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Protein

B-cell lymphoma 6 protein

Gene

BCL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.14 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 541C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri546 – 568C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 681C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Immunity, Inflammatory response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113916-MONOMER.
ReactomeiR-HSA-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.
SIGNORiP41182.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma 6 protein
Short name:
BCL-6
Alternative name(s):
B-cell lymphoma 5 protein
Short name:
BCL-5
Protein LAZ-3
Zinc finger and BTB domain-containing protein 27
Zinc finger protein 51
Gene namesi
Name:BCL6
Synonyms:BCL5, LAZ3, ZBTB27, ZNF51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1001. BCL6.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving BCL6 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL), including diffuse large B-cell lymphoma and follicular lymphoma. Approximately 40% of diffuse large B-cell lymphomas and 5 to 10% of follicular lymphomas are associated with chromosomal translocations that deregulate expression of BCL6 by juxtaposing heterologous promoters to the BCL6 coding domain. Translocation t(3;14)(q27;q32). Translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Translocation t(3;7)(q27;p12) with IKZF1 gene 5'non-coding region. Translocation t(3;6)(q27;p21) with Histone H4. Translocation t(3;16)(q27;p11) with IL21R. Translocation t(3;13)(q27;q14) with LCP1.

A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.

A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi21N → K: Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with A-116 and 376-Q--Q-379. 1 Publication1
Mutagenesisi116H → A: Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with K-21 and 376-Q--Q-379. 1 Publication1
Mutagenesisi190T → A: No effect on interaction with PIN1. 1 Publication1
Mutagenesisi250S → A: No effect on interaction with PIN1. 1 Publication1
Mutagenesisi260S → A: Strongly reduces interaction with PIN1. 1 Publication1
Mutagenesisi333S → A: Decrease in phosphorylation by MAPK1. 1 Publication1
Mutagenesisi343S → A: Decrease in phosphorylation by MAPK1. 1 Publication1
Mutagenesisi376 – 379KKYK → QQYQ: Abolishes interaction with HDAC2 and MTA3 as well as transcriptional repressor and transforming activities. Abolishes interaction with NCOR2 and HDAC2, no effect on interaction with CTBP1 and transcriptional autoinhibition; when associated with K-21 and A-116. 2 Publications4
Mutagenesisi376K → R: No effect on acetylation. 1 Publication1
Mutagenesisi377K → R: No effect on acetylation. 1 Publication1
Mutagenesisi379K → R: Abolishes acetylation. No effect on interaction with MTA3, NCOR1 and NCOR2. 2 Publications1
Mutagenesisi520 – 523CNEC → GNEG: No effect on DNA-binding, nuclear localization, transcriptional repression activity and interaction with HDAC5. 1 Publication4
Mutagenesisi548 – 551CDRC → GDRG: No effect on DNA-binding, nuclear localization, transcriptional repression activity and interaction with HDAC5. 1 Publication4
Mutagenesisi576 – 579CNIC → GNIG: Abolishes DNA-binding and transcriptional repression activity, no effect on nuclear localization and interaction with HDAC5. 1 Publication4
Mutagenesisi604 – 607CETC → GETG: Abolishes DNA-binding and transcriptional repression activity, perturbs nuclear localization. No effect on interaction with HDAC5. 1 Publication4
Mutagenesisi632 – 635CEIC → GEIG: Abolishes DNA-binding and transcriptional repression activity, no effect on nuclear localization and interaction with HDAC5. 1 Publication4
Mutagenesisi660 – 663CEKC → GEKG: Abolishes DNA-binding and transcriptional repression activity, perturbs nuclear localization. No effect on interaction with HDAC5. 1 Publication4

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi604.
MalaCardsiBCL6.
OpenTargetsiENSG00000113916.
Orphaneti545. Follicular lymphoma.
98839. Intravascular large B-cell lymphoma.
98838. Primary mediastinal large B-cell lymphoma.
PharmGKBiPA25312.

Polymorphism and mutation databases

BioMutaiBCL6.
DMDMi728952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470981 – 706B-cell lymphoma 6 proteinAdd BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333Phosphoserine; by MAPK1Combined sources1 Publication1
Modified residuei343Phosphoserine; by MAPK11 Publication1
Modified residuei361PhosphoserineBy similarity1
Modified residuei379N6-acetyllysine1 Publication1
Modified residuei404PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.3 Publications
Polyubiquitinated. Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome.
Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP41182.
PaxDbiP41182.
PeptideAtlasiP41182.
PRIDEiP41182.
TopDownProteomicsiP41182-2. [P41182-2]

PTM databases

iPTMnetiP41182.
PhosphoSitePlusiP41182.

Expressioni

Tissue specificityi

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.8 Publications

Inductioni

Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial lipopolysaccharides (LPS), CD40LG and zymosan. Protein levels decreases upon genotoxic stress in a dose- and time-dependent way.2 Publications

Gene expression databases

BgeeiENSG00000113916.
CleanExiHS_BCL6.
ExpressionAtlasiP41182. baseline and differential.
GenevisibleiP41182. HS.

Organism-specific databases

HPAiCAB000307.
HPA004899.

Interactioni

Subunit structurei

Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.12 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-765407,EBI-765407
AESQ081173EBI-765407,EBI-717810
BCL6BA8KA133EBI-765407,EBI-10174813
BLZF1Q9H2G93EBI-765407,EBI-2548012
CUTCQ9NTM93EBI-765407,EBI-714918
GOLGA2A0A0C4DGS54EBI-765407,EBI-11522202
HDAC4P565243EBI-765407,EBI-308629
HDAC9Q9UKV02EBI-765407,EBI-765444
KIFC3Q9BVG83EBI-765407,EBI-2125614
LIMS4P0CW203EBI-765407,EBI-10196832
SIAH1Q8IUQ43EBI-765407,EBI-747107
TRAF1Q130775EBI-765407,EBI-359224
ZBTB7BO151563EBI-765407,EBI-740434
ZMYND8Q9ULU43EBI-765407,EBI-765834

Protein-protein interaction databases

BioGridi107076. 117 interactors.
DIPiDIP-2651N.
IntActiP41182. 98 interactors.
MINTiMINT-158757.
STRINGi9606.ENSP00000232014.

Structurei

Secondary structure

1706
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Helixi14 – 27Combined sources14
Turni29 – 31Combined sources3
Beta strandi34 – 38Combined sources5
Beta strandi41 – 45Combined sources5
Helixi47 – 53Combined sources7
Helixi55 – 61Combined sources7
Turni64 – 68Combined sources5
Beta strandi70 – 73Combined sources4
Helixi80 – 92Combined sources13
Beta strandi93 – 95Combined sources3
Turni99 – 101Combined sources3
Helixi102 – 111Combined sources10
Helixi115 – 126Combined sources12
Beta strandi521 – 523Combined sources3
Beta strandi527 – 529Combined sources3
Helixi530 – 540Combined sources11
Helixi558 – 568Combined sources11
Beta strandi573 – 575Combined sources3
Turni577 – 579Combined sources3
Beta strandi582 – 584Combined sources3
Helixi586 – 596Combined sources11
Beta strandi601 – 603Combined sources3
Turni605 – 607Combined sources3
Beta strandi610 – 613Combined sources4
Helixi614 – 620Combined sources7
Helixi622 – 625Combined sources4
Beta strandi633 – 635Combined sources3
Beta strandi639 – 641Combined sources3
Helixi642 – 648Combined sources7
Turni649 – 652Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R28X-ray2.20A/B5-129[»]
1R29X-ray1.30A5-129[»]
1R2BX-ray2.20A/B5-129[»]
2EN2NMR-A598-626[»]
2EOSNMR-A626-654[»]
2LCENMR-A540-602[»]
2YRMNMR-A515-544[»]
3BIMX-ray2.60A/B/C/D/E/F/G/H5-129[»]
3E4UX-ray2.10A/B/C/D/E/F5-129[»]
3LBZX-ray2.30A/B5-129[»]
4CP3X-ray2.30A/B9-128[»]
4U2MX-ray2.23A/B/C/D5-129[»]
ProteinModelPortaliP41182.
SMRiP41182.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP41182.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 99BTBPROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni376 – 379Required for interaction with NuRD complex and for transcriptional repressor activity4

Domaini

The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity).By similarity1 Publication

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri518 – 541C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri546 – 568C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 681C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129871.
HOGENOMiHOG000001556.
HOVERGENiHBG004831.
InParanoidiP41182.
KOiK15618.
OMAiNECDCRF.
OrthoDBiEOG091G025U.
PhylomeDBiP41182.
TreeFamiTF330912.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P41182-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL
60 70 80 90 100
MACSGLFYSI FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG
110 120 130 140 150
NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMVSAIKPPR EEFLNSRMLM
160 170 180 190 200
PQDIMAYRGR EVVENNLPLR SAPGCESRAF APSLYSGLST PPASYSMYSH
210 220 230 240 250
LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG EYSRPTLEVS
260 270 280 290 300
PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS
310 320 330 340 350
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS
360 370 380 390 400
KNACILQASG SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL
410 420 430 440 450
GRLSPRAYTA PPACQPPMEP ENLDLQSPTK LSASGEDSTI PQASRLNNIV
460 470 480 490 500
NRSMTGSPRS SSESHSPLYM HPPKCTSCGS QSPQHAEMCL HTAGPTFPEE
510 520 530 540 550
MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT HSDKPYKCDR
560 570 580 590 600
CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK
610 620 630 640 650
PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR
660 670 680 690 700
IHTGEKPYHC EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP

ELPKAC
Length:706
Mass (Da):78,846
Last modified:February 1, 1995 - v1
Checksum:iE38D83C213DAE2D0
GO
Isoform 2 (identifier: P41182-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-569: Missing.

Note: No experimental confirmation available.
Show »
Length:650
Mass (Da):72,367
Checksum:iADDA180461FAFCE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti347S → A in AAC50054 (PubMed:8235596).Curated1
Sequence conflicti393E → G in AAC50054 (PubMed:8235596).Curated1
Sequence conflicti498P → A in AAC50054 (PubMed:8235596).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052709252N → S.Corresponds to variant rs34463990dbSNPEnsembl.1
Natural variantiVAR_019970493A → T.Corresponds to variant rs2229362dbSNPEnsembl.1
Natural variantiVAR_014825676H → Y.Corresponds to variant rs1056936dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042709514 – 569Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21943 mRNA. Translation: CAA79937.1.
U00115 mRNA. Translation: AAC50054.1.
S67779 mRNA. No translation available.
EU139066 mRNA. Translation: ABX45135.1.
AC072022 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78140.1.
CH471052 Genomic DNA. Translation: EAW78141.1.
BC150184 mRNA. Translation: AAI50185.1.
CCDSiCCDS3289.1. [P41182-1]
CCDS46975.1. [P41182-2]
PIRiA48752.
I52586.
RefSeqiNP_001124317.1. NM_001130845.1. [P41182-1]
NP_001128210.1. NM_001134738.1. [P41182-2]
NP_001697.2. NM_001706.4. [P41182-1]
XP_005247751.1. XM_005247694.3. [P41182-1]
XP_011511364.1. XM_011513062.2. [P41182-2]
UniGeneiHs.478588.

Genome annotation databases

EnsembliENST00000232014; ENSP00000232014; ENSG00000113916. [P41182-1]
ENST00000406870; ENSP00000384371; ENSG00000113916. [P41182-1]
ENST00000450123; ENSP00000413122; ENSG00000113916. [P41182-2]
ENST00000621333; ENSP00000479784; ENSG00000113916. [P41182-2]
GeneIDi604.
KEGGihsa:604.
UCSCiuc003frp.4. human. [P41182-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21943 mRNA. Translation: CAA79937.1.
U00115 mRNA. Translation: AAC50054.1.
S67779 mRNA. No translation available.
EU139066 mRNA. Translation: ABX45135.1.
AC072022 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78140.1.
CH471052 Genomic DNA. Translation: EAW78141.1.
BC150184 mRNA. Translation: AAI50185.1.
CCDSiCCDS3289.1. [P41182-1]
CCDS46975.1. [P41182-2]
PIRiA48752.
I52586.
RefSeqiNP_001124317.1. NM_001130845.1. [P41182-1]
NP_001128210.1. NM_001134738.1. [P41182-2]
NP_001697.2. NM_001706.4. [P41182-1]
XP_005247751.1. XM_005247694.3. [P41182-1]
XP_011511364.1. XM_011513062.2. [P41182-2]
UniGeneiHs.478588.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R28X-ray2.20A/B5-129[»]
1R29X-ray1.30A5-129[»]
1R2BX-ray2.20A/B5-129[»]
2EN2NMR-A598-626[»]
2EOSNMR-A626-654[»]
2LCENMR-A540-602[»]
2YRMNMR-A515-544[»]
3BIMX-ray2.60A/B/C/D/E/F/G/H5-129[»]
3E4UX-ray2.10A/B/C/D/E/F5-129[»]
3LBZX-ray2.30A/B5-129[»]
4CP3X-ray2.30A/B9-128[»]
4U2MX-ray2.23A/B/C/D5-129[»]
ProteinModelPortaliP41182.
SMRiP41182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107076. 117 interactors.
DIPiDIP-2651N.
IntActiP41182. 98 interactors.
MINTiMINT-158757.
STRINGi9606.ENSP00000232014.

PTM databases

iPTMnetiP41182.
PhosphoSitePlusiP41182.

Polymorphism and mutation databases

BioMutaiBCL6.
DMDMi728952.

Proteomic databases

MaxQBiP41182.
PaxDbiP41182.
PeptideAtlasiP41182.
PRIDEiP41182.
TopDownProteomicsiP41182-2. [P41182-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232014; ENSP00000232014; ENSG00000113916. [P41182-1]
ENST00000406870; ENSP00000384371; ENSG00000113916. [P41182-1]
ENST00000450123; ENSP00000413122; ENSG00000113916. [P41182-2]
ENST00000621333; ENSP00000479784; ENSG00000113916. [P41182-2]
GeneIDi604.
KEGGihsa:604.
UCSCiuc003frp.4. human. [P41182-1]

Organism-specific databases

CTDi604.
DisGeNETi604.
GeneCardsiBCL6.
HGNCiHGNC:1001. BCL6.
HPAiCAB000307.
HPA004899.
MalaCardsiBCL6.
MIMi109565. gene.
neXtProtiNX_P41182.
OpenTargetsiENSG00000113916.
Orphaneti545. Follicular lymphoma.
98839. Intravascular large B-cell lymphoma.
98838. Primary mediastinal large B-cell lymphoma.
PharmGKBiPA25312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129871.
HOGENOMiHOG000001556.
HOVERGENiHBG004831.
InParanoidiP41182.
KOiK15618.
OMAiNECDCRF.
OrthoDBiEOG091G025U.
PhylomeDBiP41182.
TreeFamiTF330912.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113916-MONOMER.
ReactomeiR-HSA-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.
SIGNORiP41182.

Miscellaneous databases

ChiTaRSiBCL6. human.
EvolutionaryTraceiP41182.
GeneWikiiBCL6.
GenomeRNAii604.
PROiP41182.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113916.
CleanExiHS_BCL6.
ExpressionAtlasiP41182. baseline and differential.
GenevisibleiP41182. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCL6_HUMAN
AccessioniPrimary (citable) accession number: P41182
Secondary accession number(s): A7E241, B8PSA7, D3DNV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.