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Protein

ATP-binding cassette sub-family A member 2

Gene

Abca2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1024 – 10318ATP 1PROSITE-ProRule annotation
Nucleotide bindingi2088 – 20958ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 2
Alternative name(s):
ATP-binding cassette transporter 2
Short name:
ATP-binding cassette 2
Gene namesi
Name:Abca2
Synonyms:Abc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99606. Abca2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Transmembranei698 – 71821HelicalSequence analysisAdd
BLAST
Transmembranei749 – 76921HelicalSequence analysisAdd
BLAST
Transmembranei781 – 80121HelicalSequence analysisAdd
BLAST
Transmembranei812 – 83221HelicalSequence analysisAdd
BLAST
Transmembranei893 – 91321HelicalSequence analysisAdd
BLAST
Transmembranei1461 – 148121HelicalSequence analysisAdd
BLAST
Transmembranei1793 – 181321HelicalSequence analysisAdd
BLAST
Transmembranei1842 – 186221HelicalSequence analysisAdd
BLAST
Transmembranei1873 – 189321HelicalSequence analysisAdd
BLAST
Transmembranei1906 – 192621HelicalSequence analysisAdd
BLAST
Transmembranei1992 – 201221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24342434ATP-binding cassette sub-family A member 2PRO_0000093291Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence analysis
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence analysis
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence analysis
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence analysis
Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence analysis
Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence analysis
Glycosylationi599 – 5991N-linked (GlcNAc...)Sequence analysis
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence analysis
Modified residuei1238 – 12381PhosphoserineBy similarity
Modified residuei1327 – 13271PhosphoserineCombined sources
Modified residuei1331 – 13311PhosphoserineCombined sources
Glycosylationi1408 – 14081N-linked (GlcNAc...)Sequence analysis
Glycosylationi1496 – 14961N-linked (GlcNAc...)Sequence analysis
Glycosylationi1549 – 15491N-linked (GlcNAc...)Sequence analysis
Glycosylationi1557 – 15571N-linked (GlcNAc...)Sequence analysis
Glycosylationi1613 – 16131N-linked (GlcNAc...)Sequence analysis
Glycosylationi1678 – 16781N-linked (GlcNAc...)Sequence analysis
Glycosylationi1776 – 17761N-linked (GlcNAc...)Sequence analysis
Glycosylationi2055 – 20551N-linked (GlcNAc...)Sequence analysis
Modified residuei2411 – 24111PhosphothreonineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP41234.
MaxQBiP41234.
PaxDbiP41234.
PRIDEiP41234.

PTM databases

iPTMnetiP41234.
PhosphoSiteiP41234.

Expressioni

Tissue specificityi

Widely expressed in adult tissues. Highest levels are found in brain and pregnant uterus.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099983.

Structurei

3D structure databases

ProteinModelPortaliP41234.
SMRiP41234. Positions 955-1212, 1983-2347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini990 – 1221232ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini2051 – 2286236ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiP41234.
PhylomeDBiP41234.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030366. ABCA2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 4 hits.
PTHR19229:SF116. PTHR19229:SF116. 4 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS
60 70 80 90 100
VKEAFYTAAP LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLH
110 120 130 140 150
RVVEEGNLFD PVRPSLGSEL EALRQRLEAL SSGPGTWESH SARPAVSSFS
160 170 180 190 200
LDSVARDQRE LWRFLMQNLS LPNSTAQALL AARVDPSEVY RLLFGPLPDL
210 220 230 240 250
DGKLGFLRKQ EPWSRLGSNP LLQMEELLLA PALLEQLTCA PGSGELGRIL
260 270 280 290 300
TMPEGHQVDL QGYRDAVCSG QATARAQRFS DLAAELRNQL DTAKIAQQLG
310 320 330 340 350
FDVPNGSDPQ PQAPSPQSLP ALLGDLLDAQ KLLQDVDVLS ALALLLPQGA
360 370 380 390 400
CAGQASAPQA SSLNGLANST GIGANSGSNT TVEEGTQSPV SPASPDTLQG
410 420 430 440 450
QCSAFVQLWA GLQPILCGNN RTIEPEALRR GNMSSLGFTS KEQRNLGLLV
460 470 480 490 500
HLMTSNPKIL YAPVGSEADR VILKANETFA FVGNVTHYAQ VWLNISTEIR
510 520 530 540 550
SFLEQGRLQQ HLQWLQQYVA DLQLHPEAMN LSLEELPPAL RQDFSLPNGT
560 570 580 590 600
ALLQQLDTID NAACGWIQFM SKVSVDIFKG FPDEESIVNY TLNQAYQDNV
610 620 630 640 650
TVFASVIFQT RKDGSLPPHV HYKIRQNSSF TEKTNEIRRA YWRPGPNTGG
660 670 680 690 700
RFYFLYGLRL DQDMMERAII NTFVGHDVVE PGNYVQMFPY PCYTRDDFLF
710 720 730 740 750
VIEHMMPLCM VISWVYSVAM TIQHIVAEKE HRLKEVMKTM GLNNAVHWVA
760 770 780 790 800
WFITGFVQLS ISVTALTAIL KYCQVLMHSH VLIIWLFLAV YAVATIMFCF
810 820 830 840 850
LVSVLYSKAK LASACGGIIY FLSYVPYMYV AIREEVAHDK ITAFEKCIAS
860 870 880 890 900
RCPQQPLAWV PSTLHCMKWQ EWASIQWHTF SQSPVEGDDF NLLLAVTMLM
910 920 930 940 950
VDTVVYGVLT WYIEAVHPGM YGLPRPWYSR YRSPIGWAVG GQKPGSGAGH
960 970 980 990 1000
GHTHRASALW RRIQACAMES RHFEETRGME EEPTHLPLVV CVDKLTKVYK
1010 1020 1030 1040 1050
NDKKLALNKL SLNLYENQVV SFLGHNGAGK TTTMSILTGL FPPTSGSATI
1060 1070 1080 1090 1100
YGHDIRTEMD EIRKNLGMCP QHNVLFDRLT VEEHLWFYSR LKSMAQEEIR
1110 1120 1130 1140 1150
KETDKMIEDL ELSNKRHSLV QTLSGGMKRK LSVAIAFVGG SRAIILDEPT
1160 1170 1180 1190 1200
AGVDPYARRA IWDLILKYKP GRTILLSTHH MDEADLLGDR IAIISHGKLK
1210 1220 1230 1240 1250
CCGSPLFLKG AYGDGYRLTL VKQPAEPGTS QEPGLASSPS GCPRLSSCSE
1260 1270 1280 1290 1300
PQVSQFIRKH VASSLLVSDT STELSYILPS EAVKKGAFER LFQQLEHSLD
1310 1320 1330 1340 1350
ALHLSSFGLM DTTLEEVFLK VSEEDQSLEN SEADVKESRK DVLPGAEGLT
1360 1370 1380 1390 1400
AVGGQAGNLA RCSELAQSQA SLQSASSVGS ARGEEGTGYS DGYGDYRPLF
1410 1420 1430 1440 1450
DNLQDPDNVS LQEAEMEALA QVGQGSRKLE GWWLKMRQFH GLLVKRFHCA
1460 1470 1480 1490 1500
RRNSKALCSQ ILLPAFFVCV AMTVALSVPE IGDLPPLVLS PSQYHNYTQP
1510 1520 1530 1540 1550
RGNFIPYANE ERQEYRLRLS PDASPQQLVS TFRLPSGVGA TCVLKSPANG
1560 1570 1580 1590 1600
SLGPMLNLSS GESRLLAARF FDSMCLESFT QGLPLSNFVP PPPSPAPSDS
1610 1620 1630 1640 1650
PVSPDEDSLQ AWNMSLPPTA GPETWTSAPS LPRLVHEPVR CTCSAQGTGF
1660 1670 1680 1690 1700
SCPSSVGGHP PQMRVVTGDI LTDITGHNVS EYLLFTSDRF RLHRYGAITF
1710 1720 1730 1740 1750
GNVQKSIPAS FGARVPPMVR KIAVRRVAQV LYNNKGYHSM PTYLNSLNNA
1760 1770 1780 1790 1800
ILRANLPKSK GNPAAYGITV TNHPMNKTSA SLSLDYLLQG TDVVIAIFII
1810 1820 1830 1840 1850
VAMSFVPASF VVFLVAEKST KAKHLQFVSG CNPVIYWLAN YVWDMLNYLV
1860 1870 1880 1890 1900
PATCCVIILF VFDLPAYTSP TNFPAVLSLF LLYGWSITPI MYPASFWFEV
1910 1920 1930 1940 1950
PSSAYVFLIV INLFIGITAT VATFLLQLFE HDKDLKVVNS YLKSCFLIFP
1960 1970 1980 1990 2000
NYNLGHGLME MAYNEYINEY YAKIGQFDKM KSPFEWDIVT RGLVAMTVEG
2010 2020 2030 2040 2050
FVGFFLTIMC QYNFLRQPQR LPVSTKPVED DVDVASERQR VLRGDADNDM
2060 2070 2080 2090 2100
VKIENLTKVY KSRKIGRILA VDRLCLGVRP GECFGLLGVN GAGKTSTFKM
2110 2120 2130 2140 2150
LTGDESTTGG EAFVNGHSVL KDLLQVQQSL GYCPQFDALF DELTAREHLQ
2160 2170 2180 2190 2200
LYTRLRGIPW KDEAQVVKWA LEKLELTKYA DKPAGTYSGG NKRKLSTAIA
2210 2220 2230 2240 2250
LIGYPAFIFL DEPTTGMDPK ARRFLWNLIL DLIKTGRSVV LTSHSMEECE
2260 2270 2280 2290 2300
ALCTRLAIMV NGRLRCLGSI QHLKNRFGDG YMITVRTKSS QNVKDVVRFF
2310 2320 2330 2340 2350
NRNFPEAMLK ERHHTKVQYQ LKSEHISLAQ VFSKMEQVVG VLGIEDYSVS
2360 2370 2380 2390 2400
QTTLDNVFVN FAKKQSDNVE QQEAEPSSLP SPLGLLSLLR PRPAPTELRA
2410 2420 2430
LVADEPEDLD TEDEGLISFE EERAQLSFNT DTLC
Length:2,434
Mass (Da):270,509
Last modified:April 12, 2005 - v4
Checksum:i38564C2989F0CFCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75927 mRNA. Translation: CAA53531.2.
PIRiB54774.
UniGeneiMm.2210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75927 mRNA. Translation: CAA53531.2.
PIRiB54774.
UniGeneiMm.2210.

3D structure databases

ProteinModelPortaliP41234.
SMRiP41234. Positions 955-1212, 1983-2347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099983.

PTM databases

iPTMnetiP41234.
PhosphoSiteiP41234.

Proteomic databases

EPDiP41234.
MaxQBiP41234.
PaxDbiP41234.
PRIDEiP41234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:99606. Abca2.

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiP41234.
PhylomeDBiP41234.

Miscellaneous databases

ChiTaRSiAbca2. mouse.
PROiP41234.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030366. ABCA2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 4 hits.
PTHR19229:SF116. PTHR19229:SF116. 4 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCA2_MOUSE
AccessioniPrimary (citable) accession number: P41234
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 12, 2005
Last modified: July 6, 2016
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.