ID   SOX3_HUMAN              Reviewed;         446 AA.
AC   P41225; P35714; Q5JWI3; Q9NP49;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 2.
DT   24-JAN-2024, entry version 184.
DE   RecName: Full=Transcription factor SOX-3;
GN   Name=SOX3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8111369; DOI=10.1093/hmg/2.12.2013;
RA   Stevanovic M., Lovell-Badge R., Collignon J., Goodfellow P.N.;
RT   "SOX3 is an X-linked gene related to SRY.";
RL   Hum. Mol. Genet. 2:2013-2018(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Gorry M.C., Hart P.S., Sashi V., Hart T.C.;
RT   "Clarification of the genomic sequence for human SOX3.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 150-203.
RX   PubMed=1614875; DOI=10.1093/nar/20.11.2887;
RA   Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.;
RT   "A conserved family of genes related to the testis determining gene, SRY.";
RL   Nucleic Acids Res. 20:2887-2887(1992).
RN   [6]
RP   FUNCTION, AND INVOLVEMENT IN SRXX3.
RX   PubMed=21183788; DOI=10.1172/jci42580;
RA   Sutton E., Hughes J., White S., Sekido R., Tan J., Arboleda V., Rogers N.,
RA   Knower K., Rowley L., Eyre H., Rizzoti K., McAninch D., Goncalves J.,
RA   Slee J., Turbitt E., Bruno D., Bengtsson H., Harley V., Vilain E.,
RA   Sinclair A., Lovell-Badge R., Thomas P.;
RT   "Identification of SOX3 as an XX male sex reversal gene in mice and
RT   humans.";
RL   J. Clin. Invest. 121:328-341(2011).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [8]
RP   9AATAD MOTIF.
RX   PubMed=34342803; DOI=10.1007/s12015-021-10225-8;
RA   Piskacek M., Otasevic T., Repko M., Knight A.;
RT   "The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4,
RT   Sox2, Myc, and Klf4.";
RL   Stem. Cell. Rev. Rep. 17:1934-1936(2021).
RN   [9]
RP   VARIANT MRXGH ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-248 INS.
RX   PubMed=12428212; DOI=10.1086/344661;
RA   Laumonnier F., Ronce N., Hamel B.C.J., Thomas P., Lespinasse J.,
RA   Raynaud M., Paringaux C., Van Bokhoven H., Kalscheuer V., Fryns J.-P.,
RA   Chelly J., Moraine C., Briault S.;
RT   "Transcription factor SOX3 is involved in X-linked mental retardation with
RT   growth hormone deficiency.";
RL   Am. J. Hum. Genet. 71:1450-1455(2002).
RN   [10]
RP   VARIANT PHPX ALA-ALA-ALA-ALA-ALA-ALA-ALA-248 INS, AND VARIANT THR-43.
RX   PubMed=15800844; DOI=10.1086/430134;
RA   Woods K.S., Cundall M., Turton J., Rizotti K., Mehta A., Palmer R.,
RA   Wong J., Chong W.K., Al-Zyoud M., El-Ali M., Otonkoski T.,
RA   Martinez-Barbera J.-P., Thomas P.Q., Robinson I.C., Lovell-Badge R.,
RA   Woodward K.J., Dattani M.T.;
RT   "Over- and underdosage of SOX3 is associated with infundibular hypoplasia
RT   and hypopituitarism.";
RL   Am. J. Hum. Genet. 76:833-849(2005).
RN   [11]
RP   INVOLVEMENT IN HYPX, AND CHROMOSOMAL REARRANGEMENT.
RX   PubMed=16167084; DOI=10.1172/jci24156;
RA   Bowl M.R., Nesbit M.A., Harding B., Levy E., Jefferson A., Volpi E.,
RA   Rizzoti K., Lovell-Badge R., Schlessinger D., Whyte M.P., Thakker R.V.;
RT   "An interstitial deletion-insertion involving chromosomes 2p25.3 and
RT   Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism.";
RL   J. Clin. Invest. 115:2822-2831(2005).
CC   -!- FUNCTION: Transcription factor required during the formation of the
CC       hypothalamo-pituitary axis. May function as a switch in neuronal
CC       development. Keeps neural cells undifferentiated by counteracting the
CC       activity of proneural proteins and suppresses neuronal differentiation.
CC       Required also within the pharyngeal epithelia for craniofacial
CC       morphogenesis. Controls a genetic switch in male development. Is
CC       necessary for initiating male sex determination by directing the
CC       development of supporting cell precursors (pre-Sertoli cells) as
CC       Sertoli rather than granulosa cells (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:21183788}.
CC   -!- SUBUNIT: Interacts with SOX2 and FGFR1. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P41225; P54253: ATXN1; NbExp=3; IntAct=EBI-9078386, EBI-930964;
CC       P41225; O43186: CRX; NbExp=3; IntAct=EBI-9078386, EBI-748171;
CC       P41225; Q12933: TRAF2; NbExp=3; IntAct=EBI-9078386, EBI-355744;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000269|PubMed:34342803}.
