Reviewed, UniProtKB/Swiss-Prot P41223 (BUD31_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein BUD31 homolog
Alternative name(s):
    Protein G10 homolog
    EDG-2

Gene names

Name:	BUD31
Synonyms:	EDG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the BUD31 (G10) family.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Ref.1 Traceable author statement. Source: ProtInc
Molecular function	transcription factor activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 144	144	Protein BUD31 homolog		PRO_0000193897
Regions
	Zinc finger	101 – 119	19	Potential
	Motif	2 – 10	9	Nuclear localization signal Potential
Experimental info
	Sequence conflict	12	1	P → Q in AAA20008. Ref.1
	Sequence conflict	12	1	P → Q in AAB33291. Ref.1
	Sequence conflict	24	1	E → Q in AAA20008. Ref.1
	Sequence conflict	24	1	E → Q in AAB33291. Ref.1
	Sequence conflict	70	1	I → Y in AAA20008. Ref.1
	Sequence conflict	70	1	I → Y in AAB33291. Ref.1
	Sequence conflict	75 – 79	5	YEYCI → LDICY in AAA20008. Ref.1
	Sequence conflict	83	1	Y → L in AAA20008. Ref.1
	Sequence conflict	83	1	Y → L in AAB33291. Ref.1
	Sequence conflict	89	1	I → L in AAA20008. Ref.1
	Sequence conflict	89	1	I → L in AAB33291. Ref.1
	Sequence conflict	97 – 98	2	YE → IG in AAA20008. Ref.1
	Sequence conflict	97 – 98	2	YE → IG in AAB33291. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P41223-1 [UniParc]. Last modified October 10, 2002. Version 2. Checksum: 520B8E74C97D0926	FASTA	144	17,000
	10 20 30 40 50 60 MPKVKRSRKA PPDGWELIEP TLDELDQKMR EAETEPHEGK RKVESLWPIF RIHHQKTRYI 70 80 90 100 110 120 FDLFYKRKAI SRELYEYCIK EGYADKNLIA KWKKQGYENL CCLRCIQTRD TNFGTNCICR 130 140 VPKSKLEVGR IIECTHCGCR GCSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells." Hla T., Jackson A.Q., Appleby S.B., Maciag T. Biochim. Biophys. Acta 1260:227-229(1995) [PubMed: 7841202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U11861 mRNA. Translation: AAA20008.1. S77329 mRNA. Translation: AAB33291.1. CR456951 mRNA. Translation: CAG33232.1. AC004922 Genomic DNA. No translation available. BC022821 mRNA. Translation: AAH22821.1. BC104670 mRNA. Translation: AAI04671.1.
IPI	IPI00013180.
PIR	S52131.
RefSeq	NP_003901.2.
UniGene	Hs.380233
3D structure databases
ModBase	Search...
Proteomic databases
PeptideAtlas	P41223.
PRIDE	P41223.
Genome annotation databases
Ensembl	ENSG00000106245. Homo sapiens. [Contig view]
GeneID	8896.
KEGG	hsa:8896.
Organism-specific databases
GeneCards	GC07P098844.
HGNC	HGNC:29629. BUD31.
MIM	603477. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P41223.
OMA	P41223. PPPDGWE.
Gene expression databases
Bgee	P41223.
CleanEx	HS_BUD31.
GermOnline	ENSG00000106245. Homo sapiens.
Family and domain databases
InterPro	IPR018230. BUD31/G10-rel_CS. IPR001748. G10. [Graphical view]
PANTHER	PTHR19411. G10. 1 hit.
Pfam	PF01125. G10. 1 hit. [Graphical view]
PRINTS	PR00322. G10.
ProDom	PD009460. G10. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00997. G10_1. 1 hit. PS00998. G10_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33411.
SOURCE	Search...

Entry information

Entry name

BUD31_HUMAN

Accession

Primary (citable) accession number: P41223
Secondary accession number(s): Q6IB53, Q9UDV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	October 10, 2002
Last modified:	June 16, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)