Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Centrin-1

Gene

Cetn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi41 – 52121CuratedAdd
BLAST
Calcium bindingi150 – 161122CuratedAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G-protein beta/gamma-subunit complex binding Source: MGI
  • heterotrimeric G-protein binding Source: MGI
  • microtubule binding Source: MGI

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular response to heat Source: MGI
  • mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-1
Alternative name(s):
Caltractin
Gene namesi
Name:Cetn1
Synonyms:Calt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1347086. Cetn1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: MGI
  • centrosome Source: MGI
  • microtubule organizing center Source: MGI
  • photoreceptor connecting cilium Source: MGI
  • spindle pole Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Centrin-1PRO_0000073560Add
BLAST

Proteomic databases

EPDiP41209.
PaxDbiP41209.
PeptideAtlasiP41209.
PRIDEiP41209.

PTM databases

iPTMnetiP41209.
PhosphoSiteiP41209.

Expressioni

Tissue specificityi

Expressed exclusively in testis. Localizes to the caudal portion of spermatozoa in seminiferous tubule and epididymis.1 Publication

Developmental stagei

First expressed at 14 days postpartum (dpp). Levels increase dramatically between 14 dpp and 17 dpp.1 Publication

Gene expression databases

BgeeiP41209.
CleanExiMM_CETN1.
GenevisibleiP41209. MM.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with PIFO.By similarity1 Publication

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: MGI
  • heterotrimeric G-protein binding Source: MGI
  • microtubule binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057392.

Structurei

3D structure databases

ProteinModelPortaliP41209.
SMRiP41209. Positions 26-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini64 – 9936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini101 – 13636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 17236EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the centrin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP41209.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG7H1JN9.
PhylomeDBiP41209.
TreeFamiTF101141.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTFRKSNV ASTSYKRKVG PKPELTEDQK QEVREAFDLF DSDGSGTIDV
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK KMISEVDKEA TGKISFNDFL AVMTQKMAEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGESLTDE ELQEMIDEAD
160 170
RDGDGEVNEE EFLKIMKKTN LY
Length:172
Mass (Da):19,696
Last modified:February 1, 1995 - v1
Checksum:i45ABF106F58E4B60
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951Q → R in BAB24213 (PubMed:16141072).Curated
Sequence conflicti145 – 1451M → K in BAB24798 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16301 mRNA. Translation: BAA03806.1.
AF080591 Genomic DNA. Translation: AAD46390.1.
AK005736 mRNA. Translation: BAB24213.1.
AK005743 mRNA. Translation: BAB24217.1.
AK005837 mRNA. Translation: BAB24266.1.
AK006940 mRNA. Translation: BAB24798.1.
AK015808 mRNA. Translation: BAB29985.1.
AK076986 mRNA. Translation: BAC36550.1.
AK132753 mRNA. Translation: BAE21334.1.
BC048488 mRNA. Translation: AAH48488.1.
BC061155 mRNA. Translation: AAH61155.1.
CCDSiCCDS37731.1.
PIRiS38531.
RefSeqiNP_031619.3. NM_007593.5.
UniGeneiMm.195831.

Genome annotation databases

EnsembliENSMUST00000062769; ENSMUSP00000057392; ENSMUSG00000050996.
GeneIDi26369.
KEGGimmu:26369.
UCSCiuc012aze.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16301 mRNA. Translation: BAA03806.1.
AF080591 Genomic DNA. Translation: AAD46390.1.
AK005736 mRNA. Translation: BAB24213.1.
AK005743 mRNA. Translation: BAB24217.1.
AK005837 mRNA. Translation: BAB24266.1.
AK006940 mRNA. Translation: BAB24798.1.
AK015808 mRNA. Translation: BAB29985.1.
AK076986 mRNA. Translation: BAC36550.1.
AK132753 mRNA. Translation: BAE21334.1.
BC048488 mRNA. Translation: AAH48488.1.
BC061155 mRNA. Translation: AAH61155.1.
CCDSiCCDS37731.1.
PIRiS38531.
RefSeqiNP_031619.3. NM_007593.5.
UniGeneiMm.195831.

3D structure databases

ProteinModelPortaliP41209.
SMRiP41209. Positions 26-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057392.

PTM databases

iPTMnetiP41209.
PhosphoSiteiP41209.

Proteomic databases

EPDiP41209.
PaxDbiP41209.
PeptideAtlasiP41209.
PRIDEiP41209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062769; ENSMUSP00000057392; ENSMUSG00000050996.
GeneIDi26369.
KEGGimmu:26369.
UCSCiuc012aze.1. mouse.

Organism-specific databases

CTDi1068.
MGIiMGI:1347086. Cetn1.

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP41209.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG7H1JN9.
PhylomeDBiP41209.
TreeFamiTF101141.

Miscellaneous databases

ChiTaRSiCetn1. mouse.
PROiP41209.
SOURCEiSearch...

Gene expression databases

BgeeiP41209.
CleanExiMM_CETN1.
GenevisibleiP41209. MM.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Testis.
  2. "Testis-specific murine centrin, Cetn1: genomic characterization and evidence for retroposition of a gene encoding a centrosome protein."
    Hart P.E., Glantz J.N., Orth J.D., Poynter G.M., Salisbury J.L.
    Genomics 60:111-120(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/Ola.
    Tissue: Testis.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.
  6. Cited for: INTERACTION WITH PIFO.

Entry informationi

Entry nameiCETN1_MOUSE
AccessioniPrimary (citable) accession number: P41209
Secondary accession number(s): Q3V119, Q9D9G9, Q9DAL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 6, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two moles of calcium per mole of protein.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.