P41212 (ETV6_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 130.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Transcription factor ETV6 Alternative name(s): ETS translocation variant 6 ETS-related protein Tel1 Short name=Tel | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 452 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. |
| Subunit structure | Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9. Ref.14 Ref.15 |
| Subcellular location | |
| Tissue specificity | Ubiquitous. |
| Post-translational modification | Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression. |
| Involvement in disease | Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). Ref.12 Note=Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2. Ref.7 Ref.8 Ref.16 Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:131440]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Ref.7 Ref.8 Ref.16 Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. |
| Sequence similarities | Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. |
| Sequence caution | The sequence ABI30005.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Chromosomal rearrangement |
| Disease | Disease mutation Proto-oncogene |
| Ligand | DNA-binding |
| Molecular function | Repressor |
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein domain specific binding Inferred from physical interaction Ref.14. Source: UniProtKB sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activityTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| HDAC9 | Q9UKV0-3 | 3 | EBI-1372759,EBI-765476 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 452 | 452 | Transcription factor ETV6 | PRO_0000204121 | |||||||||||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||||||||||
| Domain | 40 – 124 | 85 | PNT | ||||||||||||||||||||||||||||||||||||||||||||
| DNA binding | 339 – 420 | 82 | ETS | ||||||||||||||||||||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||||||||||||||||||
| Site | 11 – 12 | 2 | Breakpoint for translocation to form CHIC2-ETV6 in AML | ||||||||||||||||||||||||||||||||||||||||||||
| Site | 54 – 55 | 2 | Breakpoint for translocation to form ETV6-MDS2 in MDS | ||||||||||||||||||||||||||||||||||||||||||||
| Site | 55 – 56 | 2 | Breakpoint for translocation to form PAX5-ETV6 | ||||||||||||||||||||||||||||||||||||||||||||
| Site | 336 – 337 | 2 | Breakpoint for translocation to form ETV6-AML1 in ALL | ||||||||||||||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 11 | 1 | N6-acetyllysine Ref.20 | ||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 16 | 1 | Phosphoserine Ref.18 Ref.19 | ||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 18 | 1 | Phosphothreonine Ref.17 Ref.19 | ||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 22 | 1 | Phosphoserine Ref.11 Ref.17 Ref.18 Ref.19 | ||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 213 | 1 | Phosphoserine Ref.18 | ||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 257 | 1 | Phosphoserine; by MAPK14 Ref.11 | ||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 302 | 1 | N6-acetyllysine Ref.20 | ||||||||||||||||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 344 | 1 | Y → YG in one individual with AML; somatic mutation; unable to repress transcription. Ref.16 | VAR_034600 | |||||||||||||||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||||||||||||||
| Mutagenesis | 22 | 1 | S → A: No effect. | ||||||||||||||||||||||||||||||||||||||||||||
| Mutagenesis | 213 | 1 | S → A: No effect. Ref.11 | ||||||||||||||||||||||||||||||||||||||||||||
| Mutagenesis | 238 | 1 | S → A: No effect. Ref.11 | ||||||||||||||||||||||||||||||||||||||||||||
| Mutagenesis | 257 | 1 | S → A: No phosphorylation by MAPK14. Ref.11 | ||||||||||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 52 – 54 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 58 – 60 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 63 – 76 | 14 | |||||||||||||||||||||||||||||||||||||||||||||
| Turn | 84 – 87 | 4 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 91 – 94 | 4 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 99 – 105 | 7 | |||||||||||||||||||||||||||||||||||||||||||||
