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P41251

- NRAM1_MOUSE

UniProt

P41251 - NRAM1_MOUSE

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Protein
Natural resistance-associated macrophage protein 1
Gene
Slc11a1, Bcg, Ity, Lsh, Nramp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.UniRule annotation

GO - Molecular functioni

  1. manganese ion transmembrane transporter activity Source: MGI
  2. metal ion:proton antiporter activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. L-arginine import Source: MGI
  2. MAPK cascade Source: MGI
  3. MHC class II biosynthetic process Source: MGI
  4. T cell cytokine production Source: MGI
  5. T cell proliferation involved in immune response Source: MGI
  6. activation of protein kinase activity Source: MGI
  7. antigen processing and presentation of peptide antigen Source: MGI
  8. cadmium ion transmembrane transport Source: Ensembl
  9. cellular cadmium ion homeostasis Source: Ensembl
  10. cellular iron ion homeostasis Source: MGI
  11. defense response to Gram-negative bacterium Source: MGI
  12. defense response to bacterium Source: MGI
  13. defense response to protozoan Source: MGI
  14. divalent metal ion export Source: BHF-UCL
  15. inflammatory response Source: MGI
  16. interleukin-2 production Source: MGI
  17. interleukin-3 production Source: MGI
  18. iron ion homeostasis Source: MGI
  19. iron ion transport Source: MGI
  20. mRNA stabilization Source: MGI
  21. macrophage activation Source: MGI
  22. manganese ion transmembrane transport Source: GOC
  23. manganese ion transport Source: MGI
  24. multicellular organismal iron ion homeostasis Source: MGI
  25. negative regulation of cytokine production Source: MGI
  26. nitrite transport Source: MGI
  27. phagocytosis Source: MGI
  28. positive regulation of T-helper 1 type immune response Source: MGI
  29. positive regulation of cytokine production Source: MGI
  30. positive regulation of dendritic cell antigen processing and presentation Source: MGI
  31. positive regulation of gene expression Source: MGI
  32. positive regulation of interferon-gamma production Source: MGI
  33. positive regulation of phagocytosis Source: MGI
  34. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  35. protein import into nucleus, translocation Source: MGI
  36. respiratory burst Source: MGI
  37. response to bacterium Source: MGI
  38. response to interferon-gamma Source: MGI
  39. response to lipopolysaccharide Source: MGI
  40. vacuolar acidification Source: MGI
  41. wound healing Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).

Names & Taxonomyi

Protein namesi
Recommended name:
Natural resistance-associated macrophage protein 1
Short name:
NRAMP 1
Alternative name(s):
Solute carrier family 11 member 1
Gene namesi
Name:Slc11a1
Synonyms:Bcg, Ity, Lsh, Nramp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1345275. Slc11a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei56 – 7318Helical; Reviewed prediction
Add
BLAST
Topological domaini74 – 829Extracellular Reviewed prediction
Transmembranei83 – 10220Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 13937Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Reviewed prediction
Add
BLAST
Topological domaini161 – 1644Extracellular Reviewed prediction
Transmembranei165 – 18420Helical; Reviewed prediction
Add
BLAST
Topological domaini185 – 1939Cytoplasmic Reviewed prediction
Transmembranei194 – 21421Helical; Reviewed prediction
Add
BLAST
Topological domaini215 – 23723Extracellular Reviewed prediction
Add
BLAST
Transmembranei238 – 25619Helical; Reviewed prediction
Add
BLAST
Topological domaini257 – 28428Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei285 – 30420Helical; Reviewed prediction
Add
BLAST
Topological domaini305 – 34642Extracellular Reviewed prediction
Add
BLAST
Transmembranei347 – 36620Helical; Reviewed prediction
Add
BLAST
Topological domaini367 – 39731Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei398 – 41518Helical; Reviewed prediction
Add
BLAST
Topological domaini416 – 42611Extracellular Reviewed prediction
Add
BLAST
Transmembranei427 – 44721Helical; Reviewed prediction
Add
BLAST
Topological domaini448 – 46316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei464 – 48522Helical; Reviewed prediction
Add
BLAST
Topological domaini486 – 4938Extracellular Reviewed prediction
Transmembranei494 – 51320Helical; Reviewed prediction
Add
BLAST
Topological domaini514 – 54835Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell outer membrane Source: MGI
  2. endosome membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. late endosome Source: MGI
  5. lysosome Source: MGI
  6. phagocytic vesicle membrane Source: MGI
  7. plasma membrane Source: Ensembl
  8. tertiary granule membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Natural resistance-associated macrophage protein 1UniRule annotation
PRO_0000212589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP41251.
PRIDEiP41251.

PTM databases

PhosphoSiteiP41251.

Expressioni

Tissue specificityi

Macrophages; spleen and liver.

Developmental stagei

Expressed in the early stages of infection.UniRule annotation

Inductioni

In response to lymphokine or bacterial products.UniRule annotation

Gene expression databases

BgeeiP41251.
GenevestigatoriP41251.

Interactioni

Protein-protein interaction databases

BioGridi201840. 5 interactions.
STRINGi10090.ENSMUSP00000027368.

Structurei

3D structure databases

ProteinModelPortaliP41251.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 7775Pro/Ser-richUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the NRAMP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1914.
GeneTreeiENSGT00390000006526.
HOGENOMiHOG000152203.
HOVERGENiHBG052665.
InParanoidiQ3TB84.
KOiK12347.
OMAiSHKHFLY.
OrthoDBiEOG77127K.
TreeFamiTF315185.

Family and domain databases

HAMAPiMF_00221. NRAMP.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.

Sequencei

Sequence statusi: Complete.

P41251-1 [UniParc]FASTAAdd to Basket

« Hide

MISDKSPPRL SRPSYGSISS LPGPAPQPAP CRETYLSEKI PIPSADQGTF    50
SLRKLWAFTG PGFLMSIAFL DPGNIESDLQ AGAVAGFKLL WVLLWATVLG 100
LLCQRLAARL GVVTGKDLGE VCHLYYPKVP RILLWLTIEL AIVGSDMQEV 150
IGTAISFNLL SAGRIPLWDG VLITIVDTFF FLFLDNYGLR KLEAFFGLLI 200
TIMALTFGYE YVVAHPSQGA LLKGLVLPTC PGCGQPELLQ AVGIVGAIIM 250
PHNIYLHSAL VKSREVDRTR RVDVREANMY FLIEATIALS VSFIINLFVM 300
AVFGQAFYQQ TNEEAFNICA NSSLQNYAKI FPRDNNTVSV DIYQGGVILG 350
CLFGPAALYI WAVGLLAAGQ SSTMTGTYAG QFVMEGFLKL RWSRFARVLL 400
TRSCAILPTV LVAVFRDLKD LSGLNDLLNV LQSLLLPFAV LPILTFTSMP 450
AVMQEFANGR MSKAITSCIM ALVCAINLYF VISYLPSLPH PAYFGLVALF 500
AIGYLGLTAY LAWTCCIAHG ATFLTHSSHK HFLYGLPNEE QGGVQGSG 548
Length:548
Mass (Da):59,741
Last modified:July 27, 2011 - v2
Checksum:iE5F0C1EC9FC0C2FD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti169 – 1691D → G.3 Publications

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75355 mRNA. Translation: CAA53102.1.
S79389
, S79360, S79361, S79362, S79364, S79365, S79367, S79395, S79396, S79369, S79375, S79380, S79381, S79386, S79387 Genomic DNA. Translation: AAB35205.2.
AK171393 mRNA. Translation: BAE42430.1.
BC109137 mRNA. Translation: AAI09138.1.
BC109138 mRNA. Translation: AAI09139.1.
L13732 mRNA. Translation: AAA39838.1.
CCDSiCCDS15047.1.
PIRiI48693.
RefSeqiNP_038640.2. NM_013612.2.
UniGeneiMm.2913.

Genome annotation databases

EnsembliENSMUST00000027368; ENSMUSP00000027368; ENSMUSG00000026177.
GeneIDi18173.
KEGGimmu:18173.
UCSCiuc007bly.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75355 mRNA. Translation: CAA53102.1 .
S79389
, S79360 , S79361 , S79362 , S79364 , S79365 , S79367 , S79395 , S79396 , S79369 , S79375 , S79380 , S79381 , S79386 , S79387 Genomic DNA. Translation: AAB35205.2 .
AK171393 mRNA. Translation: BAE42430.1 .
BC109137 mRNA. Translation: AAI09138.1 .
BC109138 mRNA. Translation: AAI09139.1 .
L13732 mRNA. Translation: AAA39838.1 .
CCDSi CCDS15047.1.
PIRi I48693.
RefSeqi NP_038640.2. NM_013612.2.
UniGenei Mm.2913.

3D structure databases

ProteinModelPortali P41251.
ModBasei Search...

Protein-protein interaction databases

BioGridi 201840. 5 interactions.
STRINGi 10090.ENSMUSP00000027368.

PTM databases

PhosphoSitei P41251.

Proteomic databases

PaxDbi P41251.
PRIDEi P41251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027368 ; ENSMUSP00000027368 ; ENSMUSG00000026177 .
GeneIDi 18173.
KEGGi mmu:18173.
UCSCi uc007bly.2. mouse.

Organism-specific databases

CTDi 6556.
MGIi MGI:1345275. Slc11a1.

Phylogenomic databases

eggNOGi COG1914.
GeneTreei ENSGT00390000006526.
HOGENOMi HOG000152203.
HOVERGENi HBG052665.
InParanoidi Q3TB84.
KOi K12347.
OMAi SHKHFLY.
OrthoDBi EOG77127K.
TreeFami TF315185.

Enzyme and pathway databases

Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).

Miscellaneous databases

NextBioi 293474.
PROi P41251.
SOURCEi Search...

Gene expression databases

Bgeei P41251.
Genevestigatori P41251.

Family and domain databases

HAMAPi MF_00221. NRAMP.
InterProi IPR001046. NRAMP_fam.
[Graphical view ]
PANTHERi PTHR11706. PTHR11706. 1 hit.
Pfami PF01566. Nramp. 1 hit.
[Graphical view ]
PRINTSi PR00447. NATRESASSCMP.
TIGRFAMsi TIGR01197. nramp. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain."
    Barton C.H., White J.K., Roach T.I.A., Blackwell J.M.
    J. Exp. Med. 179:1683-1687(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-169.
    Strain: B10.L-LSH.
    Tissue: Bone marrow.
  2. "Genomic structure, promoter sequence, and induction of expression of the mouse Nramp1 gene in macrophages."
    Govoni G., Vidal S., Cellier M., Lepage P., Malo D., Gros P.
    Genomics 27:9-19(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-169.
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg."
    Vidal S.M., Malo D., Vogan K., Skamene E., Gros P.
    Cell 73:469-485(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-548, VARIANT GLY-169.
    Strain: DBA/2.
    Tissue: Pre-B cell.

Entry informationi

Entry nameiNRAM1_MOUSE
AccessioniPrimary (citable) accession number: P41251
Secondary accession number(s): Q3TB84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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