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Protein

Protein BUD31 homolog

Gene

BUD31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  • nuclear hormone receptor binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • positive regulation of androgen receptor activity Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BUD31 homolog
Alternative name(s):
Protein EDG-2
Protein G10 homolog
Gene namesi
Name:BUD31
Synonyms:EDG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:29629. BUD31.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: ProtInc
  • spliceosomal complex Source: GO_Central

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8896.
OpenTargetsiENSG00000106245.
PharmGKBiPA144596513.

Polymorphism and mutation databases

BioMutaiBUD31.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938971 – 144Protein BUD31 homologAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP41223.
MaxQBiP41223.
PaxDbiP41223.
PeptideAtlasiP41223.
PRIDEiP41223.

PTM databases

iPTMnetiP41223.
PhosphoSitePlusiP41223.

Expressioni

Gene expression databases

BgeeiENSG00000106245.
CleanExiHS_BUD31.
ExpressionAtlasiP41223. baseline and differential.
GenevisibleiP41223. HS.

Organism-specific databases

HPAiHPA028943.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • nuclear hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114413. 47 interactors.
IntActiP41223. 11 interactors.
MINTiMINT-3015365.
STRINGi9606.ENSP00000222969.

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi60 – 65Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OEDX-ray2.79B56-70[»]
4OH6X-ray3.56B56-70[»]
4OKBX-ray2.95B56-70[»]
5MQFelectron microscopy5.90Q1-144[»]
ProteinModelPortaliP41223.
SMRiP41223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2 – 10Nuclear localization signalSequence analysis9

Sequence similaritiesi

Belongs to the BUD31 (G10) family.Curated

Phylogenomic databases

eggNOGiKOG3404. Eukaryota.
COG5132. LUCA.
GeneTreeiENSGT00390000014300.
HOGENOMiHOG000235066.
HOVERGENiHBG080938.
InParanoidiP41223.
KOiK12873.
OMAiCRGCSSD.
OrthoDBiEOG091G0PEI.
PhylomeDBiP41223.
TreeFamiTF105609.

Family and domain databases

InterProiView protein in InterPro
IPR018230. BUD31/G10-rel_CS.
IPR001748. G10.
PANTHERiPTHR19411. PTHR19411. 1 hit.
PfamiView protein in Pfam
PF01125. G10. 1 hit.
PRINTSiPR00322. G10.
PROSITEiView protein in PROSITE
PS00997. G10_1. 1 hit.
PS00998. G10_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41223-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKVKRSRKA PPDGWELIEP TLDELDQKMR EAETEPHEGK RKVESLWPIF
60 70 80 90 100
RIHHQKTRYI FDLFYKRKAI SRELYEYCIK EGYADKNLIA KWKKQGYENL
110 120 130 140
CCLRCIQTRD TNFGTNCICR VPKSKLEVGR IIECTHCGCR GCSG
Length:144
Mass (Da):17,000
Last modified:October 10, 2002 - v2
Checksum:i520B8E74C97D0926
GO
Isoform 2 (identifier: P41223-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-144: GRIIECTHCGCRGCSG → VMSDTQAWCCFQLKILP

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):17,331
Checksum:i00598D743480CF95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → Q in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti12P → Q in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti24E → Q in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti24E → Q in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti70I → Y in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti70I → Y in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti75 – 79YEYCI → LDICY in AAA20008 (PubMed:7841202).Curated5
Sequence conflicti83Y → L in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti83Y → L in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti89I → L in AAA20008 (PubMed:7841202).Curated1
Sequence conflicti89I → L in AAB33291 (PubMed:7841202).Curated1
Sequence conflicti97 – 98YE → IG in AAA20008 (PubMed:7841202).Curated2
Sequence conflicti97 – 98YE → IG in AAB33291 (PubMed:7841202).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055558129 – 144GRIIE…RGCSG → VMSDTQAWCCFQLKILP in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11861 mRNA. Translation: AAA20008.1.
S77329 mRNA. Translation: AAB33291.1.
AK297784 mRNA. Translation: BAH12665.1.
AK316477 mRNA. Translation: BAH14848.1.
CR456951 mRNA. Translation: CAG33232.1.
AC004922 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23881.1.
CH471091 Genomic DNA. Translation: EAW76670.1.
CH471091 Genomic DNA. Translation: EAW76671.1.
CH471091 Genomic DNA. Translation: EAW76672.1.
CH471091 Genomic DNA. Translation: EAW76673.1.
BC022821 mRNA. Translation: AAH22821.1.
BC104670 mRNA. Translation: AAI04671.1.
CCDSiCCDS5663.1. [P41223-1]
PIRiS52131.
RefSeqiNP_003901.2. NM_003910.3. [P41223-1]
XP_005250727.1. XM_005250670.4. [P41223-2]
XP_005250728.1. XM_005250671.4. [P41223-2]
XP_005250731.1. XM_005250674.3. [P41223-1]
XP_016868249.1. XM_017012760.1. [P41223-2]
XP_016868250.1. XM_017012761.1. [P41223-2]
XP_016868251.1. XM_017012762.1. [P41223-1]
UniGeneiHs.380233.

Genome annotation databases

EnsembliENST00000222969; ENSP00000222969; ENSG00000106245. [P41223-1]
ENST00000403633; ENSP00000386023; ENSG00000106245. [P41223-1]
GeneIDi8896.
KEGGihsa:8896.
UCSCiuc003uqf.4. human. [P41223-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBUD31_HUMAN
AccessioniPrimary (citable) accession number: P41223
Secondary accession number(s): A4D274
, B7Z4S9, D6W5S6, Q6IB53, Q9UDV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 10, 2002
Last modified: June 7, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families