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Protein

Protein phosphatase inhibitor 2

Gene

PPP1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

  • protein serine/threonine phosphatase inhibitor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCarbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

SignaLinkiP41236.
SIGNORiP41236.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2
Short name:
IPP-2
Gene namesi
Name:PPP1R2
Synonyms:IPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000184203.7.
HGNCiHGNC:9288. PPP1R2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5504.
OpenTargetsiENSG00000184203.
PharmGKBiPA33641.

Polymorphism and mutation databases

BioMutaiPPP1R2.
DMDMi729856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedHMP:1 Publication
ChainiPRO_00000714812 – 205Protein phosphatase inhibitor 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineHMP:1
Modified residuei44Phosphoserine; by ATM1 Publication1
Modified residuei73Phosphothreonine; by GSK3HMP:1
Modified residuei87PhosphoserineND:1
Modified residuei89PhosphothreonineND:1
Modified residuei92PhosphothreonineND:1
Modified residuei121Phosphoserine1 Publication1
Modified residuei122Phosphoserine1 Publication1
Modified residuei127Phosphoserine1 Publication1
Modified residuei130PhosphoserineHMP:1

Post-translational modificationi

Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.HMP:2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP41236.
MaxQBiP41236.
PaxDbiP41236.
PeptideAtlasiP41236.
PRIDEiP41236.
TopDownProteomicsiP41236.

PTM databases

iPTMnetiP41236.
PhosphoSitePlusiP41236.

Expressioni

Gene expression databases

BgeeiENSG00000184203.
CleanExiHS_PPP1R2.
ExpressionAtlasiP41236. baseline and differential.
GenevisibleiP41236. HS.

Organism-specific databases

HPAiHPA043729.
HPA059420.

Interactioni

Subunit structurei

Heterodimer with PP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111497. 51 interactors.
DIPiDIP-781N.
ELMiP41236.
IntActiP41236. 16 interactors.
MINTiMINT-2803186.
STRINGi9606.ENSP00000328178.

Structurei

3D structure databases

DisProtiDP00816.
ProteinModelPortaliP41236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Required for binding PPP1CCHMP:6
Regioni43 – 55Required for binding PPP1CCHMP:Add BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activityHMP:4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4041. Eukaryota.
ENOG4111SYV. LUCA.
GeneTreeiENSGT00390000004757.
HOVERGENiHBG006170.
InParanoidiP41236.
KOiK16833.
OMAiMHYNEGR.
OrthoDBiEOG091G12FK.
PhylomeDBiP41236.
TreeFamiTF105536.

Family and domain databases

InterProiView protein in InterPro
IPR007062. PPI-2.
PANTHERiPTHR12398. PTHR12398. 1 hit.
PfamiView protein in Pfam
PF04979. IPP-2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL
110 120 130 140 150
ARKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN

KLRSS
Length:205
Mass (Da):23,015
Last modified:January 23, 2007 - v2
Checksum:iFFC005B07CD5ABFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78873 mRNA. Translation: CAA55475.1.
Z29646 mRNA. Translation: CAA82754.1.
U68111
, U68106, U68107, U68108, U68109, U68110 Genomic DNA. Translation: AAC51206.1.
AJ133812 mRNA. Translation: CAB41680.1.
AY063767 mRNA. Translation: AAL48322.1.
BC007655 mRNA. Translation: AAH07655.1.
CCDSiCCDS3309.1.
PIRiS42406.
RefSeqiNP_001303254.1. NM_001316325.1.
NP_006232.1. NM_006241.7.
UniGeneiHs.535731.
Hs.706920.

Genome annotation databases

EnsembliENST00000618156; ENSP00000484580; ENSG00000184203.
GeneIDi5504.
KEGGihsa:5504.
UCSCiuc032sob.2. human.

Similar proteinsi

Entry informationi

Entry nameiIPP2_HUMAN
AccessioniPrimary (citable) accession number: P41236
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families