P41186 (RS4_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
30S ribosomal protein S4

Gene names

Name:	rpsD
Ordered Locus Names:	BUsg_481

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit By similarity. HAMAP-Rule MF_01306 With S5 and S12 plays an important role in translational accuracy By similarity. HAMAP-Rule MF_01306
Subunit structure	Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity By similarity.
Sequence similarities	Belongs to the ribosomal protein S4P family. Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	small ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	30S ribosomal protein S4 HAMAP-Rule MF_01306		PRO_0000132354
Regions
	Domain	96 – 156	61	S4 RNA-binding
Experimental info
	Sequence conflict	53	1	I → Y in AAC05398. Ref.1
	Sequence conflict	174	1	N → D in AAC05398. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P41186 [UniParc]. Last modified August 30, 2002. Version 3. Checksum: C6B7C5828B57EFBC	FASTA	206	24,140
	10 20 30 40 50 60 MARYLGPKLK LSRREGTDLF LKSGFRSIDS KCKLEHPPGQ HGVRKPRLSD YAIQLREKQK 70 80 90 100 110 120 VRRLYGVLER QFRIYYKKAS RSKGNTGENL LQLLERRLDN VVYRMGFGCT RSESRQLISH 130 140 150 160 170 180 KSIKVNNNIV NIASYQISPN DRISVRDKSK NQSRIKAALE LTEQREKLMW IEVNVTKMEG 190 200 IFKRFPERSD LSAEINEHLI VELYSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Buchnera aphidicola, the endosymbiont of aphids, contains genes for four ribosomal RNA proteins, initiation factor-3, and the alpha subunit of RNA polymerase." Munson M.A., Baumann L., Baumann P. Curr. Microbiol. 24:23-29(1992) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M74510 Genomic DNA. Translation: AAC05398.1. AE013218 Genomic DNA. Translation: AAM68024.1.
RefSeq	NP_660813.1. NC_004061.1.
3D structure databases
ProteinModelPortal	P41186.
SMR	P41186. Positions 2-206.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg481.
Proteomic databases
PRIDE	P41186.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM68024; AAM68024; BUsg_481.
GeneID	1005688.
KEGG	bas:BUsg481.
PATRIC	21247826. VBIBucAph100086_0508.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0522.
KO	K02986.
OMA	THGHILV.
ProtClustDB	PRK05327.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-526-MONOMER.
Family and domain databases
Gene3D	1.10.1050.10. 1 hit. 3.10.290.10. 1 hit.
HAMAP	MF_01306_B. Ribosomal_S4_B.
InterPro	IPR022801. Ribosomal_S4/S9. IPR001912. Ribosomal_S4/S9_N. IPR005709. Ribosomal_S4_bac-type. IPR018079. Ribosomal_S4_CS. IPR002942. S4_RNA-bd. [Graphical view]
PANTHER	PTHR11831. PTHR11831. 1 hit.
Pfam	PF00163. Ribosomal_S4. 1 hit. PF01479. S4. 1 hit. [Graphical view]
SMART	SM00363. S4. 1 hit. [Graphical view]
TIGRFAMs	TIGR01017. rpsD_bact. 1 hit.
PROSITE	PS00632. RIBOSOMAL_S4. 1 hit. PS50889. S4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RS4_BUCAP

Accession

Primary (citable) accession number: P41186

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	August 30, 2002
Last modified:	May 1, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program