Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P41221

- WNT5A_HUMAN

UniProt

P41221 - WNT5A_HUMAN

Protein

Protein Wnt-5a

Gene

WNT5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.2 Publications

    GO - Molecular functioni

    1. frizzled binding Source: UniProtKB
    2. receptor agonist activity Source: BHF-UCL
    3. receptor tyrosine kinase-like orphan receptor binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. activation of JUN kinase activity Source: BHF-UCL
    2. activation of MAPK activity Source: BHF-UCL
    3. activation of protein kinase B activity Source: BHF-UCL
    4. ameboidal cell migration Source: Ensembl
    5. anterior/posterior axis specification, embryo Source: Ensembl
    6. axon guidance Source: UniProtKB
    7. canonical Wnt signaling pathway Source: Ensembl
    8. cartilage development Source: UniProtKB-KW
    9. cell fate commitment Source: RefGenome
    10. cellular protein localization Source: UniProtKB
    11. cellular response to calcium ion Source: UniProtKB
    12. cellular response to interferon-gamma Source: UniProtKB
    13. cellular response to lipopolysaccharide Source: UniProtKB
    14. cellular response to retinoic acid Source: UniProtKB
    15. cellular response to transforming growth factor beta stimulus Source: UniProtKB
    16. cervix development Source: Ensembl
    17. cochlea morphogenesis Source: Ensembl
    18. convergent extension involved in organogenesis Source: Ensembl
    19. dopaminergic neuron differentiation Source: Ensembl
    20. embryonic digit morphogenesis Source: Ensembl
    21. embryonic skeletal system development Source: BHF-UCL
    22. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
    23. epithelial to mesenchymal transition Source: UniProtKB
    24. establishment of planar polarity Source: Ensembl
    25. face development Source: BHF-UCL
    26. genitalia development Source: BHF-UCL
    27. heart looping Source: Ensembl
    28. hematopoietic stem cell proliferation Source: BHF-UCL
    29. hindgut morphogenesis Source: Ensembl
    30. hypophysis morphogenesis Source: Ensembl
    31. keratinocyte differentiation Source: BHF-UCL
    32. lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
    33. lens development in camera-type eye Source: BHF-UCL
    34. lung development Source: Ensembl
    35. male gonad development Source: UniProtKB
    36. mammary gland branching involved in thelarche Source: Ensembl
    37. mesenchymal-epithelial cell signaling Source: Ensembl
    38. midgut development Source: Ensembl
    39. negative chemotaxis Source: Ensembl
    40. negative regulation of apoptotic process Source: UniProtKB
    41. negative regulation of axon extension involved in axon guidance Source: Ensembl
    42. negative regulation of BMP signaling pathway Source: Ensembl
    43. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    44. negative regulation of epithelial cell proliferation Source: Ensembl
    45. negative regulation of fat cell differentiation Source: BHF-UCL
    46. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
    47. negative regulation of mesenchymal cell proliferation Source: UniProtKB
    48. negative regulation of prostatic bud formation Source: Ensembl
    49. negative regulation of synapse assembly Source: Ensembl
    50. negative regulation of transcription, DNA-templated Source: UniProtKB
    51. neural tube closure Source: Ensembl
    52. neuron differentiation Source: UniProtKB
    53. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
    54. olfactory bulb interneuron development Source: UniProtKB
    55. optic cup formation involved in camera-type eye development Source: BHF-UCL
    56. palate development Source: BHF-UCL
    57. planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: Ensembl
    58. planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: Ensembl
    59. planar cell polarity pathway involved in neural tube closure Source: Ensembl
    60. planar cell polarity pathway involved in outflow tract morphogenesis Source: Ensembl
    61. planar cell polarity pathway involved in pericardium morphogenesis Source: Ensembl
    62. planar cell polarity pathway involved in ventricular septum morphogenesis Source: Ensembl
    63. positive regulation of angiogenesis Source: UniProtKB
    64. positive regulation of cartilage development Source: Ensembl
    65. positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
    66. positive regulation of cGMP metabolic process Source: BHF-UCL
    67. positive regulation of chemokine biosynthetic process Source: UniProtKB
    68. positive regulation of cytokine secretion involved in immune response Source: UniProtKB
    69. positive regulation of endothelial cell migration Source: UniProtKB
    70. positive regulation of endothelial cell proliferation Source: UniProtKB
    71. positive regulation of fibroblast proliferation Source: UniProtKB
    72. positive regulation of inflammatory response Source: BHF-UCL
    73. positive regulation of interferon-gamma production Source: Ensembl
    74. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
    75. positive regulation of interleukin-6 production Source: BHF-UCL
    76. positive regulation of interleukin-8 secretion Source: Ensembl
    77. positive regulation of JNK cascade Source: Ensembl
    78. positive regulation of macrophage activation Source: BHF-UCL
    79. positive regulation of macrophage cytokine production Source: UniProtKB
    80. positive regulation of meiosis Source: Ensembl
    81. positive regulation of mesenchymal cell proliferation Source: Ensembl
    82. positive regulation of neuron projection development Source: UniProtKB
    83. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    84. positive regulation of ossification Source: BHF-UCL
    85. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    86. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
    87. positive regulation of protein catabolic process Source: MGI
    88. positive regulation of protein kinase C signaling Source: UniProtKB
    89. positive regulation of response to cytokine stimulus Source: UniProtKB
    90. positive regulation of T cell chemotaxis Source: UniProtKB
    91. positive regulation of thymocyte apoptotic process Source: Ensembl
    92. positive regulation of transcription, DNA-templated Source: UniProtKB
    93. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    94. positive regulation of type I interferon-mediated signaling pathway Source: BHF-UCL
    95. post-anal tail morphogenesis Source: Ensembl
    96. primitive streak formation Source: Ensembl
    97. protein phosphorylation Source: Ensembl
    98. regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
    99. response to organic substance Source: UniProtKB
    100. somitogenesis Source: Ensembl
    101. type B pancreatic cell development Source: Ensembl
    102. urinary bladder development Source: Ensembl
    103. uterus development Source: Ensembl
    104. vagina development Source: Ensembl
    105. Wnt signaling pathway Source: BHF-UCL
    106. Wnt signaling pathway, calcium modulating pathway Source: UniProtKB
    107. wound healing Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_172581. PCP/CE pathway.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
    REACT_172761. Ca2+ pathway.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
    REACT_200777. TCF dependent signaling in response to WNT.
    SignaLinkiP41221.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-5a
    Gene namesi
    Name:WNT5A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:12784. WNT5A.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. clathrin-coated endocytic vesicle membrane Source: Reactome
    3. endoplasmic reticulum lumen Source: Reactome
    4. extracellular region Source: Reactome
    5. extracellular space Source: UniProtKB
    6. extracellular vesicular exosome Source: Reactome
    7. Golgi lumen Source: Reactome
    8. plasma membrane Source: Reactome
    9. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Robinow syndrome autosomal dominant (DRS) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831C → S in DRS; hypomorphic mutation. 1 Publication
    VAR_066623
    Natural varianti182 – 1821C → R in DRS; hypomorphic mutation. 1 Publication
    VAR_066629

    Keywords - Diseasei

    Disease mutation, Dwarfism

    Organism-specific databases

    MIMi180700. phenotype.
    Orphaneti3107. Autosomal dominant Robinow syndrome.
    PharmGKBiPA37385.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Propeptidei36 – 6126By similarityPRO_0000352796Add
    BLAST
    Chaini62 – 380319Protein Wnt-5aPRO_0000041427Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi104 ↔ 115By similarity
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi154 ↔ 162By similarity
    Disulfide bondi164 ↔ 182By similarity
    Disulfide bondi238 ↔ 252By similarity
    Disulfide bondi240 ↔ 247By similarity
    Lipidationi244 – 2441O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi325 ↔ 340By similarity
    Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi355 ↔ 370By similarity
    Disulfide bondi357 ↔ 367By similarity
    Disulfide bondi362 ↔ 363By similarity

    Post-translational modificationi

    Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding.By similarity
    Glycosylation is necessary for secretion but not for activity.By similarity
    Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity
    Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP41221.
    PaxDbiP41221.
    PRIDEiP41221.

    Expressioni

    Tissue specificityi

    Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP41221.
    BgeeiP41221.
    CleanExiHS_WNT5A.
    GenevestigatoriP41221.

    Interactioni

    Subunit structurei

    Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS By similarity.By similarity

    Protein-protein interaction databases

    BioGridi113311. 5 interactions.
    DIPiDIP-29735N.
    IntActiP41221. 1 interaction.
    STRINGi9606.ENSP00000264634.

    Structurei

    3D structure databases

    ProteinModelPortaliP41221.
    SMRiP41221. Positions 94-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    HOVERGENiHBG001595.
    InParanoidiP41221.
    KOiK00444.
    OMAiIVERCHC.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP41221.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026538. Wnt5a.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF33. PTHR12027:SF33. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P41221-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG    50
    MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG 100
    IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM 150
    SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR 200
    ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK 250
    TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 300
    YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV 350
    QTERCHCKFH WCCYVKCKKC TEIVDQFVCK 380
    Length:380
    Mass (Da):42,339
    Last modified:November 4, 2008 - v2
    Checksum:i50E73AC7FE96C7B5
    GO
    Isoform 2 (identifier: P41221-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: Missing.

    Show »
    Length:365
    Mass (Da):40,887
    Checksum:i1B869E60D53D583B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831C → S in DRS; hypomorphic mutation. 1 Publication
    VAR_066623
    Natural varianti182 – 1821C → R in DRS; hypomorphic mutation. 1 Publication
    VAR_066629

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1515Missing in isoform 2. 2 PublicationsVSP_035594Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20861 mRNA. Translation: AAA16842.1.
    AK290375 mRNA. Translation: BAF83064.1.
    AK290869 mRNA. Translation: BAF83558.1.
    CH471055 Genomic DNA. Translation: EAW65310.1.
    BC064694 mRNA. Translation: AAH64694.1.
    CCDSiCCDS46850.1. [P41221-1]
    CCDS58835.1. [P41221-2]
    PIRiA48914.
    RefSeqiNP_001243034.1. NM_001256105.1. [P41221-2]
    NP_003383.2. NM_003392.4. [P41221-1]
    XP_006713387.1. XM_006713324.1. [P41221-2]
    UniGeneiHs.643085.

    Genome annotation databases

    EnsembliENST00000264634; ENSP00000264634; ENSG00000114251. [P41221-1]
    ENST00000474267; ENSP00000417310; ENSG00000114251. [P41221-1]
    ENST00000497027; ENSP00000420104; ENSG00000114251. [P41221-2]
    GeneIDi7474.
    KEGGihsa:7474.
    UCSCiuc003dhm.3. human. [P41221-1]

    Polymorphism databases

    DMDMi212276478.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20861 mRNA. Translation: AAA16842.1 .
    AK290375 mRNA. Translation: BAF83064.1 .
    AK290869 mRNA. Translation: BAF83558.1 .
    CH471055 Genomic DNA. Translation: EAW65310.1 .
    BC064694 mRNA. Translation: AAH64694.1 .
    CCDSi CCDS46850.1. [P41221-1 ]
    CCDS58835.1. [P41221-2 ]
    PIRi A48914.
    RefSeqi NP_001243034.1. NM_001256105.1. [P41221-2 ]
    NP_003383.2. NM_003392.4. [P41221-1 ]
    XP_006713387.1. XM_006713324.1. [P41221-2 ]
    UniGenei Hs.643085.

    3D structure databases

    ProteinModelPortali P41221.
    SMRi P41221. Positions 94-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113311. 5 interactions.
    DIPi DIP-29735N.
    IntActi P41221. 1 interaction.
    STRINGi 9606.ENSP00000264634.

    Polymorphism databases

    DMDMi 212276478.

    Proteomic databases

    MaxQBi P41221.
    PaxDbi P41221.
    PRIDEi P41221.

    Protocols and materials databases

    DNASUi 7474.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264634 ; ENSP00000264634 ; ENSG00000114251 . [P41221-1 ]
    ENST00000474267 ; ENSP00000417310 ; ENSG00000114251 . [P41221-1 ]
    ENST00000497027 ; ENSP00000420104 ; ENSG00000114251 . [P41221-2 ]
    GeneIDi 7474.
    KEGGi hsa:7474.
    UCSCi uc003dhm.3. human. [P41221-1 ]

    Organism-specific databases

    CTDi 7474.
    GeneCardsi GC03M055474.
    HGNCi HGNC:12784. WNT5A.
    MIMi 164975. gene.
    180700. phenotype.
    neXtProti NX_P41221.
    Orphaneti 3107. Autosomal dominant Robinow syndrome.
    PharmGKBi PA37385.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284879.
    HOVERGENi HBG001595.
    InParanoidi P41221.
    KOi K00444.
    OMAi IVERCHC.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P41221.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_172581. PCP/CE pathway.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
    REACT_172761. Ca2+ pathway.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
    REACT_200777. TCF dependent signaling in response to WNT.
    SignaLinki P41221.

    Miscellaneous databases

    ChiTaRSi WNT5A. human.
    GeneWikii WNT5A.
    GenomeRNAii 7474.
    NextBioi 29276.
    PROi P41221.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41221.
    Bgeei P41221.
    CleanExi HS_WNT5A.
    Genevestigatori P41221.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026538. Wnt5a.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF33. PTHR12027:SF33. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21."
      Clark C.C., Cohen I.R., Eichstetter I., Cannizarro L.A., McPherson J.D., Wasmuth J.J., Iozzo R.V.
      Genomics 18:249-260(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Mesangial cell and Tongue.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    5. Cited for: FUNCTION, TISSUE SPECIFICITY.
    6. "The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition."
      Dissanayake S.K., Wade M., Johnson C.E., O'Connell M.P., Leotlela P.D., French A.D., Shah K.V., Hewitt K.J., Rosenthal D.T., Indig F.E., Jiang Y., Nickoloff B.J., Taub D.D., Trent J.M., Moon R.T., Bittner M., Weeraratna A.T.
      J. Biol. Chem. 282:17259-17271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. Cited for: VARIANTS DRS SER-83 AND ARG-182, CHARACTERIZATION OF VARIANTS DRS SER-83 AND ARG-182.

    Entry informationi

    Entry nameiWNT5A_HUMAN
    AccessioniPrimary (citable) accession number: P41221
    Secondary accession number(s): A8K4A4, Q6P278
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3