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P41231

- P2RY2_HUMAN

UniProt

P41231 - P2RY2_HUMAN

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Protein

P2Y purinoceptor 2

Gene

P2RY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. cellular ion homeostasis Source: ProtInc
  2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  3. positive regulation of mucus secretion Source: Ensembl
  4. regulation of vasodilation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
SignaLinkiP41231.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 2
Short name:
P2Y2
Alternative name(s):
ATP receptor
P2U purinoceptor 1
Short name:
P2U1
P2U receptor 1
Purinergic receptor
Gene namesi
Name:P2RY2
Synonyms:P2RU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8541. P2RY2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5927Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini60 – 7011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei71 – 9323Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 11017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei111 – 12919Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 15223CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini173 – 19422ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 22026Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 24626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei247 – 26923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini270 – 28718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30922Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 37768CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377P2Y purinoceptor 2PRO_0000070013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP41231.
PaxDbiP41231.
PRIDEiP41231.

PTM databases

PhosphoSiteiP41231.

Expressioni

Tissue specificityi

Spleen, testis, kidney, liver, lung, heart and brain.

Gene expression databases

BgeeiP41231.
CleanExiHS_P2RY2.
GenevestigatoriP41231.

Organism-specific databases

HPAiCAB022642.

Interactioni

Protein-protein interaction databases

BioGridi111068. 2 interactions.
IntActiP41231. 1 interaction.
MINTiMINT-1796620.
STRINGi9606.ENSP00000310305.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z8Emodel-A1-377[»]
ProteinModelPortaliP41231.
SMRiP41231. Positions 34-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147537.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP41231.
KOiK04269.
OMAiAVILVCY.
OrthoDBiEOG7QNVM4.
PhylomeDBiP41231.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF17. PTHR24231:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41231-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL
60 70 80 90 100
NAVALYIFLC RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP
110 120 130 140 150
FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SLRWGRARYA
160 170 180 190 200
RRVAGAVWVL VLACQAPVLY FVTTSARGGR VTCHDTSAPE LFSRFVAYSS
210 220 230 240 250
VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK RKSVRTIAVV
260 270 280 290 300
LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC
310 320 330 340 350
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE
360 370
DVLGSSEDSR RTESTPAGSE NTKDIRL
Length:377
Mass (Da):42,273
Last modified:November 2, 2010 - v4
Checksum:iF71DAF4A8DCB4062
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501E → G in AAC04923. (PubMed:8159738)Curated
Sequence conflicti359 – 3591S → F in AAC04923. (PubMed:8159738)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461P → L.5 Publications
Corresponds to variant rs2511241 [ dbSNP | Ensembl ].
VAR_054870
Natural varianti312 – 3121R → S.1 Publication
Corresponds to variant rs3741156 [ dbSNP | Ensembl ].
VAR_054871
Natural varianti334 – 3341R → C.2 Publications
Corresponds to variant rs1626154 [ dbSNP | Ensembl ].
VAR_054872

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07225 mRNA. Translation: AAC04923.1.
AY136753 mRNA. Translation: AAN01279.1.
AK313942 mRNA. Translation: BAG36660.1.
AP002761 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74882.1.
BC012104 mRNA. Translation: AAH12104.1.
BC028135 mRNA. Translation: AAH28135.1.
CCDSiCCDS8219.1.
PIRiA54946.
RefSeqiNP_002555.3. NM_002564.3.
NP_788085.2. NM_176071.2.
NP_788086.2. NM_176072.2.
XP_005274076.1. XM_005274019.2.
XP_005274077.1. XM_005274020.2.
XP_005274078.1. XM_005274021.2.
UniGeneiHs.339.
Hs.572077.

Genome annotation databases

EnsembliENST00000311131; ENSP00000310305; ENSG00000175591.
ENST00000393596; ENSP00000377221; ENSG00000175591.
ENST00000393597; ENSP00000377222; ENSG00000175591.
GeneIDi5029.
KEGGihsa:5029.
UCSCiuc001otj.4. human.

Polymorphism databases

DMDMi311033490.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07225 mRNA. Translation: AAC04923.1 .
AY136753 mRNA. Translation: AAN01279.1 .
AK313942 mRNA. Translation: BAG36660.1 .
AP002761 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74882.1 .
BC012104 mRNA. Translation: AAH12104.1 .
BC028135 mRNA. Translation: AAH28135.1 .
CCDSi CCDS8219.1.
PIRi A54946.
RefSeqi NP_002555.3. NM_002564.3.
NP_788085.2. NM_176071.2.
NP_788086.2. NM_176072.2.
XP_005274076.1. XM_005274019.2.
XP_005274077.1. XM_005274020.2.
XP_005274078.1. XM_005274021.2.
UniGenei Hs.339.
Hs.572077.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Z8E model - A 1-377 [» ]
ProteinModelPortali P41231.
SMRi P41231. Positions 34-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111068. 2 interactions.
IntActi P41231. 1 interaction.
MINTi MINT-1796620.
STRINGi 9606.ENSP00000310305.

Chemistry

BindingDBi P41231.
ChEMBLi CHEMBL4398.
DrugBanki DB04786. Suramin.
GuidetoPHARMACOLOGYi 324.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P41231.

Polymorphism databases

DMDMi 311033490.

Proteomic databases

MaxQBi P41231.
PaxDbi P41231.
PRIDEi P41231.

Protocols and materials databases

DNASUi 5029.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311131 ; ENSP00000310305 ; ENSG00000175591 .
ENST00000393596 ; ENSP00000377221 ; ENSG00000175591 .
ENST00000393597 ; ENSP00000377222 ; ENSG00000175591 .
GeneIDi 5029.
KEGGi hsa:5029.
UCSCi uc001otj.4. human.

Organism-specific databases

CTDi 5029.
GeneCardsi GC11P072929.
H-InvDB HIX0009916.
HGNCi HGNC:8541. P2RY2.
HPAi CAB022642.
MIMi 600041. gene.
neXtProti NX_P41231.
PharmGKBi PA32870.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147537.
GeneTreei ENSGT00760000118784.
HOGENOMi HOG000231307.
HOVERGENi HBG101120.
InParanoidi P41231.
KOi K04269.
OMAi AVILVCY.
OrthoDBi EOG7QNVM4.
PhylomeDBi P41231.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.
SignaLinki P41231.

Miscellaneous databases

GeneWikii P2RY2.
GenomeRNAii 5029.
NextBioi 19366.
PROi P41231.
SOURCEi Search...

Gene expression databases

Bgeei P41231.
CleanExi HS_P2RY2.
Genevestigatori P41231.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000356. P2Y2_rcpt.
[Graphical view ]
PANTHERi PTHR24231:SF17. PTHR24231:SF17. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00594. P2Y2PRNOCPTR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy."
    Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T.
    Proc. Natl. Acad. Sci. U.S.A. 91:3275-3279(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-46.
    Tissue: Airway epithelium.
  2. "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy."
    Parr C.E., Sullivan D.M., Paradiso A.M., Lazarowski E.R., Burch L.H., Olsen J.C., Erb L., Weisman G.A., Boucher R.C., Turner J.T.
    Proc. Natl. Acad. Sci. U.S.A. 91:13067-13067(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-46.
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-46 AND CYS-334.
    Tissue: Pericardium.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-46 AND CYS-334.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-46 AND SER-312.
    Tissue: Kidney and Leukocyte.

Entry informationi

Entry nameiP2RY2_HUMAN
AccessioniPrimary (citable) accession number: P41231
Secondary accession number(s): B2R9W3, Q96EM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3