P41217 (OX2G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
OX-2 membrane glycoprotein

Alternative name(s):
CD_antigen=CD200

Gene names

Name:	CD200
Synonyms:	MOX1, MOX2
ORF Names:	My033

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Subunit structure	Interacts with CD200R1.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of immune response Traceable author statement. Source: Reactome
Cellular_component	integral to plasma membrane Traceable author statement Ref.8. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CD200R1	Q8TD46	2	EBI-3910563,EBI-4314412

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P41217-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P41217-2)

The sequence of this isoform differs from the canonical sequence as follows:
     268-278: GELSQGVQKMT → EP

Isoform 3 (identifier: P41217-3)

The sequence of this isoform differs from the canonical sequence as follows:
     4-4: L → LTLTRTIGGPLLTATLLGKTTINDYQ
     268-278: GELSQGVQKMT → EP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 278	248	OX-2 membrane glycoprotein		PRO_0000015124
Regions
	Topological domain	31 – 232	202	Extracellular Potential
	Transmembrane	233 – 259	27	Helical; Potential
	Topological domain	260 – 278	19	Cytoplasmic Potential
	Domain	31 – 141	111	Ig-like V-type
	Domain	142 – 232	91	Ig-like C2-type
Amino acid modifications
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	181	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Disulfide bond	51 ↔ 121		Potential
	Disulfide bond	160 ↔ 214		Potential
Natural variations
	Alternative sequence	4	1	L → LTLTRTIGGPLLTATLLGKT TINDYQ in isoform 3.		VSP_040027
	Alternative sequence	268 – 278	11	GELSQGVQKMT → EP in isoform 2 and isoform 3.		VSP_002613
	Natural variant	11	1	S → C. Ref.1 Ref.3 Ref.4 Ref.7 Corresponds to variant rs1131199 [ dbSNP | Ensembl ].		VAR_027605
	Natural variant	46	1	P → T. Ref.8 Corresponds to variant rs2272022 [ dbSNP | Ensembl ].		VAR_027606
	Natural variant	76	1	V → G. Corresponds to variant rs35465733 [ dbSNP | Ensembl ].		VAR_056110
Experimental info
	Sequence conflict	181	1	N → D in AAT37533. Ref.1
	Sequence conflict	225	1	F → S in AAT37533. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 4. Checksum: 38DF327B382CC970	FASTA	278	31,264
	10 20 30 40 50 60 MERLVIRMPF SHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK CSLQNAQEAL 70 80 90 100 110 120 IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG LQNSTITFWN ITLEDEGCYM 130 140 150 160 170 180 CLFNTFGFGK ISGTACLTVY VQPIVSLHYK FSEDHLNITC SATARPAPMV FWKVPRSGIE 190 200 210 220 230 240 NSTVTLSHPN GTTSVTSILH IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL 250 260 270 LSIVSLVILL VLISILLYWK RHRNQDRGEL SQGVQKMT
	Isoform 2 [UniParc]. Checksum: 7EE08BD6760BACEC	FASTA	269	30,331
	10 20 30 40 50 60 MERLVIRMPF SHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK CSLQNAQEAL 70 80 90 100 110 120 IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG LQNSTITFWN ITLEDEGCYM 130 140 150 160 170 180 CLFNTFGFGK ISGTACLTVY VQPIVSLHYK FSEDHLNITC SATARPAPMV FWKVPRSGIE 190 200 210 220 230 240 NSTVTLSHPN GTTSVTSILH IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL 250 260 LSIVSLVILL VLISILLYWK RHRNQDREP
	Isoform 3 [UniParc]. Checksum: D40A34379E9D7A3B	FASTA	294	32,975
	10 20 30 40 50 60 MERLTLTRTI GGPLLTATLL GKTTINDYQV IRMPFSHLST YSLVWVMAAV VLCTAQVQVV 70 80 90 100 110 120 TQDEREQLYT PASLKCSLQN AQEALIVTWQ KKKAVSPENM VTFSENHGVV IQPAYKDKIN 130 140 150 160 170 180 ITQLGLQNST ITFWNITLED EGCYMCLFNT FGFGKISGTA CLTVYVQPIV SLHYKFSEDH 190 200 210 220 230 240 LNITCSATAR PAPMVFWKVP RSGIENSTVT LSHPNGTTSV TSILHIKDPK NQVGKEVICQ 250 260 270 280 290 VLHLGTVTDF KQTVNKGYWF SVPLLLSIVS LVILLVLISI LLYWKRHRNQ DREP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Hou Z.F., Gao S., Zheng Y.C., Hao B., Wang W.Z., Bu L.S., Yang S.J., Hou R.Z., Gao S. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT CYS-11.
[2]	Mao Y.M., Xie Y., Zheng Z.H. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Fetal brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT CYS-11. Tissue: Brain.
[4]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-11.
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-11. Tissue: Brain.
[8]	"Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein." McCaughan G.W., Clark M.J., Barclay A.N. Immunogenetics 25:329-335(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-278 (ISOFORM 1), VARIANT THR-46. Tissue: Blood.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY603771 mRNA. Translation: AAT37533.1. AF063591 mRNA. Translation: AAG43150.1. AK297194 mRNA. Translation: BAG59681.1. AK074972 mRNA. Translation: BAG52043.1. AC112487 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW79672.1. CH471052 Genomic DNA. Translation: EAW79676.1. BC022522 mRNA. Translation: AAH22522.1. BC031103 mRNA. Translation: AAH31103.1. X05323 , X05324, X05325, X05326 Genomic DNA. Translation: CAA28943.1.
IPI	IPI00013162. IPI00465447. IPI00971173.
PIR	A47639.
RefSeq	NP_001004196.2. NM_001004196.2. NP_005935.4. NM_005944.5.
UniGene	Hs.79015.
3D structure databases
ProteinModelPortal	P41217.
SMR	P41217. Positions 45-226.
ModBase	Search...
Protein-protein interaction databases
IntAct	P41217. 2 interactions.
STRING	9606.ENSP00000420298.
PTM databases
PhosphoSite	P41217.
Polymorphism databases
DMDM	311033489.
Proteomic databases
PaxDb	P41217.
PRIDE	P41217.
Protocols and materials databases
DNASU	4345.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315711; ENSP00000312766; ENSG00000091972. ENST00000473539; ENSP00000420298; ENSG00000091972.
GeneID	4345.
KEGG	hsa:4345.
UCSC	uc003dyw.3. human. uc003dyx.3. human.
Organism-specific databases
CTD	4345.
GeneCards	GC03P112051.
HGNC	HGNC:7203. CD200.
HPA	HPA031149.
MIM	155970. gene.
neXtProt	NX_P41217.
PharmGKB	PA30911.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72791.
HOVERGEN	HBG031790.
KO	K06556.
OMA	FCHLSTY.
OrthoDB	EOG40ZQZ2.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P41217.
Bgee	P41217.
CleanEx	HS_CD200.
Genevestigator	P41217.
GermOnline	ENSG00000091972. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013151. Immunoglobulin. [Graphical view]
Pfam	PF00047. ig. 2 hits. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4345.
NextBio	17104.
SOURCE	Search...

Entry information

Entry name

OX2G_HUMAN

Accession

Primary (citable) accession number: P41217
Secondary accession number(s): B3KQI1 , B4DLW9, D3DN65, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 122 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.