Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

P2Y purinoceptor 2

Gene

P2RY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

GO - Molecular functioni

  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-5683826 Surfactant metabolism
SignaLinkiP41231

Protein family/group databases

TCDBi9.A.14.13.16 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 2
Short name:
P2Y2
Alternative name(s):
ATP receptor
P2U purinoceptor 1
Short name:
P2U1
P2U receptor 1
Purinergic receptor
Gene namesi
Name:P2RY2
Synonyms:P2RU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175591.11
HGNCiHGNC:8541 P2RY2
MIMi600041 gene
neXtProtiNX_P41231

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 59Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini60 – 70CytoplasmicSequence analysisAdd BLAST11
Transmembranei71 – 93Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini94 – 110ExtracellularSequence analysisAdd BLAST17
Transmembranei111 – 129Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini130 – 152CytoplasmicSequence analysisAdd BLAST23
Transmembranei153 – 172Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini173 – 194ExtracellularSequence analysisAdd BLAST22
Transmembranei195 – 220Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini221 – 246CytoplasmicSequence analysisAdd BLAST26
Transmembranei247 – 269Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini270 – 287ExtracellularSequence analysisAdd BLAST18
Transmembranei288 – 309Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini310 – 377CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5029
OpenTargetsiENSG00000175591
PharmGKBiPA32870

Chemistry databases

ChEMBLiCHEMBL4398
DrugBankiDB04983 Denufosol
DB05390 INS 316
DB04786 Suramin
GuidetoPHARMACOLOGYi324

Polymorphism and mutation databases

DMDMi311033490

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700131 – 377P2Y purinoceptor 2Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP41231
MaxQBiP41231
PaxDbiP41231
PeptideAtlasiP41231
PRIDEiP41231

PTM databases

iPTMnetiP41231
PhosphoSitePlusiP41231

Expressioni

Tissue specificityi

Spleen, testis, kidney, liver, lung, heart and brain.

Gene expression databases

BgeeiENSG00000175591
CleanExiHS_P2RY2
GenevisibleiP41231 HS

Organism-specific databases

HPAiCAB022642

Interactioni

Protein-protein interaction databases

BioGridi111068, 3 interactors
CORUMiP41231
IntActiP41231, 1 interactor
MINTiP41231
STRINGi9606.ENSP00000310305

Chemistry databases

BindingDBiP41231

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]
ProteinModelPortaliP41231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIAQ Eukaryota
ENOG410XQNZ LUCA
GeneTreeiENSGT00910000144002
HOGENOMiHOG000231307
HOVERGENiHBG101120
InParanoidiP41231
KOiK04269
OMAiCISVHRC
OrthoDBiEOG091G09D4
PhylomeDBiP41231
TreeFamiTF350009

Family and domain databases

CDDicd15373 7tmA_P2Y2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000356 P2Y2_rcpt
PANTHERiPTHR24231:SF17 PTHR24231:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00594 P2Y2PRNOCPTR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P41231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL
60 70 80 90 100
NAVALYIFLC RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP
110 120 130 140 150
FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SLRWGRARYA
160 170 180 190 200
RRVAGAVWVL VLACQAPVLY FVTTSARGGR VTCHDTSAPE LFSRFVAYSS
210 220 230 240 250
VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK RKSVRTIAVV
260 270 280 290 300
LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC
310 320 330 340 350
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE
360 370
DVLGSSEDSR RTESTPAGSE NTKDIRL
Length:377
Mass (Da):42,273
Last modified:November 2, 2010 - v4
Checksum:iF71DAF4A8DCB4062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti350E → G in AAC04923 (PubMed:8159738).Curated1
Sequence conflicti359S → F in AAC04923 (PubMed:8159738).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05487046P → L5 PublicationsCorresponds to variant dbSNP:rs2511241Ensembl.1
Natural variantiVAR_054871312R → S1 PublicationCorresponds to variant dbSNP:rs3741156Ensembl.1
Natural variantiVAR_054872334R → C2 PublicationsCorresponds to variant dbSNP:rs1626154Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07225 mRNA Translation: AAC04923.1
AY136753 mRNA Translation: AAN01279.1
AK313942 mRNA Translation: BAG36660.1
AP002761 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74882.1
BC012104 mRNA Translation: AAH12104.1
BC028135 mRNA Translation: AAH28135.1
CCDSiCCDS8219.1
PIRiA54946
RefSeqiNP_002555.3, NM_002564.3
NP_788085.2, NM_176071.2
NP_788086.2, NM_176072.2
XP_005274076.1, XM_005274019.4
XP_005274077.1, XM_005274020.4
XP_005274078.1, XM_005274021.4
XP_011543376.1, XM_011545074.2
XP_016873328.1, XM_017017839.1
UniGeneiHs.339
Hs.572077

Genome annotation databases

EnsembliENST00000311131; ENSP00000310305; ENSG00000175591
ENST00000393596; ENSP00000377221; ENSG00000175591
ENST00000393597; ENSP00000377222; ENSG00000175591
GeneIDi5029
KEGGihsa:5029
UCSCiuc001otj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP2RY2_HUMAN
AccessioniPrimary (citable) accession number: P41231
Secondary accession number(s): B2R9W3, Q96EM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 169 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health