P41221 (WNT5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-5a

Gene names

Name:

WNT5A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. Ref.5 Ref.6
Subunit structure	Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). Ref.5
Post-translational modification	Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding By similarity. Glycosylation is necessary for secretion but not for activity By similarity. Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-104. Palmitoylation is necessary for proper trafficking to cell surface By similarity. Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A By similarity.
Involvement in disease	Robinow syndrome autosomal dominant (DRS) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing
Disease	Disease mutation Dwarfism
Domain	Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway, calcium modulating pathway Inferred from mutant phenotype PubMed 17986384. Source: UniProtKB Wnt receptor signaling pathway, planar cell polarity pathway Inferred from Biological aspect of Ancestor. Source: RefGenome activation of JUN kinase activity Inferred from direct assay PubMed 20034610. Source: BHF-UCL activation of protein kinase B activity Inferred from direct assay PubMed 20034610. Source: BHF-UCL ameboidal cell migration Inferred from electronic annotation. Source: Compara anterior/posterior axis specification, embryo Inferred from electronic annotation. Source: Compara axon guidance Inferred from sequence or structural similarity. Source: UniProtKB canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: UniProtKB-KW cellular protein localization Inferred from direct assay PubMed 19177143. Source: UniProtKB cellular response to calcium ion Inferred from expression pattern PubMed 18703641. Source: UniProtKB cellular response to interferon-gamma Inferred from expression pattern PubMed 18174455. Source: UniProtKB cellular response to lipopolysaccharide Inferred from expression pattern PubMed 18174455. Source: UniProtKB cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB cellular response to transforming growth factor beta stimulus Inferred from expression pattern PubMed 15040835. Source: UniProtKB cervix development Inferred from Biological aspect of Ancestor. Source: RefGenome cochlea morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome convergent extension involved in organogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome digestive tract morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome dopaminergic neuron differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome dorsal/ventral axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome embryonic digit morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome embryonic skeletal system development Inferred from mutant phenotype Ref.7. Source: BHF-UCL epithelial cell proliferation involved in mammary gland duct elongation Inferred from Biological aspect of Ancestor. Source: RefGenome epithelial to mesenchymal transition Inferred from expression pattern PubMed 12841867. Source: UniProtKB establishment of planar polarity Inferred from electronic annotation. Source: Compara face development Inferred from mutant phenotype Ref.7. Source: BHF-UCL heart looping Inferred from Biological aspect of Ancestor. Source: RefGenome hematopoietic stem cell proliferation Inferred from direct assay PubMed 9787155. Source: BHF-UCL hindgut morphogenesis Inferred from electronic annotation. Source: Compara hypophysis morphogenesis Inferred from electronic annotation. Source: Compara keratinocyte differentiation Inferred from expression pattern PubMed 19399181. Source: BHF-UCL lateral sprouting involved in mammary gland duct morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome lens development in camera-type eye Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL lung development Inferred from electronic annotation. Source: Compara male gonad development Inferred from expression pattern PubMed 17848411. Source: UniProtKB mammary gland branching involved in thelarche Inferred from Biological aspect of Ancestor. Source: RefGenome mesenchymal-epithelial cell signaling Inferred from electronic annotation. Source: Compara midgut development Inferred from electronic annotation. Source: Compara negative chemotaxis Inferred from electronic annotation. Source: Compara negative regulation of BMP signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of apoptotic process Inferred from direct assay PubMed 19251946. Source: UniProtKB negative regulation of axon extension involved in axon guidance Inferred from electronic annotation. Source: Compara negative regulation of canonical Wnt receptor signaling pathway Inferred from direct assay PubMed 17976063. Source: UniProtKB negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of fat cell differentiation Inferred from mutant phenotype PubMed 20032469. Source: BHF-UCL negative regulation of fibroblast growth factor receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of mesenchymal cell proliferation Inferred from direct assay PubMed 19878652. Source: UniProtKB negative regulation of prostatic bud formation Inferred from electronic annotation. Source: Compara negative regulation of synapse assembly Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 19277043. Source: UniProtKB neural tube closure Inferred from Biological aspect of Ancestor. Source: RefGenome non-canonical Wnt receptor signaling pathway via JNK cascade Inferred from electronic annotation. Source: Compara olfactory bulb interneuron development Inferred from sequence or structural similarity. Source: UniProtKB optic cup formation involved in camera-type