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Protein

Aquaporin-2

Gene

AQP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

GO - Molecular functioni

GO - Biological processi

  • cellular response to copper ion Source: UniProtKB
  • cellular response to mercury ion Source: UniProtKB
  • cellular response to water deprivation Source: Ensembl
  • cellular water homeostasis Source: GO_Central
  • excretion Source: ProtInc
  • glycerol transport Source: UniProtKB
  • ion transmembrane transport Source: GO_Central
  • metanephric collecting duct development Source: Ensembl
  • renal water homeostasis Source: Reactome
  • renal water transport Source: Ensembl
  • water transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167580-MONOMER.
ReactomeiR-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-432047. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.8.8. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-2
Short name:
AQP-2
Alternative name(s):
ADH water channel
Aquaporin-CD
Short name:
AQP-CD
Collecting duct water channel protein
WCH-CD
Water channel protein for renal collecting duct
Gene namesi
Name:AQP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:634. AQP2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 34HelicalSequence analysisAdd BLAST18
Topological domaini35 – 40ExtracellularSequence analysis6
Transmembranei41 – 59HelicalSequence analysisAdd BLAST19
Topological domaini60 – 85CytoplasmicSequence analysisAdd BLAST26
Transmembranei86 – 107HelicalSequence analysisAdd BLAST22
Topological domaini108 – 127ExtracellularSequence analysisAdd BLAST20
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 156CytoplasmicSequence analysis8
Transmembranei157 – 176HelicalSequence analysisAdd BLAST20
Topological domaini177 – 202ExtracellularSequence analysisAdd BLAST26
Transmembranei203 – 224HelicalSequence analysisAdd BLAST22
Topological domaini225 – 271CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB
  • recycling endosome Source: Ensembl
  • transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes insipidus, nephrogenic, autosomal (ANDI)16 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.
See also OMIM:125800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01523922L → V in ANDI. 1 PublicationCorresponds to variant rs104894336dbSNPEnsembl.1
Natural variantiVAR_01524028L → P in ANDI. 1 Publication1
Natural variantiVAR_01524147A → V in ANDI. 1 Publication1
Natural variantiVAR_01525657Q → P in ANDI. 1 PublicationCorresponds to variant rs28931580dbSNPEnsembl.1
Natural variantiVAR_00440164G → R in ANDI. 1 PublicationCorresponds to variant rs104894326dbSNPEnsembl.1
Natural variantiVAR_01524268N → S in ANDI. 1 PublicationCorresponds to variant rs104894331dbSNPEnsembl.1
Natural variantiVAR_06258570A → D in ANDI. 1 Publication1
Natural variantiVAR_01524371V → M in ANDI. 1 PublicationCorresponds to variant rs149659001dbSNPEnsembl.1
Natural variantiVAR_062586100G → R in ANDI. 1 Publication1
Natural variantiVAR_015257100G → V in ANDI. 1 PublicationCorresponds to variant rs28929477dbSNPEnsembl.1
Natural variantiVAR_071370108T → M in ANDI. 1 Publication1
Natural variantiVAR_015244125T → M in ANDI. 3 PublicationsCorresponds to variant rs104894333dbSNPEnsembl.1
Natural variantiVAR_015245126T → M in ANDI. 1 PublicationCorresponds to variant rs104894330dbSNPEnsembl.1
Natural variantiVAR_015246147A → T in ANDI. 1 PublicationCorresponds to variant rs104894334dbSNPEnsembl.1
Natural variantiVAR_015247168V → M in ANDI. 1 PublicationCorresponds to variant rs755694590dbSNPEnsembl.1
Natural variantiVAR_015248175G → R in ANDI. 3 PublicationsCorresponds to variant rs104894335dbSNPEnsembl.1
Natural variantiVAR_062587180G → S in ANDI. 1 Publication1
Natural variantiVAR_015249181C → W in ANDI. 1 PublicationCorresponds to variant rs104894337dbSNPEnsembl.1
Natural variantiVAR_015250185P → A in ANDI. 1 PublicationCorresponds to variant rs761713751dbSNPEnsembl.1
Natural variantiVAR_004402187R → C in ANDI; mutant protein does not fold properly and is not functional. 2 PublicationsCorresponds to variant rs104894328dbSNPEnsembl.1
Natural variantiVAR_062588187R → H in ANDI. 1 PublicationCorresponds to variant rs193922495dbSNPEnsembl.1
Natural variantiVAR_015251190A → T in ANDI; mutant protein does not fold properly and is not functional. 2 PublicationsCorresponds to variant rs104894341dbSNPEnsembl.1
Natural variantiVAR_015253202W → C in ANDI. 1 Publication1
Natural variantiVAR_004403216S → P in ANDI. 2 PublicationsCorresponds to variant rs104894329dbSNPEnsembl.1
Natural variantiVAR_062589254R → L in ANDI; results in the loss of arginine vasopressin-mediated phosphorylation at S-256. 1 Publication1
Natural variantiVAR_062590254R → Q in ANDI; exerts a dominant-negative effect on wild-type-AQP2 in that it interferes with its trafficking to the apical membrane; is a loss of function instead of a gain of function mutation on dominant nephrogenic diabetes insipidus. 1 Publication1
Natural variantiVAR_015254258E → K in ANDI; retained in the Golgi compartment. 2 PublicationsCorresponds to variant rs104894332dbSNPEnsembl.1
Natural variantiVAR_015255262P → L in ANDI; mutant protein folds properly and is functional but is retained in intracellular vesicles and does not localize to the ER; upon coexpression with wild-type AQP2 mutant protein interacts with wild-type AQP2 and the resulting heterotetramer properly localizes to the apical membrane. 2 PublicationsCorresponds to variant rs104894339dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi148S → A: No effect on sorting from the ER to the vesicles, redistribution to apical membrane, or endocytosis. 1 Publication1
Mutagenesisi148S → D: Retained in the endoplasmic reticulum. 1 Publication1
Mutagenesisi229S → A: No effect on sorting from the ER to the vesicles, redistribution to apical membrane, or endocytosis. 1 Publication1
Mutagenesisi229S → D: No effect on sorting from the ER to the vesicles, redistribution to apical membrane, or endocytosis. 1 Publication1
Mutagenesisi231S → A: No effect on sorting from the ER to the vesicles, redistribution to apical membrane, or endocytosis. 1 Publication1
Mutagenesisi231S → D: No effect on sorting from the ER to the vesicles, redistribution to apical membrane, or endocytosis. 1 Publication1
Mutagenesisi244T → A: No effect on sorting from the ER to the vesicles, redistribution to apical membrane, or endocytosis. 1 Publication1
Mutagenesisi244T → E: No effect on sorting from the ER to the vesicles, redistribution to apical membrane, or endocytosis. 1 Publication1
Mutagenesisi256S → A: Retained in vesicles. 1 Publication1
Mutagenesisi256S → D: Expressed in the apical membrane. 1 Publication1

Keywords - Diseasei

Diabetes insipidus, Disease mutation

Organism-specific databases

DisGeNETi359.
MalaCardsiAQP2.
MIMi125800. phenotype.
OpenTargetsiENSG00000167580.
Orphaneti223. Nephrogenic diabetes insipidus.
PharmGKBiPA24920.

Polymorphism and mutation databases

BioMutaiAQP2.
DMDMi728874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639341 – 271Aquaporin-2Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Modified residuei256Phosphoserine; by PKA1 Publication1

Post-translational modificationi

Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP41181.
PeptideAtlasiP41181.
PRIDEiP41181.

PTM databases

iPTMnetiP41181.
PhosphoSitePlusiP41181.

Expressioni

Tissue specificityi

Expressed in renal collecting tubules.

Gene expression databases

BgeeiENSG00000167580.
CleanExiHS_AQP2.
ExpressionAtlasiP41181. baseline and differential.
GenevisibleiP41181. HS.

Organism-specific databases

HPAiHPA046834.

Interactioni

Protein-protein interaction databases

BioGridi106855. 1 interactor.
STRINGi9606.ENSP00000199280.

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 32Combined sources26
Beta strandi35 – 37Combined sources3
Helixi41 – 63Combined sources23
Helixi69 – 77Combined sources9
Helixi83 – 107Combined sources25
Helixi110 – 113Combined sources4
Helixi127 – 148Combined sources22
Helixi159 – 179Combined sources21
Helixi185 – 195Combined sources11
Turni199 – 202Combined sources4
Helixi203 – 221Combined sources19
Helixi232 – 237Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NEFX-ray2.75A/B/C/D3-241[»]
4OJ2X-ray3.05X1-271[»]
ProteinModelPortaliP41181.
SMRiP41181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi68 – 70NPA 13
Motifi184 – 186NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiP41181.
KOiK09865.
OMAiDHSPADY.
OrthoDBiEOG091G166T.
PhylomeDBiP41181.
TreeFamiTF312940.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELRSIAFS RAVFAEFLAT LLFVFFGLGS ALNWPQALPS VLQIAMAFGL
60 70 80 90 100
GIGTLVQALG HISGAHINPA VTVACLVGCH VSVLRAAFYV AAQLLGAVAG
110 120 130 140 150
AALLHEITPA DIRGDLAVNA LSNSTTAGQA VTVELFLTLQ LVLCIFASTD
160 170 180 190 200
ERRGENPGTP ALSIGFSVAL GHLLGIHYTG CSMNPARSLA PAVVTGKFDD
210 220 230 240 250
HWVFWIGPLV GAILGSLLYN YVLFPPAKSL SERLAVLKGL EPDTDWEERE
260 270
VRRRQSVELH SPQSLPRGTK A
Length:271
Mass (Da):28,837
Last modified:February 1, 1995 - v1
Checksum:iC2DDE2AF4DDD192A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35 – 38PQAL → ATAP (PubMed:7510718).Curated4
Sequence conflicti83V → F (PubMed:7510718).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01523922L → V in ANDI. 1 PublicationCorresponds to variant rs104894336dbSNPEnsembl.1
Natural variantiVAR_01524028L → P in ANDI. 1 Publication1
Natural variantiVAR_01524147A → V in ANDI. 1 Publication1
Natural variantiVAR_01525657Q → P in ANDI. 1 PublicationCorresponds to variant rs28931580dbSNPEnsembl.1
Natural variantiVAR_00440164G → R in ANDI. 1 PublicationCorresponds to variant rs104894326dbSNPEnsembl.1
Natural variantiVAR_01524268N → S in ANDI. 1 PublicationCorresponds to variant rs104894331dbSNPEnsembl.1
Natural variantiVAR_06258570A → D in ANDI. 1 Publication1
Natural variantiVAR_01524371V → M in ANDI. 1 PublicationCorresponds to variant rs149659001dbSNPEnsembl.1
Natural variantiVAR_062586100G → R in ANDI. 1 Publication1
Natural variantiVAR_015257100G → V in ANDI. 1 PublicationCorresponds to variant rs28929477dbSNPEnsembl.1
Natural variantiVAR_071370108T → M in ANDI. 1 Publication1
Natural variantiVAR_037577121L → F.Corresponds to variant rs11169226dbSNPEnsembl.1
Natural variantiVAR_015244125T → M in ANDI. 3 PublicationsCorresponds to variant rs104894333dbSNPEnsembl.1
Natural variantiVAR_015245126T → M in ANDI. 1 PublicationCorresponds to variant rs104894330dbSNPEnsembl.1
Natural variantiVAR_015246147A → T in ANDI. 1 PublicationCorresponds to variant rs104894334dbSNPEnsembl.1
Natural variantiVAR_015247168V → M in ANDI. 1 PublicationCorresponds to variant rs755694590dbSNPEnsembl.1
Natural variantiVAR_015248175G → R in ANDI. 3 PublicationsCorresponds to variant rs104894335dbSNPEnsembl.1
Natural variantiVAR_062587180G → S in ANDI. 1 Publication1
Natural variantiVAR_015249181C → W in ANDI. 1 PublicationCorresponds to variant rs104894337dbSNPEnsembl.1
Natural variantiVAR_015250185P → A in ANDI. 1 PublicationCorresponds to variant rs761713751dbSNPEnsembl.1
Natural variantiVAR_004402187R → C in ANDI; mutant protein does not fold properly and is not functional. 2 PublicationsCorresponds to variant rs104894328dbSNPEnsembl.1
Natural variantiVAR_062588187R → H in ANDI. 1 PublicationCorresponds to variant rs193922495dbSNPEnsembl.1
Natural variantiVAR_015251190A → T in ANDI; mutant protein does not fold properly and is not functional. 2 PublicationsCorresponds to variant rs104894341dbSNPEnsembl.1
Natural variantiVAR_015252194V → I.1 PublicationCorresponds to variant rs772051028dbSNPEnsembl.1
Natural variantiVAR_015253202W → C in ANDI. 1 Publication1
Natural variantiVAR_004403216S → P in ANDI. 2 PublicationsCorresponds to variant rs104894329dbSNPEnsembl.1
Natural variantiVAR_062589254R → L in ANDI; results in the loss of arginine vasopressin-mediated phosphorylation at S-256. 1 Publication1
Natural variantiVAR_062590254R → Q in ANDI; exerts a dominant-negative effect on wild-type-AQP2 in that it interferes with its trafficking to the apical membrane; is a loss of function instead of a gain of function mutation on dominant nephrogenic diabetes insipidus. 1 Publication1
Natural variantiVAR_015254258E → K in ANDI; retained in the Golgi compartment. 2 PublicationsCorresponds to variant rs104894332dbSNPEnsembl.1
Natural variantiVAR_015255262P → L in ANDI; mutant protein folds properly and is functional but is retained in intracellular vesicles and does not localize to the ER; upon coexpression with wild-type AQP2 mutant protein interacts with wild-type AQP2 and the resulting heterotetramer properly localizes to the apical membrane. 2 PublicationsCorresponds to variant rs104894339dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29491 Genomic DNA. Translation: CAA82627.1.
D31846 Genomic DNA. Translation: BAA06632.1.
S73196 mRNA. Translation: AAB31999.1.
S73197 mRNA. Translation: AAB31998.1.
AF147093, AF147092 Genomic DNA. Translation: AAD38692.1.
BC042496 mRNA. Translation: AAH42496.1.
CCDSiCCDS8792.1.
PIRiA53442.
I64818.
RefSeqiNP_000477.1. NM_000486.5.
UniGeneiHs.130730.

Genome annotation databases

EnsembliENST00000199280; ENSP00000199280; ENSG00000167580.
GeneIDi359.
KEGGihsa:359.
UCSCiuc001rvn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29491 Genomic DNA. Translation: CAA82627.1.
D31846 Genomic DNA. Translation: BAA06632.1.
S73196 mRNA. Translation: AAB31999.1.
S73197 mRNA. Translation: AAB31998.1.
AF147093, AF147092 Genomic DNA. Translation: AAD38692.1.
BC042496 mRNA. Translation: AAH42496.1.
CCDSiCCDS8792.1.
PIRiA53442.
I64818.
RefSeqiNP_000477.1. NM_000486.5.
UniGeneiHs.130730.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NEFX-ray2.75A/B/C/D3-241[»]
4OJ2X-ray3.05X1-271[»]
ProteinModelPortaliP41181.
SMRiP41181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106855. 1 interactor.
STRINGi9606.ENSP00000199280.

Protein family/group databases

TCDBi1.A.8.8.8. the major intrinsic protein (mip) family.

PTM databases

iPTMnetiP41181.
PhosphoSitePlusiP41181.

Polymorphism and mutation databases

BioMutaiAQP2.
DMDMi728874.

Proteomic databases

PaxDbiP41181.
PeptideAtlasiP41181.
PRIDEiP41181.

Protocols and materials databases

DNASUi359.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199280; ENSP00000199280; ENSG00000167580.
GeneIDi359.
KEGGihsa:359.
UCSCiuc001rvn.4. human.

Organism-specific databases

CTDi359.
DisGeNETi359.
GeneCardsiAQP2.
GeneReviewsiAQP2.
HGNCiHGNC:634. AQP2.
HPAiHPA046834.
MalaCardsiAQP2.
MIMi107777. gene.
125800. phenotype.
neXtProtiNX_P41181.
OpenTargetsiENSG00000167580.
Orphaneti223. Nephrogenic diabetes insipidus.
PharmGKBiPA24920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiP41181.
KOiK09865.
OMAiDHSPADY.
OrthoDBiEOG091G166T.
PhylomeDBiP41181.
TreeFamiTF312940.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167580-MONOMER.
ReactomeiR-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-432047. Passive transport by Aquaporins.

Miscellaneous databases

GeneWikiiAquaporin_2.
GenomeRNAii359.
PROiP41181.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167580.
CleanExiHS_AQP2.
ExpressionAtlasiP41181. baseline and differential.
GenevisibleiP41181. HS.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP2_HUMAN
AccessioniPrimary (citable) accession number: P41181
Secondary accession number(s): Q9UD68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.