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Protein

OX-2 membrane glycoprotein

Gene

CD200

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
OX-2 membrane glycoprotein
Alternative name(s):
CD_antigen: CD200
Gene namesi
Name:CD200
Synonyms:MOX1, MOX2
ORF Names:My033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000091972.18.
HGNCiHGNC:7203. CD200.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 232ExtracellularSequence analysisAdd BLAST202
Transmembranei233 – 259HelicalSequence analysisAdd BLAST27
Topological domaini260 – 278CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4345.
OpenTargetsiENSG00000091972.
PharmGKBiPA30911.

Chemistry databases

ChEMBLiCHEMBL3712870.

Polymorphism and mutation databases

BioMutaiCD200.
DMDMi311033489.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001512431 – 278OX-2 membrane glycoproteinAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 121PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 136PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 214PROSITE-ProRule annotation
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP41217.
PaxDbiP41217.
PeptideAtlasiP41217.
PRIDEiP41217.
TopDownProteomicsiP41217-3. [P41217-3]

PTM databases

iPTMnetiP41217.
PhosphoSitePlusiP41217.

Expressioni

Gene expression databases

BgeeiENSG00000091972.
CleanExiHS_CD200.
ExpressionAtlasiP41217. baseline and differential.
GenevisibleiP41217. HS.

Organism-specific databases

HPAiHPA031149.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

Binary interactionsi

WithEntry#Exp.IntActNotes
CD200R1Q8TD462EBI-3910563,EBI-4314412

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110486. 2 interactors.
IntActiP41217. 2 interactors.
STRINGi9606.ENSP00000420298.

Structurei

3D structure databases

ProteinModelPortaliP41217.
SMRiP41217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 141Ig-like V-typeAdd BLAST111
Domaini142 – 232Ig-like C2-typeAdd BLAST91

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWZ9. Eukaryota.
ENOG410YRD3. LUCA.
GeneTreeiENSGT00530000063970.
HOVERGENiHBG031790.
InParanoidiP41217.
KOiK06556.
OMAiCYMCLFN.
OrthoDBiEOG091G0FSB.
PhylomeDBiP41217.
TreeFamiTF334493.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR033321. CD200.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
PANTHERiPTHR23277:SF72. PTHR23277:SF72. 1 hit.
PfamiView protein in Pfam
PF00047. ig. 2 hits.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41217-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERLVIRMPF SHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK
60 70 80 90 100
CSLQNAQEAL IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG
110 120 130 140 150
LQNSTITFWN ITLEDEGCYM CLFNTFGFGK ISGTACLTVY VQPIVSLHYK
160 170 180 190 200
FSEDHLNITC SATARPAPMV FWKVPRSGIE NSTVTLSHPN GTTSVTSILH
210 220 230 240 250
IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL LSIVSLVILL
260 270
VLISILLYWK RHRNQDRGEL SQGVQKMT
Length:278
Mass (Da):31,264
Last modified:November 2, 2010 - v4
Checksum:i38DF327B382CC970
GO
Isoform 2 (identifier: P41217-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-278: GELSQGVQKMT → EP

Show »
Length:269
Mass (Da):30,331
Checksum:i7EE08BD6760BACEC
GO
Isoform 3 (identifier: P41217-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-4: L → LTLTRTIGGPLLTATLLGKTTINDYQ
     268-278: GELSQGVQKMT → EP

Show »
Length:294
Mass (Da):32,975
Checksum:iD40A34379E9D7A3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181N → D in AAT37533 (Ref. 1) Curated1
Sequence conflicti225F → S in AAT37533 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02760511S → C4 PublicationsCorresponds to variant dbSNP:rs1131199Ensembl.1
Natural variantiVAR_02760646P → T1 PublicationCorresponds to variant dbSNP:rs2272022Ensembl.1
Natural variantiVAR_05611076V → G. Corresponds to variant dbSNP:rs35465733Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0400274L → LTLTRTIGGPLLTATLLGKT TINDYQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_002613268 – 278GELSQGVQKMT → EP in isoform 2 and isoform 3. 5 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603771 mRNA. Translation: AAT37533.1.
AF063591 mRNA. Translation: AAG43150.1.
AK297194 mRNA. Translation: BAG59681.1.
AK074972 mRNA. Translation: BAG52043.1.
AC112487 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79672.1.
CH471052 Genomic DNA. Translation: EAW79676.1.
BC022522 mRNA. Translation: AAH22522.1.
BC031103 mRNA. Translation: AAH31103.1.
X05323
, X05324, X05325, X05326 Genomic DNA. Translation: CAA28943.1.
CCDSiCCDS2965.1. [P41217-2]
CCDS33818.1. [P41217-3]
PIRiA47639.
RefSeqiNP_001004196.2. NM_001004196.3. [P41217-3]
NP_001305757.1. NM_001318828.1.
NP_005935.4. NM_005944.6. [P41217-2]
XP_005247539.1. XM_005247482.2. [P41217-1]
UniGeneiHs.79015.

Genome annotation databases

EnsembliENST00000315711; ENSP00000312766; ENSG00000091972. [P41217-2]
ENST00000473539; ENSP00000420298; ENSG00000091972. [P41217-3]
GeneIDi4345.
KEGGihsa:4345.
UCSCiuc003dyw.4. human. [P41217-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOX2G_HUMAN
AccessioniPrimary (citable) accession number: P41217
Secondary accession number(s): B3KQI1
, B4DLW9, D3DN65, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2010
Last modified: October 25, 2017
This is version 156 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot