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P41221

- WNT5A_HUMAN

UniProt

P41221 - WNT5A_HUMAN

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Protein

Protein Wnt-5a

Gene

WNT5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.2 Publications

GO - Molecular functioni

  1. frizzled binding Source: UniProtKB
  2. receptor agonist activity Source: BHF-UCL
  3. receptor tyrosine kinase-like orphan receptor binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. activation of JUN kinase activity Source: BHF-UCL
  2. activation of MAPK activity Source: BHF-UCL
  3. activation of protein kinase B activity Source: BHF-UCL
  4. ameboidal cell migration Source: Ensembl
  5. anterior/posterior axis specification, embryo Source: Ensembl
  6. axon guidance Source: UniProtKB
  7. canonical Wnt signaling pathway Source: Ensembl
  8. cartilage development Source: UniProtKB-KW
  9. cell fate commitment Source: RefGenome
  10. cellular protein localization Source: UniProtKB
  11. cellular response to calcium ion Source: UniProtKB
  12. cellular response to interferon-gamma Source: UniProtKB
  13. cellular response to lipopolysaccharide Source: UniProtKB
  14. cellular response to retinoic acid Source: UniProtKB
  15. cellular response to transforming growth factor beta stimulus Source: UniProtKB
  16. cervix development Source: Ensembl
  17. cochlea morphogenesis Source: Ensembl
  18. convergent extension involved in organogenesis Source: Ensembl
  19. dopaminergic neuron differentiation Source: Ensembl
  20. embryonic digit morphogenesis Source: Ensembl
  21. embryonic skeletal system development Source: BHF-UCL
  22. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  23. epithelial to mesenchymal transition Source: UniProtKB
  24. establishment of planar polarity Source: Ensembl
  25. face development Source: BHF-UCL
  26. genitalia development Source: BHF-UCL
  27. heart looping Source: Ensembl
  28. hematopoietic stem cell proliferation Source: BHF-UCL
  29. hindgut morphogenesis Source: Ensembl
  30. hypophysis morphogenesis Source: Ensembl
  31. keratinocyte differentiation Source: BHF-UCL
  32. lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
  33. lens development in camera-type eye Source: BHF-UCL
  34. lung development Source: Ensembl
  35. male gonad development Source: UniProtKB
  36. mammary gland branching involved in thelarche Source: Ensembl
  37. mesenchymal-epithelial cell signaling Source: Ensembl
  38. midgut development Source: Ensembl
  39. negative chemotaxis Source: Ensembl
  40. negative regulation of apoptotic process Source: UniProtKB
  41. negative regulation of axon extension involved in axon guidance Source: Ensembl
  42. negative regulation of BMP signaling pathway Source: Ensembl
  43. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  44. negative regulation of epithelial cell proliferation Source: Ensembl
  45. negative regulation of fat cell differentiation Source: BHF-UCL
  46. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  47. negative regulation of mesenchymal cell proliferation Source: UniProtKB
  48. negative regulation of prostatic bud formation Source: Ensembl
  49. negative regulation of synapse assembly Source: Ensembl
  50. negative regulation of transcription, DNA-templated Source: UniProtKB
  51. neural tube closure Source: Ensembl
  52. neuron differentiation Source: UniProtKB
  53. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
  54. olfactory bulb interneuron development Source: UniProtKB
  55. optic cup formation involved in camera-type eye development Source: BHF-UCL
  56. palate development Source: BHF-UCL
  57. planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: Ensembl
  58. planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: Ensembl
  59. planar cell polarity pathway involved in neural tube closure Source: Ensembl
  60. planar cell polarity pathway involved in outflow tract morphogenesis Source: Ensembl
  61. planar cell polarity pathway involved in pericardium morphogenesis Source: Ensembl
  62. planar cell polarity pathway involved in ventricular septum morphogenesis Source: Ensembl
  63. positive regulation of angiogenesis Source: UniProtKB
  64. positive regulation of cartilage development Source: Ensembl
  65. positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
  66. positive regulation of cGMP metabolic process Source: BHF-UCL
  67. positive regulation of chemokine biosynthetic process Source: UniProtKB
  68. positive regulation of cytokine secretion involved in immune response Source: UniProtKB
  69. positive regulation of endothelial cell migration Source: UniProtKB
  70. positive regulation of endothelial cell proliferation Source: UniProtKB
  71. positive regulation of fibroblast proliferation Source: UniProtKB
  72. positive regulation of inflammatory response Source: BHF-UCL
  73. positive regulation of interferon-gamma production Source: Ensembl
  74. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
  75. positive regulation of interleukin-6 production Source: BHF-UCL
  76. positive regulation of interleukin-8 secretion Source: Ensembl
  77. positive regulation of JNK cascade Source: Ensembl
  78. positive regulation of macrophage activation Source: BHF-UCL
  79. positive regulation of macrophage cytokine production Source: UniProtKB
  80. positive regulation of meiosis Source: Ensembl
  81. positive regulation of mesenchymal cell proliferation Source: Ensembl
  82. positive regulation of neuron projection development Source: UniProtKB
  83. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  84. positive regulation of ossification Source: BHF-UCL
  85. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  86. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
  87. positive regulation of protein catabolic process Source: MGI
  88. positive regulation of protein kinase C signaling Source: UniProtKB
  89. positive regulation of response to cytokine stimulus Source: UniProtKB
  90. positive regulation of T cell chemotaxis Source: UniProtKB
  91. positive regulation of thymocyte apoptotic process Source: Ensembl
  92. positive regulation of transcription, DNA-templated Source: UniProtKB
  93. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  94. positive regulation of type I interferon-mediated signaling pathway Source: BHF-UCL
  95. post-anal tail morphogenesis Source: Ensembl
  96. primitive streak formation Source: Ensembl
  97. protein phosphorylation Source: Ensembl
  98. regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
  99. response to organic substance Source: UniProtKB
  100. somitogenesis Source: Ensembl
  101. type B pancreatic cell development Source: Ensembl
  102. urinary bladder development Source: Ensembl
  103. uterus development Source: Ensembl
  104. vagina development Source: Ensembl
  105. Wnt signaling pathway Source: BHF-UCL
  106. Wnt signaling pathway, calcium modulating pathway Source: UniProtKB
  107. wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_172581. PCP/CE pathway.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_172761. Ca2+ pathway.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_200777. TCF dependent signaling in response to WNT.
SignaLinkiP41221.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5a
Gene namesi
Name:WNT5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:12784. WNT5A.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. clathrin-coated endocytic vesicle membrane Source: Reactome
  3. endoplasmic reticulum lumen Source: Reactome
  4. extracellular region Source: Reactome
  5. extracellular space Source: UniProtKB
  6. extracellular vesicular exosome Source: Reactome
  7. Golgi lumen Source: Reactome
  8. plasma membrane Source: Reactome
  9. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Robinow syndrome autosomal dominant (DRS) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831C → S in DRS; hypomorphic mutation. 1 Publication
VAR_066623
Natural varianti182 – 1821C → R in DRS; hypomorphic mutation. 1 Publication
VAR_066629

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

MIMi180700. phenotype.
Orphaneti3107. Autosomal dominant Robinow syndrome.
PharmGKBiPA37385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Propeptidei36 – 6126By similarityPRO_0000352796Add
BLAST
Chaini62 – 380319Protein Wnt-5aPRO_0000041427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 115By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi154 ↔ 162By similarity
Disulfide bondi164 ↔ 182By similarity
Disulfide bondi238 ↔ 252By similarity
Disulfide bondi240 ↔ 247By similarity
Lipidationi244 – 2441O-palmitoyl serine; by PORCNBy similarity
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 340By similarity
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi355 ↔ 370By similarity
Disulfide bondi357 ↔ 367By similarity
Disulfide bondi362 ↔ 363By similarity

Post-translational modificationi

Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding.By similarity
Glycosylation is necessary for secretion but not for activity.By similarity
Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP41221.
PaxDbiP41221.
PRIDEiP41221.

Expressioni

Tissue specificityi

Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).1 Publication

Gene expression databases

BgeeiP41221.
CleanExiHS_WNT5A.
ExpressionAtlasiP41221. baseline and differential.
GenevestigatoriP41221.

Interactioni

Subunit structurei

Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS By similarity.By similarity

Protein-protein interaction databases

BioGridi113311. 8 interactions.
DIPiDIP-29735N.
IntActiP41221. 1 interaction.
STRINGi9606.ENSP00000264634.

Structurei

3D structure databases

ProteinModelPortaliP41221.
SMRiP41221. Positions 94-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOVERGENiHBG001595.
InParanoidiP41221.
KOiK00444.
OMAiIVERCHC.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP41221.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P41221-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG
60 70 80 90 100
MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG
110 120 130 140 150
IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM
160 170 180 190 200
SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR
210 220 230 240 250
ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK
260 270 280 290 300
TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV
310 320 330 340 350
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV
360 370 380
QTERCHCKFH WCCYVKCKKC TEIVDQFVCK
Length:380
Mass (Da):42,339
Last modified:November 4, 2008 - v2
Checksum:i50E73AC7FE96C7B5
GO
Isoform 2 (identifier: P41221-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Show »
Length:365
Mass (Da):40,887
Checksum:i1B869E60D53D583B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831C → S in DRS; hypomorphic mutation. 1 Publication
VAR_066623
Natural varianti182 – 1821C → R in DRS; hypomorphic mutation. 1 Publication
VAR_066629

