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P41243

- MATK_RAT

UniProt

P41243 - MATK_RAT

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Protein

Megakaryocyte-associated tyrosine-protein kinase

Gene

Matk

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei221 – 2211ATPPROSITE-ProRule annotation
Active sitei311 – 3111Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2089ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.
ReactomeiREACT_203466. Signaling by ERBB2.

Names & Taxonomyi

Protein namesi
Recommended name:
Megakaryocyte-associated tyrosine-protein kinase (EC:2.7.10.2)
Alternative name(s):
Protein kinase BATK
Tyrosine-protein kinase CTK
Gene namesi
Name:Matk
Synonyms:Batk, Ctk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi69058. Matk.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity
Note: In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Megakaryocyte-associated tyrosine-protein kinasePRO_0000088075Add
BLAST

Proteomic databases

PaxDbiP41243.
PRIDEiP41243.

PTM databases

PhosphoSiteiP41243.

Expressioni

Tissue specificityi

Enriched in lymphoid tissues.

Gene expression databases

GenevestigatoriP41243.

Interactioni

Subunit structurei

Interacts with KIT.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060994.

Structurei

3D structure databases

ProteinModelPortaliP41243.
SMRiP41243. Positions 1-72, 76-172, 186-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 6948SH3PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 17090SH2PROSITE-ProRule annotationAdd
BLAST
Domaini194 – 443250Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiP41243.
KOiK08888.
OMAiYRAKHHA.
OrthoDBiEOG7SV0V5.
PhylomeDBiP41243.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41243-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTQRWAPGT QCMTKCENSR PKPGELAFRK GDMVTILEAC EDKSWYRAKH
60 70 80 90 100
HSSGQEGLLA AAALRQREAL STDPKLSLMP WFHGKISGQE AIQQLQPPED
110 120 130 140 150
GLFLVRESAR HPGDYVLCVS FGRDVIHYRV LHRDGHLTID EAVCFCNLMD
160 170 180 190 200
MVEHYTRDKG AICTKLVKPK RKQGAKSAEE ELAKAGWLLD LQHLTLGAQI
210 220 230 240 250
GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT KLQHRNLVRL
260 270 280 290 300
LGVILHHGLY IVMEHVSKGN LVNFLRTRGR ALVSTSQLLQ FALHVAEGME
310 320 330 340 350
YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAELRKG LDSSRLPVKW
360 370 380 390 400
TAPEALKNGR FSSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG
410 420 430 440 450
YRMEPPDSCP GPVHTLMGSC WEAEPSRRPP FRKIVEKLGR ELRSVGVAAP
460
AGGQEAEGSA PTRSQDP
Length:467
Mass (Da):51,897
Last modified:February 1, 1995 - v1
Checksum:i283FF9348BB5FA8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34542 Genomic DNA. Translation: AAA64524.1.
BC087726 mRNA. Translation: AAH87726.1.
PIRiI56579.
RefSeqiNP_068631.1. NM_021859.2.
XP_006241051.1. XM_006240989.2.
XP_006241052.1. XM_006240990.2.
XP_008763350.1. XM_008765128.1.
UniGeneiRn.44303.

Genome annotation databases

EnsembliENSRNOT00000027730; ENSRNOP00000027730; ENSRNOG00000020431.
GeneIDi60450.
KEGGirno:60450.
UCSCiRGD:69058. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34542 Genomic DNA. Translation: AAA64524.1 .
BC087726 mRNA. Translation: AAH87726.1 .
PIRi I56579.
RefSeqi NP_068631.1. NM_021859.2.
XP_006241051.1. XM_006240989.2.
XP_006241052.1. XM_006240990.2.
XP_008763350.1. XM_008765128.1.
UniGenei Rn.44303.

3D structure databases

ProteinModelPortali P41243.
SMRi P41243. Positions 1-72, 76-172, 186-439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000060994.

PTM databases

PhosphoSitei P41243.

Proteomic databases

PaxDbi P41243.
PRIDEi P41243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027730 ; ENSRNOP00000027730 ; ENSRNOG00000020431 .
GeneIDi 60450.
KEGGi rno:60450.
UCSCi RGD:69058. rat.

Organism-specific databases

CTDi 4145.
RGDi 69058. Matk.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119011.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi P41243.
KOi K08888.
OMAi YRAKHHA.
OrthoDBi EOG7SV0V5.
PhylomeDBi P41243.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 5301.
Reactomei REACT_203466. Signaling by ERBB2.

Miscellaneous databases

NextBioi 612204.
PROi P41243.

Gene expression databases

Genevestigatori P41243.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk."
    Kuo S.S., Moran P., Gripp J., Armanini M., Phillips H.S., Goddard A., Caras I.W.
    J. Neurosci. Res. 38:705-715(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMATK_RAT
AccessioniPrimary (citable) accession number: P41243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3