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Protein

Protein Wnt-5a

Gene

WNT5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.2 Publications

GO - Molecular functioni

  • frizzled binding Source: UniProtKB
  • receptor agonist activity Source: BHF-UCL
  • receptor tyrosine kinase-like orphan receptor binding Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • activation of JUN kinase activity Source: BHF-UCL
  • activation of MAPK activity Source: BHF-UCL
  • activation of protein kinase B activity Source: BHF-UCL
  • ameboidal-type cell migration Source: Ensembl
  • anterior/posterior axis specification, embryo Source: Ensembl
  • axon guidance Source: UniProtKB
  • canonical Wnt signaling pathway Source: Ensembl
  • cartilage development Source: UniProtKB-KW
  • cell fate commitment Source: GO_Central
  • cellular protein localization Source: UniProtKB
  • cellular response to calcium ion Source: UniProtKB
  • cellular response to interferon-gamma Source: UniProtKB
  • cellular response to lipopolysaccharide Source: UniProtKB
  • cellular response to retinoic acid Source: UniProtKB
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • cervix development Source: Ensembl
  • cochlea morphogenesis Source: Ensembl
  • convergent extension involved in organogenesis Source: Ensembl
  • dopaminergic neuron differentiation Source: Ensembl
  • embryonic digit morphogenesis Source: Ensembl
  • embryonic skeletal system development Source: BHF-UCL
  • epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  • epithelial to mesenchymal transition Source: UniProtKB
  • establishment of planar polarity Source: Ensembl
  • face development Source: BHF-UCL
  • genitalia development Source: BHF-UCL
  • heart looping Source: Ensembl
  • hematopoietic stem cell proliferation Source: BHF-UCL
  • hindgut morphogenesis Source: Ensembl
  • hypophysis morphogenesis Source: Ensembl
  • keratinocyte differentiation Source: BHF-UCL
  • lateral sprouting involved in mammary gland duct morphogenesis Source: Ensembl
  • lens development in camera-type eye Source: BHF-UCL
  • lung development Source: Ensembl
  • male gonad development Source: UniProtKB
  • mammary gland branching involved in thelarche Source: Ensembl
  • mesenchymal-epithelial cell signaling Source: Ensembl
  • midgut development Source: Ensembl
  • negative chemotaxis Source: Ensembl
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of axon extension involved in axon guidance Source: Ensembl
  • negative regulation of BMP signaling pathway Source: Ensembl
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: Ensembl
  • negative regulation of fat cell differentiation Source: BHF-UCL
  • negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  • negative regulation of mesenchymal cell proliferation Source: UniProtKB
  • negative regulation of prostatic bud formation Source: Ensembl
  • negative regulation of synapse assembly Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • neural tube closure Source: Ensembl
  • neuron differentiation Source: UniProtKB
  • non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
  • olfactory bulb interneuron development Source: UniProtKB
  • optic cup formation involved in camera-type eye development Source: BHF-UCL
  • palate development Source: BHF-UCL
  • planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: Ensembl
  • planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: Ensembl
  • planar cell polarity pathway involved in neural tube closure Source: Ensembl
  • planar cell polarity pathway involved in outflow tract morphogenesis Source: Ensembl
  • planar cell polarity pathway involved in pericardium morphogenesis Source: Ensembl
  • planar cell polarity pathway involved in ventricular septum morphogenesis Source: Ensembl
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of cartilage development Source: Ensembl
  • positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
  • positive regulation of cGMP metabolic process Source: BHF-UCL
  • positive regulation of chemokine biosynthetic process Source: UniProtKB
  • positive regulation of cytokine secretion involved in immune response Source: UniProtKB
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: UniProtKB
  • positive regulation of fibroblast proliferation Source: UniProtKB
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of interferon-gamma production Source: Ensembl
  • positive regulation of interleukin-1 beta secretion Source: BHF-UCL
  • positive regulation of interleukin-6 production Source: BHF-UCL
  • positive regulation of interleukin-8 secretion Source: Ensembl
  • positive regulation of macrophage activation Source: BHF-UCL
  • positive regulation of macrophage cytokine production Source: UniProtKB
  • positive regulation of meiotic nuclear division Source: Ensembl
  • positive regulation of mesenchymal cell proliferation Source: Ensembl
  • positive regulation of neuron projection development Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • positive regulation of ossification Source: BHF-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  • positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
  • positive regulation of protein catabolic process Source: MGI
  • positive regulation of protein kinase C activity Source: CACAO
  • positive regulation of protein kinase C signaling Source: UniProtKB
  • positive regulation of response to cytokine stimulus Source: UniProtKB
  • positive regulation of T cell chemotaxis Source: UniProtKB
  • positive regulation of thymocyte apoptotic process Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of type I interferon-mediated signaling pathway Source: BHF-UCL
  • post-anal tail morphogenesis Source: Ensembl
  • primitive streak formation Source: Ensembl
  • protein phosphorylation Source: Ensembl
  • regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
  • response to organic substance Source: UniProtKB
  • somitogenesis Source: Ensembl
  • type B pancreatic cell development Source: Ensembl
  • urinary bladder development Source: Ensembl
  • uterus development Source: Ensembl
  • vagina development Source: Ensembl
  • Wnt signaling pathway Source: BHF-UCL
  • Wnt signaling pathway, calcium modulating pathway Source: UniProtKB
  • wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_263890. WNT5A-dependent internalization of FZD4.
REACT_263982. Ca2+ pathway.
REACT_264199. PCP/CE pathway.
REACT_264383. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_264478. Asymmetric localization of PCP proteins.
REACT_264533. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_264596. TCF dependent signaling in response to WNT.
SignaLinkiP41221.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5a
Gene namesi
Name:WNT5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12784. WNT5A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Robinow syndrome autosomal dominant (DRS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.

See also OMIM:180700
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831C → S in DRS; hypomorphic mutation. 1 Publication
VAR_066623
Natural varianti182 – 1821C → R in DRS; hypomorphic mutation. 1 Publication
VAR_066629

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

MIMi180700. phenotype.
Orphaneti3107. Autosomal dominant Robinow syndrome.
PharmGKBiPA37385.

Polymorphism and mutation databases

BioMutaiWNT5A.
DMDMi212276478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Propeptidei36 – 6126By similarityPRO_0000352796Add
BLAST
Chaini62 – 380319Protein Wnt-5aPRO_0000041427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 115By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi154 ↔ 162By similarity
Disulfide bondi164 ↔ 182By similarity
Disulfide bondi238 ↔ 252By similarity
Disulfide bondi240 ↔ 247By similarity
Lipidationi244 – 2441O-palmitoleyl serine; by PORCNBy similarity
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 340By similarity
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi355 ↔ 370By similarity
Disulfide bondi357 ↔ 367By similarity
Disulfide bondi362 ↔ 363By similarity

Post-translational modificationi

Glycosylation is necessary for secretion but not for activity.By similarity
Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiP41221.
PaxDbiP41221.
PRIDEiP41221.

Expressioni

Tissue specificityi

Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).1 Publication

Gene expression databases

BgeeiP41221.
CleanExiHS_WNT5A.
ExpressionAtlasiP41221. baseline and differential.
GenevestigatoriP41221.

Interactioni

Subunit structurei

Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS (By similarity).By similarity

Protein-protein interaction databases

BioGridi113311. 13 interactions.
DIPiDIP-29735N.
IntActiP41221. 1 interaction.
STRINGi9606.ENSP00000264634.

Structurei

3D structure databases

ProteinModelPortaliP41221.
SMRiP41221. Positions 94-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOVERGENiHBG001595.
InParanoidiP41221.
KOiK00444.
OMAiIVERCHC.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP41221.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41221-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKSIGILSP GVALGMAGSA MSSKFFLVAL AIFFSFAQVV IEANSWWSLG
60 70 80 90 100
MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG
110 120 130 140 150
IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM
160 170 180 190 200
SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR
210 220 230 240 250
ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK
260 270 280 290 300
TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV
310 320 330 340 350
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV
360 370 380
QTERCHCKFH WCCYVKCKKC TEIVDQFVCK
Length:380
Mass (Da):42,339
Last modified:November 4, 2008 - v2
Checksum:i50E73AC7FE96C7B5
GO
Isoform 2 (identifier: P41221-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Show »
Length:365
Mass (Da):40,887
Checksum:i1B869E60D53D583B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831C → S in DRS; hypomorphic mutation. 1 Publication
VAR_066623
Natural varianti182 – 1821C → R in DRS; hypomorphic mutation. 1 Publication
VAR_066629

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1515Missing in isoform 2. 2 PublicationsVSP_035594Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20861 mRNA. Translation: AAA16842.1.
AK290375 mRNA. Translation: BAF83064.1.
AK290869 mRNA. Translation: BAF83558.1.
CH471055 Genomic DNA. Translation: EAW65310.1.
BC064694 mRNA. Translation: AAH64694.1.
CCDSiCCDS46850.1. [P41221-1]
CCDS58835.1. [P41221-2]
PIRiA48914.
RefSeqiNP_001243034.1. NM_001256105.1. [P41221-2]
NP_003383.2. NM_003392.4. [P41221-1]
XP_006713387.1. XM_006713324.1. [P41221-2]
UniGeneiHs.643085.

