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P41217 (OX2G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OX-2 membrane glycoprotein
Alternative name(s):
CD_antigen=CD200
Gene names
Name:CD200
Synonyms:MOX1, MOX2
ORF Names:My033
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Subunit structure

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CD200R1Q8TD462EBI-3910563,EBI-4314412

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P41217-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P41217-2)

The sequence of this isoform differs from the canonical sequence as follows:
     268-278: GELSQGVQKMT → EP
Isoform 3 (identifier: P41217-3)

The sequence of this isoform differs from the canonical sequence as follows:
     4-4: L → LTLTRTIGGPLLTATLLGKTTINDYQ
     268-278: GELSQGVQKMT → EP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 278248OX-2 membrane glycoprotein
PRO_0000015124

Regions

Topological domain31 – 232202Extracellular Potential
Transmembrane233 – 25927Helical; Potential
Topological domain260 – 27819Cytoplasmic Potential
Domain31 – 141111Ig-like V-type
Domain142 – 23291Ig-like C2-type

Amino acid modifications

Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Disulfide bond51 ↔ 121 By similarity
Disulfide bond118 ↔ 136 By similarity
Disulfide bond160 ↔ 214 By similarity

Natural variations

Alternative sequence41L → LTLTRTIGGPLLTATLLGKT TINDYQ in isoform 3.
VSP_040027
Alternative sequence268 – 27811GELSQGVQKMT → EP in isoform 2 and isoform 3.
VSP_002613
Natural variant111S → C. Ref.1 Ref.3 Ref.4 Ref.7
Corresponds to variant rs1131199 [ dbSNP | Ensembl ].
VAR_027605
Natural variant461P → T. Ref.8
Corresponds to variant rs2272022 [ dbSNP | Ensembl ].
VAR_027606
Natural variant761V → G.
Corresponds to variant rs35465733 [ dbSNP | Ensembl ].
VAR_056110

Experimental info

Sequence conflict1811N → D in AAT37533. Ref.1
Sequence conflict2251F → S in AAT37533. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2010. Version 4.
Checksum: 38DF327B382CC970

FASTA27831,264
        10         20         30         40         50         60 
MERLVIRMPF SHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK CSLQNAQEAL 

        70         80         90        100        110        120 
IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG LQNSTITFWN ITLEDEGCYM 

       130        140        150        160        170        180 
CLFNTFGFGK ISGTACLTVY VQPIVSLHYK FSEDHLNITC SATARPAPMV FWKVPRSGIE 

       190        200        210        220        230        240 
NSTVTLSHPN GTTSVTSILH IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL 

       250        260        270 
LSIVSLVILL VLISILLYWK RHRNQDRGEL SQGVQKMT 

« Hide

Isoform 2 [UniParc].

Checksum: 7EE08BD6760BACEC
Show »

FASTA26930,331
Isoform 3 [UniParc].

Checksum: D40A34379E9D7A3B
Show »

FASTA29432,975

References

« Hide 'large scale' references
[1]Hou Z.F., Gao S., Zheng Y.C., Hao B., Wang W.Z., Bu L.S., Yang S.J., Hou R.Z., Gao S.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT CYS-11.
[2]Mao Y.M., Xie Y., Zheng Z.H.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT CYS-11.
Tissue: Brain.
[4]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-11.
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-11.
Tissue: Brain.
[8]"Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein."
McCaughan G.W., Clark M.J., Barclay A.N.
Immunogenetics 25:329-335(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-278 (ISOFORM 1), VARIANT THR-46.
Tissue: Blood.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY603771 mRNA. Translation: AAT37533.1.
AF063591 mRNA. Translation: AAG43150.1.
AK297194 mRNA. Translation: BAG59681.1.
AK074972 mRNA. Translation: BAG52043.1.
AC112487 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79672.1.
CH471052 Genomic DNA. Translation: EAW79676.1.
BC022522 mRNA. Translation: AAH22522.1.
BC031103 mRNA. Translation: AAH31103.1.
X05323 expand/collapse EMBL AC list , X05324, X05325, X05326 Genomic DNA. Translation: CAA28943.1.
CCDSCCDS2965.1. [P41217-2]
CCDS33818.1. [P41217-3]
PIRA47639.
RefSeqNP_001004196.2. NM_001004196.2. [P41217-3]
NP_005935.4. NM_005944.5. [P41217-2]
XP_005247539.1. XM_005247482.1. [P41217-1]
UniGeneHs.79015.

3D structure databases

ProteinModelPortalP41217.
SMRP41217. Positions 32-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110486. 2 interactions.
IntActP41217. 2 interactions.
STRING9606.ENSP00000420298.

PTM databases

PhosphoSiteP41217.

Polymorphism databases

DMDM311033489.

Proteomic databases

PaxDbP41217.
PRIDEP41217.

Protocols and materials databases

DNASU4345.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315711; ENSP00000312766; ENSG00000091972. [P41217-2]
ENST00000473539; ENSP00000420298; ENSG00000091972. [P41217-3]
GeneID4345.
KEGGhsa:4345.
UCSCuc003dyw.3. human. [P41217-3]
uc003dyx.3. human. [P41217-2]

Organism-specific databases

CTD4345.
GeneCardsGC03P112051.
HGNCHGNC:7203. CD200.
HPAHPA031149.
MIM155970. gene.
neXtProtNX_P41217.
PharmGKBPA30911.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72791.
HOVERGENHBG031790.
KOK06556.
OMACYMCLFN.
PhylomeDBP41217.
TreeFamTF334493.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP41217.
BgeeP41217.
CleanExHS_CD200.
GenevestigatorP41217.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 2 hits.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCD200.
GenomeRNAi4345.
NextBio17104.
PROP41217.
SOURCESearch...

Entry information

Entry nameOX2G_HUMAN
AccessionPrimary (citable) accession number: P41217
Secondary accession number(s): B3KQI1 expand/collapse secondary AC list , B4DLW9, D3DN65, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries