UniProtKB - P41231 (P2RY2_HUMAN)
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Protein
P2Y purinoceptor 2
Gene
P2RY2
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
GO - Molecular functioni
- G-protein coupled purinergic nucleotide receptor activity Source: InterPro
- receptor activity Source: ProtInc
GO - Biological processi
- cellular ion homeostasis Source: ProtInc
- G-protein coupled receptor signaling pathway Source: Reactome
- phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
- positive regulation of mucus secretion Source: InterPro
- regulation of blood vessel diameter Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-416476. G alpha (q) signalling events. R-HSA-417957. P2Y receptors. R-HSA-5683826. Surfactant metabolism. |
SignaLinki | P41231. |
Protein family/group databases
TCDBi | 9.A.14.13.16. the g-protein-coupled receptor (gpcr) family. |
Names & Taxonomyi
Protein namesi | Recommended name: P2Y purinoceptor 2Short name: P2Y2 Alternative name(s): ATP receptor P2U purinoceptor 1 Short name: P2U1 P2U receptor 1 Purinergic receptor |
Gene namesi | Name:P2RY2 Synonyms:P2RU1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175591.11. |
HGNCi | HGNC:8541. P2RY2. |
MIMi | 600041. gene. |
neXtProti | NX_P41231. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 59 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 60 – 70 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 71 – 93 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 94 – 110 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 111 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 19 | |
Topological domaini | 130 – 152 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 153 – 172 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 173 – 194 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 195 – 220 | Helical; Name=5Sequence analysisAdd BLAST | 26 | |
Topological domaini | 221 – 246 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 247 – 269 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 270 – 287 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 288 – 309 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 310 – 377 | CytoplasmicSequence analysisAdd BLAST | 68 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5029. |
OpenTargetsi | ENSG00000175591. |
PharmGKBi | PA32870. |
Chemistry databases
ChEMBLi | CHEMBL4398. |
DrugBanki | DB04983. Denufosol. DB05390. INS 316. DB04786. Suramin. |
GuidetoPHARMACOLOGYi | 324. |
Polymorphism and mutation databases
DMDMi | 311033490. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070013 | 1 – 377 | P2Y purinoceptor 2Add BLAST | 377 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 106 ↔ 183 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P41231. |
MaxQBi | P41231. |
PaxDbi | P41231. |
PeptideAtlasi | P41231. |
PRIDEi | P41231. |
PTM databases
iPTMneti | P41231. |
PhosphoSitePlusi | P41231. |
Expressioni
Tissue specificityi
Spleen, testis, kidney, liver, lung, heart and brain.
Gene expression databases
Bgeei | ENSG00000175591. |
CleanExi | HS_P2RY2. |
Genevisiblei | P41231. HS. |
Organism-specific databases
HPAi | CAB022642. |
Interactioni
Protein-protein interaction databases
BioGridi | 111068. 3 interactors. |
CORUMi | P41231. |
IntActi | P41231. 1 interactor. |
MINTi | P41231. |
STRINGi | 9606.ENSP00000310305. |
Chemistry databases
BindingDBi | P41231. |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z8E | model | - | A | 1-377 | [»] | |
ProteinModelPortali | P41231. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IIAQ. Eukaryota. ENOG410XQNZ. LUCA. |
GeneTreei | ENSGT00910000144002. |
HOGENOMi | HOG000231307. |
HOVERGENi | HBG101120. |
InParanoidi | P41231. |
KOi | K04269. |
OMAi | CISVHRC. |
OrthoDBi | EOG091G09D4. |
PhylomeDBi | P41231. |
TreeFami | TF350009. |
Family and domain databases
CDDi | cd15373. 7tmA_P2Y2. 1 hit. |
InterProi | View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000356. P2Y2_rcpt. |
PANTHERi | PTHR24231:SF17. PTHR24231:SF17. 1 hit. |
Pfami | View protein in Pfam PF00001. 7tm_1. 1 hit. |
PRINTSi | PR00237. GPCRRHODOPSN. PR00594. P2Y2PRNOCPTR. |
PROSITEi | View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P41231-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL
60 70 80 90 100
NAVALYIFLC RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP
110 120 130 140 150
FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SLRWGRARYA
160 170 180 190 200
RRVAGAVWVL VLACQAPVLY FVTTSARGGR VTCHDTSAPE LFSRFVAYSS
210 220 230 240 250
VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK RKSVRTIAVV
260 270 280 290 300
LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC
310 320 330 340 350
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE
360 370
DVLGSSEDSR RTESTPAGSE NTKDIRL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 350 | E → G in AAC04923 (PubMed:8159738).Curated | 1 | |
Sequence conflicti | 359 | S → F in AAC04923 (PubMed:8159738).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054870 | 46 | P → L5 PublicationsCorresponds to variant dbSNP:rs2511241Ensembl. | 1 | |
Natural variantiVAR_054871 | 312 | R → S1 PublicationCorresponds to variant dbSNP:rs3741156Ensembl. | 1 | |
Natural variantiVAR_054872 | 334 | R → C2 PublicationsCorresponds to variant dbSNP:rs1626154Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07225 mRNA. Translation: AAC04923.1. AY136753 mRNA. Translation: AAN01279.1. AK313942 mRNA. Translation: BAG36660.1. AP002761 Genomic DNA. No translation available. CH471076 Genomic DNA. Translation: EAW74882.1. BC012104 mRNA. Translation: AAH12104.1. BC028135 mRNA. Translation: AAH28135.1. |
CCDSi | CCDS8219.1. |
PIRi | A54946. |
RefSeqi | NP_002555.3. NM_002564.3. NP_788085.2. NM_176071.2. NP_788086.2. NM_176072.2. XP_005274076.1. XM_005274019.4. XP_005274077.1. XM_005274020.4. XP_005274078.1. XM_005274021.4. XP_011543376.1. XM_011545074.2. XP_016873328.1. XM_017017839.1. |
UniGenei | Hs.339. Hs.572077. |
Genome annotation databases
Ensembli | ENST00000311131; ENSP00000310305; ENSG00000175591. ENST00000393596; ENSP00000377221; ENSG00000175591. ENST00000393597; ENSP00000377222; ENSG00000175591. |
GeneIDi | 5029. |
KEGGi | hsa:5029. |
UCSCi | uc001otj.5. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | P2RY2_HUMAN | |
Accessioni | P41231Primary (citable) accession number: P41231 Secondary accession number(s): B2R9W3, Q96EM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | November 2, 2010 | |
Last modified: | March 28, 2018 | |
This is version 168 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |