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Protein

ATP-binding cassette sub-family A member 1

Gene

Abca1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi933 – 940ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1946 – 1953ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cellular response to cholesterol Source: Ensembl
  • cellular response to lipopolysaccharide Source: UniProtKB
  • cellular response to retinoic acid Source: UniProtKB
  • cholesterol efflux Source: MGI
  • cholesterol homeostasis Source: MGI
  • cholesterol metabolic process Source: MGI
  • endosomal transport Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • high-density lipoprotein particle assembly Source: MGI
  • interleukin-1 beta secretion Source: MGI
  • intracellular cholesterol transport Source: MGI
  • lipoprotein biosynthetic process Source: MGI
  • lipoprotein metabolic process Source: MGI
  • lysosome organization Source: MGI
  • peptide secretion Source: MGI
  • phagocytosis, engulfment Source: MGI
  • phospholipid efflux Source: MGI
  • phospholipid homeostasis Source: MGI
  • phospholipid translocation Source: MGI
  • platelet dense granule organization Source: MGI
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cholesterol efflux Source: BHF-UCL
  • protein lipidation Source: MGI
  • regulation of Cdc42 protein signal transduction Source: MGI
  • response to drug Source: Ensembl
  • response to laminar fluid shear stress Source: Ensembl
  • response to low-density lipoprotein particle Source: Ensembl
  • response to nutrient Source: Ensembl
  • reverse cholesterol transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194223. HDL-mediated lipid transport.

Protein family/group databases

TCDBi3.A.1.211.1. the atp-binding cassette (abc) superfamily.

Chemistry databases

SwissLipidsiSLP:000000484.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 1
Alternative name(s):
ATP-binding cassette transporter 1
Short name:
ABC-1
Short name:
ATP-binding cassette 1
Gene namesi
Name:Abca1
Synonyms:Abc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99607. Abca1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 639ExtracellularBy similarityAdd BLAST597
Transmembranei640 – 660HelicalSequence analysisAdd BLAST21
Transmembranei683 – 703HelicalSequence analysisAdd BLAST21
Transmembranei716 – 736HelicalSequence analysisAdd BLAST21
Transmembranei745 – 765HelicalSequence analysisAdd BLAST21
Transmembranei777 – 797HelicalSequence analysisAdd BLAST21
Transmembranei827 – 847HelicalSequence analysisAdd BLAST21
Transmembranei941 – 961HelicalSequence analysisAdd BLAST21
Transmembranei1351 – 1371HelicalSequence analysisAdd BLAST21
Topological domaini1372 – 1656ExtracellularBy similarityAdd BLAST285
Transmembranei1657 – 1677HelicalSequence analysisAdd BLAST21
Transmembranei1703 – 1723HelicalSequence analysisAdd BLAST21
Transmembranei1735 – 1755HelicalSequence analysisAdd BLAST21
Transmembranei1768 – 1788HelicalSequence analysisAdd BLAST21
Transmembranei1802 – 1822HelicalSequence analysisAdd BLAST21
Transmembranei1852 – 1872HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endocytic vesicle Source: MGI
  • external side of plasma membrane Source: MGI
  • Golgi apparatus Source: MGI
  • high-density lipoprotein particle Source: Ensembl
  • integral component of plasma membrane Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • membrane raft Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • phagocytic vesicle Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1641361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000932891 – 2261ATP-binding cassette sub-family A member 1Add BLAST2261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi3S-palmitoyl cysteineBy similarity1
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Lipidationi23S-palmitoyl cysteineBy similarity1
Disulfide bondi75 ↔ 309By similarity
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Glycosylationi337N-linked (GlcNAc...)Sequence analysis1
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Glycosylationi489N-linked (GlcNAc...)1 Publication1
Glycosylationi521N-linked (GlcNAc...)Sequence analysis1
Glycosylationi820N-linked (GlcNAc...)Sequence analysis1
Modified residuei1042Phosphoserine; by PKABy similarity1
Lipidationi1110S-palmitoyl cysteineBy similarity1
Lipidationi1111S-palmitoyl cysteineBy similarity1
Glycosylationi1144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1294N-linked (GlcNAc...)Sequence analysis1
Modified residuei1296PhosphoserineCombined sources1
Glycosylationi1453N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1463 ↔ 1477By similarity
Glycosylationi1499N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1504N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1637N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2044N-linked (GlcNAc...)Sequence analysis1
Modified residuei2054Phosphoserine; by PKABy similarity1
Glycosylationi2238N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylation on Ser-2054 regulates phospholipid efflux.By similarity
Palmitoylation by DHHC8 is essential for membrane localization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP41233.
PaxDbiP41233.
PeptideAtlasiP41233.
PRIDEiP41233.

PTM databases

iPTMnetiP41233.
PhosphoSitePlusiP41233.
SwissPalmiP41233.

Miscellaneous databases

PMAP-CutDBB1AWZ8.

Expressioni

Tissue specificityi

Widely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.

Inductioni

Down-regulated by endotoxins (LPS) or cytokines (TNF and IL-1) in J774 macrophages. The down-regulation by endotoxin in macrophages is not likely to be mediated by the liver X receptor/retinoic X receptor (LXR/RXR).1 Publication

Gene expression databases

BgeeiENSMUSG00000015243.
GenevisibleiP41233. MM.

Interactioni

Subunit structurei

Interacts with MEGF10.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197900. 1 interactor.
IntActiP41233. 2 interactors.
STRINGi10090.ENSMUSP00000030010.

Chemistry databases

BindingDBiP41233.

Structurei

3D structure databases

ProteinModelPortaliP41233.
SMRiP41233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini899 – 1131ABC transporter 1PROSITE-ProRule annotationAdd BLAST233
Domaini1912 – 2144ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiP41233.
KOiK05641.
OMAiKRMSEIC.
OrthoDBiEOG091G007E.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030365. ABCA1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 6 hits.
PTHR19229:SF34. PTHR19229:SF34. 6 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACWPQLRLL LWKNLTFRRR QTCQLLLEVA WPLFIFLILI SVRLSYPPYE
60 70 80 90 100
QHECHFPNKA MPSAGTLPWV QGIICNANNP CFRYPTPGEA PGVVGNFNKS
110 120 130 140 150
IVSRLFSDAQ RLLLYSQRDT SIKDMHKVLR MLRQIKHPNS NLKLQDFLVD
160 170 180 190 200
NETFSGFLQH NLSLPRSTVD SLLQANVGLQ KVFLQGYQLH LASLCNGSKL
210 220 230 240 250
EEIIQLGDAE VSALCGLPRK KLDAAERVLR YNMDILKPVV TKLNSTSHLP
260 270 280 290 300
TQHLAEATTV LLDSLGGLAQ ELFSTKSWSD MRQEVMFLTN VNSSSSSTQI
310 320 330 340 350
YQAVSRIVCG HPEGGGLKIK SLNWYEDNNY KALFGGNNTE EDVDTFYDNS
360 370 380 390 400
TTPYCNDLMK NLESSPLSRI IWKALKPLLV GKILYTPDTP ATRQVMAEVN
410 420 430 440 450
KTFQELAVFH DLEGMWEELS PQIWTFMENS QEMDLVRTLL DSRGNDQFWE
460 470 480 490 500
QKLDGLDWTA QDIMAFLAKN PEDVQSPNGS VYTWREAFNE TNQAIQTISR
510 520 530 540 550
FMECVNLNKL EPIPTEVRLI NKSMELLDER KFWAGIVFTG ITPDSVELPH
560 570 580 590 600
HVKYKIRMDI DNVERTNKIK DGYWDPGPRA DPFEDMRYVW GGFAYLQDVV
610 620 630 640 650
EQAIIRVLTG SEKKTGVYVQ QMPYPCYVDD IFLRVMSRSM PLFMTLAWIY
660 670 680 690 700
SVAVIIKSIV YEKEARLKET MRIMGLDNGI LWFSWFVSSL IPLLVSAGLL
710 720 730 740 750
VVILKLGNLL PYSDPSVVFV FLSVFAMVTI LQCFLISTLF SRANLAAACG
760 770 780 790 800