Genome annotation databases

EnsembliENST00000264634; ENSP00000264634; ENSG00000114251. [P41221-1]
ENST00000474267; ENSP00000417310; ENSG00000114251. [P41221-1]
ENST00000497027; ENSP00000420104; ENSG00000114251. [P41221-2]
GeneIDi7474.
KEGGihsa:7474.
UCSCiuc003dhm.3. human. [P41221-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20861 mRNA. Translation: AAA16842.1.
AK290375 mRNA. Translation: BAF83064.1.
AK290869 mRNA. Translation: BAF83558.1.
CH471055 Genomic DNA. Translation: EAW65310.1.
BC064694 mRNA. Translation: AAH64694.1.
CCDSiCCDS46850.1. [P41221-1]
CCDS58835.1. [P41221-2]
PIRiA48914.
RefSeqiNP_001243034.1. NM_001256105.1. [P41221-2]
NP_003383.2. NM_003392.4. [P41221-1]
XP_006713387.1. XM_006713324.1. [P41221-2]
UniGeneiHs.643085.

3D structure databases

ProteinModelPortaliP41221.
SMRiP41221. Positions 94-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113311. 13 interactions.
DIPiDIP-29735N.
IntActiP41221. 1 interaction.
STRINGi9606.ENSP00000264634.

Polymorphism and mutation databases

BioMutaiWNT5A.
DMDMi212276478.

Proteomic databases

MaxQBiP41221.
PaxDbiP41221.
PRIDEiP41221.

Protocols and materials databases

DNASUi7474.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264634; ENSP00000264634; ENSG00000114251. [P41221-1]
ENST00000474267; ENSP00000417310; ENSG00000114251. [P41221-1]
ENST00000497027; ENSP00000420104; ENSG00000114251. [P41221-2]
GeneIDi7474.
KEGGihsa:7474.
UCSCiuc003dhm.3. human. [P41221-1]

Organism-specific databases

CTDi7474.
GeneCardsiGC03M055474.
HGNCiHGNC:12784. WNT5A.
MIMi164975. gene.
180700. phenotype.
neXtProtiNX_P41221.
Orphaneti3107. Autosomal dominant Robinow syndrome.
PharmGKBiPA37385.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOVERGENiHBG001595.
InParanoidiP41221.
KOiK00444.
OMAiIVERCHC.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP41221.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_263890. WNT5A-dependent internalization of FZD4.
REACT_263982. Ca2+ pathway.
REACT_264199. PCP/CE pathway.
REACT_264383. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_264478. Asymmetric localization of PCP proteins.
REACT_264533. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_264596. TCF dependent signaling in response to WNT.
SignaLinkiP41221.

Miscellaneous databases

ChiTaRSiWNT5A. human.
GeneWikiiWNT5A.
GenomeRNAii7474.
NextBioi29276.
PROiP41221.
SOURCEiSearch...

Gene expression databases

BgeeiP41221.
CleanExiHS_WNT5A.
ExpressionAtlasiP41221. baseline and differential.
GenevestigatoriP41221.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21."
    Clark C.C., Cohen I.R., Eichstetter I., Cannizarro L.A., McPherson J.D., Wasmuth J.J., Iozzo R.V.
    Genomics 18:249-260(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mesangial cell and Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition."
    Dissanayake S.K., Wade M., Johnson C.E., O'Connell M.P., Leotlela P.D., French A.D., Shah K.V., Hewitt K.J., Rosenthal D.T., Indig F.E., Jiang Y., Nickoloff B.J., Taub D.D., Trent J.M., Moon R.T., Bittner M., Weeraratna A.T.
    J. Biol. Chem. 282:17259-17271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: VARIANTS DRS SER-83 AND ARG-182, CHARACTERIZATION OF VARIANTS DRS SER-83 AND ARG-182.

Entry informationi

Entry nameiWNT5A_HUMAN
AccessioniPrimary (citable) accession number: P41221
Secondary accession number(s): A8K4A4, Q6P278
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 4, 2008
Last modified: May 27, 2015
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.