CC   -!- DISEASE: Panhypopituitarism X-linked (PHPX) [MIM:312000]: Affected
CC       individuals have absent infundibulum, anterior pituitary hypoplasia,
CC       and ectopic posterior pituitary. {ECO:0000269|PubMed:15800844}.
CC       Note=The disease is caused by variants affecting the gene represented
CC       in this entry.
CC   -!- DISEASE: Intellectual developmental disorder, X-linked, with isolated
CC       growth hormone deficiency (MRXGH) [MIM:300123]: A disorder
CC       characterized by the association of variable degrees of intellectual
CC       disability with panhypopituitarism, variable combinations of
CC       hypothyroidism, delayed pubertal development, and short stature due to
CC       growth hormone deficiency. {ECO:0000269|PubMed:12428212}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
CC   -!- DISEASE: 46,XX sex reversal 3 (SRXX3) [MIM:300833]: A condition in
CC       which male gonads develop in a genetic female (female to male sex
CC       reversal). {ECO:0000269|PubMed:21183788}. Note=The disease is caused by
CC       variants affecting the gene represented in this entry. Copy number
CC       variations (CNV) encompassing or in close proximity to SOX3 are
CC       responsible for XX male reversal. These variations include two
CC       duplications of approximately 123 kb and 85 kb, the former of which
CC       spans the entire SOX3 gene; a 343 kb deletion immediately upstream of
CC       SOX3 that is probably responsible of altered regulation (and not
CC       increased dosage) of SOX3; a large (approximately 6 Mb) duplication
CC       that encompasses SOX3 and at least 18 additional distally located
CC       genes. Its proximal breakpoint falls within the SOX3 regulatory region.
CC       This large rearrangement has been found in a patient with XX male
CC       reversal and a complex phenotype that also includes a scrotal
CC       hypoplasia, microcephaly, developmental delay, and growth retardation.
CC   -!- DISEASE: Hypoparathyroidism, X-linked (HYPX) [MIM:307700]: An X-linked
CC       form of true hypoparathyroidism characterized by neonatal or infantile
CC       onset and absence of parathyroid glands. Clinical features are
CC       hypocalcemia, hyperphosphatemia, seizures, tetany and cramps.
CC       {ECO:0000269|PubMed:16167084}. Note=The gene represented in this entry
CC       may be involved in disease pathogenesis. A disease causing, complex
CC       chromosomal rearrangement [del(X)(q27.1)inv ins(X;2)(q27.1;p25.3)] has
CC       been found in a family with X-linked hypoparathyroidism. This
CC       chromosomal abnormality is located 67 kb downstream of SOX3 and likely
CC       results in altered SOX3 expression with pathological consequences.
CC       {ECO:0000269|PubMed:16167084}.
CC   -!- CAUTION: Was originally termed SOX-9. {ECO:0000305|PubMed:1614875}.
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DR   EMBL; X71135; CAA50465.1; -; Genomic_DNA.
DR   EMBL; AF264713; AAF73059.1; -; Genomic_DNA.
DR   EMBL; AL121875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC093863; AAH93863.1; -; mRNA.
DR   EMBL; BC093865; AAH93865.1; -; mRNA.
DR   EMBL; X65665; CAA46616.1; -; mRNA.
DR   CCDS; CCDS14669.1; -.
DR   PIR; I38239; I38239.
DR   PIR; S22942; S22942.
DR   RefSeq; NP_005625.2; NM_005634.2.
DR   AlphaFoldDB; P41225; -.
DR   SMR; P41225; -.
DR   BioGRID; 112541; 17.
DR   IntAct; P41225; 4.
DR   STRING; 9606.ENSP00000359567; -.
DR   GlyGen; P41225; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P41225; -.
DR   PhosphoSitePlus; P41225; -.
DR   BioMuta; SOX3; -.
DR   DMDM; 48429228; -.
DR   EPD; P41225; -.
DR   jPOST; P41225; -.
DR   MassIVE; P41225; -.
DR   PaxDb; 9606-ENSP00000359567; -.
DR   PeptideAtlas; P41225; -.
DR   ProteomicsDB; 55433; -.
DR   Antibodypedia; 16808; 327 antibodies from 34 providers.
DR   DNASU; 6658; -.
DR   Ensembl; ENST00000370536.5; ENSP00000359567.2; ENSG00000134595.9.
DR   GeneID; 6658; -.
DR   KEGG; hsa:6658; -.
DR   MANE-Select; ENST00000370536.5; ENSP00000359567.2; NM_005634.3; NP_005625.2.
DR   UCSC; uc004fbd.2; human.
DR   AGR; HGNC:11199; -.
DR   CTD; 6658; -.
DR   DisGeNET; 6658; -.
DR   GeneCards; SOX3; -.
DR   GeneReviews; SOX3; -.
DR   HGNC; HGNC:11199; SOX3.
DR   HPA; ENSG00000134595; Tissue enhanced (brain, fallopian tube, testis).
