P41177 (DHKR_STRCM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Monensin polyketide synthase putative ketoacyl reductase EC=1.3.1.- Alternative name(s): ORF5
Organism	Streptomyces cinnamonensis
Taxonomic identifier	1900 [NCBI]
Taxonomic lineage	cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Pathway	Antifungal biosynthesis; monensin biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Monensin polyketide synthase putative ketoacyl reductase		PRO_0000054634
Regions
	Nucleotide binding	10 – 34	25	NAD By similarity
Sites
	Active site	157	1	Proton acceptor By similarity
	Binding site	144	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P41177 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 095743C37FF63CCC	FASTA	261	27,081
	10 20 30 40 50 60 MTQSTSRVAL VTGATSGIGL ATARLLAAQG HLVFLGARTE SDVIATVKAL RNDGLEAEGQ 70 80 90 100 110 120 VLDVRDGASV TAFVQAAVDR YGRIDVLVNN AGRSGGGVTA DLTDELWDDV IDTNLNSVFR 130 140 150 160 170 180 MTRAVLTTGG MRTRERGRII NVASTAGKQG VVLGAPYSAS KHGVVGFTKA LGNELAPTGI 190 200 210 220 230 240 TVNAVCPGYV ETPMAQRVRQ GYAAAYDTTE EAILTKFQAK IPLGRYSTPE EVAGLIGYLA 250 260 SDTAASITSQ ALNVCGGLGN F

References

[1]

"Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis." Arrowsmith T.J., Malpartida F., Sherman D.H., Birch A., Hopwood D.A., Robinson J.A. Mol. Gen. Genet. 234:254-264(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A3823.5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z11511 Genomic DNA. Translation: CAA77599.1.
PIR	S25079.
3D structure databases
ProteinModelPortal	P41177.
SMR	P41177. Positions 6-261.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00178.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHKR_STRCM

Accession

Primary (citable) accession number: P41177

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program