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P41231 (P2RY2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 2

Short name=P2Y2
Alternative name(s):
ATP receptor
P2U purinoceptor 1
Short name=P2U1
P2U receptor 1
Purinergic receptor
Gene names
Name:P2RY2
Synonyms:P2RU1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Spleen, testis, kidney, liver, lung, heart and brain.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377P2Y purinoceptor 2
PRO_0000070013

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 5927Helical; Name=1; Potential
Topological domain60 – 7011Cytoplasmic Potential
Transmembrane71 – 9323Helical; Name=2; Potential
Topological domain94 – 11017Extracellular Potential
Transmembrane111 – 12919Helical; Name=3; Potential
Topological domain130 – 15223Cytoplasmic Potential
Transmembrane153 – 17220Helical; Name=4; Potential
Topological domain173 – 19422Extracellular Potential
Transmembrane195 – 22026Helical; Name=5; Potential
Topological domain221 – 24626Cytoplasmic Potential
Transmembrane247 – 26923Helical; Name=6; Potential
Topological domain270 – 28718Extracellular Potential
Transmembrane288 – 30922Helical; Name=7; Potential
Topological domain310 – 37768Cytoplasmic Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation131N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 183 By similarity

Natural variations

Natural variant461P → L. Ref.1 Ref.3 Ref.4 Ref.6 Ref.7
Corresponds to variant rs2511241 [ dbSNP | Ensembl ].
VAR_054870
Natural variant3121R → S. Ref.7
Corresponds to variant rs3741156 [ dbSNP | Ensembl ].
VAR_054871
Natural variant3341R → C. Ref.4 Ref.6
Corresponds to variant rs1626154 [ dbSNP | Ensembl ].
VAR_054872

Experimental info

Sequence conflict3501E → G in AAC04923. Ref.1
Sequence conflict3591S → F in AAC04923. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P41231 [UniParc].

Last modified November 2, 2010. Version 4.
Checksum: F71DAF4A8DCB4062

FASTA37742,273
        10         20         30         40         50         60 
MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL NAVALYIFLC 

        70         80         90        100        110        120 
RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP FSTVLCKLVR FLFYTNLYCS 

       130        140        150        160        170        180 
ILFLTCISVH RCLGVLRPLR SLRWGRARYA RRVAGAVWVL VLACQAPVLY FVTTSARGGR 

       190        200        210        220        230        240 
VTCHDTSAPE LFSRFVAYSS VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK 

       250        260        270        280        290        300 
RKSVRTIAVV LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC 

       310        320        330        340        350        360 
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE DVLGSSEDSR 

       370 
RTESTPAGSE NTKDIRL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy."
Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T.
Proc. Natl. Acad. Sci. U.S.A. 91:3275-3279(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-46.
Tissue: Airway epithelium.
[2]"Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy."
Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T.
Proc. Natl. Acad. Sci. U.S.A. 91:13067-13067(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-46.
Tissue: Placenta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-46 AND CYS-334.
Tissue: Pericardium.
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-46 AND CYS-334.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-46 AND SER-312.
Tissue: Kidney and Leukocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U07225 mRNA. Translation: AAC04923.1.
AY136753 mRNA. Translation: AAN01279.1.
AK313942 mRNA. Translation: BAG36660.1.
AP002761 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74882.1.
BC012104 mRNA. Translation: AAH12104.1.
BC028135 mRNA. Translation: AAH28135.1.
CCDSCCDS8219.1.
PIRA54946.
RefSeqNP_002555.3. NM_002564.3.
NP_788085.2. NM_176071.2.
NP_788086.2. NM_176072.2.
XP_005274076.1. XM_005274019.2.
XP_005274077.1. XM_005274020.2.
XP_005274078.1. XM_005274021.2.
UniGeneHs.339.
Hs.572077.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]
ProteinModelPortalP41231.
SMRP41231. Positions 34-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111068. 2 interactions.
IntActP41231. 1 interaction.
MINTMINT-1796620.
STRING9606.ENSP00000310305.

Chemistry

BindingDBP41231.
ChEMBLCHEMBL4398.
DrugBankDB04786. Suramin.
GuidetoPHARMACOLOGY324.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP41231.

Polymorphism databases

DMDM311033490.

Proteomic databases

MaxQBP41231.
PaxDbP41231.
PRIDEP41231.

Protocols and materials databases

DNASU5029.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311131; ENSP00000310305; ENSG00000175591.
ENST00000393596; ENSP00000377221; ENSG00000175591.
ENST00000393597; ENSP00000377222; ENSG00000175591.
GeneID5029.
KEGGhsa:5029.
UCSCuc001otj.4. human.

Organism-specific databases

CTD5029.
GeneCardsGC11P072929.
H-InvDBHIX0009916.
HGNCHGNC:8541. P2RY2.
HPACAB022642.
MIM600041. gene.
neXtProtNX_P41231.
PharmGKBPA32870.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147537.
HOGENOMHOG000231307.
HOVERGENHBG101120.
InParanoidP41231.
KOK04269.
OMAAVILVCY.
OrthoDBEOG7QNVM4.
PhylomeDBP41231.
TreeFamTF350009.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP41231.

Gene expression databases

BgeeP41231.
CleanExHS_P2RY2.
GenevestigatorP41231.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
[Graphical view]
PANTHERPTHR24231:SF17. PTHR24231:SF17. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiP2RY2.
GenomeRNAi5029.
NextBio19366.
PROP41231.
SOURCESearch...

Entry information

Entry nameP2RY2_HUMAN
AccessionPrimary (citable) accession number: P41231
Secondary accession number(s): B2R9W3, Q96EM8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries