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P41231

- P2RY2_HUMAN

UniProt

P41231 - P2RY2_HUMAN

Protein

P2Y purinoceptor 2

Gene

P2RY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

    GO - Molecular functioni

    1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
    2. receptor activity Source: ProtInc

    GO - Biological processi

    1. cellular ion homeostasis Source: ProtInc
    2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
    3. positive regulation of mucus secretion Source: Ensembl
    4. regulation of vasodilation Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.
    SignaLinkiP41231.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 2
    Short name:
    P2Y2
    Alternative name(s):
    ATP receptor
    P2U purinoceptor 1
    Short name:
    P2U1
    P2U receptor 1
    Purinergic receptor
    Gene namesi
    Name:P2RY2
    Synonyms:P2RU1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8541. P2RY2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32870.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377P2Y purinoceptor 2PRO_0000070013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP41231.
    PaxDbiP41231.
    PRIDEiP41231.

    PTM databases

    PhosphoSiteiP41231.

    Expressioni

    Tissue specificityi

    Spleen, testis, kidney, liver, lung, heart and brain.

    Gene expression databases

    BgeeiP41231.
    CleanExiHS_P2RY2.
    GenevestigatoriP41231.

    Organism-specific databases

    HPAiCAB022642.

    Interactioni

    Protein-protein interaction databases

    BioGridi111068. 2 interactions.
    IntActiP41231. 1 interaction.
    MINTiMINT-1796620.
    STRINGi9606.ENSP00000310305.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Z8Emodel-A1-377[»]
    ProteinModelPortaliP41231.
    SMRiP41231. Positions 34-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini60 – 7011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 11017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 15223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 19422ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini270 – 28718ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 37768CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5927Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9323Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 12919Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 22026Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 26923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147537.
    HOGENOMiHOG000231307.
    HOVERGENiHBG101120.
    InParanoidiP41231.
    KOiK04269.
    OMAiAVILVCY.
    OrthoDBiEOG7QNVM4.
    PhylomeDBiP41231.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000356. P2Y2_rcpt.
    [Graphical view]
    PANTHERiPTHR24231:SF17. PTHR24231:SF17. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00594. P2Y2PRNOCPTR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41231-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL    50
    NAVALYIFLC RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP 100
    FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SLRWGRARYA 150
    RRVAGAVWVL VLACQAPVLY FVTTSARGGR VTCHDTSAPE LFSRFVAYSS 200
    VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK RKSVRTIAVV 250
    LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC 300
    LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE 350
    DVLGSSEDSR RTESTPAGSE NTKDIRL 377
    Length:377
    Mass (Da):42,273
    Last modified:November 2, 2010 - v4
    Checksum:iF71DAF4A8DCB4062
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti350 – 3501E → G in AAC04923. (PubMed:8159738)Curated
    Sequence conflicti359 – 3591S → F in AAC04923. (PubMed:8159738)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461P → L.5 Publications
    Corresponds to variant rs2511241 [ dbSNP | Ensembl ].
    VAR_054870
    Natural varianti312 – 3121R → S.1 Publication
    Corresponds to variant rs3741156 [ dbSNP | Ensembl ].
    VAR_054871
    Natural varianti334 – 3341R → C.2 Publications
    Corresponds to variant rs1626154 [ dbSNP | Ensembl ].
    VAR_054872

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07225 mRNA. Translation: AAC04923.1.
    AY136753 mRNA. Translation: AAN01279.1.
    AK313942 mRNA. Translation: BAG36660.1.
    AP002761 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74882.1.
    BC012104 mRNA. Translation: AAH12104.1.
    BC028135 mRNA. Translation: AAH28135.1.
    CCDSiCCDS8219.1.
    PIRiA54946.
    RefSeqiNP_002555.3. NM_002564.3.
    NP_788085.2. NM_176071.2.
    NP_788086.2. NM_176072.2.
    XP_005274076.1. XM_005274019.2.
    XP_005274077.1. XM_005274020.2.
    XP_005274078.1. XM_005274021.2.
    UniGeneiHs.339.
    Hs.572077.

