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P41221 (WNT5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-5a
Gene names
Name:WNT5A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. Ref.5 Ref.6

Subunit structure

Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). Ref.5

Post-translational modification

Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding By similarity.

Glycosylation is necessary for secretion but not for activity By similarity.

Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-104. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A By similarity.

Involvement in disease

Robinow syndrome autosomal dominant (DRS) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Wnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
   DiseaseDisease mutation
Dwarfism
   DomainSignal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from direct assay PubMed 20034610. Source: BHF-UCL

Wnt signaling pathway, calcium modulating pathway

Inferred from mutant phenotype PubMed 17986384. Source: UniProtKB

activation of JUN kinase activity

Inferred from direct assay PubMed 20034610. Source: BHF-UCL

activation of MAPK activity

Inferred from direct assay PubMed 20034610. Source: BHF-UCL

activation of protein kinase B activity

Inferred from direct assay PubMed 20034610. Source: BHF-UCL

ameboidal cell migration

Inferred from electronic annotation. Source: Ensembl

anterior/posterior axis specification, embryo

Inferred from electronic annotation. Source: Ensembl

axon guidance

Inferred from sequence or structural similarity. Source: UniProtKB

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

cartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular protein localization

Inferred from direct assay PubMed 19177143. Source: UniProtKB

cellular response to calcium ion

Inferred from expression pattern PubMed 18703641. Source: UniProtKB

cellular response to interferon-gamma

Inferred from expression pattern PubMed 18174455. Source: UniProtKB

cellular response to lipopolysaccharide

Inferred from expression pattern PubMed 18174455. Source: UniProtKB

cellular response to retinoic acid

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to transforming growth factor beta stimulus

Inferred from expression pattern PubMed 15040835. Source: UniProtKB

cervix development

Inferred from electronic annotation. Source: Ensembl

cochlea morphogenesis

Inferred from electronic annotation. Source: Ensembl

convergent extension involved in organogenesis

Inferred from electronic annotation. Source: Ensembl

dopaminergic neuron differentiation

Inferred from electronic annotation. Source: Ensembl

embryonic digit morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system development

Inferred from mutant phenotype Ref.7. Source: BHF-UCL

epithelial cell proliferation involved in mammary gland duct elongation

Inferred from electronic annotation. Source: Ensembl

epithelial to mesenchymal transition

Inferred from expression pattern PubMed 12841867. Source: UniProtKB

establishment of planar polarity

Inferred from electronic annotation. Source: Ensembl

face development

Inferred from mutant phenotype Ref.7. Source: BHF-UCL

genitalia development

Inferred from mutant phenotype Ref.7. Source: BHF-UCL

heart looping

Inferred from electronic annotation. Source: Ensembl

hematopoietic stem cell proliferation

Inferred from direct assay PubMed 9787155. Source: BHF-UCL

hindgut morphogenesis

Inferred from electronic annotation. Source: Ensembl

hypophysis morphogenesis

Inferred from electronic annotation. Source: Ensembl

keratinocyte differentiation

Inferred from expression pattern PubMed 19399181. Source: BHF-UCL

lateral sprouting involved in mammary gland duct morphogenesis

Inferred from electronic annotation. Source: Ensembl

lens development in camera-type eye

Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL

lung development

Inferred from electronic annotation. Source: Ensembl

male gonad development

Inferred from expression pattern PubMed 17848411. Source: UniProtKB

mammary gland branching involved in thelarche

Inferred from electronic annotation. Source: Ensembl

mesenchymal-epithelial cell signaling

Inferred from electronic annotation. Source: Ensembl

midgut development

Inferred from electronic annotation. Source: Ensembl

negative chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of BMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from direct assay PubMed 19251946. Source: UniProtKB

negative regulation of axon extension involved in axon guidance

Inferred from electronic annotation. Source: Ensembl

negative regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 17976063. Source: UniProtKB

negative regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 20032469. Source: BHF-UCL

negative regulation of fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of mesenchymal cell proliferation

Inferred from direct assay PubMed 19878652. Source: UniProtKB

negative regulation of prostatic bud formation

Inferred from electronic annotation. Source: Ensembl

negative regulation of synapse assembly

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 19277043. Source: UniProtKB

neural tube closure

Inferred from electronic annotation. Source: Ensembl

neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

non-canonical Wnt signaling pathway via JNK cascade

Inferred from electronic annotation. Source: Ensembl

olfactory bulb interneuron development

Inferred from sequence or structural similarity. Source: UniProtKB

optic cup formation involved in camera-type eye development

Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL

palate development

Inferred from mutant phenotype PubMed 18413325. Source: BHF-UCL

planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

planar cell polarity pathway involved in cardiac right atrium morphogenesis

Inferred from electronic annotation. Source: Ensembl

planar cell polarity pathway involved in neural tube closure

Inferred from electronic annotation. Source: Ensembl

planar cell polarity pathway involved in outflow tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

planar cell polarity pathway involved in pericardium morphogenesis

Inferred from electronic annotation. Source: Ensembl

planar cell polarity pathway involved in ventricular septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of JNK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of NF-kappaB transcription factor activity

Inferred from direct assay PubMed 18287027. Source: UniProtKB

positive regulation of T cell chemotaxis

Inferred from mutant phenotype PubMed 19520808. Source: UniProtKB

positive regulation of angiogenesis

Inferred from mutant phenotype PubMed 17035633. Source: UniProtKB

positive regulation of cGMP metabolic process

Inferred from direct assay PubMed 19946729. Source: BHF-UCL

positive regulation of cartilage development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-cell adhesion mediated by cadherin

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine biosynthetic process

Inferred from mutant phenotype PubMed 19520808. Source: UniProtKB

positive regulation of cytokine secretion involved in immune response

Inferred from mutant phenotype PubMed 18174455. Source: UniProtKB

positive regulation of endothelial cell migration

Inferred from mutant phenotype PubMed 17035633PubMed 17986384. Source: UniProtKB

positive regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 17986384. Source: UniProtKB

positive regulation of fibroblast proliferation

Inferred from direct assay PubMed 19251946. Source: UniProtKB

positive regulation of inflammatory response

Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL

positive regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta secretion

Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL

positive regulation of interleukin-6 production

Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL

positive regulation of interleukin-8 secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage activation

Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL

positive regulation of macrophage cytokine production

Inferred from mutant phenotype PubMed 18174455. Source: UniProtKB

positive regulation of meiosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron projection development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of ossification

Inferred from mutant phenotype PubMed 20032469. Source: BHF-UCL

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-threonine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein catabolic process

Inferred from genetic interaction PubMed 12952940. Source: MGI

positive regulation of protein kinase C signaling

Inferred from mutant phenotype PubMed 19099253. Source: UniProtKB

positive regulation of response to cytokine stimulus

Inferred from direct assay PubMed 19399181. Source: UniProtKB

positive regulation of thymocyte apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 18174455. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 19847889. Source: UniProtKB

positive regulation of type I interferon-mediated signaling pathway

Inferred from direct assay PubMed 19399181. Source: BHF-UCL

post-anal tail morphogenesis

Inferred from electronic annotation. Source: Ensembl

primitive streak formation

Inferred from electronic annotation. Source: Ensembl

protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

regulation of branching involved in mammary gland duct morphogenesis

Inferred from electronic annotation. Source: Ensembl

response to organic substance

Inferred from expression pattern PubMed 17486081. Source: UniProtKB

somitogenesis

Inferred from electronic annotation. Source: Ensembl

type B pancreatic cell development

Inferred from electronic annotation. Source: Ensembl

urinary bladder development

Inferred from electronic annotation. Source: Ensembl

uterus development

Inferred from electronic annotation. Source: Ensembl

vagina development

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from direct assay PubMed 19878652. Source: UniProtKB

   Cellular_componentGolgi lumen

Traceable author statement. Source: Reactome

cell surface

Inferred from electronic annotation. Source: Ensembl

clathrin-coated endocytic vesicle membrane

Traceable author statement. Source: Reactome

endoplasmic reticulum lumen

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 18703641PubMed 19048125. Source: UniProtKB

extracellular vesicular exosome

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from physical interaction PubMed 18174455. Source: UniProtKB

receptor agonist activity

Inferred by curator PubMed 18174455. Source: BHF-UCL

receptor tyrosine kinase-like orphan receptor binding

Inferred from physical interaction PubMed 18287027. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype PubMed 19847889. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay PubMed 19847889. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P41221-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P41221-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Propeptide36 – 6126 By similarity
PRO_0000352796
Chain62 – 380319Protein Wnt-5a
PRO_0000041427

Amino acid modifications

Lipidation1041S-palmitoyl cysteine By similarity
Lipidation2441O-palmitoyl serine; by PORCN By similarity
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3261N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 1515Missing in isoform 2.
VSP_035594
Natural variant831C → S in DRS; hypomorphic mutation. Ref.7
VAR_066623
Natural variant1821C → R in DRS; hypomorphic mutation. Ref.7
VAR_066629

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 4, 2008. Version 2.
Checksum: 50E73AC7FE96C7B5

FASTA38042,339
        10         20         30         40         50         60 
MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG MNNPVQMSEV 

        70         80         90        100        110        120 
YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN 

       130        140        150        160        170        180 
TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG 

       190        200        210        220        230        240 
GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC 

       250        260        270        280        290        300 
HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 

       310        320        330        340        350        360 
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH 

       370        380 
WCCYVKCKKC TEIVDQFVCK 

« Hide

Isoform 2 [UniParc].

Checksum: 1B869E60D53D583B
Show »

FASTA36540,887

References

« Hide 'large scale' references
[1]"Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21."
Clark C.C., Cohen I.R., Eichstetter I., Cannizarro L.A., McPherson J.D., Wasmuth J.J., Iozzo R.V.
Genomics 18:249-260(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Mesangial cell and Tongue.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[5]"Wnt-5a has tumor suppressor activity in thyroid carcinoma."
Kremenevskaja N., von Wasielewski R., Rao A.S., Schoefl C., Andersson T., Brabant G.
Oncogene 24:2144-2154(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[6]"The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition."
Dissanayake S.K., Wade M., Johnson C.E., O'Connell M.P., Leotlela P.D., French A.D., Shah K.V., Hewitt K.J., Rosenthal D.T., Indig F.E., Jiang Y., Nickoloff B.J., Taub D.D., Trent J.M., Moon R.T., Bittner M., Weeraratna A.T.
J. Biol. Chem. 282:17259-17271(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"WNT5A mutations in patients with autosomal dominant Robinow syndrome."
Person A.D., Beiraghi S., Sieben C.M., Hermanson S., Neumann A.N., Robu M.E., Schleiffarth J.R., Billington C.J. Jr., van Bokhoven H., Hoogeboom J.M., Mazzeu J.F., Petryk A., Schimmenti L.A., Brunner H.G., Ekker S.C., Lohr J.L.
Dev. Dyn. 239:327-337(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS DRS SER-83 AND ARG-182, CHARACTERIZATION OF VARIANTS DRS SER-83 AND ARG-182.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L20861 mRNA. Translation: AAA16842.1.
AK290375 mRNA. Translation: BAF83064.1.
AK290869 mRNA. Translation: BAF83558.1.
CH471055 Genomic DNA. Translation: EAW65310.1.
BC064694 mRNA. Translation: AAH64694.1.
PIRA48914.
RefSeqNP_001243034.1. NM_001256105.1.
NP_003383.2. NM_003392.4.
UniGeneHs.643085.

3D structure databases

ProteinModelPortalP41221.
SMRP41221. Positions 94-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113311. 5 interactions.
DIPDIP-29735N.
STRING9606.ENSP00000264634.

Polymorphism databases

DMDM212276478.

Proteomic databases

PaxDbP41221.
PRIDEP41221.

Protocols and materials databases

DNASU7474.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264634; ENSP00000264634; ENSG00000114251. [P41221-1]
ENST00000474267; ENSP00000417310; ENSG00000114251. [P41221-1]
ENST00000497027; ENSP00000420104; ENSG00000114251. [P41221-2]
GeneID7474.
KEGGhsa:7474.
UCSCuc003dhm.3. human. [P41221-1]

Organism-specific databases

CTD7474.
GeneCardsGC03M055474.
HGNCHGNC:12784. WNT5A.
MIM164975. gene.
180700. phenotype.
neXtProtNX_P41221.
Orphanet3107. Autosomal dominant Robinow syndrome.
PharmGKBPA37385.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284879.
HOVERGENHBG001595.
InParanoidP41221.
KOK00444.
OMAIVERCHC.
OrthoDBEOG7C8GJ8.
PhylomeDBP41221.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP41221.

Gene expression databases

ArrayExpressP41221.
BgeeP41221.
CleanExHS_WNT5A.
GenevestigatorP41221.

Family and domain databases

InterProIPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSWNT5A. human.
GeneWikiWNT5A.
GenomeRNAi7474.
NextBio29276.
PROP41221.
SOURCESearch...

Entry information

Entry nameWNT5A_HUMAN
AccessionPrimary (citable) accession number: P41221
Secondary accession number(s): A8K4A4, Q6P278
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 4, 2008
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM