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P41243

- MATK_RAT

UniProt

P41243 - MATK_RAT

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Protein

Megakaryocyte-associated tyrosine-protein kinase

Gene
Matk, Batk, Ctk
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei221 – 2211ATP By similarity
Active sitei311 – 3111Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2089ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.
ReactomeiREACT_203466. Signaling by ERBB2.

Names & Taxonomyi

Protein namesi
Recommended name:
Megakaryocyte-associated tyrosine-protein kinase (EC:2.7.10.2)
Alternative name(s):
Protein kinase BATK
Tyrosine-protein kinase CTK
Gene namesi
Name:Matk
Synonyms:Batk, Ctk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi69058. Matk.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity
Note: In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Megakaryocyte-associated tyrosine-protein kinasePRO_0000088075Add
BLAST

Proteomic databases

PaxDbiP41243.
PRIDEiP41243.

PTM databases

PhosphoSiteiP41243.

Expressioni

Tissue specificityi

Enriched in lymphoid tissues.

Gene expression databases

ArrayExpressiP41243.
GenevestigatoriP41243.

Interactioni

Subunit structurei

Interacts with KIT By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060994.

Structurei

3D structure databases

ProteinModelPortaliP41243.
SMRiP41243. Positions 1-72, 76-172, 186-439.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 6948SH3Add
BLAST
Domaini81 – 17090SH2Add
BLAST
Domaini194 – 443250Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117264.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiP41243.
KOiK08888.
OMAiYRAKHHA.
OrthoDBiEOG7SV0V5.
PhylomeDBiP41243.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41243-1 [UniParc]FASTAAdd to Basket

« Hide

MPTQRWAPGT QCMTKCENSR PKPGELAFRK GDMVTILEAC EDKSWYRAKH    50
HSSGQEGLLA AAALRQREAL STDPKLSLMP WFHGKISGQE AIQQLQPPED 100
GLFLVRESAR HPGDYVLCVS FGRDVIHYRV LHRDGHLTID EAVCFCNLMD 150
MVEHYTRDKG AICTKLVKPK RKQGAKSAEE ELAKAGWLLD LQHLTLGAQI 200
GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT KLQHRNLVRL 250
LGVILHHGLY IVMEHVSKGN LVNFLRTRGR ALVSTSQLLQ FALHVAEGME 300
YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAELRKG LDSSRLPVKW 350
TAPEALKNGR FSSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG 400
YRMEPPDSCP GPVHTLMGSC WEAEPSRRPP FRKIVEKLGR ELRSVGVAAP 450
AGGQEAEGSA PTRSQDP 467
Length:467
Mass (Da):51,897
Last modified:February 1, 1995 - v1
Checksum:i283FF9348BB5FA8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34542 Genomic DNA. Translation: AAA64524.1.
BC087726 mRNA. Translation: AAH87726.1.
PIRiI56579.
RefSeqiNP_068631.1. NM_021859.2.
XP_006241051.1. XM_006240989.1.
XP_006241052.1. XM_006240990.1.
UniGeneiRn.44303.

Genome annotation databases

EnsembliENSRNOT00000027730; ENSRNOP00000027730; ENSRNOG00000020431.
GeneIDi60450.
KEGGirno:60450.
UCSCiRGD:69058. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34542 Genomic DNA. Translation: AAA64524.1 .
BC087726 mRNA. Translation: AAH87726.1 .
PIRi I56579.
RefSeqi NP_068631.1. NM_021859.2.
XP_006241051.1. XM_006240989.1.
XP_006241052.1. XM_006240990.1.
UniGenei Rn.44303.

3D structure databases

ProteinModelPortali P41243.
SMRi P41243. Positions 1-72, 76-172, 186-439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000060994.

PTM databases

PhosphoSitei P41243.

Proteomic databases

PaxDbi P41243.
PRIDEi P41243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027730 ; ENSRNOP00000027730 ; ENSRNOG00000020431 .
GeneIDi 60450.
KEGGi rno:60450.
UCSCi RGD:69058. rat.

Organism-specific databases

CTDi 4145.
RGDi 69058. Matk.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117264.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi P41243.
KOi K08888.
OMAi YRAKHHA.
OrthoDBi EOG7SV0V5.
PhylomeDBi P41243.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 5301.
Reactomei REACT_203466. Signaling by ERBB2.

Miscellaneous databases

NextBioi 612204.
PROi P41243.

Gene expression databases

ArrayExpressi P41243.
Genevestigatori P41243.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk."
    Kuo S.S., Moran P., Gripp J., Armanini M., Phillips H.S., Goddard A., Caras I.W.
    J. Neurosci. Res. 38:705-715(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMATK_RAT
AccessioniPrimary (citable) accession number: P41243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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