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P41217

- OX2G_HUMAN

UniProt

P41217 - OX2G_HUMAN

Protein

OX-2 membrane glycoprotein

Gene

CD200

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of immune response Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OX-2 membrane glycoprotein
    Alternative name(s):
    CD_antigen: CD200
    Gene namesi
    Name:CD200
    Synonyms:MOX1, MOX2
    ORF Names:My033
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:7203. CD200.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30911.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 278248OX-2 membrane glycoproteinPRO_0000015124Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 121PROSITE-ProRule annotation
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi118 ↔ 136PROSITE-ProRule annotation
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi160 ↔ 214PROSITE-ProRule annotation
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP41217.
    PRIDEiP41217.

    PTM databases

    PhosphoSiteiP41217.

    Expressioni

    Gene expression databases

    ArrayExpressiP41217.
    BgeeiP41217.
    CleanExiHS_CD200.
    GenevestigatoriP41217.

    Organism-specific databases

    HPAiHPA031149.

    Interactioni

    Subunit structurei

    CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CD200R1Q8TD462EBI-3910563,EBI-4314412

    Protein-protein interaction databases

    BioGridi110486. 2 interactions.
    IntActiP41217. 2 interactions.
    STRINGi9606.ENSP00000420298.

    Structurei

    3D structure databases

    ProteinModelPortaliP41217.
    SMRiP41217. Positions 32-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 232202ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27819CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei233 – 25927HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 141111Ig-like V-typeAdd
    BLAST
    Domaini142 – 23291Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72791.
    HOVERGENiHBG031790.
    KOiK06556.
    OMAiCYMCLFN.
    PhylomeDBiP41217.
    TreeFamiTF334493.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 2 hits.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P41217-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERLVIRMPF SHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK    50
    CSLQNAQEAL IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG 100
    LQNSTITFWN ITLEDEGCYM CLFNTFGFGK ISGTACLTVY VQPIVSLHYK 150
    FSEDHLNITC SATARPAPMV FWKVPRSGIE NSTVTLSHPN GTTSVTSILH 200
    IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL LSIVSLVILL 250
    VLISILLYWK RHRNQDRGEL SQGVQKMT 278
    Length:278
    Mass (Da):31,264
    Last modified:November 2, 2010 - v4
    Checksum:i38DF327B382CC970
    GO
    Isoform 2 (identifier: P41217-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-278: GELSQGVQKMT → EP

    Show »
    Length:269
    Mass (Da):30,331
    Checksum:i7EE08BD6760BACEC
    GO
    Isoform 3 (identifier: P41217-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4-4: L → LTLTRTIGGPLLTATLLGKTTINDYQ
         268-278: GELSQGVQKMT → EP

    Show »
    Length:294
    Mass (Da):32,975
    Checksum:iD40A34379E9D7A3B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811N → D in AAT37533. 1 PublicationCurated
    Sequence conflicti225 – 2251F → S in AAT37533. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111S → C.4 Publications
    Corresponds to variant rs1131199 [ dbSNP | Ensembl ].
    VAR_027605
    Natural varianti46 – 461P → T.1 Publication
    Corresponds to variant rs2272022 [ dbSNP | Ensembl ].
    VAR_027606
    Natural varianti76 – 761V → G.
    Corresponds to variant rs35465733 [ dbSNP | Ensembl ].
    VAR_056110

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei4 – 41L → LTLTRTIGGPLLTATLLGKT TINDYQ in isoform 3. 1 PublicationVSP_040027
    Alternative sequencei268 – 27811GELSQGVQKMT → EP in isoform 2 and isoform 3. 5 PublicationsVSP_002613Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY603771 mRNA. Translation: AAT37533.1.
    AF063591 mRNA. Translation: AAG43150.1.
    AK297194 mRNA. Translation: BAG59681.1.
    AK074972 mRNA. Translation: BAG52043.1.
    AC112487 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79672.1.
    CH471052 Genomic DNA. Translation: EAW79676.1.
    BC022522 mRNA. Translation: AAH22522.1.
    BC031103 mRNA. Translation: AAH31103.1.
    X05323
    , X05324, X05325, X05326 Genomic DNA. Translation: CAA28943.1.
    CCDSiCCDS2965.1. [P41217-2]
    CCDS33818.1. [P41217-3]
    PIRiA47639.
    RefSeqiNP_001004196.2. NM_001004196.2. [P41217-3]
    NP_005935.4. NM_005944.5. [P41217-2]
    XP_005247539.1. XM_005247482.1. [P41217-1]
    UniGeneiHs.79015.

    Genome annotation databases

    EnsembliENST00000315711; ENSP00000312766; ENSG00000091972. [P41217-2]
    ENST00000473539; ENSP00000420298; ENSG00000091972. [P41217-3]
    GeneIDi4345.
    KEGGihsa:4345.
    UCSCiuc003dyw.3. human. [P41217-3]
    uc003dyx.3. human. [P41217-2]

    Polymorphism databases

    DMDMi311033489.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY603771 mRNA. Translation: AAT37533.1 .
    AF063591 mRNA. Translation: AAG43150.1 .
    AK297194 mRNA. Translation: BAG59681.1 .
    AK074972 mRNA. Translation: BAG52043.1 .
    AC112487 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79672.1 .
    CH471052 Genomic DNA. Translation: EAW79676.1 .
    BC022522 mRNA. Translation: AAH22522.1 .
    BC031103 mRNA. Translation: AAH31103.1 .
    X05323
    , X05324 , X05325 , X05326 Genomic DNA. Translation: CAA28943.1 .
    CCDSi CCDS2965.1. [P41217-2 ]
    CCDS33818.1. [P41217-3 ]
    PIRi A47639.
    RefSeqi NP_001004196.2. NM_001004196.2. [P41217-3 ]
    NP_005935.4. NM_005944.5. [P41217-2 ]
    XP_005247539.1. XM_005247482.1. [P41217-1 ]
    UniGenei Hs.79015.

    3D structure databases

    ProteinModelPortali P41217.
    SMRi P41217. Positions 32-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110486. 2 interactions.
    IntActi P41217. 2 interactions.
    STRINGi 9606.ENSP00000420298.

    PTM databases

    PhosphoSitei P41217.

    Polymorphism databases

    DMDMi 311033489.

    Proteomic databases

    PaxDbi P41217.
    PRIDEi P41217.

    Protocols and materials databases

    DNASUi 4345.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315711 ; ENSP00000312766 ; ENSG00000091972 . [P41217-2 ]
    ENST00000473539 ; ENSP00000420298 ; ENSG00000091972 . [P41217-3 ]
    GeneIDi 4345.
    KEGGi hsa:4345.
    UCSCi uc003dyw.3. human. [P41217-3 ]
    uc003dyx.3. human. [P41217-2 ]

    Organism-specific databases

    CTDi 4345.
    GeneCardsi GC03P112051.
    HGNCi HGNC:7203. CD200.
    HPAi HPA031149.
    MIMi 155970. gene.
    neXtProti NX_P41217.
    PharmGKBi PA30911.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72791.
    HOVERGENi HBG031790.
    KOi K06556.
    OMAi CYMCLFN.
    PhylomeDBi P41217.
    TreeFami TF334493.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    GeneWikii CD200.
    GenomeRNAii 4345.
    NextBioi 17104.
    PROi P41217.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41217.
    Bgeei P41217.
    CleanExi HS_CD200.
    Genevestigatori P41217.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 2 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hou Z.F., Gao S., Zheng Y.C., Hao B., Wang W.Z., Bu L.S., Yang S.J., Hou R.Z., Gao S.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT CYS-11.
    2. Mao Y.M., Xie Y., Zheng Z.H.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT CYS-11.
      Tissue: Brain.
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-11.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-11.
      Tissue: Brain.
    8. "Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein."
      McCaughan G.W., Clark M.J., Barclay A.N.
      Immunogenetics 25:329-335(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-278 (ISOFORM 1), VARIANT THR-46.
      Tissue: Blood.

    Entry informationi

    Entry nameiOX2G_HUMAN
    AccessioniPrimary (citable) accession number: P41217
    Secondary accession number(s): B3KQI1
    , B4DLW9, D3DN65, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3