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P41243 (MATK_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Megakaryocyte-associated tyrosine-protein kinase
EC=2.7.10.2
Alternative name(s):
Protein kinase BATK
Tyrosine-protein kinase CTK
Gene names
Name:Matk
Synonyms:Batk, Ctk
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with KIT By similarity.

Subcellular location

Cytoplasm By similarity. Membrane By similarity. Note: In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation By similarity.

Tissue specificity

Enriched in lymphoid tissues.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Megakaryocyte-associated tyrosine-protein kinase
PRO_0000088075

Regions

Domain22 – 6948SH3
Domain81 – 17090SH2
Domain194 – 443250Protein kinase
Nucleotide binding200 – 2089ATP By similarity

Sites

Active site3111Proton acceptor By similarity
Binding site2211ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P41243 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 283FF9348BB5FA8F

FASTA46751,897
        10         20         30         40         50         60 
MPTQRWAPGT QCMTKCENSR PKPGELAFRK GDMVTILEAC EDKSWYRAKH HSSGQEGLLA 

        70         80         90        100        110        120 
AAALRQREAL STDPKLSLMP WFHGKISGQE AIQQLQPPED GLFLVRESAR HPGDYVLCVS 

       130        140        150        160        170        180 
FGRDVIHYRV LHRDGHLTID EAVCFCNLMD MVEHYTRDKG AICTKLVKPK RKQGAKSAEE 

       190        200        210        220        230        240 
ELAKAGWLLD LQHLTLGAQI GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT 

       250        260        270        280        290        300 
KLQHRNLVRL LGVILHHGLY IVMEHVSKGN LVNFLRTRGR ALVSTSQLLQ FALHVAEGME 

       310        320        330        340        350        360 
YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAELRKG LDSSRLPVKW TAPEALKNGR 

       370        380        390        400        410        420 
FSSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG YRMEPPDSCP GPVHTLMGSC 

       430        440        450        460 
WEAEPSRRPP FRKIVEKLGR ELRSVGVAAP AGGQEAEGSA PTRSQDP

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk."
Kuo S.S., Moran P., Gripp J., Armanini M., Phillips H.S., Goddard A., Caras I.W.
J. Neurosci. Res. 38:705-715(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
Tissue: Hippocampus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L34542 Genomic DNA. Translation: AAA64524.1.
BC087726 mRNA. Translation: AAH87726.1.
IPIIPI00191366.
PIRI56579.
RefSeqNP_068631.1. NM_021859.2.
UniGeneRn.44303.

3D structure databases

ProteinModelPortalP41243.
SMRP41243. Positions 1-72, 76-172, 186-439.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000060994.

PTM databases

PhosphoSiteP41243.

Proteomic databases

PaxDbP41243.
PRIDEP41243.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000027730; ENSRNOP00000027730; ENSRNOG00000020431.
GeneID60450.
KEGGrno:60450.
UCSCRGD:69058. rat.

Organism-specific databases

CTD4145.
RGD69058. Matk.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00600000084126.
HOGENOMHOG000233858.
HOVERGENHBG008761.
InParanoidP41243.
KOK08888.
OrthoDBEOG48SGT4.

Enzyme and pathway databases

BRENDA2.7.10.2. 5301.

Gene expression databases

ArrayExpressP41243.
GenevestigatorP41243.
GermOnlineENSRNOG00000020431. Rattus norvegicus.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
SSF50044. SH3. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612204.

Entry information

Entry nameMATK_RAT
AccessionPrimary (citable) accession number: P41243
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 3, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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