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Protein

Myeloid cell nuclear differentiation antigen

Gene

MNDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

GO - Molecular functioni

GO - Biological processi

  • B cell receptor signaling pathway Source: UniProtKB
  • cellular defense response Source: ProtInc
  • cellular response to DNA damage stimulus Source: UniProtKB
  • negative regulation of B cell proliferation Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163563-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid cell nuclear differentiation antigen
Gene namesi
Name:MNDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7183. MNDA.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4332.
OpenTargetsiENSG00000163563.
PharmGKBiPA30895.

Polymorphism and mutation databases

BioMutaiMNDA.
DMDMi730038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537241 – 407Myeloid cell nuclear differentiation antigenAdd BLAST407

Proteomic databases

EPDiP41218.
PaxDbiP41218.
PeptideAtlasiP41218.
PRIDEiP41218.

PTM databases

iPTMnetiP41218.
PhosphoSitePlusiP41218.

Expressioni

Tissue specificityi

Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.1 Publication

Inductioni

Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3.1 Publication

Gene expression databases

BgeeiENSG00000163563.
CleanExiHS_MNDA.
ExpressionAtlasiP41218. baseline and differential.
GenevisibleiP41218. HS.

Organism-specific databases

HPAiHPA034532.

Interactioni

Subunit structurei

Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23.

Binary interactionsi

WithEntry#Exp.IntActNotes
WHSC1L1Q9BZ952EBI-2829677,EBI-3390132

Protein-protein interaction databases

BioGridi110475. 7 interactors.
IntActiP41218. 163 interactors.
MINTiMINT-8373462.
STRINGi9606.ENSP00000357123.

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 11Combined sources8
Turni12 – 16Combined sources5
Helixi19 – 33Combined sources15
Helixi37 – 42Combined sources6
Helixi45 – 55Combined sources11
Helixi60 – 68Combined sources9
Helixi73 – 75Combined sources3
Helixi76 – 89Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBGNMR-A1-90[»]
ProteinModelPortaliP41218.
SMRiP41218.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88PyrinPROSITE-ProRule annotationAdd BLAST88
Domaini196 – 394HIN-200PROSITE-ProRule annotationAdd BLAST199

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 137Nuclear localization signalSequence analysis7

Domaini

Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.

Sequence similaritiesi

Contains 1 HIN-200 domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J5NP. Eukaryota.
ENOG410Y78B. LUCA.
GeneTreeiENSGT00390000013296.
HOGENOMiHOG000033871.
HOVERGENiHBG006122.
InParanoidiP41218.
OMAiGKWHNIK.
OrthoDBiEOG091G02W0.
PhylomeDBiP41218.
TreeFamiTF337385.

Family and domain databases

InterProiIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
[Graphical view]
PfamiPF02760. HIN. 1 hit.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
PROSITEiPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD
60 70 80 90 100
LMEKKFQGVA CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP
110 120 130 140 150
VKKINQEEVG LAAPAPTARN KLTSEARGRI PVAQKRKTPN KEKTEAKRNK
160 170 180 190 200
VSQEQSKPPG PSGASTSAAV DHPPLPQTSS STPSNTSFTP NQETQAQRQV
210 220 230 240 250
DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV ASKTQYFHVK
260 270 280 290 300
VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII
310 320 330 340 350
EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV
360 370 380 390 400
VGSGKWHNIK CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK

EGPMNVN
Length:407
Mass (Da):45,836
Last modified:February 1, 1995 - v1
Checksum:iF4943C38033C5A83
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034107156S → R.Corresponds to variant rs35417083dbSNPEnsembl.1
Natural variantiVAR_012055286V → L.Corresponds to variant rs1056771dbSNPEnsembl.1
Natural variantiVAR_020483357H → Y.Corresponds to variant rs2276403dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81750 mRNA. Translation: AAA69696.1.
BC032319 mRNA. Translation: AAH32319.1.
CCDSiCCDS1177.1.
PIRiI55525.
RefSeqiNP_002423.1. NM_002432.1.
UniGeneiHs.153837.

Genome annotation databases

EnsembliENST00000368141; ENSP00000357123; ENSG00000163563.
GeneIDi4332.
KEGGihsa:4332.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81750 mRNA. Translation: AAA69696.1.
BC032319 mRNA. Translation: AAH32319.1.
CCDSiCCDS1177.1.
PIRiI55525.
RefSeqiNP_002423.1. NM_002432.1.
UniGeneiHs.153837.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBGNMR-A1-90[»]
ProteinModelPortaliP41218.
SMRiP41218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110475. 7 interactors.
IntActiP41218. 163 interactors.
MINTiMINT-8373462.
STRINGi9606.ENSP00000357123.

PTM databases

iPTMnetiP41218.
PhosphoSitePlusiP41218.

Polymorphism and mutation databases

BioMutaiMNDA.
DMDMi730038.

Proteomic databases

EPDiP41218.
PaxDbiP41218.
PeptideAtlasiP41218.
PRIDEiP41218.

Protocols and materials databases

DNASUi4332.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368141; ENSP00000357123; ENSG00000163563.
GeneIDi4332.
KEGGihsa:4332.

Organism-specific databases

CTDi4332.
DisGeNETi4332.
GeneCardsiMNDA.
HGNCiHGNC:7183. MNDA.
HPAiHPA034532.
MIMi159553. gene.
neXtProtiNX_P41218.
OpenTargetsiENSG00000163563.
PharmGKBiPA30895.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5NP. Eukaryota.
ENOG410Y78B. LUCA.
GeneTreeiENSGT00390000013296.
HOGENOMiHOG000033871.
HOVERGENiHBG006122.
InParanoidiP41218.
OMAiGKWHNIK.
OrthoDBiEOG091G02W0.
PhylomeDBiP41218.
TreeFamiTF337385.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163563-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiMNDA. human.
EvolutionaryTraceiP41218.
GeneWikiiMNDA.
GenomeRNAii4332.
PROiP41218.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163563.
CleanExiHS_MNDA.
ExpressionAtlasiP41218. baseline and differential.
GenevisibleiP41218. HS.

Family and domain databases

InterProiIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
[Graphical view]
PfamiPF02760. HIN. 1 hit.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
PROSITEiPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNDA_HUMAN
AccessioniPrimary (citable) accession number: P41218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.