P41244 (VEGP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Von Ebner gland protein 2
Short name=VEG protein 2

Gene names

Name:

Vegp2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Biological process	Sensory transduction Taste Transport
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of taste Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 177	159	Von Ebner gland protein 2		PRO_0000017977
Amino acid modifications
	Disulfide bond	80 ↔ 172		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41244 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 73149ABD1F52EC15	FASTA	177	19,699
	10 20 30 40 50 60 MKALLLTFSL SLLAALQAQA FPTTEENQDV SGTWYLKAAA WDKEIPDKKF GSVSVTPMKI 70 80 90 100 110 120 KTLEGGNLQV KFTVLISGRC QEMSTVLEKT DEPGKYTAYS GKQVVYSIPS AVEDHYIFYY 130 140 150 160 170 EGKIHRHHFQ IAKLVGRNPE INQEALEDFQ NAVRAGGLNP DNIFIPKQSE TCPLGSN

References

[1]

"Structural organization of the genes for rat von Ebner's gland proteins 1 and 2 reveals their close relationship to lipocalins." Kock K., Ahlers C., Schmale H. Eur. J. Biochem. 221:905-916(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PARTIAL PROTEIN SEQUENCE. Strain: Wistar. Tissue: Lingual salivary gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74806 mRNA. Translation: CAA52810.1. X74807 Genomic DNA. Translation: CAA52811.1.
IPI	IPI00191367.
PIR	S43647.
RefSeq	NP_446026.1. NM_053574.1.
UniGene	Rn.11217.
3D structure databases
ProteinModelPortal	P41244.
SMR	P41244. Positions 29-169.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	94106.
KEGG	rno:94106.
UCSC	RGD:620384. rat.
Organism-specific databases
CTD	94106.
RGD	620384. Vegp2.
Phylogenomic databases
eggNOG	NOG29410.
HOGENOM	HOG000231562.
HOVERGEN	HBG101411.
OrthoDB	EOG4NP74J.
Gene expression databases
Genevestigator	P41244.
GermOnline	ENSRNOG00000033020. Rattus norvegicus.
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000566. Lipocln_cytosolic_FA-bd_dom. IPR002450. von_Ebner_gland. [Graphical view]
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR01175. VNEBNERGLAND.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00213. LIPOCALIN. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	617794.

Entry information

Entry name

VEGP2_RAT

Accession

Primary (citable) accession number: P41244

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program