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P41183

- BCL6_MOUSE

UniProt

P41183 - BCL6_MOUSE

Protein

B-cell lymphoma 6 protein homolog

Gene

Bcl6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.5 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri519 – 54224C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri547 – 56923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri575 – 59723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri603 – 62523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri631 – 65323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri659 – 68224C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. chromatin DNA binding Source: MGI
    3. DNA binding Source: MGI
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: IntAct
    6. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    7. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    8. sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. B cell differentiation Source: MGI
    3. cell morphogenesis Source: MGI
    4. cellular response to DNA damage stimulus Source: Ensembl
    5. erythrocyte development Source: MGI
    6. germinal center formation Source: MGI
    7. inflammatory response Source: UniProtKB-KW
    8. negative regulation of apoptotic process Source: MGI
    9. negative regulation of cell differentiation Source: MGI
    10. negative regulation of cell growth Source: Ensembl
    11. negative regulation of cell-matrix adhesion Source: MGI
    12. negative regulation of cell proliferation Source: MGI
    13. negative regulation of isotype switching to IgE isotypes Source: MGI
    14. negative regulation of mast cell cytokine production Source: MGI
    15. negative regulation of Notch signaling pathway Source: MGI
    16. negative regulation of Rho protein signal transduction Source: MGI
    17. negative regulation of T-helper 2 cell differentiation Source: MGI
    18. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    19. negative regulation of type 2 immune response Source: MGI
    20. positive regulation of apoptotic process Source: Ensembl
    21. positive regulation of B cell proliferation Source: MGI
    22. positive regulation of cellular component movement Source: MGI
    23. positive regulation of histone deacetylation Source: MGI
    24. positive regulation of neuron differentiation Source: MGI
    25. protein import into nucleus, translocation Source: Ensembl
    26. protein localization Source: MGI
    27. regulation of cell proliferation Source: MGI
    28. regulation of inflammatory response Source: MGI
    29. regulation of memory T cell differentiation Source: MGI
    30. regulation of Rho GTPase activity Source: MGI
    31. Rho protein signal transduction Source: MGI
    32. spermatogenesis Source: MGI
    33. type 2 immune response Source: MGI

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Immunity, Inflammatory response, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell lymphoma 6 protein homolog
    Gene namesi
    Name:Bcl6
    Synonyms:Bcl-6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:107187. Bcl6.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. replication fork Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    More than 50% of lethality by 6 weeks of age. Mice have infiltrates of inflammatory cells in their lungs, as well as multinodular lesions with eosinophil infiltrations into the spleen, significantly more T(H)2 and T(H)17 cells and up-regulated levels of inflammtaroy chemokines in macrophages, but, express low levels of memory CD8+ T-cells and, in spleen, GC B and T(FH) cells are both undetectable. B-cells express 10-fold lower levels of surface IgM than control littermates and macrophages divide faster. From 12.5 dpc to at least 21 days after birth, animals have reduced size of the cerebral hemispheres and a reduced thickness of the frontal and parietal cortex with all the cortical layers affected. At 12.5 and 15.5 dpc, marked reduction of cell-cyle exit indicating defective transition from neural progenitor Cells to postmitotic neurons.4 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi21 – 211N → K: Abolishes interaction with NCOR2; mice have impaired GC formation and immunoglobulin affinity maturation with lower proliferation and survival of GC B-cells but normal differentiation of helper T-cell subsets and inflammatory response; in macrophages, no effect on transcriptional repression of genes encoding inflammatory molecules; when associated with A-116. In macrophages, no effect on competition with STAT5 for DNA-binding and transcriptional repression of genes encoding inflammatory molecules; when associated with A-116 and 377-Q--Q-380. 2 Publications
    Mutagenesisi116 – 1161H → A: Abolishes interaction with NCOR2; mice have impaired GC formation and immunoglobulin affinity maturation with lower proliferation and survival of GC B-cells but normal differentiation of helper T-cell subsets and inflammatory response; in macrophages, no effect on transcriptional repression of genes encoding inflammatory molecules; when associated with K-21. In macrophages, no effect on competition with STAT5 for DNA-binding and transcriptional repression of genes encoding inflammatory molecules; when associated with K-21 and 377-Q--Q-380. 2 Publications
    Mutagenesisi377 – 3804KKYK → QQYQ in macrophages, no effect on transcriptional repression of genes encoding inflammatory molecules. In macrophages, no effect on competition with STAT5 for DNA-binding and transcriptional repression of genes encoding inflammatory molecules; when associated with K-21 and A-116.
    Mutagenesisi577 – 5804CNIC → GNIG in macrophages, inhibits competition with STAT5 for DNA-binding and abolishes transcriptional repression of genes encoding inflammatory molecules.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707B-cell lymphoma 6 protein homologPRO_0000047099Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei334 – 3341Phosphoserine; by MAPK1By similarity
    Modified residuei344 – 3441Phosphoserine; by MAPK1By similarity
    Modified residuei380 – 3801N6-acetyllysine; by EP300By similarity

    Post-translational modificationi

    Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-334 and Ser-344. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway By similarity.By similarity
    Polyubiquitinated. Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome By similarity.By similarity
    Acetylated at Lys-380 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP41183.

    PTM databases

    PhosphoSiteiP41183.

    Expressioni

    Tissue specificityi

    Expressed at least in germinal center B-cells of spleen.2 Publications

    Developmental stagei

    Detected in the cerebral cortex from 12.5 dpc until birth, with highest levels in the frontal and parietal parts of the neocortex than the occipital parts.1 Publication

    Gene expression databases

    ArrayExpressiP41183.
    BgeeiP41183.
    CleanExiMM_BCL6.
    GenevestigatoriP41183.

    Interactioni

    Subunit structurei

    Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Tbx21Q9JKD83EBI-6253762,EBI-3863870

    Protein-protein interaction databases

    BioGridi198327. 5 interactions.
    DIPiDIP-59432N.
    IntActiP41183. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP41183.
    SMRiP41183. Positions 5-129, 473-679.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 9968BTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni377 – 3804Required for interaction with NuRD complex and for transcriptional repressor activity

    Domaini

    Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiation required for GC formation.1 Publication

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri519 – 54224C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri547 – 56923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri575 – 59723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri603 – 62523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri631 – 65323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri659 – 68224C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000001556.
    HOVERGENiHBG004831.
    InParanoidiP41183.
    KOiK15618.
    OMAiNECDCRF.
    OrthoDBiEOG7KQ22S.
    PhylomeDBiP41183.
    TreeFamiTF330912.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41183-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL    50
    MACSGLFYSI FTDQLKCNLS VINLDPEISP EGFCILLDFM YTSRLNLREG 100
    NIMAVMTTAM YLQMEHVVDT CRKFIKASEA EMAPALKPPR EEFLNSRMLM 150
    PHDIMAYRGR EVVENNMPLR NTPGCESRAF APPLYSGLST PPASYPMYSH 200
    LPLSTFLFSD EELRDAPRMP VANPFPKERA LPCDSARQVP NEYSRPAMEV 250
    SPSLCHSNIY SPKEAVPEEA RSDIHYSVPE GPKPAVPSAR NAPYFPCDKA 300
    SKEEERPSSE DEIALHFEPP NAPLNRKGLV SPQSPQKSDC QPNSPTESCS 350
    SKNACILQAS GSPPAKSPTD PKACNWKKYK FIVLNSLNQN AKPEGSEQAE 400
    LGRLSPRAYP APPACQPPME PANLDLQSPT KLSASGEDST IPQASRLNNL 450
    VNRSLAGSPR SSSESHSPLY MHPPKCTSCG SQSPQHTEMC LHTAGPTFPE 500
    EMGETQSEYS DSSCENGTFF CNECDCRFSE EASLKRHTLQ THSDKPYKCD 550
    RCQASFRYKG NLASHKTVHT GEKPYRCNIC GAQFNRPANL KTHTRIHSGE 600
    KPYKCETCGA RFVQVAHLRA HVLIHTGEKP YPCEICGTRF RHLQTLKSHL 650
    RIHTGEKPYH CEKCNLHFRH KSQLRLHLRQ KHGAITNTKV QYRVSAADLP 700
    PELPKAC 707
    Length:707
    Mass (Da):78,982
    Last modified:February 1, 1995 - v1
    Checksum:i2051DD808D32D5EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti456 – 4561A → G in AAB17432. (PubMed:8652841)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38377 mRNA. Translation: BAA07456.1.
    U41465 mRNA. Translation: AAB17432.1.
    BC052315 mRNA. Translation: AAH52315.1.
    CCDSiCCDS28082.1.
    RefSeqiNP_033874.1. NM_009744.3.
    XP_006521785.1. XM_006521722.1.
    UniGeneiMm.347398.

    Genome annotation databases

    EnsembliENSMUST00000023151; ENSMUSP00000023151; ENSMUSG00000022508.
    GeneIDi12053.
    KEGGimmu:12053.
    UCSCiuc007ytz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38377 mRNA. Translation: BAA07456.1 .
    U41465 mRNA. Translation: AAB17432.1 .
    BC052315 mRNA. Translation: AAH52315.1 .
    CCDSi CCDS28082.1.
    RefSeqi NP_033874.1. NM_009744.3.
    XP_006521785.1. XM_006521722.1.
    UniGenei Mm.347398.

    3D structure databases

    ProteinModelPortali P41183.
    SMRi P41183. Positions 5-129, 473-679.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198327. 5 interactions.
    DIPi DIP-59432N.
    IntActi P41183. 1 interaction.

    PTM databases

    PhosphoSitei P41183.

    Proteomic databases

    PRIDEi P41183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023151 ; ENSMUSP00000023151 ; ENSMUSG00000022508 .
    GeneIDi 12053.
    KEGGi mmu:12053.
    UCSCi uc007ytz.1. mouse.

    Organism-specific databases

    CTDi 604.
    MGIi MGI:107187. Bcl6.

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000001556.
    HOVERGENi HBG004831.
    InParanoidi P41183.
    KOi K15618.
    OMAi NECDCRF.
    OrthoDBi EOG7KQ22S.
    PhylomeDBi P41183.
    TreeFami TF330912.

    Miscellaneous databases

    ChiTaRSi BCL6. mouse.
    NextBioi 280351.
    PROi P41183.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41183.
    Bgeei P41183.
    CleanExi MM_BCL6.
    Genevestigatori P41183.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene."
      Fukuda T., Miki T., Yoshida T., Hatano M., Ohashi K., Hirosawa S., Tokuhisa T.
      Oncogene 11:1657-1663(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Skeletal muscle.
    2. "BCL-6 expression during B-cell activation."
      Allman D., Jain A., Dent A., Maile R.R., Selvaggi T., Kehry M.R., Staudt L.M.
      Blood 87:5257-5268(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    4. "BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor."
      Okabe S., Fukuda T., Ishibashi K., Kojima S., Okada S., Hatano M., Ebara M., Saisho H., Tokuhisa T.
      Mol. Cell. Biol. 18:4235-4244(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCL6B.
    5. "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene."
      Davies J.M., Hawe N., Kabarowski J., Huang Q.-H., Zhu J., Brand N.J., Leprince D., Dhordain P., Cook M., Moriss-Kay G., Zelent A.
      Oncogene 18:365-375(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZBTB7, SUBCELLULAR LOCATION.
    6. "BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control."
      Shaffer A.L., Yu X., He Y., Boldrick J., Chan E.P., Staudt L.M.
      Immunity 13:199-212(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS TRANSCRIPTIONAL REPRESSOR, DISRUPTION PHENOTYPE.
    7. "Role for Bcl-6 in the generation and maintenance of memory CD8+ T-cells."
      Ichii H., Sakamoto A., Hatano M., Okada S., Toyama H., Taki S., Arima M., Kuroda Y., Tokuhisa T.
      Nat. Immunol. 3:558-563(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN MEMORY CD8(+) T-CELL MAINTENANCE, DISRUPTION PHENOTYPE.
    8. "Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells."
      Phan R.T., Saito M., Kitagawa Y., Means A.R., Dalla-Favera R.
      Nat. Immunol. 8:1132-1139(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
      Basso K., Schneider C., Shen Q., Holmes A.B., Setty M., Leslie C., Dalla-Favera R.
      J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN MIRNA REGULATION, TISSUE SPECIFICITY.
    10. "BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets."
      Tiberi L., van den Ameele J., Dimidschstein J., Piccirilli J., Gall D., Herpoel A., Bilheu A., Bonnefont J., Iacovino M., Kyba M., Bouschet T., Vanderhaeghen P.
      Nat. Neurosci. 15:1627-1635(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NEUROGENESIS, INTERACTION WITH NOTCH1 AND SIRT1, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    11. Cited for: MUTAGENESIS OF ASN-21 AND HIS-116.
    12. "Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms."
      Huang C., Hatzi K., Melnick A.
      Nat. Immunol. 14:380-388(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN GERMINAL CENTER REACTIONS, DNA-BINDING, DOMAIN, INTERACTION WITH SMRT, DISRUPTION PHENOTYPE, MUTAGENESIS OF ASN-21; HIS-116; 377-LYS--LYS-380 AND 577-CYS--CYS-580.

    Entry informationi

    Entry nameiBCL6_MOUSE
    AccessioniPrimary (citable) accession number: P41183
    Secondary accession number(s): Q61065
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3