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UniProtKB - P41231 (P2RY2_HUMAN)

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Protein

P2Y purinoceptor 2

Gene

P2RY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

GO - Molecular functioni

  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • receptor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  • cellular ion homeostasis Source: ProtInc
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  • positive regulation of mucus secretion Source: InterPro
  • regulation of blood vessel diameter Source: InterPro
Complete GO annotation...

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
R-HSA-5683826. Surfactant metabolism.
SignaLinkiP41231.

Protein family/group databases

TCDBi9.A.14.13.16. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 2
Short name:
P2Y2
Alternative name(s):
ATP receptor
P2U purinoceptor 1
Short name:
P2U1
P2U receptor 1
Purinergic receptor
Gene namesi
Name:P2RY2
Synonyms:P2RU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8541. P2RY2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 59Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini60 – 70CytoplasmicSequence analysisAdd BLAST11
Transmembranei71 – 93Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini94 – 110ExtracellularSequence analysisAdd BLAST17
Transmembranei111 – 129Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini130 – 152CytoplasmicSequence analysisAdd BLAST23
Transmembranei153 – 172Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini173 – 194ExtracellularSequence analysisAdd BLAST22
Transmembranei195 – 220Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini221 – 246CytoplasmicSequence analysisAdd BLAST26
Transmembranei247 – 269Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini270 – 287ExtracellularSequence analysisAdd BLAST18
Transmembranei288 – 309Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini310 – 377CytoplasmicSequence analysisAdd BLAST68

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5029.
OpenTargetsiENSG00000175591.
PharmGKBiPA32870.

Chemistry databases

ChEMBLiCHEMBL4398.
DrugBankiDB04983. Denufosol.
DB05390. INS 316.
DB04786. Suramin.
GuidetoPHARMACOLOGYi324.

Polymorphism and mutation databases

DMDMi311033490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700131 – 377P2Y purinoceptor 2Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP41231.
MaxQBiP41231.
PaxDbiP41231.
PeptideAtlasiP41231.
PRIDEiP41231.

PTM databases

iPTMnetiP41231.
PhosphoSitePlusiP41231.

Expressioni

Tissue specificityi

Spleen, testis, kidney, liver, lung, heart and brain.

Gene expression databases

BgeeiENSG00000175591.
CleanExiHS_P2RY2.
GenevisibleiP41231. HS.

Organism-specific databases

HPAiCAB022642.

Interactioni

Protein-protein interaction databases

BioGridi111068. 2 interactors.
IntActiP41231. 1 interactor.
MINTiMINT-1796620.
STRINGi9606.ENSP00000310305.

Chemistry databases

BindingDBiP41231.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]
ProteinModelPortaliP41231.
SMRiP41231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIAQ. Eukaryota.
ENOG410XQNZ. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP41231.
KOiK04269.
OMAiCISVHRC.
OrthoDBiEOG091G09D4.
PhylomeDBiP41231.
TreeFamiTF350009.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
PANTHERiPTHR24231:SF62. PTHR24231:SF62. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P41231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL 
        60         70         80         90        100
NAVALYIFLC RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP 
       110        120        130        140        150
FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SLRWGRARYA 
       160        170        180        190        200
RRVAGAVWVL VLACQAPVLY FVTTSARGGR VTCHDTSAPE LFSRFVAYSS 
       210        220        230        240        250
VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK RKSVRTIAVV 
       260        270        280        290        300
LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC 
       310        320        330        340        350
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE 
       360        370 
DVLGSSEDSR RTESTPAGSE NTKDIRL
Length:377
Mass (Da):42,273
Last modified:November 2, 2010 - v4
Checksum:iF71DAF4A8DCB4062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti350E → G in AAC04923 (PubMed:8159738).Curated1
Sequence conflicti359S → F in AAC04923 (PubMed:8159738).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05487046P → L5 PublicationsCorresponds to variant dbSNP:rs2511241Ensembl.1
Natural variantiVAR_054871312R → S1 PublicationCorresponds to variant dbSNP:rs3741156Ensembl.1
Natural variantiVAR_054872334R → C2 PublicationsCorresponds to variant dbSNP:rs1626154Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07225 mRNA. Translation: AAC04923.1.
AY136753 mRNA. Translation: AAN01279.1.
AK313942 mRNA. Translation: BAG36660.1.
AP002761 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74882.1.
BC012104 mRNA. Translation: AAH12104.1.
BC028135 mRNA. Translation: AAH28135.1.
CCDSiCCDS8219.1.
PIRiA54946.
RefSeqiNP_002555.3. NM_002564.3.
NP_788085.2. NM_176071.2.
NP_788086.2. NM_176072.2.
XP_005274076.1. XM_005274019.4.
XP_005274077.1. XM_005274020.4.
XP_005274078.1. XM_005274021.4.
XP_011543376.1. XM_011545074.2.
XP_016873328.1. XM_017017839.1.
UniGeneiHs.339.
Hs.572077.

