P41223 (BUD31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein BUD31 homolog

Alternative name(s):
Protein EDG-2
Protein G10 homolog

Gene names

Name:	BUD31
Synonyms:	EDG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the BUD31 (G10) family.

Ontologies

Keywords
Cellular component	Nucleus
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	nucleus Traceable author statement. Source: ProtInc
Molecular function	sequence-specific DNA binding transcription factor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 144	144	Protein BUD31 homolog		PRO_0000193897
Regions
	Motif	2 – 10	9	Nuclear localization signal Potential
Amino acid modifications
	Modified residue	125	1	N6-acetyllysine Ref.7
Experimental info
	Sequence conflict	12	1	P → Q in AAA20008. Ref.1
	Sequence conflict	12	1	P → Q in AAB33291. Ref.1
	Sequence conflict	24	1	E → Q in AAA20008. Ref.1
	Sequence conflict	24	1	E → Q in AAB33291. Ref.1
	Sequence conflict	70	1	I → Y in AAA20008. Ref.1
	Sequence conflict	70	1	I → Y in AAB33291. Ref.1
	Sequence conflict	75 – 79	5	YEYCI → LDICY in AAA20008. Ref.1
	Sequence conflict	83	1	Y → L in AAA20008. Ref.1
	Sequence conflict	83	1	Y → L in AAB33291. Ref.1
	Sequence conflict	89	1	I → L in AAA20008. Ref.1
	Sequence conflict	89	1	I → L in AAB33291. Ref.1
	Sequence conflict	97 – 98	2	YE → IG in AAA20008. Ref.1
	Sequence conflict	97 – 98	2	YE → IG in AAB33291. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P41223 [UniParc]. Last modified October 10, 2002. Version 2. Checksum: 520B8E74C97D0926	FASTA	144	17,000
	10 20 30 40 50 60 MPKVKRSRKA PPDGWELIEP TLDELDQKMR EAETEPHEGK RKVESLWPIF RIHHQKTRYI 70 80 90 100 110 120 FDLFYKRKAI SRELYEYCIK EGYADKNLIA KWKKQGYENL CCLRCIQTRD TNFGTNCICR 130 140 VPKSKLEVGR IIECTHCGCR GCSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells." Hla T., Jackson A.Q., Appleby S.B., Maciag T. Biochim. Biophys. Acta 1260:227-229(1995) [PubMed: 7841202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[7]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-125, MASS SPECTROMETRY.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U11861 mRNA. Translation: AAA20008.1. S77329 mRNA. Translation: AAB33291.1. CR456951 mRNA. Translation: CAG33232.1. AC004922 Genomic DNA. No translation available. CH236956 Genomic DNA. Translation: EAL23881.1. CH471091 Genomic DNA. Translation: EAW76670.1. CH471091 Genomic DNA. Translation: EAW76672.1. CH471091 Genomic DNA. Translation: EAW76673.1. BC022821 mRNA. Translation: AAH22821.1. BC104670 mRNA. Translation: AAI04671.1.
IPI	IPI00013180.
PIR	S52131.
RefSeq	NP_003901.2. NM_003910.3.
UniGene	Hs.380233.
3D structure databases
ProteinModelPortal	P41223.
ModBase	Search...
Protein-protein interaction databases
IntAct	P41223. 2 interactions.
STRING	P41223.
PTM databases
PhosphoSite	P41223.
Polymorphism databases
DMDM	23831082.
Proteomic databases
PeptideAtlas	P41223.
PRIDE	P41223.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222969; ENSP00000222969; ENSG00000106245. ENST00000403633; ENSP00000386023; ENSG00000106245.
GeneID	8896.
KEGG	hsa:8896.
UCSC	uc003uqf.1. human.
Organism-specific databases
CTD	8896.
GeneCards	GC07P099006.
H-InvDB	HIX0025322.
HGNC	HGNC:29629. BUD31.
HPA	HPA028943.
MIM	603477. gene.
neXtProt	NX_P41223.
PharmGKB	PA144596513.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000014300.
HOGENOM	HBG328980.
HOVERGEN	HBG080938.
InParanoid	P41223.
OMA	SRYIFDL.
OrthoDB	EOG47M202.
PhylomeDB	P41223.
Gene expression databases
ArrayExpress	P41223.
Bgee	P41223.
CleanEx	HS_BUD31.
Genevestigator	P41223.
GermOnline	ENSG00000106245. Homo sapiens.
Family and domain databases
InterPro	IPR018230. BUD31/G10-rel_CS. IPR001748. G10. [Graphical view]
KO	K12873.
PANTHER	PTHR19411. G10. 1 hit.
Pfam	PF01125. G10. 1 hit. [Graphical view]
PRINTS	PR00322. G10.
PROSITE	PS00997. G10_1. 1 hit. PS00998. G10_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	33411.
SOURCE	Search...

Entry information

Entry name

BUD31_HUMAN

Accession

Primary (citable) accession number: P41223
Secondary accession number(s): A4D274 , D6W5S6, Q6IB53, Q9UDV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	October 10, 2002
Last modified:	January 25, 2012
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.