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P41218 (MNDA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myeloid cell nuclear differentiation antigen
Gene names
Name:MNDA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

Subunit structure

Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23.

Subcellular location

Nucleus. Cytoplasm. Note: Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.

Tissue specificity

Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia. Ref.5

Induction

Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3. Ref.4 Ref.5 Ref.6

Domain

Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.

Sequence similarities

Contains 1 DAPIN domain.

Contains 1 HIN-200 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

WHSC1L1Q9BZ952EBI-2829677,EBI-3390132

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Myeloid cell nuclear differentiation antigen
PRO_0000153724

Regions

Domain1 – 8888DAPIN
Domain196 – 394199HIN-200
Motif131 – 1377Nuclear localization signal Potential

Natural variations

Natural variant1561S → R.
Corresponds to variant rs35417083 [ dbSNP | Ensembl ].
VAR_034107
Natural variant2861V → L.
Corresponds to variant rs1056771 [ dbSNP | Ensembl ].
VAR_012055
Natural variant3571H → Y.
Corresponds to variant rs2276403 [ dbSNP | Ensembl ].
VAR_020483

Secondary structure

............... 407
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P41218 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: F4943C38033C5A83

FASTA40745,836
        10         20         30         40         50         60 
MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD LMEKKFQGVA 

        70         80         90        100        110        120 
CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP VKKINQEEVG LAAPAPTARN 

       130        140        150        160        170        180 
KLTSEARGRI PVAQKRKTPN KEKTEAKRNK VSQEQSKPPG PSGASTSAAV DHPPLPQTSS 

       190        200        210        220        230        240 
STPSNTSFTP NQETQAQRQV DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV 

       250        260        270        280        290        300 
ASKTQYFHVK VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII 

       310        320        330        340        350        360 
EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV VGSGKWHNIK 

       370        380        390        400 
CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK EGPMNVN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha."
Briggs J.A., Burrus G.R., Stickney B.D., Briggs R.C.
J. Cell. Biochem. 49:82-92(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[3]"Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins."
Burrus G.R., Briggs J.A., Briggs R.C.
J. Cell. Biochem. 48:190-202(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
[4]"The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells."
Briggs R.C., Briggs J.A., Ozer J., Sealy L., Dworkin L.L., Kingsmore S.F., Seldin M.F., Kaur G.P., Athwal R.S., Dessypris E.N.
Blood 83:2153-2162(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage."
Briggs R., Dworkin L., Briggs J., Dessypris E., Stein J., Stein G., Lian J.
J. Cell. Biochem. 54:198-206(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY OF ALPHA-INTERFERON INDUCTION.
[6]"The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression."
Dawson M.J., Trapani J.A., Briggs R.C., Nicholl J.K., Sutherland G.R., Baker E.
Immunogenetics 41:40-43(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL LOCATION, TISSUE SPECIFIC INDUCTION.
[7]"Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding."
Xie J., Briggs J.A., Briggs R.C.
J. Cell. Biochem. 70:489-506(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION.
[8]"Solution structure of the pyrin (PAAD-DAPIN) domain in human myeloid cell nuclear differentiation antigen."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1-90.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81750 mRNA. Translation: AAA69696.1.
BC032319 mRNA. Translation: AAH32319.1.
CCDSCCDS1177.1.
PIRI55525.
RefSeqNP_002423.1. NM_002432.1.
UniGeneHs.153837.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DBGNMR-A1-90[»]
ProteinModelPortalP41218.
SMRP41218. Positions 1-90, 205-393.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110475. 3 interactions.
IntActP41218. 6 interactions.
MINTMINT-8373462.
STRING9606.ENSP00000357123.

PTM databases

PhosphoSiteP41218.

Polymorphism databases

DMDM730038.

Proteomic databases

MaxQBP41218.
PaxDbP41218.
PeptideAtlasP41218.
PRIDEP41218.

Protocols and materials databases

DNASU4332.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368141; ENSP00000357123; ENSG00000163563.
GeneID4332.
KEGGhsa:4332.
UCSCuc001fsz.1. human.

Organism-specific databases

CTD4332.
GeneCardsGC01P158801.
HGNCHGNC:7183. MNDA.
HPAHPA034532.
MIM159553. gene.
neXtProtNX_P41218.
PharmGKBPA30895.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81691.
HOGENOMHOG000033871.
HOVERGENHBG006122.
InParanoidP41218.
OMAGKWHNIK.
OrthoDBEOG7ZD1V8.
PhylomeDBP41218.
TreeFamTF337385.

Gene expression databases

ArrayExpressP41218.
BgeeP41218.
CleanExHS_MNDA.
GenevestigatorP41218.

Family and domain databases

Gene3D2.40.50.140. 2 hits.
InterProIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF02760. HIN. 1 hit.
PF02758. PYRIN. 1 hit.
[Graphical view]
PROSITEPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMNDA. human.
EvolutionaryTraceP41218.
GeneWikiMNDA.
GenomeRNAi4332.
NextBio17047.
PROP41218.
SOURCESearch...

Entry information

Entry nameMNDA_HUMAN
AccessionPrimary (citable) accession number: P41218
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM