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Protein

C->U-editing enzyme APOBEC-1

Gene

APOBEC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.1 Publication

Catalytic activityi

Cytosine(6666) in apolipoprotein B mRNA + H2O = uracil(6666) in apolipoprotein B mRNA + NH3.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 Zn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Zinc; catalyticBy similarity1
Active sitei63Proton donorBy similarity1
Metal bindingi93Zinc; catalyticBy similarity1
Metal bindingi96Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.5.4.36 2681
3.5.4.37 2681
ReactomeiR-HSA-72200 mRNA Editing: C to U Conversion
R-HSA-75094 Formation of the Editosome

Names & Taxonomyi

Protein namesi
Recommended name:
C->U-editing enzyme APOBEC-1 (EC:3.5.4.361 Publication)
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme 1
HEPR
mRNA(cytosine(6666)) deaminase 1
Gene namesi
Name:APOBEC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111701.6
HGNCiHGNC:604 APOBEC1
MIMi600130 gene
neXtProtiNX_P41238

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi339
OpenTargetsiENSG00000111701
PharmGKBiPA24889

Polymorphism and mutation databases

BioMutaiAPOBEC1
DMDMi152013530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717421 – 236C->U-editing enzyme APOBEC-1Add BLAST236

Proteomic databases

PaxDbiP41238
PRIDEiP41238

PTM databases

iPTMnetiP41238
PhosphoSitePlusiP41238

Expressioni

Tissue specificityi

Expressed exclusively in the small intestine.

Gene expression databases

BgeeiENSG00000111701
CleanExiHS_APOBEC1
ExpressionAtlasiP41238 baseline and differential
GenevisibleiP41238 HS

Interactioni

Subunit structurei

Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106836, 9 interactors
IntActiP41238, 4 interactors
STRINGi9606.ENSP00000229304

Structurei

3D structure databases

ProteinModelPortaliP41238
SMRiP41238
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 134CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 193Leu-richAdd BLAST14

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKDF Eukaryota
ENOG4111BJA LUCA
GeneTreeiENSGT00530000062933
HOGENOMiHOG000033766
HOVERGENiHBG050445
KOiK16932
OMAiNFVNYPP
OrthoDBiEOG091G0PT8
PhylomeDBiP41238
TreeFamiTF331356

Family and domain databases

InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEKGPSTG DPTLRRRIEP WEFDVFYDPR ELRKEACLLY EIKWGMSRKI
60 70 80 90 100
WRSSGKNTTN HVEVNFIKKF TSERDFHPSM SCSITWFLSW SPCWECSQAI
110 120 130 140 150
REFLSRHPGV TLVIYVARLF WHMDQQNRQG LRDLVNSGVT IQIMRASEYY
160 170 180 190 200
HCWRNFVNYP PGDEAHWPQY PPLWMMLYAL ELHCIILSLP PCLKISRRWQ
210 220 230
NHLTFFRLHL QNCHYQTIPP HILLATGLIH PSVAWR
Length:236
Mass (Da):28,192
Last modified:March 6, 2007 - v3
Checksum:i28466B43F7FD82F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53S → T in AAD10701 (Ref. 5) Curated1
Sequence conflicti83S → T in AAD10701 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01377980M → I4 PublicationsCorresponds to variant dbSNP:rs2302515Ensembl.1
Natural variantiVAR_048720236R → K. Corresponds to variant dbSNP:rs12820011Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25877 mRNA Translation: AAA86766.1
L26234 mRNA Translation: AAA64230.1
U72891 mRNA Translation: AAD00185.1
AB009426 Genomic DNA Translation: BAA23882.1
U78720 mRNA Translation: AAD10701.1
CCDSiCCDS8579.1
PIRiI59323
RefSeqiNP_001291495.1, NM_001304566.1
NP_001635.2, NM_001644.4
NP_005880.2, NM_005889.3
UniGeneiHs.560

Genome annotation databases

EnsembliENST00000229304; ENSP00000229304; ENSG00000111701
GeneIDi339
KEGGihsa:339
UCSCiuc001qtb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABEC1_HUMAN
AccessioniPrimary (citable) accession number: P41238
Secondary accession number(s): Q9UE64, Q9UM71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: March 6, 2007
Last modified: February 28, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health