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Reviewed, UniProtKB/Swiss-Prot P41182 (BCL6_HUMAN)

Last modified June 16, 2009. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    B-cell lymphoma 6 protein
      Short name=BCL-6
Alternative name(s):
    Zinc finger protein 51
    LAZ-3 protein
    BCL-5
    Zinc finger and BTB domain-containing protein 27
Gene names
Name: BCL6
Synonyms: BCL5, LAZ3, ZBTB27, ZNF51
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length706 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. Ref.5

Subunit structure

Interacts with ZBTB7 and BCL6B By similarity. Interacts with the catalytic domain of HDAC9.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in germinal center T and B cells and in primary immature dendritic cells. Ref.5 Ref.7

Induction

Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan. Ref.7

Post-translational modification

Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.

Involvement in disease

Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.

A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.

A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityChromosomal rearrangement
Polymorphism
   DiseaseProto-oncogene
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Repressor
   PTMPhosphoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Biological processnegative regulation of B cell apoptosis

Non-traceable author statement. Source: UniProtKB

negative regulation of S phase of mitotic cell cycle

Non-traceable author statement. Source: UniProtKB

negative regulation of cell growth

Inferred from direct assay. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: UniProtKB

positive regulation of apoptosis

Inferred from direct assay. Source: UniProtKB

protein import into nucleus, translocation

Inferred from genetic interaction. Source: UniProtKB

regulation of germinal center formation

Non-traceable author statement. Source: UniProtKB

response to DNA damage stimulus

Inferred from direct assay. Source: UniProtKB

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from direct assay. Source: UniProtKB

   Molecular functionprotein binding Ref.6

Inferred from physical interaction. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay. Source: UniProtKB

transcription factor activity

Inferred from mutant phenotype. Source: UniProtKB

transcription repressor activity

Inferred from mutant phenotype. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 706706B-cell lymphoma 6 protein
PRO_0000047098

Regions

Domain32 – 9968BTB
Zinc finger518 – 54124C2H2-type 1
Zinc finger546 – 56823C2H2-type 2
Zinc finger574 – 59623C2H2-type 3
Zinc finger602 – 62423C2H2-type 4
Zinc finger630 – 65223C2H2-type 5
Zinc finger658 – 68124C2H2-type 6

Natural variations

Natural variant2521N → S: dbSNP rs34463990.
VAR_052709
Natural variant4931A → T: dbSNP rs2229362.
VAR_019970
Natural variant6761H → Y: dbSNP rs1056936.
VAR_014825

Experimental info

Mutagenesis3331S → A: Decrease in phosphorylation by MAPK1. Ref.5
Mutagenesis3431S → A: Decrease in phosphorylation by MAPK1. Ref.5
Sequence conflict3471S → A in AAC50054. Ref.2
Sequence conflict3931E → G in AAC50054. Ref.2
Sequence conflict4981P → A in AAC50054. Ref.2

Secondary structure

........................................... 706
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P41182-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: E38D83C213DAE2D0

FASTA70678,846
        10         20         30         40         50         60 
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 

        70         80         90        100        110        120 
FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 

       130        140        150        160        170        180 
CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF 

       190        200        210        220        230        240 
APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG 

       250        260        270        280        290        300 
EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS 

       310        320        330        340        350        360 
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS KNACILQASG 

       370        380        390        400        410        420 
SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL GRLSPRAYTA PPACQPPMEP 

       430        440        450        460        470        480 
ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS 

       490        500        510        520        530        540 
QSPQHAEMCL HTAGPTFPEE MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT 

       550        560        570        580        590        600 
HSDKPYKCDR CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK 

       610        620        630        640        650        660 
PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR IHTGEKPYHC 

       670        680        690        700 
EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP ELPKAC 

« Hide

References

[1]"LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas."
Kerckaert J.-P., Deweindt C., Tilly H., Quief S., Lecocq G., Bastard C.
Nat. Genet. 5:66-70(1993) [PubMed: 8220427] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma."
Ye B.H., Lista F., Lo Coco F., Knowles D.M., Offit K., Chaganti R.S.K., Dalla-Favera R.
Science 262:747-750(1993) [PubMed: 8235596] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein."
Miki T., Kawamata N., Hirosawa S., Aoki N.
Blood 83:26-32(1994) [PubMed: 8274740] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[4]"Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas."
Baron B.W., Nucifora G., McCabe N., Espinosa R. III, le Beau M.M., McKeithan T.W.
Proc. Natl. Acad. Sci. U.S.A. 90:5262-5266(1993) [PubMed: 8506375] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor."
Niu H., Ye B.H., Dalla-Favera R.
Genes Dev. 12:1953-1961(1998) [PubMed: 9649500] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, PTM, MUTAGENESIS OF SER-333 AND SER-343.
[6]"The histone deacetylase 9 gene encodes multiple protein isoforms."
Petrie K., Guidez F., Howell L., Healy L., Waxman S., Greaves M., Zelent A.
J. Biol. Chem. 278:16059-16072(2003) [PubMed: 12590135] [Abstract]
Cited for: INTERACTION WITH HDAC9.
[7]"Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells."
Pantano S., Jarrossay D., Saccani S., Bosisio D., Natoli G.
Exp. Cell Res. 312:1312-1322(2006) [PubMed: 16455075] [Abstract]
Cited for: INDUCTION, TISSUE SPECIFICITY.
[8]"Solution structure of the C2H2 type zinc finger (region 598-654) of human B-cell lymphoma 6 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 598-657.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z21943 mRNA. Translation: CAA79937.1.
U00115 mRNA. Translation: AAC50054.1.
S67779 mRNA. No translation available.
IPIIPI00012820.
PIRA48752.
I52586.
RefSeqNP_001124317.1.
NP_001128210.1.
NP_001697.2.
UniGeneHs.478588

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1R28X-ray2.20A/B5-129[»]
1R29X-ray1.30A5-129[»]
1R2BX-ray2.20A/B5-129[»]
2EN2NMR-A598-626[»]
2EOSNMR-A626-654[»]
2YRMNMR-A515-544[»]
3BIMX-ray2.60A/B/C/D/E/F/G/H5-129[»]
3E4UX-ray2.10A/B/C/D/E/F5-129[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP41182. 65 interactions.

PTM databases

PhosphoSiteP41182.

Proteomic databases

PRIDEP41182.

Genome annotation databases

EnsemblENSG00000113916. Homo sapiens. [Contig view]
GeneID604.
KEGGhsa:604.

Organism-specific databases

GeneCardsGC03M188921.
HGNCHGNC:1001. BCL6.
HPACAB000307.
HPA004899.
MIM109565. gene.
Orphanet545. Follicular lymphoma.
PharmGKBPA25312.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP41182.
HOVERGENP41182.
OMAP41182. QASFRYK.

Enzyme and pathway databases

Pathway_Interaction_DBfoxopathway. FoxO family signaling.
il4_2pathway. IL4-mediated signaling events.
hdac_classii_pathway. Signaling events mediated by HDAC Class II.

Gene expression databases

ArrayExpressP41182.
BgeeP41182.
CleanExHS_BCL6.
GermOnlineENSG00000113916. Homo sapiens.

Family and domain databases

InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
PfamPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio2453.
SOURCESearch...

Entry information

Entry nameBCL6_HUMAN
AccessionPrimary (citable) accession number: P41182
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 16, 2009
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents