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Protein

P2Y purinoceptor 2

Gene

P2ry2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

GO - Molecular functioni

  • A1 adenosine receptor binding Source: BHF-UCL
  • ATP binding Source: RGD
  • G-protein coupled purinergic nucleotide receptor activity Source: RGD
  • UTP-activated nucleotide receptor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to purine-containing compound Source: RGD
  • in utero embryonic development Source: RGD
  • negative regulation of ossification Source: RGD
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: InterPro
  • positive regulation of chemokine production Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of mucus secretion Source: InterPro
  • positive regulation of neuron projection development Source: RGD
  • positive regulation of penile erection Source: RGD
  • positive regulation of prostaglandin secretion Source: RGD
  • positive regulation of smooth muscle cell migration Source: RGD
  • regulation of vasodilation Source: RGD
  • response to growth factor Source: RGD
  • sensory perception of pain Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 2
Short name:
P2Y2
Alternative name(s):
ATP receptor
P2U purinoceptor 1
Short name:
P2U1
Purinergic receptor
Gene namesi
Name:P2ry2
Synonyms:P2ru1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62088. P2ry2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 59Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini60 – 70CytoplasmicSequence analysisAdd BLAST11
Transmembranei71 – 93Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini94 – 110ExtracellularSequence analysisAdd BLAST17
Transmembranei111 – 129Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini130 – 152CytoplasmicSequence analysisAdd BLAST23
Transmembranei153 – 172Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini173 – 194ExtracellularSequence analysisAdd BLAST22
Transmembranei195 – 220Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini221 – 245CytoplasmicSequence analysisAdd BLAST25
Transmembranei246 – 268Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini269 – 286ExtracellularSequence analysisAdd BLAST18
Transmembranei287 – 308Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini309 – 374CytoplasmicSequence analysisAdd BLAST66

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basolateral plasma membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700161 – 374P2Y purinoceptor 2Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP41232.
PRIDEiP41232.

PTM databases

iPTMnetiP41232.
PhosphoSitePlusiP41232.

Interactioni

GO - Molecular functioni

  • A1 adenosine receptor binding Source: BHF-UCL

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026115.

Chemistry databases

BindingDBiP41232.

Structurei

3D structure databases

ProteinModelPortaliP41232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIAQ. Eukaryota.
ENOG410XQNZ. LUCA.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP41232.
KOiK04269.
PhylomeDBiP41232.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF17. PTHR24231:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGLDSWNS TINGTWEGDE LGYKCRFNED FKYVLLPVSY GVVCVLGLCL
60 70 80 90 100
NVVALYIFLC RLKTWNASTT YMFHLAVSDS LYAASLPLLV YYYAQGDHWP
110 120 130 140 150
FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLH SLSWGHARYA
160 170 180 190 200
RRVAAVVWVL VLACQAPVLY FVTTSVRGTR ITCHDTSARE LFSHFVAYSS
210 220 230 240 250
VMLGLLFAVP FSIILVCYVL MARRLLKPAY GTTGLPRAKR KSVRTIALVL
260 270 280 290 300
AVFALCFLPF HVTRTLYYSF RSLDLSCHTL NAINMAYKIT RPLASANSCL
310 320 330 340 350
DPVLYFLAGQ RLVRFARDAK PATEPTPSPQ ARRKLGLHRP NRTDTVRKDL
360 370
SISSDDSRRT ESTPAGSETK DIRL
Length:374
Mass (Da):42,137
Last modified:October 1, 1996 - v2
Checksum:i2DA6853AA20A1AF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132C → S in AAA61565 (PubMed:7811468).Curated1
Sequence conflicti143S → R in AAA61565 (PubMed:7811468).Curated1
Sequence conflicti166A → T in AAA61565 (PubMed:7811468).Curated1
Sequence conflicti188A → D in AAA61565 (PubMed:7811468).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09402 mRNA. Translation: AAA61565.1.
L46865 mRNA. Translation: AAB02099.1.
U56839 mRNA. Translation: AAC00048.1.
BC061754 mRNA. Translation: AAH61754.1.
RefSeqiNP_058951.1. NM_017255.1.
UniGeneiRn.11102.

Genome annotation databases

GeneIDi29597.
KEGGirno:29597.
UCSCiRGD:62088. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09402 mRNA. Translation: AAA61565.1.
L46865 mRNA. Translation: AAB02099.1.
U56839 mRNA. Translation: AAC00048.1.
BC061754 mRNA. Translation: AAH61754.1.
RefSeqiNP_058951.1. NM_017255.1.
UniGeneiRn.11102.

3D structure databases

ProteinModelPortaliP41232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026115.

Chemistry databases

BindingDBiP41232.
ChEMBLiCHEMBL4419.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP41232.
PhosphoSitePlusiP41232.

Proteomic databases

PaxDbiP41232.
PRIDEiP41232.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29597.
KEGGirno:29597.
UCSCiRGD:62088. rat.

Organism-specific databases

CTDi5029.
RGDi62088. P2ry2.

Phylogenomic databases

eggNOGiENOG410IIAQ. Eukaryota.
ENOG410XQNZ. LUCA.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP41232.
KOiK04269.
PhylomeDBiP41232.

Miscellaneous databases

PROiP41232.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF17. PTHR24231:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY2_RAT
AccessioniPrimary (citable) accession number: P41232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.