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P41230

- KDM5C_MOUSE

UniProt

P41230 - KDM5C_MOUSE

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Protein

Lysine-specific demethylase 5C

Gene

Kdm5c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements By similarity. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.By similarity1 Publication

Cofactori

Alpha-ketoglutarate.By similarity
Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi514 – 5141Iron; catalyticPROSITE-ProRule annotation
Metal bindingi517 – 5171Iron; catalyticPROSITE-ProRule annotation
Metal bindingi602 – 6021Iron; catalyticPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri326 – 37247PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1187 – 124862PHD-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone demethylase activity (H3-K4 specific) Source: Ensembl
  3. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of circadian rhythm Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase 5C (EC:1.14.11.-)
Alternative name(s):
Histone demethylase JARID1C
Jumonji/ARID domain-containing protein 1C
Protein SmcX
Protein Xe169
Gene namesi
Name:Kdm5c
Synonyms:Jarid1c, Kiaa0234, Smcx, Xe169
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:99781. Kdm5c.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15541554Lysine-specific demethylase 5CPRO_0000200587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei317 – 3171PhosphoserineBy similarity
Modified residuei1353 – 13531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP41230.
PaxDbiP41230.
PRIDEiP41230.

PTM databases

PhosphoSiteiP41230.

Expressioni

Gene expression databases

BgeeiP41230.
ExpressionAtlasiP41230. baseline and differential.
GenevestigatoriP41230.

Interactioni

Subunit structurei

Part of two distinct complexes, one containing E2F6, and the other containing REST.By similarity

Protein-protein interaction databases

BioGridi203341. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP41230.
SMRiP41230. Positions 13-188, 261-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 5542JmjNPROSITE-ProRule annotationAdd
BLAST
Domaini79 – 16991ARIDPROSITE-ProRule annotationAdd
BLAST
Domaini468 – 634167JmjCPROSITE-ProRule annotationAdd
BLAST

Domaini

The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.By similarity
Both the JmjC domain and the JmjN domain are required for enzymatic activity.By similarity

Sequence similaritiesi

Belongs to the JARID1 histone demethylase family.Curated
Contains 1 ARID domain.PROSITE-ProRule annotation
Contains 1 JmjC domain.PROSITE-ProRule annotation
Contains 1 JmjN domain.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri326 – 37247PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1187 – 124862PHD-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG327026.
GeneTreeiENSGT00530000063118.
InParanoidiP41230.
KOiK11446.
OMAiTTSICVC.
OrthoDBiEOG7D85VK.
PhylomeDBiP41230.
TreeFamiTF106476.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR001606. ARID/BRIGHT_DNA-bd.
IPR003347. JmjC_dom.
IPR013637. Lys_sp_deMease_like_dom.
IPR003349. TF_JmjN.
IPR019786. Zinc_finger_PHD-type_CS.
IPR004198. Znf_C5HC2.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
PF02373. JmjC. 1 hit.
PF02375. JmjN. 1 hit.
PF00628. PHD. 1 hit.
PF08429. PLU-1. 1 hit.
PF02928. zf-C5HC2. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
SM00558. JmjC. 1 hit.
SM00545. JmjN. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiPS51011. ARID. 1 hit.
PS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P41230-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGSDDFLP PPECPVFEPS WAEFRDPLGY IAKIRPIAEK SGICKIRPPA
60 70 80 90 100
DWQPPFAVEV DNFRFTPRIQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL
110 120 130 140 150
KIPNVERRIL DLYSLSKIVV EEGGYETICK DRRWARVAQR LNYPPGKNIG
160 170 180 190 200
SLLRSHYERI VYPYEMYQSG ANLVQCNTRP FDNEEKDKEY KPHSIPLRQS
210 220 230 240 250
VQPSKFNSYG RRAKRLQPDP EPTEEDIEKN PELKKLQIYG AGPKMMGLGL
260 270 280 290 300
MAKDKTLRKK DKEGPECPPT VVVKEELGGD VKMESTSPKT FLEGKEELSH
310 320 330 340 350
SPEPCTKMTM RLRRNHSNAQ FIESYVCRMC SRGDEDDKLL LCDGCDDNYH
360 370 380 390 400
IFCLLPPLPE IPKGVWRCPK CVMAECKRPP EAFGFEQATR EYTLQSFGEM
410 420 430 440 450
ADSFKADYFN MPVHMVPTEL VEKEFWRLVN SIEEDVTVEY GADIHSKEFG
460 470 480 490 500
SGFPVSDSKR HLTPEEEEYA TSGWNLNVMP VLEQSVLCHI NADISGMKVP
510 520 530 540 550
WLYVGMVFSA FCWHIEDHWS YSINYLHWGE PKTWYGVPSL AAEHLEEVMK
560 570 580 590 600
KLTPELFDSQ PDLLHQLVTL MNPNTLMSHG VPVVRTNQCA GEFVITFPRA
610 620 630 640 650
YHSGFNQGYN FAEAVNFCTA DWLPAGRQCI EHYRRLRRYC VFSHEELICK
660 670 680 690 700
MAACPEKLDL NLAAAVHKEM FIMVQEERRL RKALLEKGIT EAEREAFELL
710 720 730 740 750
PDDERQCIKC KTTCFLSALA CYDCPDGLVC LSHINDLCKC SSSRQYLRYR
760 770 780 790 800
YTLDELPAML HKLKVRAESF DTWANKVRVA LEVEDGRKRS LEELRALESE
810 820 830 840 850
ARERRFPNSE LLQRLKNCLS EAEACVSRAL GLVSGQEAGP DRVAGLQMTL
860 870 880 890 900
AELRDFLGQM NNLPCAMHQI GDVKGILEQV EAYQTEAREA LVSQPSSPGL
910 920 930 940 950
LQSLLERGQQ LGVEVPEAQQ LQRQVEQARW LDEVKRTLAP SARRGTLAIM
960 970 980 990 1000
RGLLVAGASV APSPAVDKAQ AELQELLTIA ERWEEKAHLC LEARQKHPPA
1010 1020 1030 1040 1050
TLEAIIHEAE NIPVHLPNIQ SLKEALAKAR AWIADVDEIQ NGDHYPCLDD
1060 1070 1080 1090 1100
LEGLVAVGRD LPVGLEELRQ LELQVLTAHS WREKASKTFL KKNSCYTLLE
1110 1120 1130 1140 1150
VLCPCADAGS DSTKRSRWME KELGLYKSDT ELLGLSAQDL RDPGSVIVAF
1160 1170 1180 1190 1200
KEGEQKEKEG ILQLRRTNSA KPSPLALLTT ASSTASICVC GQVPAGVGAL
1210 1220 1230 1240 1250
QCDLCQDWFH GRCVTVPRLL SSQRSSLPSS PLLAWWEWDT KFLCPLCMRS
1260 1270 1280 1290 1300
RRPRLETILA LLVALQRLPV RLPEGEALQC LTERAISWQG RARQVLASEE
1310 1320 1330 1340 1350
VTALLGRLAE LRQRLQAESK PEESLAYPSD GGEGTGNMPK VQGLLENGDS
1360 1370 1380 1390 1400
VTSPEKVATE EGSGKRDLEL LSSILPQLSG PVLELPEATR APLEELMMEG
1410 1420 1430 1440 1450
DLLEVTLDEN HSIWQLLQAG QPPDLKRVQT LLELEKAERH GSRTRGRALE
1460 1470 1480 1490 1500
RRRRRKVDRG GEPDDPAREE LEPKRVRSSG PEAEEVQEEE ELEEETGGEV
1510 1520 1530 1540 1550
PPVPFPNSGS PSIQEDQDGL EPVLEAGSDT SAPFSTLTSR LLMSCPQQPS

LQQL
Length:1,554
Mass (Da):175,313
Last modified:June 26, 2007 - v4
Checksum:i585EA9F890B0D9A0
GO
Isoform 2 (identifier: P41230-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1364-1366: Missing.

Show »
Length:1,551
Mass (Da):174,972
Checksum:iC2061676EA2DC238
GO
Isoform 3 (identifier: P41230-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-117: Missing.
     1364-1366: Missing.