GIIYFTLYLP YVLCVAWQDY VGFSIKIFAS LLSPVAFGFG CEYFALFEEQ
810 820 830 840 850
GIGVQWDNLF ESPVEEDGFN LTTAVSMMLF DTFLYGVMTW YIEAVFPGQY
860 870 880 890 900
GIPRPWYFPC TKSYWFGEEI DEKSHPGSSQ KGVSEICMEE EPTHLRLGVS
910 920 930 940 950
IQNLVKVYRD GMKVAVDGLA LNFYEGQITS FLGHNGAGKT TTMSILTGLF
960 970 980 990 1000
PPTSGTAYIL GKDIRSEMSS IRQNLGVCPQ HNVLFDMLTV EEHIWFYARL
1010 1020 1030 1040 1050
KGLSEKHVKA EMEQMALDVG LPPSKLKSKT SQLSGGMQRK LSVALAFVGG
1060 1070 1080 1090 1100
SKVVILDEPT AGVDPYSRRG IWELLLKYRQ GRTIILSTHH MDEADILGDR
1110 1120 1130 1140 1150
IAIISHGKLC CVGSSLFLKN QLGTGYYLTL VKKDVESSLS SCRNSSSTVS
1160 1170 1180 1190 1200
CLKKEDSVSQ SSSDAGLGSD HESDTLTIDV SAISNLIRKH VSEARLVEDI
1210 1220 1230 1240 1250
GHELTYVLPY EAAKEGAFVE LFHEIDDRLS DLGISSYGIS ETTLEEIFLK
1260 1270 1280 1290 1300
VAEESGVDAE TSDGTLPARR NRRAFGDKQS CLHPFTEDDA VDPNDSDIDP
1310 1320 1330 1340 1350
ESRETDLLSG MDGKGSYQLK GWKLTQQQFV ALLWKRLLIA RRSRKGFFAQ
1360 1370 1380 1390 1400
IVLPAVFVCI ALVFSLIVPP FGKYPSLELQ PWMYNEQYTF VSNDAPEDMG
1410 1420 1430 1440 1450
TQELLNALTK DPGFGTRCME GNPIPDTPCL AGEEDWTISP VPQSIVDLFQ
1460 1470 1480 1490 1500
NGNWTMKNPS PACQCSSDKI KKMLPVCPPG AGGLPPPQRK QKTADILQNL
1510 1520 1530 1540 1550
TGRNISDYLV KTYVQIIAKS LKNKIWVNEF RYGGFSLGVS NSQALPPSHE
1560 1570 1580 1590 1600
VNDAIKQMKK LLKLTKDSSA DRFLSSLGRF MAGLDTKNNV KVWFNNKGWH
1610 1620 1630 1640 1650
AISSFLNVIN NAILRANLQK GENPSQYGIT AFNHPLNLTK QQLSEVALMT
1660 1670 1680 1690 1700
TSVDVLVSIC VIFAMSFVPA SFVVFLIQER VSKAKHLQFI SGVKPVIYWL
1710 1720 1730 1740 1750
SNFVWDMCNY VVPATLVIII FICFQQKSYV SSTNLPVLAL LLLLYGWSIT
1760 1770 1780 1790 1800
PLMYPASFVF KIPSTAYVVL TSVNLFIGIN GSVATFVLEL FTNNKLNDIN
1810 1820 1830 1840 1850
DILKSVFLIF PHFCLGRGLI DMVKNQAMAD ALERFGENRF VSPLSWDLVG
1860 1870 1880 1890 1900
RNLFAMAVEG VVFFLITVLI QYRFFIRPRP VKAKLPPLND EDEDVRRERQ
1910 1920 1930 1940 1950
RILDGGGQND ILEIKELTKI YRRKRKPAVD RICIGIPPGE CFGLLGVNGA
1960 1970 1980 1990 2000
GKSTTFKMLT GDTPVTRGDA FLNKNSILSN IHEVHQNMGY CPQFDAITEL
2010 2020 2030 2040 2050
LTGREHVEFF ALLRGVPEKE VGKVGEWAIR KLGLVKYGEK YASNYSGGNK
2060 2070 2080 2090 2100
RKLSTAMALI GGPPVVFLDE PTTGMDPKAR RFLWNCALSI VKEGRSVVLT
2110 2120 2130 2140 2150
SHSMEECEAL CTRMAIMVNG RFRCLGSVQH LKNRFGDGYT IVVRIAGSNP
2160 2170 2180 2190 2200
DLKPVQEFFG LAFPGSVLKE KHRNMLQYQL PSSLSSLARI FSILSQSKKR
2210 2220 2230 2240 2250
LHIEDYSVSQ TTLDQVFVNF AKDQSDDDHL KDLSLHKNQT VVDVAVLTSF
2260
LQDEKVKESY V
Length:2,261
Mass (Da):253,912
Last modified:July 27, 2011 - v4
Checksum:iE041DA4FA73C2660
GO