    Genome annotation databases

    EnsembliENST00000311131; ENSP00000310305; ENSG00000175591.
    ENST00000393596; ENSP00000377221; ENSG00000175591.
    ENST00000393597; ENSP00000377222; ENSG00000175591.
    GeneIDi5029.
    KEGGihsa:5029.
    UCSCiuc001otj.4. human.

    Polymorphism databases

    DMDMi311033490.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07225 mRNA. Translation: AAC04923.1 .
    AY136753 mRNA. Translation: AAN01279.1 .
    AK313942 mRNA. Translation: BAG36660.1 .
    AP002761 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74882.1 .
    BC012104 mRNA. Translation: AAH12104.1 .
    BC028135 mRNA. Translation: AAH28135.1 .
    CCDSi CCDS8219.1.
    PIRi A54946.
    RefSeqi NP_002555.3. NM_002564.3.
    NP_788085.2. NM_176071.2.
    NP_788086.2. NM_176072.2.
    XP_005274076.1. XM_005274019.2.
    XP_005274077.1. XM_005274020.2.
    XP_005274078.1. XM_005274021.2.
    UniGenei Hs.339.
    Hs.572077.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Z8E model - A 1-377 [» ]
    ProteinModelPortali P41231.
    SMRi P41231. Positions 34-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111068. 2 interactions.
    IntActi P41231. 1 interaction.
    MINTi MINT-1796620.
    STRINGi 9606.ENSP00000310305.

    Chemistry

    BindingDBi P41231.
    ChEMBLi CHEMBL4398.
    DrugBanki DB04786. Suramin.
    GuidetoPHARMACOLOGYi 324.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P41231.

    Polymorphism databases

    DMDMi 311033490.

    Proteomic databases

    MaxQBi P41231.
    PaxDbi P41231.
    PRIDEi P41231.

    Protocols and materials databases

    DNASUi 5029.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311131 ; ENSP00000310305 ; ENSG00000175591 .
    ENST00000393596 ; ENSP00000377221 ; ENSG00000175591 .
    ENST00000393597 ; ENSP00000377222 ; ENSG00000175591 .
    GeneIDi 5029.
    KEGGi hsa:5029.
    UCSCi uc001otj.4. human.

    Organism-specific databases

    CTDi 5029.
    GeneCardsi GC11P072929.
    H-InvDB HIX0009916.
    HGNCi HGNC:8541. P2RY2.
    HPAi CAB022642.
    MIMi 600041. gene.
    neXtProti NX_P41231.
    PharmGKBi PA32870.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147537.
    HOGENOMi HOG000231307.
    HOVERGENi HBG101120.
    InParanoidi P41231.
    KOi K04269.
    OMAi AVILVCY.
    OrthoDBi EOG7QNVM4.
    PhylomeDBi P41231.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.
    SignaLinki P41231.

    Miscellaneous databases

    GeneWikii P2RY2.
    GenomeRNAii 5029.
    NextBioi 19366.
    PROi P41231.
    SOURCEi Search...

    Gene expression databases

    Bgeei P41231.
    CleanExi HS_P2RY2.
    Genevestigatori P41231.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000356. P2Y2_rcpt.
    [Graphical view ]
    PANTHERi PTHR24231:SF17. PTHR24231:SF17. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00594. P2Y2PRNOCPTR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy."
      Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T.
      Proc. Natl. Acad. Sci. U.S.A. 91:3275-3279(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-46.
      Tissue: Airway epithelium.
    2. "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy."
      Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T.
      Proc. Natl. Acad. Sci. U.S.A. 91:13067-13067(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-46.
      Tissue: Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-46 AND CYS-334.
      Tissue: Pericardium.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-46 AND CYS-334.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-46 AND SER-312.
      Tissue: Kidney and Leukocyte.

    Entry informationi

    Entry nameiP2RY2_HUMAN
    AccessioniPrimary (citable) accession number: P41231
    Secondary accession number(s): B2R9W3, Q96EM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 138 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3