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Protein

Centrin-1

Gene

Cetn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (PubMed:27530713).By similarity1 Publication

Miscellaneous

Binds two moles of calcium per mole of protein.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 521CuratedAdd BLAST12
Calcium bindingi150 – 1612CuratedAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G-protein beta/gamma-subunit complex binding Source: MGI
  • heterotrimeric G-protein binding Source: MGI
  • microtubule binding Source: MGI

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cellular response to heat Source: MGI

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-1
Alternative name(s):
Caltractin
Gene namesi
Name:Cetn1
Synonyms:Calt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1347086 Cetn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735601 – 172Centrin-1Add BLAST172

Proteomic databases

MaxQBiP41209
PaxDbiP41209
PeptideAtlasiP41209
PRIDEiP41209

PTM databases

iPTMnetiP41209
PhosphoSitePlusiP41209

Expressioni

Tissue specificityi

Expressed exclusively in testis. Localizes to the caudal portion of spermatozoa in seminiferous tubule and epididymis.1 Publication

Developmental stagei

First expressed at 14 days postpartum (dpp). Levels increase dramatically between 14 dpp and 17 dpp.1 Publication

Gene expression databases

BgeeiENSMUSG00000050996
CleanExiMM_CETN1
GenevisibleiP41209 MM

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with PIFO (PubMed:20643351).By similarity1 Publication

GO - Molecular functioni

  • microtubule binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057392

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 39Combined sources10
Beta strandi45 – 48Combined sources4
Helixi50 – 59Combined sources10
Helixi66 – 76Combined sources11
Helixi86 – 113Combined sources28
Beta strandi118 – 121Combined sources4
Helixi123 – 132Combined sources10
Helixi139 – 149Combined sources11
Beta strandi151 – 158Combined sources8
Helixi159 – 169Combined sources11
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D43X-ray2.82A/B1-172[»]
ProteinModelPortaliP41209
SMRiP41209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini101 – 136EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini137 – 172EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the centrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00670000097718
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP41209
KOiK16465
OMAiEPRKEEM
OrthoDBiEOG091G0RLZ
PhylomeDBiP41209
TreeFamiTF101141

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000629 RNA-helicase_DEAD-box_CS
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

P41209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTFRKSNV ASTSYKRKVG PKPELTEDQK QEVREAFDLF DSDGSGTIDV
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK KMISEVDKEA TGKISFNDFL AVMTQKMAEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGESLTDE ELQEMIDEAD
160 170
RDGDGEVNEE EFLKIMKKTN LY
Length:172
Mass (Da):19,696
Last modified:February 1, 1995 - v1
Checksum:i45ABF106F58E4B60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95Q → R in BAB24213 (PubMed:16141072).Curated1
Sequence conflicti145M → K in BAB24798 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16301 mRNA Translation: BAA03806.1
AF080591 Genomic DNA Translation: AAD46390.1
AK005736 mRNA Translation: BAB24213.1
AK005743 mRNA Translation: BAB24217.1
AK005837 mRNA Translation: BAB24266.1
AK006940 mRNA Translation: BAB24798.1
AK015808 mRNA Translation: BAB29985.1
AK076986 mRNA Translation: BAC36550.1
AK132753 mRNA Translation: BAE21334.1
BC048488 mRNA Translation: AAH48488.1
BC061155 mRNA Translation: AAH61155.1
CCDSiCCDS37731.1
PIRiS38531
RefSeqiNP_031619.3, NM_007593.5
UniGeneiMm.195831

Genome annotation databases

EnsembliENSMUST00000062769; ENSMUSP00000057392; ENSMUSG00000050996
GeneIDi26369
KEGGimmu:26369
UCSCiuc012aze.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCETN1_MOUSE
AccessioniPrimary (citable) accession number: P41209
Secondary accession number(s): Q3V119, Q9D9G9, Q9DAL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health