Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Megakaryocyte-associated tyrosine-protein kinase

Gene

Matk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei221 – 2211ATPPROSITE-ProRule annotation
Active sitei311 – 3111Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2089ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.
ReactomeiREACT_322319. Signaling by ERBB2.

Names & Taxonomyi

Protein namesi
Recommended name:
Megakaryocyte-associated tyrosine-protein kinase (EC:2.7.10.2)
Alternative name(s):
Protein kinase BATK
Tyrosine-protein kinase CTK
Gene namesi
Name:Matk
Synonyms:Batk, Ctk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi69058. Matk.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane By similarity

  • Note: In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Megakaryocyte-associated tyrosine-protein kinasePRO_0000088075Add
BLAST

Proteomic databases

PaxDbiP41243.
PRIDEiP41243.

PTM databases

PhosphoSiteiP41243.

Expressioni

Tissue specificityi

Enriched in lymphoid tissues.

Gene expression databases

GenevisibleiP41243. RN.

Interactioni

Subunit structurei

Interacts with KIT.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027730.

Structurei

3D structure databases

ProteinModelPortaliP41243.
SMRiP41243. Positions 1-72, 76-172, 186-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 6948SH3PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 17090SH2PROSITE-ProRule annotationAdd
BLAST
Domaini194 – 443250Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiP41243.
KOiK08888.
OMAiTKMQHKN.
OrthoDBiEOG7SV0V5.
PhylomeDBiP41243.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTQRWAPGT QCMTKCENSR PKPGELAFRK GDMVTILEAC EDKSWYRAKH
60 70 80 90 100
HSSGQEGLLA AAALRQREAL STDPKLSLMP WFHGKISGQE AIQQLQPPED
110 120 130 140 150
GLFLVRESAR HPGDYVLCVS FGRDVIHYRV LHRDGHLTID EAVCFCNLMD
160 170 180 190 200
MVEHYTRDKG AICTKLVKPK RKQGAKSAEE ELAKAGWLLD LQHLTLGAQI
210 220 230 240 250
GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT KLQHRNLVRL
260 270 280 290 300
LGVILHHGLY IVMEHVSKGN LVNFLRTRGR ALVSTSQLLQ FALHVAEGME
310 320 330 340 350
YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAELRKG LDSSRLPVKW
360 370 380 390 400
TAPEALKNGR FSSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG
410 420 430 440 450
YRMEPPDSCP GPVHTLMGSC WEAEPSRRPP FRKIVEKLGR ELRSVGVAAP
460
AGGQEAEGSA PTRSQDP
Length:467
Mass (Da):51,897
Last modified:February 1, 1995 - v1
Checksum:i283FF9348BB5FA8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34542 Genomic DNA. Translation: AAA64524.1.
BC087726 mRNA. Translation: AAH87726.1.
PIRiI56579.
RefSeqiNP_068631.1. NM_021859.2.
XP_006241051.1. XM_006240989.2.
XP_006241052.1. XM_006240990.2.
XP_008763350.1. XM_008765128.1.
UniGeneiRn.44303.

Genome annotation databases

EnsembliENSRNOT00000027730; ENSRNOP00000027730; ENSRNOG00000020431.
GeneIDi60450.
KEGGirno:60450.
UCSCiRGD:69058. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34542 Genomic DNA. Translation: AAA64524.1.
BC087726 mRNA. Translation: AAH87726.1.
PIRiI56579.
RefSeqiNP_068631.1. NM_021859.2.
XP_006241051.1. XM_006240989.2.
XP_006241052.1. XM_006240990.2.
XP_008763350.1. XM_008765128.1.
UniGeneiRn.44303.

3D structure databases

ProteinModelPortaliP41243.
SMRiP41243. Positions 1-72, 76-172, 186-439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027730.

PTM databases

PhosphoSiteiP41243.

Proteomic databases

PaxDbiP41243.
PRIDEiP41243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027730; ENSRNOP00000027730; ENSRNOG00000020431.
GeneIDi60450.
KEGGirno:60450.
UCSCiRGD:69058. rat.

Organism-specific databases

CTDi4145.
RGDi69058. Matk.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiP41243.
KOiK08888.
OMAiTKMQHKN.
OrthoDBiEOG7SV0V5.
PhylomeDBiP41243.

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.
ReactomeiREACT_322319. Signaling by ERBB2.

Miscellaneous databases

NextBioi612204.
PROiP41243.

Gene expression databases

GenevisibleiP41243. RN.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk."
    Kuo S.S., Moran P., Gripp J., Armanini M., Phillips H.S., Goddard A., Caras I.W.
    J. Neurosci. Res. 38:705-715(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMATK_RAT
AccessioniPrimary (citable) accession number: P41243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 24, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.