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1515Missing in isoform 2. 2 PublicationsVSP_035594Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20861 mRNA. Translation: AAA16842.1.
AK290375 mRNA. Translation: BAF83064.1.
AK290869 mRNA. Translation: BAF83558.1.
CH471055 Genomic DNA. Translation: EAW65310.1.
BC064694 mRNA. Translation: AAH64694.1.
CCDSiCCDS46850.1. [P41221-1]
CCDS58835.1. [P41221-2]
PIRiA48914.
RefSeqiNP_001243034.1. NM_001256105.1. [P41221-2]
NP_003383.2. NM_003392.4. [P41221-1]
XP_006713387.1. XM_006713324.1. [P41221-2]
UniGeneiHs.643085.

Genome annotation databases

EnsembliENST00000264634; ENSP00000264634; ENSG00000114251. [P41221-1]
ENST00000474267; ENSP00000417310; ENSG00000114251. [P41221-1]
ENST00000497027; ENSP00000420104; ENSG00000114251. [P41221-2]
GeneIDi7474.
KEGGihsa:7474.
UCSCiuc003dhm.3. human. [P41221-1]

Polymorphism databases

DMDMi212276478.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20861 mRNA. Translation: AAA16842.1 .
AK290375 mRNA. Translation: BAF83064.1 .
AK290869 mRNA. Translation: BAF83558.1 .
CH471055 Genomic DNA. Translation: EAW65310.1 .
BC064694 mRNA. Translation: AAH64694.1 .
CCDSi CCDS46850.1. [P41221-1 ]
CCDS58835.1. [P41221-2 ]
PIRi A48914.
RefSeqi NP_001243034.1. NM_001256105.1. [P41221-2 ]
NP_003383.2. NM_003392.4. [P41221-1 ]
XP_006713387.1. XM_006713324.1. [P41221-2 ]
UniGenei Hs.643085.

3D structure databases

ProteinModelPortali P41221.
SMRi P41221. Positions 94-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113311. 8 interactions.
DIPi DIP-29735N.
IntActi P41221. 1 interaction.
STRINGi 9606.ENSP00000264634.

Polymorphism databases

DMDMi 212276478.

Proteomic databases

MaxQBi P41221.
PaxDbi P41221.
PRIDEi P41221.

Protocols and materials databases

DNASUi 7474.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264634 ; ENSP00000264634 ; ENSG00000114251 . [P41221-1 ]
ENST00000474267 ; ENSP00000417310 ; ENSG00000114251 . [P41221-1 ]
ENST00000497027 ; ENSP00000420104 ; ENSG00000114251 . [P41221-2 ]
GeneIDi 7474.
KEGGi hsa:7474.
UCSCi uc003dhm.3. human. [P41221-1 ]

Organism-specific databases

CTDi 7474.
GeneCardsi GC03M055474.
HGNCi HGNC:12784. WNT5A.
MIMi 164975. gene.
180700. phenotype.
neXtProti NX_P41221.
Orphaneti 3107. Autosomal dominant Robinow syndrome.
PharmGKBi PA37385.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284879.
GeneTreei ENSGT00760000118943.
HOVERGENi HBG001595.
InParanoidi P41221.
KOi K00444.
OMAi IVERCHC.
OrthoDBi EOG7C8GJ8.
PhylomeDBi P41221.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_172581. PCP/CE pathway.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_172761. Ca2+ pathway.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_200777. TCF dependent signaling in response to WNT.
SignaLinki P41221.

Miscellaneous databases

ChiTaRSi WNT5A. human.
GeneWikii WNT5A.
GenomeRNAii 7474.
NextBioi 29276.
PROi P41221.
SOURCEi Search...

Gene expression databases

Bgeei P41221.
CleanExi HS_WNT5A.
ExpressionAtlasi P41221. baseline and differential.
Genevestigatori P41221.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21."
    Clark C.C., Cohen I.R., Eichstetter I., Cannizarro L.A., McPherson J.D., Wasmuth J.J., Iozzo R.V.
    Genomics 18:249-260(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mesangial cell and Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition."
    Dissanayake S.K., Wade M., Johnson C.E., O'Connell M.P., Leotlela P.D., French A.D., Shah K.V., Hewitt K.J., Rosenthal D.T., Indig F.E., Jiang Y., Nickoloff B.J., Taub D.D., Trent J.M., Moon R.T., Bittner M., Weeraratna A.T.
    J. Biol. Chem. 282:17259-17271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: VARIANTS DRS SER-83 AND ARG-182, CHARACTERIZATION OF VARIANTS DRS SER-83 AND ARG-182.

Entry informationi

Entry nameiWNT5A_HUMAN
AccessioniPrimary (citable) accession number: P41221
Secondary accession number(s): A8K4A4, Q6P278
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 4, 2008
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3