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Protein

Cortexin-1

Gene

Ctxn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.

GO - Biological processi

  • central nervous system development Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cortexin-1
Gene namesi
Name:Ctxn1
Synonyms:Ctxn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi2449. Ctxn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8282Cortexin-1PRO_0000079502Add
BLAST

Proteomic databases

PaxDbiP41237.

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

GenevisibleiP41237. RN.

Family & Domainsi

Sequence similaritiesi

Belongs to the cortexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3U7. Eukaryota.
ENOG41129SJ. LUCA.
GeneTreeiENSGT00390000018468.
HOGENOMiHOG000273868.
HOVERGENiHBG054879.
InParanoidiP41237.
OMAiMSTTWTL.
OrthoDBiEOG7CCBVK.
PhylomeDBiP41237.
TreeFamiTF333403.

Family and domain databases

InterProiIPR020066. Cortexin.
[Graphical view]
PfamiPF11057. Cortexin. 1 hit.
[Graphical view]
ProDomiPD054489. Cortexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P41237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPWTLSPE PLPPSTGPPV GAGLDVEQRT VFAFVLCLLV VLVLLMVRCV
60 70 80
RILLDPYSRM PASSWTDHKE ALERGQFDYA LV
Length:82
Mass (Da):9,069
Last modified:February 1, 1995 - v1
Checksum:iB43A07040D10F5C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15011 mRNA. No translation available.
PIRiJH0814.
RefSeqiNP_001103405.1. NM_001109935.1.
UniGeneiRn.9131.

Genome annotation databases

EnsembliENSRNOT00000001399; ENSRNOP00000001399; ENSRNOG00000001057.
GeneIDi29145.
KEGGirno:29145.
UCSCiRGD:2449. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15011 mRNA. No translation available.
PIRiJH0814.
RefSeqiNP_001103405.1. NM_001109935.1.
UniGeneiRn.9131.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP41237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001399; ENSRNOP00000001399; ENSRNOG00000001057.
GeneIDi29145.
KEGGirno:29145.
UCSCiRGD:2449. rat.

Organism-specific databases

CTDi404217.
RGDi2449. Ctxn1.

Phylogenomic databases

eggNOGiENOG410J3U7. Eukaryota.
ENOG41129SJ. LUCA.
GeneTreeiENSGT00390000018468.
HOGENOMiHOG000273868.
HOVERGENiHBG054879.
InParanoidiP41237.
OMAiMSTTWTL.
OrthoDBiEOG7CCBVK.
PhylomeDBiP41237.
TreeFamiTF333403.

Miscellaneous databases

NextBioi608131.
PROiP41237.

Gene expression databases

GenevisibleiP41237. RN.

Family and domain databases

InterProiIPR020066. Cortexin.
[Graphical view]
PfamiPF11057. Cortexin. 1 hit.
[Graphical view]
ProDomiPD054489. Cortexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex."
    Coulter P.M. II, Bautista E.A., Margulies J.E., Watson J.B.
    J. Neurochem. 61:756-759(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCTXN1_RAT
AccessioniPrimary (citable) accession number: P41237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 11, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.