| Turn | 107 – 109 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 110 – 122 | 13 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 341 – 350 | 10 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 352 – 354 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Turn | 355 – 357 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 358 – 362 | 5 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 363 – 365 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 367 – 371 | 5 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 373 – 383 | 11 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 391 – 403 | 13 | |||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 406 – 408 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 411 – 419 | 9 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 424 – 426 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 430 – 432 | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Helix | 434 – 438 | 5 | |||||||||||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation." Golub T.R., Barker G.F., Lovett M., Gilliland D.G. Cell 77:307-316(1994) [PubMed: 8168137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [5] | "Genomic organization of TEL: the human ETS-variant gene 6." Baens M., Peeters P., Guo C., Aerssens J., Marynen P. Genome Res. 6:404-413(1996) [PubMed: 8743990] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-109; 111-336 AND 338-452. |
| [6] | "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." Mullighan C.G., Goorha S., Radtke I., Miller C.B., Coustan-Smith E., Dalton J.D., Girtman K., Mathew S., Ma J., Pounds S.B., Su X., Pui C.-H., Relling M.V., Evans W.E., Shurtleff S.A., Downing J.R. Nature 446:758-764(2007) [PubMed: 17344859] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-452, CHROMOSOMAL TRANSLOCATION WITH PAX5. |
| [7] | "Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia." Golub T.R., Barker G.F., Bohlander S.K., Hiebert S.W., Ward D.C., Bray-Ward P., Morgan E., Raimondi S.C., Rowley J.D., Gilliland D.G. Proc. Natl. Acad. Sci. U.S.A. 92:4917-4921(1995) [PubMed: 7761424] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH AML1. |
| [8] | "The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion." Romana S.P., Mauchauffe M., le Coniat M., Chumakov I., le Paslier D., Berger R., Bernard O.A. Blood 85:3662-3670(1995) [PubMed: 7780150] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH AML1. |
| [9] | "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)." Yagasaki F., Jinnai I., Yoshida S., Yokoyama Y., Matsuda A., Kusumoto S., Kobayashi H., Terasaki H., Ohyashiki K., Asou N., Murohashi I., Bessho M., Hirashima K. Genes Chromosomes Cancer 26:192-202(1999) [PubMed: 10502316] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH ACSL6. |
| [10] | "Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13)." Cools J., Bilhou-Nabera C., Wlodarska I., Cabrol C., Talmant P., Bernard P., Hagemeijer A., Marynen P. Blood 94:1820-1824(1999) [PubMed: 10477709] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH CHIC2. |
| [11] | "Functional regulation of TEL by p38-induced phosphorylation." Arai H., Maki K., Waga K., Sasaki K., Nakamura Y., Imai Y., Kurokawa M., Hirai H., Mitani K. Biochem. Biophys. Res. Commun. 299:116-125(2002) [PubMed: 12435397] [Abstract] Cited for: PHOSPHORYLATION AT SER-22 AND SER-257, MUTAGENESIS OF SER-213; SER-238 AND SER-257. |
| [12] | "A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome." Odero M.D., Vizmanos J.L., Roman J.P., Lahortiga I., Panizo C., Calasanz M.J., Zeleznik-Le N.J., Rowley J.D., Novo F.J. Genes Chromosomes Cancer 35:11-19(2002) [PubMed: 12203785] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH MDS2. |
| [13] | "Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta." Apperley J.F., Gardembas M., Melo J.V., Russell-Jones R., Bain B.J., Baxter E.J., Chase A., Chessells J.M., Colombat M., Dearden C.E., Dimitrijevic S., Mahon F.-X., Marin D., Nikolova Z., Olavarria E., Silberman S., Schultheis B., Cross N.C.P., Goldman J.M. N. Engl. J. Med. 347:481-487(2002) [PubMed: 12181402] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PDGFRB. |
| [14] | "The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)." Boccuni P., MacGrogan D., Scandura J.M., Nimer S.D. J. Biol. Chem. 278:15412-15420(2003) [PubMed: 12588862] [Abstract] Cited for: INTERACTION WITH L3MBTL1. |
| [15] | "The histone deacetylase 9 gene encodes multiple protein isoforms." Petrie K., Guidez F., Howell L., Healy L., Waxman S., Greaves M., Zelent A. J. Biol. Chem. 278:16059-16072(2003) [PubMed: 12590135] [Abstract] Cited for: INTERACTION WITH HDAC9. |
| [16] | "Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia." Barjesteh van Waalwijk van Doorn-Khosrovani S., Spensberger D., de Knegt Y., Tang M., Loewenberg B., Delwel R. Oncogene 24:4129-4137(2005) [PubMed: 15806161] [Abstract] Cited for: INVOLVEMENT IN AML, VARIANT GLY-344 INS, CHARACTERIZATION OF VARIANT GLY-344 INS. |
| [17] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18 AND SER-22, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [18] | "Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-22 AND SER-213, MASS SPECTROMETRY. |
| [19] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; THR-18 AND SER-22, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| [20] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-11 AND LYS-302, MASS SPECTROMETRY. |
| [21] | "Solution structure of ets domain transcriptional factor ETV6 protein." RIKEN structural genomics initiative (RSGI) Submitted (DEC-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 338-442. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U11732 mRNA. Translation: AAA19786.1. AK289441 mRNA. Translation: BAF82130.1. CH471094 Genomic DNA. Translation: EAW96240.1. BC043399 mRNA. Translation: AAH43399.1. U61375 Genomic DNA. Translation: AAC50690.1. U63312 Genomic DNA. Translation: AAB17134.1. U63313 Genomic DNA. Translation: AAB17135.1. DQ841178 mRNA. Translation: ABI30005.1. Different initiation. | ||||||||||||||||||||||||||||||||||||||||||
| IPI | IPI00013159. | ||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NP_001978.1. NM_001987.4. | ||||||||||||||||||||||||||||||||||||||||||
| UniGene | Hs.504765. | ||||||||||||||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||||||||||||||||||||||||||
| ProteinModelPortal | P41212. | ||||||||||||||||||||||||||||||||||||||||||
| SMR | P41212. Positions 21-125, 338-442. | ||||||||||||||||||||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||||||||||||||||||||
| DIP | DIP-17028N. | ||||||||||||||||||||||||||||||||||||||||||
| IntAct | P41212. 7 interactions. | ||||||||||||||||||||||||||||||||||||||||||
| STRING | P41212. | ||||||||||||||||||||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||||||||||||||||||||
| PhosphoSite | P41212. | ||||||||||||||||||||||||||||||||||||||||||
Polymorphism databases | |||||||||||||||||||||||||||||||||||||||||||
| DMDM | 730927. | ||||||||||||||||||||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||||||||||||||||||||
| PeptideAtlas | P41212. | ||||||||||||||||||||||||||||||||||||||||||
| PRIDE | P41212. | ||||||||||||||||||||||||||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||||||||||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||||||||||||||
| Ensembl | ENST00000266427; ENSP00000266427; ENSG00000139083. | ||||||||||||||||||||||||||||||||||||||||||
| GeneID | 2120. | ||||||||||||||||||||||||||||||||||||||||||
| KEGG | hsa:2120. | ||||||||||||||||||||||||||||||||||||||||||
| UCSC | uc001qzz.1. human. | ||||||||||||||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||||||||||||||
| CTD | 2120. | ||||||||||||||||||||||||||||||||||||||||||
| GeneCards | GC12P011703. | ||||||||||||||||||||||||||||||||||||||||||
| H-InvDB | HIX0026395. | ||||||||||||||||||||||||||||||||||||||||||
| HGNC | HGNC:3495. ETV6. | ||||||||||||||||||||||||||||||||||||||||||
| HPA | HPA000264. | ||||||||||||||||||||||||||||||||||||||||||
| MIM | 131440. phenotype. 600618. gene. 601626. phenotype. | ||||||||||||||||||||||||||||||||||||||||||
| neXtProt | NX_P41212. | ||||||||||||||||||||||||||||||||||||||||||
| Orphanet | 2030. Fibrosarcoma. 99860. Precursor B-cell acute lymphoblastic leukemia. | ||||||||||||||||||||||||||||||||||||||||||
| PharmGKB | PA27909. | ||||||||||||||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||||||||||||||
| HOGENOM | HBG716146. | ||||||||||||||||||||||||||||||||||||||||||
| HOVERGEN | HBG005617. | ||||||||||||||||||||||||||||||||||||||||||
| InParanoid | P41212. | ||||||||||||||||||||||||||||||||||||||||||
| OMA | NPRHSMD. | ||||||||||||||||||||||||||||||||||||||||||
| OrthoDB | EOG4ZS938. | ||||||||||||||||||||||||||||||||||||||||||
| PhylomeDB | P41212. | ||||||||||||||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||||||||||||||
| ArrayExpress | P41212. | ||||||||||||||||||||||||||||||||||||||||||
| Bgee | P41212. | ||||||||||||||||||||||||||||||||||||||||||
| CleanEx | HS_ETV6. | ||||||||||||||||||||||||||||||||||||||||||
| Genevestigator | P41212. | ||||||||||||||||||||||||||||||||||||||||||
| GermOnline | ENSG00000139083. Homo sapiens. | ||||||||||||||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||||||||||||||
| InterPro | IPR000418. Ets. IPR003118. Pointed_dom. IPR013761. SAM/pointed. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| Gene3D | G3DSA:1.10.150.50. SAM_type. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. | ||||||||||||||||||||||||||||||||||||||||||
| KO | K03211. | ||||||||||||||||||||||||||||||||||||||||||
| Pfam | PF00178. Ets. 1 hit. PF02198. SAM_PNT. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| PRINTS | PR00454. ETSDOMAIN. | ||||||||||||||||||||||||||||||||||||||||||
| SMART | SM00413. ETS. 1 hit. SM00251. SAM_PNT. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| SUPFAM | SSF47769. SAM_homology. 1 hit. | ||||||||||||||||||||||||||||||||||||||||||
| PROSITE | PS00345. ETS_DOMAIN_1. False negative. PS00346. ETS_DOMAIN_2. 1 hit. PS50061. ETS_DOMAIN_3. 1 hit. PS51433. PNT. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||||||||||||||
Other | |||||||||||||||||||||||||||||||||||||||||||
| NextBio | 8571. | ||||||||||||||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||||||||||||||
Entry information
| Entry name | ETV6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P41212 Secondary accession number(s): A3QVP6 Q9UMG0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with