Genome annotation databases

EnsembliENST00000311131; ENSP00000310305; ENSG00000175591.
ENST00000393596; ENSP00000377221; ENSG00000175591.
ENST00000393597; ENSP00000377222; ENSG00000175591.
GeneIDi5029.
KEGGihsa:5029.
UCSCiuc001otj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07225 mRNA. Translation: AAC04923.1.
AY136753 mRNA. Translation: AAN01279.1.
AK313942 mRNA. Translation: BAG36660.1.
AP002761 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74882.1.
BC012104 mRNA. Translation: AAH12104.1.
BC028135 mRNA. Translation: AAH28135.1.
CCDSiCCDS8219.1.
PIRiA54946.
RefSeqiNP_002555.3. NM_002564.3.
NP_788085.2. NM_176071.2.
NP_788086.2. NM_176072.2.
XP_005274076.1. XM_005274019.4.
XP_005274077.1. XM_005274020.4.
XP_005274078.1. XM_005274021.4.
XP_011543376.1. XM_011545074.2.
XP_016873328.1. XM_017017839.1.
UniGeneiHs.339.
Hs.572077.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]
ProteinModelPortaliP41231.
SMRiP41231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111068. 2 interactors.
IntActiP41231. 1 interactor.
MINTiMINT-1796620.
STRINGi9606.ENSP00000310305.

Chemistry databases

BindingDBiP41231.
ChEMBLiCHEMBL4398.
DrugBankiDB04983. Denufosol.
DB05390. INS 316.
DB04786. Suramin.
GuidetoPHARMACOLOGYi324.

Protein family/group databases

TCDBi9.A.14.13.16. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP41231.
PhosphoSitePlusiP41231.

Polymorphism and mutation databases

DMDMi311033490.

Proteomic databases

EPDiP41231.
MaxQBiP41231.
PaxDbiP41231.
PeptideAtlasiP41231.
PRIDEiP41231.

Protocols and materials databases

DNASUi5029.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311131; ENSP00000310305; ENSG00000175591.
ENST00000393596; ENSP00000377221; ENSG00000175591.
ENST00000393597; ENSP00000377222; ENSG00000175591.
GeneIDi5029.
KEGGihsa:5029.
UCSCiuc001otj.5. human.

Organism-specific databases

CTDi5029.
DisGeNETi5029.
GeneCardsiP2RY2.
H-InvDBiHIX0009916.
HGNCiHGNC:8541. P2RY2.
HPAiCAB022642.
MIMi600041. gene.
neXtProtiNX_P41231.
OpenTargetsiENSG00000175591.
PharmGKBiPA32870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIAQ. Eukaryota.
ENOG410XQNZ. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP41231.
KOiK04269.
OMAiCISVHRC.
OrthoDBiEOG091G09D4.
PhylomeDBiP41231.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
R-HSA-5683826. Surfactant metabolism.
SignaLinkiP41231.

Miscellaneous databases

GeneWikiiP2RY2.
GenomeRNAii5029.
PROiPR:P41231.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175591.
CleanExiHS_P2RY2.
GenevisibleiP41231. HS.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
PANTHERiPTHR24231:SF62. PTHR24231:SF62. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY2_HUMAN
AccessioniPrimary (citable) accession number: P41231
Secondary accession number(s): B2R9W3, Q96EM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: May 10, 2017
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.