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P41217

- OX2G_HUMAN

UniProt

P41217 - OX2G_HUMAN

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Protein
OX-2 membrane glycoprotein
Gene
CD200, MOX1, MOX2, My033
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. regulation of immune response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
OX-2 membrane glycoprotein
Alternative name(s):
CD_antigen: CD200
Gene namesi
Name:CD200
Synonyms:MOX1, MOX2
ORF Names:My033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:7203. CD200.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 232202Extracellular Reviewed prediction
Add
BLAST
Transmembranei233 – 25927Helical; Reviewed prediction
Add
BLAST
Topological domaini260 – 27819Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 278248OX-2 membrane glycoprotein
PRO_0000015124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 121 By similarity
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi118 ↔ 136 By similarity
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi160 ↔ 214 By similarity
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP41217.
PRIDEiP41217.

PTM databases

PhosphoSiteiP41217.

Expressioni

Gene expression databases

ArrayExpressiP41217.
BgeeiP41217.
CleanExiHS_CD200.
GenevestigatoriP41217.

Organism-specific databases

HPAiHPA031149.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

Binary interactionsi

WithEntry#Exp.IntActNotes
CD200R1Q8TD462EBI-3910563,EBI-4314412

Protein-protein interaction databases

BioGridi110486. 2 interactions.
IntActiP41217. 2 interactions.
STRINGi9606.ENSP00000420298.

Structurei

3D structure databases

ProteinModelPortaliP41217.
SMRiP41217. Positions 32-232.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 141111Ig-like V-type
Add
BLAST
Domaini142 – 23291Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72791.
HOVERGENiHBG031790.
KOiK06556.
OMAiCYMCLFN.
PhylomeDBiP41217.
TreeFamiTF334493.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P41217-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MERLVIRMPF SHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK    50
CSLQNAQEAL IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG 100
LQNSTITFWN ITLEDEGCYM CLFNTFGFGK ISGTACLTVY VQPIVSLHYK 150
FSEDHLNITC SATARPAPMV FWKVPRSGIE NSTVTLSHPN GTTSVTSILH 200
IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL LSIVSLVILL 250
VLISILLYWK RHRNQDRGEL SQGVQKMT 278
Length:278
Mass (Da):31,264
Last modified:November 2, 2010 - v4
Checksum:i38DF327B382CC970
GO
Isoform 2 (identifier: P41217-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-278: GELSQGVQKMT → EP

Show »
Length:269
Mass (Da):30,331
Checksum:i7EE08BD6760BACEC
GO
Isoform 3 (identifier: P41217-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-4: L → LTLTRTIGGPLLTATLLGKTTINDYQ
     268-278: GELSQGVQKMT → EP

Show »
Length:294
Mass (Da):32,975
Checksum:iD40A34379E9D7A3B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111S → C.4 Publications
Corresponds to variant rs1131199 [ dbSNP | Ensembl ].
VAR_027605
Natural varianti46 – 461P → T.1 Publication
Corresponds to variant rs2272022 [ dbSNP | Ensembl ].
VAR_027606
Natural varianti76 – 761V → G.
Corresponds to variant rs35465733 [ dbSNP | Ensembl ].
VAR_056110

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4 – 41L → LTLTRTIGGPLLTATLLGKT TINDYQ in isoform 3.
VSP_040027
Alternative sequencei268 – 27811GELSQGVQKMT → EP in isoform 2 and isoform 3.
VSP_002613Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811N → D in AAT37533. 1 Publication
Sequence conflicti225 – 2251F → S in AAT37533. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY603771 mRNA. Translation: AAT37533.1.
AF063591 mRNA. Translation: AAG43150.1.
AK297194 mRNA. Translation: BAG59681.1.
AK074972 mRNA. Translation: BAG52043.1.
AC112487 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79672.1.
CH471052 Genomic DNA. Translation: EAW79676.1.
BC022522 mRNA. Translation: AAH22522.1.
BC031103 mRNA. Translation: AAH31103.1.
X05323
, X05324, X05325, X05326 Genomic DNA. Translation: CAA28943.1.
CCDSiCCDS2965.1. [P41217-2]
CCDS33818.1. [P41217-3]
PIRiA47639.
RefSeqiNP_001004196.2. NM_001004196.2. [P41217-3]
NP_005935.4. NM_005944.5. [P41217-2]
XP_005247539.1. XM_005247482.1. [P41217-1]
UniGeneiHs.79015.

Genome annotation databases

EnsembliENST00000315711; ENSP00000312766; ENSG00000091972. [P41217-2]
ENST00000473539; ENSP00000420298; ENSG00000091972. [P41217-3]
GeneIDi4345.
KEGGihsa:4345.
UCSCiuc003dyw.3. human. [P41217-3]
uc003dyx.3. human. [P41217-2]

Polymorphism databases

DMDMi311033489.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY603771 mRNA. Translation: AAT37533.1 .
AF063591 mRNA. Translation: AAG43150.1 .
AK297194 mRNA. Translation: BAG59681.1 .
AK074972 mRNA. Translation: BAG52043.1 .
AC112487 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79672.1 .
CH471052 Genomic DNA. Translation: EAW79676.1 .
BC022522 mRNA. Translation: AAH22522.1 .
BC031103 mRNA. Translation: AAH31103.1 .
X05323
, X05324 , X05325 , X05326 Genomic DNA. Translation: CAA28943.1 .
CCDSi CCDS2965.1. [P41217-2 ]
CCDS33818.1. [P41217-3 ]
PIRi A47639.
RefSeqi NP_001004196.2. NM_001004196.2. [P41217-3 ]
NP_005935.4. NM_005944.5. [P41217-2 ]
XP_005247539.1. XM_005247482.1. [P41217-1 ]
UniGenei Hs.79015.

3D structure databases

ProteinModelPortali P41217.
SMRi P41217. Positions 32-232.
ModBasei Search...

Protein-protein interaction databases

BioGridi 110486. 2 interactions.
IntActi P41217. 2 interactions.
STRINGi 9606.ENSP00000420298.

PTM databases

PhosphoSitei P41217.

Polymorphism databases

DMDMi 311033489.

Proteomic databases

PaxDbi P41217.
PRIDEi P41217.

Protocols and materials databases

DNASUi 4345.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315711 ; ENSP00000312766 ; ENSG00000091972 . [P41217-2 ]
ENST00000473539 ; ENSP00000420298 ; ENSG00000091972 . [P41217-3 ]
GeneIDi 4345.
KEGGi hsa:4345.
UCSCi uc003dyw.3. human. [P41217-3 ]
uc003dyx.3. human. [P41217-2 ]

Organism-specific databases

CTDi 4345.
GeneCardsi GC03P112051.
HGNCi HGNC:7203. CD200.
HPAi HPA031149.
MIMi 155970. gene.
neXtProti NX_P41217.
PharmGKBi PA30911.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72791.
HOVERGENi HBG031790.
KOi K06556.
OMAi CYMCLFN.
PhylomeDBi P41217.
TreeFami TF334493.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikii CD200.
GenomeRNAii 4345.
NextBioi 17104.
PROi P41217.
SOURCEi Search...

Gene expression databases

ArrayExpressi P41217.
Bgeei P41217.
CleanExi HS_CD200.
Genevestigatori P41217.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF00047. ig. 2 hits.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hou Z.F., Gao S., Zheng Y.C., Hao B., Wang W.Z., Bu L.S., Yang S.J., Hou R.Z., Gao S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT CYS-11.
  2. Mao Y.M., Xie Y., Zheng Z.H.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT CYS-11.
    Tissue: Brain.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-11.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-11.
    Tissue: Brain.
  8. "Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein."
    McCaughan G.W., Clark M.J., Barclay A.N.
    Immunogenetics 25:329-335(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-278 (ISOFORM 1), VARIANT THR-46.
    Tissue: Blood.

Entry informationi

Entry nameiOX2G_HUMAN
AccessioniPrimary (citable) accession number: P41217
Secondary accession number(s): B3KQI1
, B4DLW9, D3DN65, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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