Sequence cautioni

The sequence AAG39073 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA53530 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1567 – 1568Missing in AAG39073 (PubMed:11352567).Curated2
Sequence conflicti1568S → T in CAA53530 (PubMed:8088782).Curated1
Sequence conflicti2024V → F in CAA53530 (PubMed:8088782).Curated1
Sequence conflicti2024Missing in AAG39073 (PubMed:11352567).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75926 mRNA. Translation: CAA53530.1. Different initiation.
AF287263 Genomic DNA. Translation: AAG39073.1. Different initiation.
AL807243, AL772397 Genomic DNA. Translation: CAM18883.1.
AL772397, AL807243 Genomic DNA. Translation: CAM27437.1.
CH466565 Genomic DNA. Translation: EDL02285.1.
CCDSiCCDS18187.1.
PIRiA54774.
RefSeqiNP_038482.3. NM_013454.3.
UniGeneiMm.277376.

Genome annotation databases

EnsembliENSMUST00000030010; ENSMUSP00000030010; ENSMUSG00000015243.
GeneIDi11303.
KEGGimmu:11303.
UCSCiuc008swu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75926 mRNA. Translation: CAA53530.1. Different initiation.
AF287263 Genomic DNA. Translation: AAG39073.1. Different initiation.
AL807243, AL772397 Genomic DNA. Translation: CAM18883.1.
AL772397, AL807243 Genomic DNA. Translation: CAM27437.1.
CH466565 Genomic DNA. Translation: EDL02285.1.
CCDSiCCDS18187.1.
PIRiA54774.
RefSeqiNP_038482.3. NM_013454.3.
UniGeneiMm.277376.

3D structure databases

ProteinModelPortaliP41233.
SMRiP41233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197900. 1 interactor.
IntActiP41233. 2 interactors.
STRINGi10090.ENSMUSP00000030010.

Chemistry databases

BindingDBiP41233.
ChEMBLiCHEMBL1641361.
SwissLipidsiSLP:000000484.

Protein family/group databases

TCDBi3.A.1.211.1. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP41233.
PhosphoSitePlusiP41233.
SwissPalmiP41233.

Proteomic databases

MaxQBiP41233.
PaxDbiP41233.
PeptideAtlasiP41233.
PRIDEiP41233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030010; ENSMUSP00000030010; ENSMUSG00000015243.
GeneIDi11303.
KEGGimmu:11303.
UCSCiuc008swu.1. mouse.

Organism-specific databases

CTDi19.
MGIiMGI:99607. Abca1.

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiP41233.
KOiK05641.
OMAiKRMSEIC.
OrthoDBiEOG091G007E.
TreeFamiTF105191.

Enzyme and pathway databases

ReactomeiR-MMU-194223. HDL-mediated lipid transport.

Miscellaneous databases

PMAP-CutDBB1AWZ8.
PROiP41233.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015243.
GenevisibleiP41233. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030365. ABCA1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 6 hits.
PTHR19229:SF34. PTHR19229:SF34. 6 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCA1_MOUSE
AccessioniPrimary (citable) accession number: P41233
Secondary accession number(s): B1AWZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 163 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.