3. cadmium ion transmembrane transport Source: Ensembl
  4. cellular cadmium ion homeostasis Source: Ensembl
  5. cellular iron ion homeostasis Source: MGI
  6. defense response to bacterium Source: MGI
  7. defense response to Gram-negative bacterium Source: MGI
  8. defense response to protozoan Source: MGI
  9. divalent metal ion export Source: BHF-UCL
  10. inflammatory response Source: MGI
  11. interleukin-2 production Source: MGI
  12. interleukin-3 production Source: MGI
  13. iron ion homeostasis Source: MGI
  14. iron ion transport Source: MGI
  15. L-arginine import Source: MGI
  16. macrophage activation Source: MGI
  17. manganese ion transmembrane transport Source: GOC
  18. manganese ion transport Source: MGI
  19. MAPK cascade Source: MGI
  20. MHC class II biosynthetic process Source: MGI
  21. mRNA stabilization Source: MGI
  22. multicellular organismal iron ion homeostasis Source: MGI
  23. negative regulation of cytokine production Source: MGI
  24. nitrite transport Source: MGI
  25. phagocytosis Source: MGI
  26. positive regulation of cytokine production Source: MGI
  27. positive regulation of dendritic cell antigen processing and presentation Source: MGI
  28. positive regulation of gene expression Source: MGI
  29. positive regulation of interferon-gamma production Source: MGI
  30. positive regulation of phagocytosis Source: MGI
  31. positive regulation of T-helper 1 type immune response Source: MGI
  32. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  33. protein import into nucleus, translocation Source: MGI
  34. respiratory burst Source: MGI
  35. response to bacterium Source: MGI
  36. response to interferon-gamma Source: MGI
  37. response to lipopolysaccharide Source: MGI
  38. T cell cytokine production Source: MGI
  39. T cell proliferation involved in immune response Source: MGI
  40. vacuolar acidification Source: MGI
  41. wound healing Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_251299. Metal ion SLC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Natural resistance-associated macrophage protein 1
Short name:
NRAMP 1
Alternative name(s):
Solute carrier family 11 member 1
Gene namesi
Name:Slc11a1
Synonyms:Bcg, Ity, Lsh, Nramp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1345275. Slc11a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei56 – 7318HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 829ExtracellularSequence Analysis
Transmembranei83 – 10220HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 13937CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Topological domaini161 – 1644ExtracellularSequence Analysis
Transmembranei165 – 18420HelicalSequence AnalysisAdd
BLAST
Topological domaini185 – 1939CytoplasmicSequence Analysis
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Topological domaini215 – 23723ExtracellularSequence AnalysisAdd
BLAST
Transmembranei238 – 25619HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 28428CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei285 – 30420HelicalSequence AnalysisAdd
BLAST
Topological domaini305 – 34642ExtracellularSequence AnalysisAdd
BLAST
Transmembranei347 – 36620HelicalSequence AnalysisAdd
BLAST
Topological domaini367 – 39731CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei398 – 41518HelicalSequence AnalysisAdd
BLAST
Topological domaini416 – 42611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence AnalysisAdd
BLAST
Topological domaini448 – 46316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei464 – 48522HelicalSequence AnalysisAdd
BLAST
Topological domaini486 – 4938ExtracellularSequence Analysis
Transmembranei494 – 51320HelicalSequence AnalysisAdd
BLAST
Topological domaini514 – 54835CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell outer membrane Source: MGI
  2. endosome membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. late endosome Source: MGI
  5. lysosome Source: MGI
  6. phagocytic vesicle membrane Source: MGI
  7. plasma membrane Source: Ensembl
  8. tertiary granule membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Natural resistance-associated macrophage protein 1PRO_0000212589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP41251.
PRIDEiP41251.

PTM databases

PhosphoSiteiP41251.

Expressioni

Tissue specificityi

Macrophages; spleen and liver.

Developmental stagei

Expressed in the early stages of infection.

Inductioni

In response to lymphokine or bacterial products.

Gene expression databases

BgeeiP41251.
GenevestigatoriP41251.

Interactioni

Protein-protein interaction databases

BioGridi201840. 5 interactions.
STRINGi10090.ENSMUSP00000027368.

Structurei

3D structure databases

ProteinModelPortaliP41251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 7775Pro/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the NRAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1914.
GeneTreeiENSGT00390000006526.
HOGENOMiHOG000152203.
HOVERGENiHBG052665.
InParanoidiP41251.
KOiK12347.
OMAiSHKHFLY.
OrthoDBiEOG77127K.
TreeFamiTF315185.

Family and domain databases

HAMAPiMF_00221. NRAMP.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.

Sequencei

Sequence statusi: Complete.

