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Protein

Centrin-1

Gene

Cetn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 521CuratedAdd BLAST12
Calcium bindingi150 – 1612CuratedAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G-protein beta/gamma-subunit complex binding Source: MGI
  • heterotrimeric G-protein binding Source: MGI
  • microtubule binding Source: MGI

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular response to heat Source: MGI
  • mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-1
Alternative name(s):
Caltractin
Gene namesi
Name:Cetn1
Synonyms:Calt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1347086. Cetn1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: MGI
  • centrosome Source: MGI
  • microtubule organizing center Source: MGI
  • photoreceptor connecting cilium Source: MGI
  • spindle pole Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000735602 – 172Centrin-1Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei26PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP41209.
PaxDbiP41209.
PeptideAtlasiP41209.
PRIDEiP41209.

PTM databases

iPTMnetiP41209.
PhosphoSitePlusiP41209.

Expressioni

Tissue specificityi

Expressed exclusively in testis. Localizes to the caudal portion of spermatozoa in seminiferous tubule and epididymis.1 Publication

Developmental stagei

First expressed at 14 days postpartum (dpp). Levels increase dramatically between 14 dpp and 17 dpp.1 Publication

Gene expression databases

BgeeiENSMUSG00000050996.
CleanExiMM_CETN1.
GenevisibleiP41209. MM.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with PIFO.By similarity1 Publication

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: MGI
  • heterotrimeric G-protein binding Source: MGI
  • microtubule binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057392.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 39Combined sources10
Beta strandi45 – 48Combined sources4
Helixi50 – 59Combined sources10
Helixi66 – 76Combined sources11
Helixi86 – 113Combined sources28
Beta strandi118 – 121Combined sources4
Helixi123 – 132Combined sources10
Helixi139 – 149Combined sources11
Beta strandi151 – 158Combined sources8
Helixi159 – 169Combined sources11
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D43X-ray2.82A/B1-172[»]
ProteinModelPortaliP41209.
SMRiP41209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini101 – 136EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini137 – 172EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the centrin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP41209.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG091G0RLZ.
PhylomeDBiP41209.
TreeFamiTF101141.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P41209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTFRKSNV ASTSYKRKVG PKPELTEDQK QEVREAFDLF DSDGSGTIDV
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK KMISEVDKEA TGKISFNDFL AVMTQKMAEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGESLTDE ELQEMIDEAD
160 170
RDGDGEVNEE EFLKIMKKTN LY
Length:172
Mass (Da):19,696
Last modified:February 1, 1995 - v1
Checksum:i45ABF106F58E4B60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95Q → R in BAB24213 (PubMed:16141072).Curated1
Sequence conflicti145M → K in BAB24798 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16301 mRNA. Translation: BAA03806.1.
AF080591 Genomic DNA. Translation: AAD46390.1.
AK005736 mRNA. Translation: BAB24213.1.
AK005743 mRNA. Translation: BAB24217.1.
AK005837 mRNA. Translation: BAB24266.1.
AK006940 mRNA. Translation: BAB24798.1.
AK015808 mRNA. Translation: BAB29985.1.
AK076986 mRNA. Translation: BAC36550.1.
AK132753 mRNA. Translation: BAE21334.1.
BC048488 mRNA. Translation: AAH48488.1.
BC061155 mRNA. Translation: AAH61155.1.
CCDSiCCDS37731.1.
PIRiS38531.
RefSeqiNP_031619.3. NM_007593.5.
UniGeneiMm.195831.

Genome annotation databases

EnsembliENSMUST00000062769; ENSMUSP00000057392; ENSMUSG00000050996.
GeneIDi26369.
KEGGimmu:26369.
UCSCiuc012aze.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16301 mRNA. Translation: BAA03806.1.
AF080591 Genomic DNA. Translation: AAD46390.1.
AK005736 mRNA. Translation: BAB24213.1.
AK005743 mRNA. Translation: BAB24217.1.
AK005837 mRNA. Translation: BAB24266.1.
AK006940 mRNA. Translation: BAB24798.1.
AK015808 mRNA. Translation: BAB29985.1.
AK076986 mRNA. Translation: BAC36550.1.
AK132753 mRNA. Translation: BAE21334.1.
BC048488 mRNA. Translation: AAH48488.1.
BC061155 mRNA. Translation: AAH61155.1.
CCDSiCCDS37731.1.
PIRiS38531.
RefSeqiNP_031619.3. NM_007593.5.
UniGeneiMm.195831.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D43X-ray2.82A/B1-172[»]
ProteinModelPortaliP41209.
SMRiP41209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057392.

PTM databases

iPTMnetiP41209.
PhosphoSitePlusiP41209.

Proteomic databases

MaxQBiP41209.
PaxDbiP41209.
PeptideAtlasiP41209.
PRIDEiP41209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062769; ENSMUSP00000057392; ENSMUSG00000050996.
GeneIDi26369.
KEGGimmu:26369.
UCSCiuc012aze.1. mouse.

Organism-specific databases

CTDi1068.
MGIiMGI:1347086. Cetn1.

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP41209.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG091G0RLZ.
PhylomeDBiP41209.
TreeFamiTF101141.

Miscellaneous databases

ChiTaRSiCetn1. mouse.
PROiP41209.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050996.
CleanExiMM_CETN1.
GenevisibleiP41209. MM.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCETN1_MOUSE
AccessioniPrimary (citable) accession number: P41209
Secondary accession number(s): Q3V119, Q9D9G9, Q9DAL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two moles of calcium per mole of protein.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.