eye development Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL palate development Inferred from mutant phenotype PubMed 18413325. Source: BHF-UCL pericardium morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara planar cell polarity pathway involved in cardiac right atrium morphogenesis Inferred from electronic annotation. Source: Compara planar cell polarity pathway involved in neural tube closure Inferred from electronic annotation. Source: Compara planar cell polarity pathway involved in outflow tract morphogenesis Inferred from electronic annotation. Source: Compara planar cell polarity pathway involved in pericardium morphogenesis Inferred from electronic annotation. Source: Compara planar cell polarity pathway involved in ventricular septum morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of JNK cascade Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of NF-kappaB transcription factor activity Inferred from direct assay PubMed 18287027. Source: UniProtKB positive regulation of T cell chemotaxis Inferred from mutant phenotype PubMed 19520808. Source: UniProtKB positive regulation of angiogenesis Inferred from mutant phenotype PubMed 17035633. Source: UniProtKB positive regulation of cGMP metabolic process Inferred from direct assay PubMed 19946729. Source: BHF-UCL positive regulation of cartilage development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cell-cell adhesion mediated by cadherin Inferred from electronic annotation. Source: Compara positive regulation of chemokine biosynthetic process Inferred from mutant phenotype PubMed 19520808. Source: UniProtKB positive regulation of cytokine secretion involved in immune response Inferred from mutant phenotype PubMed 18174455. Source: UniProtKB positive regulation of endothelial cell migration Inferred from mutant phenotype PubMed 17035633PubMed 17986384. Source: UniProtKB positive regulation of endothelial cell proliferation Inferred from mutant phenotype PubMed 17986384. Source: UniProtKB positive regulation of fibroblast proliferation Inferred from direct assay PubMed 19251946. Source: UniProtKB positive regulation of inflammatory response Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-1 beta secretion Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL positive regulation of interleukin-6 production Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL positive regulation of interleukin-8 secretion Inferred from electronic annotation. Source: Compara positive regulation of macrophage activation Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL positive regulation of macrophage cytokine production Inferred from mutant phenotype PubMed 18174455. Source: UniProtKB positive regulation of meiosis Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of neuron projection development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of ossification Inferred from mutant phenotype PubMed 20032469. Source: BHF-UCL positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of protein catabolic process Inferred from genetic interaction PubMed 12952940. Source: MGI positive regulation of protein kinase C signaling cascade Inferred from mutant phenotype PubMed 19099253. Source: UniProtKB positive regulation of thymocyte apoptotic process Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL positive regulation of type I interferon-mediated signaling pathway Inferred from direct assay PubMed 19399181. Source: BHF-UCL post-anal tail morphogenesis Inferred from electronic annotation. Source: Compara primitive streak formation Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of branching involved in mammary gland duct morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome respiratory system development Inferred from Biological aspect of Ancestor. Source: RefGenome somitogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome type B pancreatic cell development Inferred from Biological aspect of Ancestor. Source: RefGenome urinary bladder development Inferred from Biological aspect of Ancestor. Source: RefGenome uterus development Inferred from Biological aspect of Ancestor. Source: RefGenome vagina development Inferred from Biological aspect of Ancestor. Source: RefGenome wound healing Inferred from direct assay PubMed 19878652. Source: UniProtKB
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara extracellular space Inferred from direct assay PubMed 18703641PubMed 19048125. Source: UniProtKB plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	frizzled-2 binding Inferred from Biological aspect of Ancestor. Source: RefGenome receptor agonist activity Inferred by curator PubMed 18174455. Source: BHF-UCL sequence-specific DNA binding transcription factor activity Inferred from mutant phenotype PubMed 19847889. Source: UniProtKB transcription regulatory region DNA binding Inferred from direct assay PubMed 19847889. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P41221-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P41221-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Propeptide	36 – 61	26	By similarity		PRO_0000352796
	Chain	62 – 380	319	Protein Wnt-5a		PRO_0000041427
Amino acid modifications
	Lipidation	104	1	S-palmitoyl cysteine By similarity
	Lipidation	244	1	O-palmitoyl serine; by PORCN By similarity
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	312	1	N-linked (GlcNAc...) Potential
	Glycosylation	326	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 15	15	Missing in isoform 2.		VSP_035594
	Natural variant	83	1	C → S in DRS; hypomorphic mutation. Ref.7		VAR_066623
	Natural variant	182	1	C → R in DRS; hypomorphic mutation. Ref.7		VAR_066629

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 4, 2008. Version 2. Checksum: 50E73AC7FE96C7B5	FASTA	380	42,339
	10 20 30 40 50 60 MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG MNNPVQMSEV 70 80 90 100 110 120 YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN 130 140 150 160 170 180 TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG 190 200 210 220 230 240 GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC 250 260 270 280 290 300 HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 310 320 330 340 350 360 YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH 370 380 WCCYVKCKKC TEIVDQFVCK
	Isoform 2 [UniParc]. Checksum: 1B869E60D53D583B	FASTA	365	40,887
	10 20 30 40 50 60 MAGSAMSSKF FLVALAIFFS FAQVVIEANS WWSLGMNNPV QMSEVYIIGA QPLCSQLAGL 70 80 90 100 110 120 SQGQKKLCHL YQDHMQYIGE GAKTGIKECQ YQFRHRRWNC STVDNTSVFG RVMQIGSRET 130 140 150 160 170 180 AFTYAVSAAG VVNAMSRACR EGELSTCGCS RAARPKDLPR DWLWGGCGDN IDYGYRFAKE 190 200 210 220 230 240 FVDARERERI HAKGSYESAR ILMNLHNNEA GRRTVYNLAD VACKCHGVSG SCSLKTCWLQ 250 260 270 280 290 300 LADFRKVGDA LKEKYDSAAA MRLNSRGKLV QVNSRFNSPT TQDLVYIDPS PDYCVRNEST 310 320 330 340 350 360 GSLGTQGRLC NKTSEGMDGC ELMCCGRGYD QFKTVQTERC HCKFHWCCYV KCKKCTEIVD QFVCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21." Clark C.C., Cohen I.R., Eichstetter I., Cannizarro L.A., McPherson J.D., Wasmuth J.J., Iozzo R.V. Genomics 18:249-260(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Mesangial cell and Tongue.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[5]	"Wnt-5a has tumor suppressor activity in thyroid carcinoma." Kremenevskaja N., von Wasielewski R., Rao A.S., Schoefl C., Andersson T., Brabant G. Oncogene 24:2144-2154(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[6]	"The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition." Dissanayake S.K., Wade M., Johnson C.E., O'Connell M.P., Leotlela P.D., French A.D., Shah K.V., Hewitt K.J., Rosenthal D.T., Indig F.E., Jiang Y., Nickoloff B.J., Taub D.D., Trent J.M., Moon R.T., Bittner M., Weeraratna A.T. J. Biol. Chem. 282:17259-17271(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"WNT5A mutations in patients with autosomal dominant Robinow syndrome." Person A.D., Beiraghi S., Sieben C.M., Hermanson S., Neumann A.N., Robu M.E., Schleiffarth J.R., Billington C.J. Jr., van Bokhoven H., Hoogeboom J.M., Mazzeu J.F., Petryk A., Schimmenti L.A., Brunner H.G., Ekker S.C., Lohr J.L. Dev. Dyn. 239:327-337(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS DRS SER-83 AND ARG-182, CHARACTERIZATION OF VARIANTS DRS SER-83 AND ARG-182.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	L20861 mRNA. Translation: AAA16842.1. AK290375 mRNA. Translation: BAF83064.1. AK290869 mRNA. Translation: BAF83558.1. CH471055 Genomic DNA. Translation: EAW65310.1. BC064694 mRNA. Translation: AAH64694.1.
IPI	IPI00013178. IPI00795811.
PIR	A48914.
RefSeq	NP_001243034.1. NM_001256105.1. NP_003383.2. NM_003392.4.
UniGene	Hs.643085.
3D structure databases
ProteinModelPortal	P41221.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29735N.
STRING	9606.ENSP00000264634.
Polymorphism databases
DMDM	212276478.
Proteomic databases
PaxDb	P41221.
PRIDE	P41221.
Protocols and materials databases
DNASU	7474.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264634; ENSP00000264634; ENSG00000114251. ENST00000474267; ENSP00000417310; ENSG00000114251. ENST00000497027; ENSP00000420104; ENSG00000114251.
GeneID	7474.
KEGG	hsa:7474.
UCSC	uc003dhm.3. human.
Organism-specific databases
CTD	7474.
GeneCards	GC03M055474.
HGNC	HGNC:12784. WNT5A.
MIM	164975. gene. 180700. phenotype.
neXtProt	NX_P41221.
Orphanet	3107. Autosomal dominant Robinow syndrome.
PharmGKB	PA37385.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284879.
HOVERGEN	HBG001595.
InParanoid	P41221.
KO	K00444.
OMA	IVERCHC.
OrthoDB	EOG4H19VP.
PhylomeDB	P41221.
Enzyme and pathway databases
Pathway_Interaction_DB	wnt_calcium_pathway. Noncanonical Wnt signaling pathway. wnt_signaling_pathway. Wnt signaling.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P41221.
Bgee	P41221.
CleanEx	HS_WNT5A.
Genevestigator	P41221.
Family and domain databases
InterPro	IPR005817. Wnt. IPR026538. Wnt5a. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF33. PTHR12027:SF33. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WNT5A. human.
GenomeRNAi	7474.
NextBio	29276.
SOURCE	Search...

Entry information

Entry name

WNT5A_HUMAN

Accession

Primary (citable) accession number: P41221
Secondary accession number(s): A8K4A4, Q6P278

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.