P41251-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISDKSPPRL SRPSYGSISS LPGPAPQPAP CRETYLSEKI PIPSADQGTF
60 70 80 90 100
SLRKLWAFTG PGFLMSIAFL DPGNIESDLQ AGAVAGFKLL WVLLWATVLG
110 120 130 140 150
LLCQRLAARL GVVTGKDLGE VCHLYYPKVP RILLWLTIEL AIVGSDMQEV
160 170 180 190 200
IGTAISFNLL SAGRIPLWDG VLITIVDTFF FLFLDNYGLR KLEAFFGLLI
210 220 230 240 250
TIMALTFGYE YVVAHPSQGA LLKGLVLPTC PGCGQPELLQ AVGIVGAIIM
260 270 280 290 300
PHNIYLHSAL VKSREVDRTR RVDVREANMY FLIEATIALS VSFIINLFVM
310 320 330 340 350
AVFGQAFYQQ TNEEAFNICA NSSLQNYAKI FPRDNNTVSV DIYQGGVILG
360 370 380 390 400
CLFGPAALYI WAVGLLAAGQ SSTMTGTYAG QFVMEGFLKL RWSRFARVLL
410 420 430 440 450
TRSCAILPTV LVAVFRDLKD LSGLNDLLNV LQSLLLPFAV LPILTFTSMP
460 470 480 490 500
AVMQEFANGR MSKAITSCIM ALVCAINLYF VISYLPSLPH PAYFGLVALF
510 520 530 540
AIGYLGLTAY LAWTCCIAHG ATFLTHSSHK HFLYGLPNEE QGGVQGSG
Length:548
Mass (Da):59,741
Last modified:July 27, 2011 - v2
Checksum:iE5F0C1EC9FC0C2FD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti169 – 1691D → G.3 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75355 mRNA. Translation: CAA53102.1.
S79389
, S79360, S79361, S79362, S79364, S79365, S79367, S79395, S79396, S79369, S79375, S79380, S79381, S79386, S79387 Genomic DNA. Translation: AAB35205.2.
AK171393 mRNA. Translation: BAE42430.1.
BC109137 mRNA. Translation: AAI09138.1.
BC109138 mRNA. Translation: AAI09139.1.
L13732 mRNA. Translation: AAA39838.1.
CCDSiCCDS15047.1.
PIRiI48693.
RefSeqiNP_038640.2. NM_013612.2.
UniGeneiMm.2913.

Genome annotation databases

EnsembliENSMUST00000027368; ENSMUSP00000027368; ENSMUSG00000026177.
GeneIDi18173.
KEGGimmu:18173.
UCSCiuc007bly.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75355 mRNA. Translation: CAA53102.1 .
S79389
, S79360 , S79361 , S79362 , S79364 , S79365 , S79367 , S79395 , S79396 , S79369 , S79375 , S79380 , S79381 , S79386 , S79387 Genomic DNA. Translation: AAB35205.2 .
AK171393 mRNA. Translation: BAE42430.1 .
BC109137 mRNA. Translation: AAI09138.1 .
BC109138 mRNA. Translation: AAI09139.1 .
L13732 mRNA. Translation: AAA39838.1 .
CCDSi CCDS15047.1.
PIRi I48693.
RefSeqi NP_038640.2. NM_013612.2.
UniGenei Mm.2913.

3D structure databases

ProteinModelPortali P41251.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201840. 5 interactions.
STRINGi 10090.ENSMUSP00000027368.

PTM databases

PhosphoSitei P41251.

Proteomic databases

PaxDbi P41251.
PRIDEi P41251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027368 ; ENSMUSP00000027368 ; ENSMUSG00000026177 .
GeneIDi 18173.
KEGGi mmu:18173.
UCSCi uc007bly.2. mouse.

Organism-specific databases

CTDi 6556.
MGIi MGI:1345275. Slc11a1.

Phylogenomic databases

eggNOGi COG1914.
GeneTreei ENSGT00390000006526.
HOGENOMi HOG000152203.
HOVERGENi HBG052665.
InParanoidi P41251.
KOi K12347.
OMAi SHKHFLY.
OrthoDBi EOG77127K.
TreeFami TF315185.

Enzyme and pathway databases

Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
REACT_251299. Metal ion SLC transporters.

Miscellaneous databases

NextBioi 293474.
PROi P41251.
SOURCEi Search...

Gene expression databases

Bgeei P41251.
Genevestigatori P41251.

Family and domain databases

HAMAPi MF_00221. NRAMP.
InterProi IPR001046. NRAMP_fam.
[Graphical view ]
PANTHERi PTHR11706. PTHR11706. 1 hit.
Pfami PF01566. Nramp. 1 hit.
[Graphical view ]
PRINTSi PR00447. NATRESASSCMP.
TIGRFAMsi TIGR01197. nramp. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain."
    Barton C.H., White J.K., Roach T.I.A., Blackwell J.M.
    J. Exp. Med. 179:1683-1687(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-169.
    Strain: B10.L-LSH.
    Tissue: Bone marrow.
  2. "Genomic structure, promoter sequence, and induction of expression of the mouse Nramp1 gene in macrophages."
    Govoni G., Vidal S., Cellier M., Lepage P., Malo D., Gros P.
    Genomics 27:9-19(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-169.
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg."
    Vidal S.M., Malo D., Vogan K., Skamene E., Gros P.
    Cell 73:469-485(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-548, VARIANT GLY-169.
    Strain: DBA/2.
    Tissue: Pre-B cell.

Entry informationi

Entry nameiNRAM1_MOUSE
AccessioniPrimary (citable) accession number: P41251
Secondary accession number(s): Q3TB84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3