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P41236

- IPP2_HUMAN

UniProt

P41236 - IPP2_HUMAN

Protein

Protein phosphatase inhibitor 2

Gene

PPP1R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Inhibitor of protein-phosphatase 1.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein serine/threonine phosphatase inhibitor activity Source: ProtInc

    GO - Biological processi

    1. generation of precursor metabolites and energy Source: ProtInc
    2. glycogen metabolic process Source: UniProtKB-KW
    3. negative regulation of catalytic activity Source: GOC
    4. regulation of phosphoprotein phosphatase activity Source: InterPro
    5. regulation of signal transduction Source: InterPro

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen metabolism

    Enzyme and pathway databases

    SignaLinkiP41236.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase inhibitor 2
    Short name:
    IPP-2
    Gene namesi
    Name:PPP1R2
    Synonyms:IPP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:9288. PPP1R2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33641.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 205204Protein phosphatase inhibitor 2PRO_0000071481Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei44 – 441Phosphoserine; by ATM1 Publication
    Modified residuei73 – 731Phosphothreonine; by GSK3By similarity
    Modified residuei87 – 871Phosphoserine2 Publications
    Modified residuei89 – 891Phosphothreonine1 Publication
    Modified residuei92 – 921Phosphothreonine1 Publication
    Modified residuei121 – 1211Phosphoserine1 Publication
    Modified residuei122 – 1221Phosphoserine1 Publication
    Modified residuei127 – 1271Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex By similarity. Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity5 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP41236.
    PRIDEiP41236.

    PTM databases

    PhosphoSiteiP41236.

    Expressioni

    Gene expression databases

    ArrayExpressiP41236.
    BgeeiP41236.
    CleanExiHS_PPP1R2.
    GenevestigatoriP41236.

    Organism-specific databases

    HPAiCAB025582.
    HPA043729.

    Interactioni

    Subunit structurei

    Heterodimer with PP1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LMTK2Q8IWU23EBI-1056517,EBI-2008933
    PPP1CAP621362EBI-1056517,EBI-357253
    PPP1CCP368734EBI-1056517,EBI-356283

    Protein-protein interaction databases

    BioGridi111497. 36 interactions.
    DIPiDIP-781N.
    IntActiP41236. 10 interactions.
    MINTiMINT-2803186.
    STRINGi9606.ENSP00000328178.

    Structurei

    3D structure databases

    ProteinModelPortaliP41236.
    SMRiP41236. Positions 127-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni12 – 176Required for binding PPP1CCBy similarity
    Regioni43 – 5513Required for binding PPP1CCBy similarityAdd
    BLAST
    Regioni147 – 1504Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catyltic activityBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG006170.
    InParanoidiP41236.
    KOiK16833.
    OMAiAAEESMN.
    PhylomeDBiP41236.
    TreeFamiTF105536.

    Family and domain databases

    InterProiIPR007062. PPI-2.
    [Graphical view]
    PfamiPF04979. IPP-2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P41236-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM    50
    NILATYHPAD KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL 100
    ARKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMKRKLHYNE 150
    GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN 200
    KLRSS 205
    Length:205
    Mass (Da):23,015
    Last modified:January 23, 2007 - v2
    Checksum:iFFC005B07CD5ABFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78873 mRNA. Translation: CAA55475.1.
    Z29646 mRNA. Translation: CAA82754.1.
    U68111
    , U68106, U68107, U68108, U68109, U68110 Genomic DNA. Translation: AAC51206.1.
    AJ133812 mRNA. Translation: CAB41680.1.
    AY063767 mRNA. Translation: AAL48322.1.
    BC007655 mRNA. Translation: AAH07655.1.
    CCDSiCCDS3309.1.
    PIRiS42406.
    RefSeqiNP_006232.1. NM_006241.7.
    UniGeneiHs.535731.
    Hs.706920.

    Genome annotation databases

    EnsembliENST00000328432; ENSP00000328178; ENSG00000184203.
    GeneIDi5504.
    KEGGihsa:5504.
    UCSCiuc003fup.3. human.

    Polymorphism databases

    DMDMi729856.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78873 mRNA. Translation: CAA55475.1 .
    Z29646 mRNA. Translation: CAA82754.1 .
    U68111
    , U68106 , U68107 , U68108 , U68109 , U68110 Genomic DNA. Translation: AAC51206.1 .
    AJ133812 mRNA. Translation: CAB41680.1 .
    AY063767 mRNA. Translation: AAL48322.1 .
    BC007655 mRNA. Translation: AAH07655.1 .
    CCDSi CCDS3309.1.
    PIRi S42406.
    RefSeqi NP_006232.1. NM_006241.7.
    UniGenei Hs.535731.
    Hs.706920.

    3D structure databases

    ProteinModelPortali P41236.
    SMRi P41236. Positions 127-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111497. 36 interactions.
    DIPi DIP-781N.
    IntActi P41236. 10 interactions.
    MINTi MINT-2803186.
    STRINGi 9606.ENSP00000328178.

    PTM databases

    PhosphoSitei P41236.

    Polymorphism databases

    DMDMi 729856.

    Proteomic databases

    MaxQBi P41236.
    PRIDEi P41236.

    Protocols and materials databases

    DNASUi 5504.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328432 ; ENSP00000328178 ; ENSG00000184203 .
    GeneIDi 5504.
    KEGGi hsa:5504.
    UCSCi uc003fup.3. human.

    Organism-specific databases

    CTDi 5504.
    GeneCardsi GC03M195241.
    H-InvDB HIX0032078.
    HIX0166147.
    HIX0166426.
    HIX0166678.
    HIX0167196.
    HIX0200910.
    HGNCi HGNC:9288. PPP1R2.
    HPAi CAB025582.
    HPA043729.
    MIMi 601792. gene.
    neXtProti NX_P41236.
    PharmGKBi PA33641.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG006170.
    InParanoidi P41236.
    KOi K16833.
    OMAi AAEESMN.
    PhylomeDBi P41236.
    TreeFami TF105536.

    Enzyme and pathway databases

    SignaLinki P41236.

    Miscellaneous databases

    GeneWikii PPP1R2.
    GenomeRNAii 5504.
    NextBioi 21294.
    PROi P41236.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41236.
    Bgeei P41236.
    CleanExi HS_PPP1R2.
    Genevestigatori P41236.

    Family and domain databases

    InterProi IPR007062. PPI-2.
    [Graphical view ]
    Pfami PF04979. IPP-2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences."
      Sanseau P., Jackson A., Alderton R.P., Beck S., Senger G., Sheer D., Kelly A., Trowsdale J.
      Mamm. Genome 5:490-496(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli."
      Helps N.R., Street A.J., Elledge S.J., Cohen P.T.W.
      FEBS Lett. 340:93-98(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians."
      Permana P.A., Mott D.M.
      Genomics 41:110-114(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Inhibitor 2 of protein phosphatase 1 is differentially expressed between the colon cancer cell lines SW480 and SW620."
      Croke D.T., McWilliam P.M., Parle-McDermott A., Dunican D., Tighe O.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Cloning of inhibitor-2 of protein phosphatase type 1 from human heart."
      Mishra S., Tiwari N., Sabbah H.N., Gupta R.C.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-33.
      Tissue: Platelet.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage."
      Tang X., Hui Z.G., Cui X.L., Garg R., Kastan M.B., Xu B.
      Mol. Cell. Biol. 28:2559-2566(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-44, SUBUNIT.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND THR-89, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: PHOSPHORYLATION AT SER-121; SER-122 AND SER-127.
      Tissue: Testis.

    Entry informationi

    Entry nameiIPP2_HUMAN
    AccessioniPrimary (citable) accession number: P41236
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3