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Protein

Protein phosphatase inhibitor 2

Gene

PPP1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

  • protein serine/threonine phosphatase inhibitor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

BioCyciZFISH:G66-33005-MONOMER.
SignaLinkiP41236.
SIGNORiP41236.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2
Short name:
IPP-2
Gene namesi
Name:PPP1R2
Synonyms:IPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9288. PPP1R2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi5504.
OpenTargetsiENSG00000184203.
PharmGKBiPA33641.

Polymorphism and mutation databases

BioMutaiPPP1R2.
DMDMi729856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00000714812 – 205Protein phosphatase inhibitor 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei44Phosphoserine; by ATM1 Publication1
Modified residuei73Phosphothreonine; by GSK3By similarity1
Modified residuei87PhosphoserineCombined sources1
Modified residuei89PhosphothreonineCombined sources1
Modified residuei92PhosphothreonineCombined sources1
Modified residuei121Phosphoserine1 Publication1
Modified residuei122Phosphoserine1 Publication1
Modified residuei127Phosphoserine1 Publication1
Modified residuei130PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP41236.
MaxQBiP41236.
PaxDbiP41236.
PeptideAtlasiP41236.
PRIDEiP41236.
TopDownProteomicsiP41236.

PTM databases

iPTMnetiP41236.
PhosphoSitePlusiP41236.

Expressioni

Gene expression databases

BgeeiENSG00000184203.
CleanExiHS_PPP1R2.
ExpressionAtlasiP41236. baseline and differential.
GenevisibleiP41236. HS.

Organism-specific databases

HPAiHPA043729.
HPA059420.

Interactioni

Subunit structurei

Heterodimer with PP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LMTK2Q8IWU23EBI-1056517,EBI-2008933
PPP1CAP621363EBI-1056517,EBI-357253
PPP1CCP368735EBI-1056517,EBI-356283
TINF2Q9BSI42EBI-1056517,EBI-717399

Protein-protein interaction databases

BioGridi111497. 50 interactors.
DIPiDIP-781N.
IntActiP41236. 15 interactors.
MINTiMINT-2803186.
STRINGi9606.ENSP00000328178.

Structurei

3D structure databases

ProteinModelPortaliP41236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Required for binding PPP1CCBy similarity6
Regioni43 – 55Required for binding PPP1CCBy similarityAdd BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activityBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
GeneTreeiENSGT00390000004757.
HOVERGENiHBG006170.
InParanoidiP41236.
KOiK16833.
OMAiMHYNEGR.
OrthoDBiEOG091G12FK.
PhylomeDBiP41236.
TreeFamiTF105536.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL
110 120 130 140 150
ARKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN

KLRSS
Length:205
Mass (Da):23,015
Last modified:January 23, 2007 - v2
Checksum:iFFC005B07CD5ABFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78873 mRNA. Translation: CAA55475.1.
Z29646 mRNA. Translation: CAA82754.1.
U68111
, U68106, U68107, U68108, U68109, U68110 Genomic DNA. Translation: AAC51206.1.
AJ133812 mRNA. Translation: CAB41680.1.
AY063767 mRNA. Translation: AAL48322.1.
BC007655 mRNA. Translation: AAH07655.1.
CCDSiCCDS3309.1.
PIRiS42406.
RefSeqiNP_001303254.1. NM_001316325.1.
NP_006232.1. NM_006241.7.
UniGeneiHs.535731.
Hs.706920.

Genome annotation databases

EnsembliENST00000618156; ENSP00000484580; ENSG00000184203.
GeneIDi5504.
KEGGihsa:5504.
UCSCiuc032sob.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78873 mRNA. Translation: CAA55475.1.
Z29646 mRNA. Translation: CAA82754.1.
U68111
, U68106, U68107, U68108, U68109, U68110 Genomic DNA. Translation: AAC51206.1.
AJ133812 mRNA. Translation: CAB41680.1.
AY063767 mRNA. Translation: AAL48322.1.
BC007655 mRNA. Translation: AAH07655.1.
CCDSiCCDS3309.1.
PIRiS42406.
RefSeqiNP_001303254.1. NM_001316325.1.
NP_006232.1. NM_006241.7.
UniGeneiHs.535731.
Hs.706920.

3D structure databases

ProteinModelPortaliP41236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111497. 50 interactors.
DIPiDIP-781N.
IntActiP41236. 15 interactors.
MINTiMINT-2803186.
STRINGi9606.ENSP00000328178.

PTM databases

iPTMnetiP41236.
PhosphoSitePlusiP41236.

Polymorphism and mutation databases

BioMutaiPPP1R2.
DMDMi729856.

Proteomic databases

EPDiP41236.
MaxQBiP41236.
PaxDbiP41236.
PeptideAtlasiP41236.
PRIDEiP41236.
TopDownProteomicsiP41236.

Protocols and materials databases

DNASUi5504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618156; ENSP00000484580; ENSG00000184203.
GeneIDi5504.
KEGGihsa:5504.
UCSCiuc032sob.2. human.

Organism-specific databases

CTDi5504.
DisGeNETi5504.
GeneCardsiPPP1R2.
H-InvDBHIX0032078.
HIX0166147.
HIX0166426.
HIX0166678.
HIX0167196.
HIX0200910.
HGNCiHGNC:9288. PPP1R2.
HPAiHPA043729.
HPA059420.
MIMi601792. gene.
neXtProtiNX_P41236.
OpenTargetsiENSG00000184203.
PharmGKBiPA33641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
GeneTreeiENSGT00390000004757.
HOVERGENiHBG006170.
InParanoidiP41236.
KOiK16833.
OMAiMHYNEGR.
OrthoDBiEOG091G12FK.
PhylomeDBiP41236.
TreeFamiTF105536.

Enzyme and pathway databases

BioCyciZFISH:G66-33005-MONOMER.
SignaLinkiP41236.
SIGNORiP41236.

Miscellaneous databases

GeneWikiiPPP1R2.
GenomeRNAii5504.
PROiP41236.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184203.
CleanExiHS_PPP1R2.
ExpressionAtlasiP41236. baseline and differential.
GenevisibleiP41236. HS.

Family and domain databases

InterProiIPR007062. PPI-2.
[Graphical view]
PfamiPF04979. IPP-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPP2_HUMAN
AccessioniPrimary (citable) accession number: P41236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.