Show »
Length:1,510
Mass (Da):170,154
Checksum:iBAA3698F0A0A1E24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31L → M in AAB96762. (PubMed:9723615)Curated
Sequence conflicti26 – 261D → G in AAB96762. (PubMed:9723615)Curated
Sequence conflicti123 – 1231G → S in BAE33161. (PubMed:16141072)Curated
Sequence conflicti123 – 1231G → S in BAE33260. (PubMed:16141072)Curated
Sequence conflicti249 – 2491G → D in BAE34464. (PubMed:16141072)Curated
Sequence conflicti726 – 7261D → N in BAC97906. (PubMed:14621295)Curated
Sequence conflicti865 – 8651C → L in AAD53049. (PubMed:10441747)Curated
Sequence conflicti865 – 8651C → L in CAA82759. (PubMed:7951230)Curated
Sequence conflicti1068 – 10681L → P in CAA82759. (PubMed:7951230)Curated
Sequence conflicti1126 – 11261Y → C in BAE33367. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei77 – 11741Missing in isoform 3. 1 PublicationVSP_026411Add
BLAST
Alternative sequencei1364 – 13663Missing in isoform 2 and isoform 3. 3 PublicationsVSP_000316

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF127245 mRNA. Translation: AAD53049.1.
AK008105 mRNA. Translation: BAB25462.1.
AK155279 mRNA. Translation: BAE33161.1.
AK155427 mRNA. Translation: BAE33260.1.
AK155651 mRNA. Translation: BAE33367.1.
AK158340 mRNA. Translation: BAE34464.1.
AK011577 mRNA. No translation available.
BC043096 mRNA. Translation: AAH43096.1.
BC054550 mRNA. Translation: AAH54550.1.
Z29651 mRNA. Translation: CAA82759.1.
AK129096 mRNA. Translation: BAC97906.1.
L29563 mRNA. Translation: AAA62384.1.
AF039894 mRNA. Translation: AAB96762.1.
CCDSiCCDS41178.1. [P41230-2]
PIRiI48775.
I84689.
RefSeqiNP_038696.2. NM_013668.4. [P41230-2]
XP_006528832.1. XM_006528769.1. [P41230-1]
XP_006528835.1. XM_006528772.1. [P41230-3]
UniGeneiMm.142655.
Mm.482277.

Genome annotation databases

EnsembliENSMUST00000082177; ENSMUSP00000080814; ENSMUSG00000025332. [P41230-3]
ENSMUST00000112584; ENSMUSP00000108203; ENSMUSG00000025332. [P41230-1]
ENSMUST00000112588; ENSMUSP00000108207; ENSMUSG00000025332. [P41230-2]
GeneIDi20591.
KEGGimmu:20591.
UCSCiuc009uqc.2. mouse. [P41230-2]
uc009uqd.2. mouse. [P41230-3]
uc009uqe.2. mouse. [P41230-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF127245 mRNA. Translation: AAD53049.1 .
AK008105 mRNA. Translation: BAB25462.1 .
AK155279 mRNA. Translation: BAE33161.1 .
AK155427 mRNA. Translation: BAE33260.1 .
AK155651 mRNA. Translation: BAE33367.1 .
AK158340 mRNA. Translation: BAE34464.1 .
AK011577 mRNA. No translation available.
BC043096 mRNA. Translation: AAH43096.1 .
BC054550 mRNA. Translation: AAH54550.1 .
Z29651 mRNA. Translation: CAA82759.1 .
AK129096 mRNA. Translation: BAC97906.1 .
L29563 mRNA. Translation: AAA62384.1 .
AF039894 mRNA. Translation: AAB96762.1 .
CCDSi CCDS41178.1. [P41230-2 ]
PIRi I48775.
I84689.
RefSeqi NP_038696.2. NM_013668.4. [P41230-2 ]
XP_006528832.1. XM_006528769.1. [P41230-1 ]
XP_006528835.1. XM_006528772.1. [P41230-3 ]
UniGenei Mm.142655.
Mm.482277.

3D structure databases

ProteinModelPortali P41230.
SMRi P41230. Positions 13-188, 261-616.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203341. 2 interactions.

PTM databases

PhosphoSitei P41230.

Proteomic databases

MaxQBi P41230.
PaxDbi P41230.
PRIDEi P41230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082177 ; ENSMUSP00000080814 ; ENSMUSG00000025332 . [P41230-3 ]
ENSMUST00000112584 ; ENSMUSP00000108203 ; ENSMUSG00000025332 . [P41230-1 ]
ENSMUST00000112588 ; ENSMUSP00000108207 ; ENSMUSG00000025332 . [P41230-2 ]
GeneIDi 20591.
KEGGi mmu:20591.
UCSCi uc009uqc.2. mouse. [P41230-2 ]
uc009uqd.2. mouse. [P41230-3 ]
uc009uqe.2. mouse. [P41230-1 ]

Organism-specific databases

CTDi 8242.
MGIi MGI:99781. Kdm5c.
Rougei Search...

Phylogenomic databases

eggNOGi NOG327026.
GeneTreei ENSGT00530000063118.
InParanoidi P41230.
KOi K11446.
OMAi TTSICVC.
OrthoDBi EOG7D85VK.
PhylomeDBi P41230.
TreeFami TF106476.

Miscellaneous databases

ChiTaRSi KDM5C. mouse.
NextBioi 298901.
PROi P41230.
SOURCEi Search...

Gene expression databases

Bgeei P41230.
ExpressionAtlasi P41230. baseline and differential.
Genevestigatori P41230.

Family and domain databases

Gene3Di 1.10.150.60. 1 hit.
3.30.40.10. 2 hits.
InterProi IPR001606. ARID/BRIGHT_DNA-bd.
IPR003347. JmjC_dom.
IPR013637. Lys_sp_deMease_like_dom.
IPR003349. TF_JmjN.
IPR019786. Zinc_finger_PHD-type_CS.
IPR004198. Znf_C5HC2.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01388. ARID. 1 hit.
PF02373. JmjC. 1 hit.
PF02375. JmjN. 1 hit.
PF00628. PHD. 1 hit.
PF08429. PLU-1. 1 hit.
PF02928. zf-C5HC2. 1 hit.
[Graphical view ]
SMARTi SM00501. BRIGHT. 1 hit.
SM00558. JmjC. 1 hit.
SM00545. JmjN. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view ]
SUPFAMi SSF46774. SSF46774. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEi PS51011. ARID. 1 hit.
PS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx."
    Agulnik A.I., Longepied G., Ty M.T., Bishop C.E., Mitchell M.J.
    Mamm. Genome 10:926-929(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell, Embryo, Inner ear and Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human."
    Agulnik A.I., Mitchell M.J., Mattei M.-G., Borsani G., Avner P.A., Lerner J.L., Bishop C.E.
    Hum. Mol. Genet. 3:879-884(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-1068.
    Strain: BALB/c.
    Tissue: Testis.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-1554 (ISOFORM 1).
    Tissue: Embryonic tail.
  6. "The murine Xe169 gene escapes X-inactivation like its human homologue."
    Wu J., Salido E., Yen P., Mohandas T., Shapiro L.J.
    Nat. Genet. 7:491-496(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1206-1385 (ISOFORM 1).
  7. "A proposed path by which genes common to mammalian X and Y chromosomes evolve to become X inactivated."
    Jegalian K.G., Page D.C.
    Nature 394:776-780(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-39.
  8. "Identification of a mouse male-specific transplantation antigen, H-Y."
    Scott D.M., Ehrmann I.E., Ellis P.S., Bishop C.E., Agulnik A.I., Simpson E., Mitchell M.J.
    Nature 376:695-698(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: C3H.
  9. "Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock."
    DiTacchio L., Le H.D., Vollmers C., Hatori M., Witcher M., Secombe J., Panda S.
    Science 333:1881-1885(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKDM5C_MOUSE
AccessioniPrimary (citable) accession number: P41230
Secondary accession number(s): O54995
, Q3TYU8, Q3U1X6, Q3U282, Q6ZQF8, Q80XQ9, Q9CVI4, Q9D0C3, Q9QVR8, Q9R039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: June 26, 2007
Last modified: October 29, 2014
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Escapes X-inactivation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3