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Protein

Protein phosphatase inhibitor 2

Gene

PPP1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

  • protein serine/threonine phosphatase inhibitor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCarbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

SignaLinkiP41236
SIGNORiP41236

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase inhibitor 2
Short name:
IPP-2
Gene namesi
Name:PPP1R2
Synonyms:IPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000184203.7
HGNCiHGNC:9288 PPP1R2
MIMi601792 gene
neXtProtiNX_P41236

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi5504
OpenTargetsiENSG00000184203
PharmGKBiPA33641

Polymorphism and mutation databases

BioMutaiPPP1R2
DMDMi729856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00000714812 – 205Protein phosphatase inhibitor 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei44Phosphoserine; by ATM1 Publication1
Modified residuei73Phosphothreonine; by GSK3By similarity1
Modified residuei87PhosphoserineCombined sources1
Modified residuei89PhosphothreonineCombined sources1
Modified residuei92PhosphothreonineCombined sources1
Modified residuei121Phosphoserine1 Publication1
Modified residuei122Phosphoserine1 Publication1
Modified residuei127Phosphoserine1 Publication1
Modified residuei130PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP41236
MaxQBiP41236
PaxDbiP41236
PeptideAtlasiP41236
PRIDEiP41236
TopDownProteomicsiP41236

PTM databases

iPTMnetiP41236
PhosphoSitePlusiP41236

Expressioni

Gene expression databases

BgeeiENSG00000184203
CleanExiHS_PPP1R2
ExpressionAtlasiP41236 baseline and differential
GenevisibleiP41236 HS

Organism-specific databases

HPAiHPA043729
HPA059420

Interactioni

Subunit structurei

Heterodimer with PP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111497, 51 interactors
DIPiDIP-781N
ELMiP41236
IntActiP41236, 16 interactors
MINTiP41236
STRINGi9606.ENSP00000328178

Structurei

3D structure databases

DisProtiDP00816
ProteinModelPortaliP41236
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Required for binding PPP1CCBy similarity6
Regioni43 – 55Required for binding PPP1CCBy similarityAdd BLAST13
Regioni147 – 150Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activityBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4041 Eukaryota
ENOG4111SYV LUCA
GeneTreeiENSGT00390000004757
HOVERGENiHBG006170
InParanoidiP41236
KOiK16833
OMAiMHYNEGR
OrthoDBiEOG091G12FK
PhylomeDBiP41236
TreeFamiTF105536

Family and domain databases

InterProiView protein in InterPro
IPR007062 PPI-2
PANTHERiPTHR12398 PTHR12398, 1 hit
PfamiView protein in Pfam
PF04979 IPP-2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM
60 70 80 90 100
NILATYHPAD KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL
110 120 130 140 150
ARKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMKRKLHYNE
160 170 180 190 200
GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN

KLRSS
Length:205
Mass (Da):23,015
Last modified:January 23, 2007 - v2
Checksum:iFFC005B07CD5ABFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78873 mRNA Translation: CAA55475.1
Z29646 mRNA Translation: CAA82754.1
U68111
, U68106, U68107, U68108, U68109, U68110 Genomic DNA Translation: AAC51206.1
AJ133812 mRNA Translation: CAB41680.1
AY063767 mRNA Translation: AAL48322.1
BC007655 mRNA Translation: AAH07655.1
CCDSiCCDS3309.1
PIRiS42406
RefSeqiNP_001303254.1, NM_001316325.1
NP_006232.1, NM_006241.7
UniGeneiHs.535731
Hs.706920

Genome annotation databases

EnsembliENST00000618156; ENSP00000484580; ENSG00000184203
GeneIDi5504
KEGGihsa:5504
UCSCiuc032sob.2 human

Similar proteinsi

Entry informationi

Entry nameiIPP2_HUMAN
AccessioniPrimary (citable) accession number: P41236
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health