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P41231 - P2RY2_HUMAN

UniProt

P41231 - P2RY2_HUMAN

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Protein

P2Y purinoceptor 2

Gene

P2RY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. cellular ion homeostasis Source: ProtInc
  2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  3. positive regulation of mucus secretion Source: Ensembl
  4. regulation of vasodilation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
SignaLinkiP41231.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 2
Short name:
P2Y2
Alternative name(s):
ATP receptor
P2U purinoceptor 1
Short name:
P2U1
P2U receptor 1
Purinergic receptor
Gene namesi
Name:P2RY2
Synonyms:P2RU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8541. P2RY2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5927Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini60 – 7011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei71 – 9323Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 11017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei111 – 12919Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 15223CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini173 – 19422ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 22026Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 24626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei247 – 26923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini270 – 28718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30922Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 37768CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377P2Y purinoceptor 2PRO_0000070013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP41231.
PaxDbiP41231.
PRIDEiP41231.

PTM databases

PhosphoSiteiP41231.

Expressioni

Tissue specificityi

Spleen, testis, kidney, liver, lung, heart and brain.

Gene expression databases

BgeeiP41231.
CleanExiHS_P2RY2.
GenevestigatoriP41231.

Organism-specific databases

HPAiCAB022642.

Interactioni

Protein-protein interaction databases

BioGridi111068. 2 interactions.
IntActiP41231. 1 interaction.
MINTiMINT-1796620.
STRINGi9606.ENSP00000310305.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]
ProteinModelPortaliP41231.
SMRiP41231. Positions 34-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147537.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP41231.
KOiK04269.
OMAiTRTLYYS.
OrthoDBiEOG7QNVM4.
PhylomeDBiP41231.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF17. PTHR24231:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41231-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL 
        60         70         80         90        100
NAVALYIFLC RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP 
       110        120        130        140        150
FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SLRWGRARYA 
       160        170        180        190        200
RRVAGAVWVL VLACQAPVLY FVTTSARGGR VTCHDTSAPE LFSRFVAYSS 
       210        220        230        240        250
VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK RKSVRTIAVV 
       260        270        280        290        300
LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC 
       310        320        330        340        350
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE 
       360        370 
DVLGSSEDSR RTESTPAGSE NTKDIRL
Length:377
Mass (Da):42,273
Last modified:November 2, 2010 - v4
Checksum:iF71DAF4A8DCB4062
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501E → G in AAC04923. (PubMed:8159738)Curated
Sequence conflicti359 – 3591S → F in AAC04923. (PubMed:8159738)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461P → L.5 Publications
Corresponds to variant rs2511241 [ dbSNP | Ensembl ].		VAR_054870
Natural varianti312 – 3121R → S.1 Publication
Corresponds to variant rs3741156 [ dbSNP | Ensembl ].		VAR_054871
Natural varianti334 – 3341R → C.2 Publications
Corresponds to variant rs1626154 [ dbSNP | Ensembl ].		VAR_054872

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07225 mRNA. Translation: AAC04923.1.
AY136753 mRNA. Translation: AAN01279.1.
AK313942 mRNA. Translation: BAG36660.1.
AP002761 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74882.1.
BC012104 mRNA. Translation: AAH12104.1.
BC028135 mRNA. Translation: AAH28135.1.
CCDSiCCDS8219.1.
PIRiA54946.
RefSeqiNP_002555.3. NM_002564.3.
NP_788085.2. NM_176071.2.
NP_788086.2. NM_176072.2.
XP_005274076.1. XM_005274019.2.
XP_005274077.1. XM_005274020.2.
XP_005274078.1. XM_005274021.2.
UniGeneiHs.339.
Hs.572077.

Genome annotation databases

EnsembliENST00000311131; ENSP00000310305; ENSG00000175591.
ENST00000393596; ENSP00000377221; ENSG00000175591.
ENST00000393597; ENSP00000377222; ENSG00000175591.
GeneIDi5029.
KEGGihsa:5029.
UCSCiuc001otj.4. human.

Polymorphism databases

DMDMi311033490.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07225 mRNA. Translation: AAC04923.1.
AY136753 mRNA. Translation: AAN01279.1.
AK313942 mRNA. Translation: BAG36660.1.
AP002761 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74882.1.
BC012104 mRNA. Translation: AAH12104.1.
BC028135 mRNA. Translation: AAH28135.1.
CCDSiCCDS8219.1.
PIRiA54946.
RefSeqiNP_002555.3. NM_002564.3.
NP_788085.2. NM_176071.2.
NP_788086.2. NM_176072.2.
XP_005274076.1. XM_005274019.2.
XP_005274077.1. XM_005274020.2.
XP_005274078.1. XM_005274021.2.
UniGeneiHs.339.
Hs.572077.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]
ProteinModelPortaliP41231.
SMRiP41231. Positions 34-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111068. 2 interactions.
IntActiP41231. 1 interaction.
MINTiMINT-1796620.
STRINGi9606.ENSP00000310305.

Chemistry

BindingDBiP41231.
ChEMBLiCHEMBL4398.
DrugBankiDB04786. Suramin.
GuidetoPHARMACOLOGYi324.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP41231.

Polymorphism databases

DMDMi311033490.

Proteomic databases

MaxQBiP41231.
PaxDbiP41231.
PRIDEiP41231.

Protocols and materials databases

DNASUi5029.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311131; ENSP00000310305; ENSG00000175591.
ENST00000393596; ENSP00000377221; ENSG00000175591.
ENST00000393597; ENSP00000377222; ENSG00000175591.
GeneIDi5029.
KEGGihsa:5029.
UCSCiuc001otj.4. human.

Organism-specific databases

CTDi5029.
GeneCardsiGC11P072929.
H-InvDBHIX0009916.
HGNCiHGNC:8541. P2RY2.
HPAiCAB022642.
MIMi600041. gene.
neXtProtiNX_P41231.
PharmGKBiPA32870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147537.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP41231.
KOiK04269.
OMAiTRTLYYS.
OrthoDBiEOG7QNVM4.
PhylomeDBiP41231.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
SignaLinkiP41231.

Miscellaneous databases

GeneWikiiP2RY2.
GenomeRNAii5029.
NextBioi19366.
PROiP41231.
SOURCEiSearch...

Gene expression databases

BgeeiP41231.
CleanExiHS_P2RY2.
GenevestigatoriP41231.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF17. PTHR24231:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy."
    Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T.
    Proc. Natl. Acad. Sci. U.S.A. 91:3275-3279(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-46.
    Tissue: Airway epithelium.
  2. "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy."
    Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T.
    Proc. Natl. Acad. Sci. U.S.A. 91:13067-13067(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-46.
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-46 AND CYS-334.
    Tissue: Pericardium.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-46 AND CYS-334.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-46 AND SER-312.
    Tissue: Kidney and Leukocyte.
+Additional computationally mapped references.

Entry informationi

Entry nameiP2RY2_HUMAN
AccessioniPrimary (citable) accession number: P41231
Secondary accession number(s): B2R9W3, Q96EM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.