DR   MalaCards; SOX3; -.
DR   MIM; 300123; phenotype.
DR   MIM; 300833; phenotype.
DR   MIM; 307700; phenotype.
DR   MIM; 312000; phenotype.
DR   MIM; 313430; gene.
DR   neXtProt; NX_P41225; -.
DR   OpenTargets; ENSG00000134595; -.
DR   Orphanet; 393; 46,XX testicular difference of sex development.
DR   Orphanet; 90695; Non-acquired panhypopituitarism.
DR   Orphanet; 3157; Septo-optic dysplasia spectrum.
DR   Orphanet; 79495; X-linked congenital generalized hypertrichosis.
DR   Orphanet; 67045; X-linked intellectual disability with isolated growth hormone deficiency.
DR   PharmGKB; PA36036; -.
DR   VEuPathDB; HostDB:ENSG00000134595; -.
DR   eggNOG; KOG0527; Eukaryota.
DR   GeneTree; ENSGT00940000162359; -.
DR   HOGENOM; CLU_021123_0_0_1; -.
DR   InParanoid; P41225; -.
DR   OMA; GWSNGAY; -.
DR   OrthoDB; 2902801at2759; -.
DR   PhylomeDB; P41225; -.
DR   TreeFam; TF351735; -.
DR   PathwayCommons; P41225; -.
DR   Reactome; R-HSA-3769402; Deactivation of the beta-catenin transactivating complex.
DR   SignaLink; P41225; -.
DR   SIGNOR; P41225; -.
DR   BioGRID-ORCS; 6658; 15 hits in 789 CRISPR screens.
DR   GeneWiki; SOX3; -.
DR   GenomeRNAi; 6658; -.
DR   Pharos; P41225; Tbio.
DR   PRO; PR:P41225; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; P41225; Protein.
DR   Bgee; ENSG00000134595; Expressed in ventricular zone and 44 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; TAS:ProtInc.
DR   GO; GO:0060324; P:face development; ISS:UniProtKB.
DR   GO; GO:0021854; P:hypothalamus development; ISS:UniProtKB.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021983; P:pituitary gland development; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007423; P:sensory organ development; ISS:UniProtKB.
DR   GO; GO:0007530; P:sex determination; IMP:UniProtKB.
DR   CDD; cd01388; HMG-box_SoxB; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR   PANTHER; PTHR10270:SF111; TRANSCRIPTION FACTOR SOX-3; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   Genevisible; P41225; HS.
PE   1: Evidence at protein level;
KW   Developmental protein; Disease variant; DNA-binding;
KW   Intellectual disability; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..446
FT                   /note="Transcription factor SOX-3"
FT                   /id="PRO_0000048720"
FT   DNA_BIND        139..207
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          29..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           399..407
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000269|PubMed:34342803"
FT   VARIANT         43
FT                   /note="A -> T (in dbSNP:rs73637709)"
FT                   /evidence="ECO:0000269|PubMed:15800844"
FT                   /id="VAR_026451"
FT   VARIANT         248
FT                   /note="A -> AAAAAAAA (in PHPX; reduced transcriptional
FT                   activity and impaired nuclear localization)"
FT                   /evidence="ECO:0000269|PubMed:15800844"
FT                   /id="VAR_026452"
FT   VARIANT         248
FT                   /note="A -> AAAAAAAAAAAA (in MRXGH)"
FT                   /evidence="ECO:0000269|PubMed:12428212"
FT                   /id="VAR_033258"
FT   CONFLICT        159
FT                   /note="L -> Q (in Ref. 5; CAA46616)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176
FT                   /note="D -> E (in Ref. 5; CAA46616)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202
FT                   /note="E -> D (in Ref. 5; CAA46616)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        297..299
FT                   /note="Missing (in Ref. 2; CAA50465)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   446 AA;  45210 MW;  F79E79C2D16BB929 CRC64;
     MRPVRENSSG ARSPRVPADL ARSILISLPF PPDSLAHRPP SSAPTESQGL FTVAAPAPGA
     PSPPATLAHL LPAPAMYSLL ETELKNPVGT PTQAAGTGGP AAPGGAGKSS ANAAGGANSG
     GGSSGGASGG GGGTDQDRVK RPMNAFMVWS RGQRRKMALE NPKMHNSEIS KRLGADWKLL
     TDAEKRPFID EAKRLRAVHM KEYPDYKYRP RRKTKTLLKK DKYSLPSGLL PPGAAAAAAA
     AAAAAAAASS PVGVGQRLDT YTHVNGWANG AYSLVQEQLG YAQPPSMSSP PPPPALPPMH
     RYDMAGLQYS PMMPPGAQSY MNVAAAAAAA SGYGGMAPSA TAAAAAAYGQ QPATAAAAAA
     AAAAMSLGPM GSVVKSEPSS PPPAIASHSQ RACLGDLRDM ISMYLPPGGD AADAASPLPG
     GRLHGVHQHY QGAGTAVNGT VPLTHI
//