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Protein

B-cell lymphoma 6 protein homolog

Gene

Bcl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri519 – 54224C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 56923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri575 – 59723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri603 – 62523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri631 – 65323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri659 – 68224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • chromatin DNA binding Source: MGI
  • DNA binding Source: MGI
  • intronic transcription regulatory region sequence-specific DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • B cell differentiation Source: MGI
  • cell morphogenesis Source: MGI
  • cellular response to DNA damage stimulus Source: MGI
  • erythrocyte development Source: MGI
  • germinal center formation Source: MGI
  • inflammatory response Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell differentiation Source: MGI
  • negative regulation of cell growth Source: MGI
  • negative regulation of cell-matrix adhesion Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cellular senescence Source: MGI
  • negative regulation of isotype switching to IgE isotypes Source: MGI
  • negative regulation of mast cell cytokine production Source: MGI
  • negative regulation of Notch signaling pathway Source: MGI
  • negative regulation of Rho protein signal transduction Source: MGI
  • negative regulation of T-helper 2 cell differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • negative regulation of type 2 immune response Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of cellular component movement Source: MGI
  • positive regulation of histone deacetylation Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • protein import into nucleus, translocation Source: MGI
  • protein localization Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of GTPase activity Source: MGI
  • regulation of inflammatory response Source: MGI
  • regulation of memory T cell differentiation Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • Rho protein signal transduction Source: MGI
  • spermatogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • type 2 immune response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Immunity, Inflammatory response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma 6 protein homolog
Gene namesi
Name:Bcl6
Synonyms:Bcl-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:107187. Bcl6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
  • replication fork Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

More than 50% of lethality by 6 weeks of age. Mice have infiltrates of inflammatory cells in their lungs, as well as multinodular lesions with eosinophil infiltrations into the spleen, significantly more T(H)2 and T(H)17 cells and up-regulated levels of inflammtaroy chemokines in macrophages, but, express low levels of memory CD8+ T-cells and, in spleen, GC B and T(FH) cells are both undetectable. B-cells express 10-fold lower levels of surface IgM than control littermates and macrophages divide faster. From 12.5 dpc to at least 21 days after birth, animals have reduced size of the cerebral hemispheres and a reduced thickness of the frontal and parietal cortex with all the cortical layers affected. At 12.5 and 15.5 dpc, marked reduction of cell-cyle exit indicating defective transition from neural progenitor Cells to postmitotic neurons.4 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi21 – 211N → K: Abolishes interaction with NCOR2; mice have impaired GC formation and immunoglobulin affinity maturation with lower proliferation and survival of GC B-cells but normal differentiation of helper T-cell subsets and inflammatory response; in macrophages, no effect on transcriptional repression of genes encoding inflammatory molecules; when associated with A-116. In macrophages, no effect on competition with STAT5 for DNA-binding and transcriptional repression of genes encoding inflammatory molecules; when associated with A-116 and 377-Q--Q-380. 2 Publications
Mutagenesisi116 – 1161H → A: Abolishes interaction with NCOR2; mice have impaired GC formation and immunoglobulin affinity maturation with lower proliferation and survival of GC B-cells but normal differentiation of helper T-cell subsets and inflammatory response; in macrophages, no effect on transcriptional repression of genes encoding inflammatory molecules; when associated with K-21. In macrophages, no effect on competition with STAT5 for DNA-binding and transcriptional repression of genes encoding inflammatory molecules; when associated with K-21 and 377-Q--Q-380. 2 Publications
Mutagenesisi377 – 3804KKYK → QQYQ in macrophages, no effect on transcriptional repression of genes encoding inflammatory molecules. In macrophages, no effect on competition with STAT5 for DNA-binding and transcriptional repression of genes encoding inflammatory molecules; when associated with K-21 and A-116. 1 Publication
Mutagenesisi577 – 5804CNIC → GNIG in macrophages, inhibits competition with STAT5 for DNA-binding and abolishes transcriptional repression of genes encoding inflammatory molecules. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707B-cell lymphoma 6 protein homologPRO_0000047099Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei334 – 3341Phosphoserine; by MAPK1By similarity
Modified residuei344 – 3441Phosphoserine; by MAPK1By similarity
Modified residuei380 – 3801N6-acetyllysine; by EP300By similarity

Post-translational modificationi

Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-334 and Ser-344. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway (By similarity).By similarity
Polyubiquitinated. Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome (By similarity).By similarity
Acetylated at Lys-380 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP41183.

PTM databases

PhosphoSiteiP41183.

Expressioni

Tissue specificityi

Expressed at least in germinal center B-cells of spleen.2 Publications

Developmental stagei

Detected in the cerebral cortex from 12.5 dpc until birth, with highest levels in the frontal and parietal parts of the neocortex than the occipital parts.1 Publication

Gene expression databases

BgeeiP41183.
CleanExiMM_BCL6.
ExpressionAtlasiP41183. baseline and differential.
GenevisibleiP41183. MM.

Interactioni

Subunit structurei

Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tbx21Q9JKD83EBI-6253762,EBI-3863870

Protein-protein interaction databases

BioGridi198327. 7 interactions.
DIPiDIP-59432N.
IntActiP41183. 1 interaction.
STRINGi10090.ENSMUSP00000023151.

Structurei

3D structure databases

ProteinModelPortaliP41183.
SMRiP41183. Positions 5-129, 473-679.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 9968BTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni377 – 3804Required for interaction with NuRD complex and for transcriptional repressor activity

Domaini

Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiation required for GC formation.1 Publication

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri519 – 54224C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 56923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri575 – 59723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri603 – 62523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri631 – 65323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri659 – 68224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00800000124096.
HOGENOMiHOG000001556.
HOVERGENiHBG004831.
InParanoidiP41183.
KOiK15618.
OMAiNECDCRF.
OrthoDBiEOG7KQ22S.
PhylomeDBiP41183.
TreeFamiTF330912.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL
60 70 80 90 100
MACSGLFYSI FTDQLKCNLS VINLDPEISP EGFCILLDFM YTSRLNLREG
110 120 130 140 150
NIMAVMTTAM YLQMEHVVDT CRKFIKASEA EMAPALKPPR EEFLNSRMLM
160 170 180 190 200
PHDIMAYRGR EVVENNMPLR NTPGCESRAF APPLYSGLST PPASYPMYSH
210 220 230 240 250
LPLSTFLFSD EELRDAPRMP VANPFPKERA LPCDSARQVP NEYSRPAMEV
260 270 280 290 300
SPSLCHSNIY SPKEAVPEEA RSDIHYSVPE GPKPAVPSAR NAPYFPCDKA
310 320 330 340 350
SKEEERPSSE DEIALHFEPP NAPLNRKGLV SPQSPQKSDC QPNSPTESCS
360 370 380 390 400
SKNACILQAS GSPPAKSPTD PKACNWKKYK FIVLNSLNQN AKPEGSEQAE
410 420 430 440 450
LGRLSPRAYP APPACQPPME PANLDLQSPT KLSASGEDST IPQASRLNNL
460 470 480 490 500
VNRSLAGSPR SSSESHSPLY MHPPKCTSCG SQSPQHTEMC LHTAGPTFPE
510 520 530 540 550
EMGETQSEYS DSSCENGTFF CNECDCRFSE EASLKRHTLQ THSDKPYKCD
560 570 580 590 600
RCQASFRYKG NLASHKTVHT GEKPYRCNIC GAQFNRPANL KTHTRIHSGE
610 620 630 640 650
KPYKCETCGA RFVQVAHLRA HVLIHTGEKP YPCEICGTRF RHLQTLKSHL
660 670 680 690 700
RIHTGEKPYH CEKCNLHFRH KSQLRLHLRQ KHGAITNTKV QYRVSAADLP

PELPKAC
Length:707
Mass (Da):78,982
Last modified:February 1, 1995 - v1
Checksum:i2051DD808D32D5EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti456 – 4561A → G in AAB17432 (PubMed:8652841).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38377 mRNA. Translation: BAA07456.1.
U41465 mRNA. Translation: AAB17432.1.
BC052315 mRNA. Translation: AAH52315.1.
CCDSiCCDS28082.1.
RefSeqiNP_033874.1. NM_009744.3.
UniGeneiMm.347398.

Genome annotation databases

EnsembliENSMUST00000023151; ENSMUSP00000023151; ENSMUSG00000022508.
GeneIDi12053.
KEGGimmu:12053.
UCSCiuc007ytz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38377 mRNA. Translation: BAA07456.1.
U41465 mRNA. Translation: AAB17432.1.
BC052315 mRNA. Translation: AAH52315.1.
CCDSiCCDS28082.1.
RefSeqiNP_033874.1. NM_009744.3.
UniGeneiMm.347398.

3D structure databases

ProteinModelPortaliP41183.
SMRiP41183. Positions 5-129, 473-679.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198327. 7 interactions.
DIPiDIP-59432N.
IntActiP41183. 1 interaction.
STRINGi10090.ENSMUSP00000023151.

PTM databases

PhosphoSiteiP41183.

Proteomic databases

PRIDEiP41183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023151; ENSMUSP00000023151; ENSMUSG00000022508.
GeneIDi12053.
KEGGimmu:12053.
UCSCiuc007ytz.1. mouse.

Organism-specific databases

CTDi604.
MGIiMGI:107187. Bcl6.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00800000124096.
HOGENOMiHOG000001556.
HOVERGENiHBG004831.
InParanoidiP41183.
KOiK15618.
OMAiNECDCRF.
OrthoDBiEOG7KQ22S.
PhylomeDBiP41183.
TreeFamiTF330912.

Miscellaneous databases

ChiTaRSiBcl6. mouse.
NextBioi280351.
PROiP41183.
SOURCEiSearch...

Gene expression databases

BgeeiP41183.
CleanExiMM_BCL6.
ExpressionAtlasiP41183. baseline and differential.
GenevisibleiP41183. MM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene."
    Fukuda T., Miki T., Yoshida T., Hatano M., Ohashi K., Hirosawa S., Tokuhisa T.
    Oncogene 11:1657-1663(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Skeletal muscle.
  2. "BCL-6 expression during B-cell activation."
    Allman D., Jain A., Dent A., Maile R.R., Selvaggi T., Kehry M.R., Staudt L.M.
    Blood 87:5257-5268(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. "BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor."
    Okabe S., Fukuda T., Ishibashi K., Kojima S., Okada S., Hatano M., Ebara M., Saisho H., Tokuhisa T.
    Mol. Cell. Biol. 18:4235-4244(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCL6B.
  5. "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene."
    Davies J.M., Hawe N., Kabarowski J., Huang Q.-H., Zhu J., Brand N.J., Leprince D., Dhordain P., Cook M., Moriss-Kay G., Zelent A.
    Oncogene 18:365-375(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZBTB7, SUBCELLULAR LOCATION.
  6. "BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control."
    Shaffer A.L., Yu X., He Y., Boldrick J., Chan E.P., Staudt L.M.
    Immunity 13:199-212(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS TRANSCRIPTIONAL REPRESSOR, DISRUPTION PHENOTYPE.
  7. "Role for Bcl-6 in the generation and maintenance of memory CD8+ T-cells."
    Ichii H., Sakamoto A., Hatano M., Okada S., Toyama H., Taki S., Arima M., Kuroda Y., Tokuhisa T.
    Nat. Immunol. 3:558-563(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MEMORY CD8(+) T-CELL MAINTENANCE, DISRUPTION PHENOTYPE.
  8. "Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells."
    Phan R.T., Saito M., Kitagawa Y., Means A.R., Dalla-Favera R.
    Nat. Immunol. 8:1132-1139(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
    Basso K., Schneider C., Shen Q., Holmes A.B., Setty M., Leslie C., Dalla-Favera R.
    J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MIRNA REGULATION, TISSUE SPECIFICITY.
  10. "BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets."
    Tiberi L., van den Ameele J., Dimidschstein J., Piccirilli J., Gall D., Herpoel A., Bilheu A., Bonnefont J., Iacovino M., Kyba M., Bouschet T., Vanderhaeghen P.
    Nat. Neurosci. 15:1627-1635(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN NEUROGENESIS, INTERACTION WITH NOTCH1 AND SIRT1, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  11. Cited for: MUTAGENESIS OF ASN-21 AND HIS-116.
  12. "Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms."
    Huang C., Hatzi K., Melnick A.
    Nat. Immunol. 14:380-388(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN GERMINAL CENTER REACTIONS, DNA-BINDING, DOMAIN, INTERACTION WITH SMRT, DISRUPTION PHENOTYPE, MUTAGENESIS OF ASN-21; HIS-116; 377-LYS--LYS-380 AND 577-CYS--CYS-580.

Entry informationi

Entry nameiBCL6_MOUSE
AccessioniPrimary (citable) accession number: P41183
Secondary accession number(s): Q61065
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.