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P41243

- MATK_RAT

UniProt

P41243 - MATK_RAT

Protein

Megakaryocyte-associated tyrosine-protein kinase

Gene

Matk

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei221 – 2211ATPPROSITE-ProRule annotation
    Active sitei311 – 3111Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi200 – 2089ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 5301.
    ReactomeiREACT_203466. Signaling by ERBB2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Megakaryocyte-associated tyrosine-protein kinase (EC:2.7.10.2)
    Alternative name(s):
    Protein kinase BATK
    Tyrosine-protein kinase CTK
    Gene namesi
    Name:Matk
    Synonyms:Batk, Ctk
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi69058. Matk.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity
    Note: In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 467467Megakaryocyte-associated tyrosine-protein kinasePRO_0000088075Add
    BLAST

    Proteomic databases

    PaxDbiP41243.
    PRIDEiP41243.

    PTM databases

    PhosphoSiteiP41243.

    Expressioni

    Tissue specificityi

    Enriched in lymphoid tissues.

    Gene expression databases

    ArrayExpressiP41243.
    GenevestigatoriP41243.

    Interactioni

    Subunit structurei

    Interacts with KIT.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000060994.

    Structurei

    3D structure databases

    ProteinModelPortaliP41243.
    SMRiP41243. Positions 1-72, 76-172, 186-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 6948SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini81 – 17090SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 443250Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117264.
    HOGENOMiHOG000233858.
    HOVERGENiHBG008761.
    InParanoidiP41243.
    KOiK08888.
    OMAiYRAKHHA.
    OrthoDBiEOG7SV0V5.
    PhylomeDBiP41243.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41243-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTQRWAPGT QCMTKCENSR PKPGELAFRK GDMVTILEAC EDKSWYRAKH    50
    HSSGQEGLLA AAALRQREAL STDPKLSLMP WFHGKISGQE AIQQLQPPED 100
    GLFLVRESAR HPGDYVLCVS FGRDVIHYRV LHRDGHLTID EAVCFCNLMD 150
    MVEHYTRDKG AICTKLVKPK RKQGAKSAEE ELAKAGWLLD LQHLTLGAQI 200
    GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT KLQHRNLVRL 250
    LGVILHHGLY IVMEHVSKGN LVNFLRTRGR ALVSTSQLLQ FALHVAEGME 300
    YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAELRKG LDSSRLPVKW 350
    TAPEALKNGR FSSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG 400
    YRMEPPDSCP GPVHTLMGSC WEAEPSRRPP FRKIVEKLGR ELRSVGVAAP 450
    AGGQEAEGSA PTRSQDP 467
    Length:467
    Mass (Da):51,897
    Last modified:February 1, 1995 - v1
    Checksum:i283FF9348BB5FA8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34542 Genomic DNA. Translation: AAA64524.1.
    BC087726 mRNA. Translation: AAH87726.1.
    PIRiI56579.
    RefSeqiNP_068631.1. NM_021859.2.
    XP_006241051.1. XM_006240989.1.
    XP_006241052.1. XM_006240990.1.
    UniGeneiRn.44303.

    Genome annotation databases

    EnsembliENSRNOT00000027730; ENSRNOP00000027730; ENSRNOG00000020431.
    GeneIDi60450.
    KEGGirno:60450.
    UCSCiRGD:69058. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34542 Genomic DNA. Translation: AAA64524.1 .
    BC087726 mRNA. Translation: AAH87726.1 .
    PIRi I56579.
    RefSeqi NP_068631.1. NM_021859.2.
    XP_006241051.1. XM_006240989.1.
    XP_006241052.1. XM_006240990.1.
    UniGenei Rn.44303.

    3D structure databases

    ProteinModelPortali P41243.
    SMRi P41243. Positions 1-72, 76-172, 186-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000060994.

    PTM databases

    PhosphoSitei P41243.

    Proteomic databases

    PaxDbi P41243.
    PRIDEi P41243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027730 ; ENSRNOP00000027730 ; ENSRNOG00000020431 .
    GeneIDi 60450.
    KEGGi rno:60450.
    UCSCi RGD:69058. rat.

    Organism-specific databases

    CTDi 4145.
    RGDi 69058. Matk.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117264.
    HOGENOMi HOG000233858.
    HOVERGENi HBG008761.
    InParanoidi P41243.
    KOi K08888.
    OMAi YRAKHHA.
    OrthoDBi EOG7SV0V5.
    PhylomeDBi P41243.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 5301.
    Reactomei REACT_203466. Signaling by ERBB2.

    Miscellaneous databases

    NextBioi 612204.
    PROi P41243.

    Gene expression databases

    ArrayExpressi P41243.
    Genevestigatori P41243.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk."
      Kuo S.S., Moran P., Gripp J., Armanini M., Phillips H.S., Goddard A., Caras I.W.
      J. Neurosci. Res. 38:705-715(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Hippocampus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiMATK_RAT
    AccessioniPrimary (citable) accession number: P41243
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3