ID   ETV1_MOUSE              Reviewed;         477 AA.
AC   P41164;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   24-JAN-2024, entry version 176.
DE   RecName: Full=ETS translocation variant 1 {ECO:0000305};
DE   AltName: Full=Ets-related protein 81 {ECO:0000312|MGI:MGI:99254};
GN   Name=Etv1 {ECO:0000312|MGI:MGI:99254};
GN   Synonyms=Er81 {ECO:0000303|PubMed:1340465}, Etsrp81
GN   {ECO:0000312|MGI:MGI:99254};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo;
RX   PubMed=1340465; DOI=10.1101/gad.6.12b.2502;
RA   Brown T.A., McKnight S.L.;
RT   "Specificities of protein-protein and protein-DNA interaction of GABP alpha
RT   and two newly defined ets-related proteins.";
RL   Genes Dev. 6:2502-2512(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NMRI; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=19287374; DOI=10.1038/nature07929;
RA   Flames N., Hobert O.;
RT   "Gene regulatory logic of dopamine neuron differentiation.";
RL   Nature 458:885-889(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Transcriptional activator that binds to DNA sequences
CC       containing the consensus pentanucleotide 5'-CGGA[AT]-3'
CC       (PubMed:1340465). Required for olfactory dopaminergic neuron
CC       differentiation; may directly activate expression of tyrosine
CC       hydroxylase (TH) (PubMed:19287374). {ECO:0000269|PubMed:1340465,
CC       ECO:0000269|PubMed:19287374}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- TISSUE SPECIFICITY: Abundant in kidney (PubMed:1340465). Moderate
CC       levels seen in the heart, brain, lung, embryo and lower levels seen in
CC       spleen, intestine, testis and thymus (PubMed:1340465).
CC       {ECO:0000269|PubMed:1340465}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the dopaminergic neurons of the
CC       olfactory bulb at postnatal day 0 (at protein level).
CC       {ECO:0000269|PubMed:19287374}.
CC   -!- PTM: Sumoylated. {ECO:0000250|UniProtKB:P50549}.
CC   -!- PTM: Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5;
CC       phosphorylation activates transcriptional activity.
CC       {ECO:0000250|UniProtKB:P50549}.
CC   -!- DISRUPTION PHENOTYPE: Significant reduction in the number of tyrosine
CC       hydroxylase (TH)-positive cells in the olfactory bulb.
CC       {ECO:0000269|PubMed:19287374}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; L10426; AAA20075.1; -; mRNA.
DR   EMBL; BC005645; AAH05645.1; -; mRNA.
DR   CCDS; CCDS49053.1; -.
DR   PIR; B46396; B46396.
DR   RefSeq; NP_031986.1; NM_007960.5.
DR   RefSeq; XP_006515028.1; XM_006514965.2.
DR   AlphaFoldDB; P41164; -.
DR   SMR; P41164; -.
DR   BioGRID; 199539; 1.
DR   DIP; DIP-60465N; -.
DR   IntAct; P41164; 1.
DR   STRING; 10090.ENSMUSP00000093442; -.
DR   iPTMnet; P41164; -.
DR   PhosphoSitePlus; P41164; -.
DR   PaxDb; 10090-ENSMUSP00000093442; -.
DR   ProteomicsDB; 267662; -.
DR   Antibodypedia; 25156; 365 antibodies from 33 providers.
DR   DNASU; 14009; -.
DR   Ensembl; ENSMUST00000095767.11; ENSMUSP00000093442.4; ENSMUSG00000004151.18.
DR   Ensembl; ENSMUST00000162563.8; ENSMUSP00000125157.2; ENSMUSG00000004151.18.
DR   GeneID; 14009; -.
DR   KEGG; mmu:14009; -.
DR   UCSC; uc033gdb.1; mouse.
DR   AGR; MGI:99254; -.
DR   CTD; 2115; -.
DR   MGI; MGI:99254; Etv1.
DR   VEuPathDB; HostDB:ENSMUSG00000004151; -.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000157123; -.
DR   HOGENOM; CLU_030025_1_0_1; -.
DR   InParanoid; P41164; -.
DR   OMA; DYQAESX; -.
DR   OrthoDB; 3915960at2759; -.
DR   PhylomeDB; P41164; -.
DR   TreeFam; TF316214; -.
DR   BioGRID-ORCS; 14009; 1 hit in 78 CRISPR screens.
DR   ChiTaRS; Etv1; mouse.
DR   PRO; PR:P41164; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; P41164; Protein.
DR   Bgee; ENSMUSG00000004151; Expressed in parotid gland and 260 other cell types or tissues.
DR   ExpressionAtlas; P41164; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0007411; P:axon guidance; IMP:MGI.
DR   GO; GO:0007638; P:mechanosensory behavior; IMP:MGI.
DR   GO; GO:0007517; P:muscle organ development; IMP:MGI.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR006715; ETS_PEA3_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF196; ETS TRANSLOCATION VARIANT 1; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF04621; ETS_PEA3_N; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   Genevisible; P41164; MM.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..477
FT                   /note="ETS translocation variant 1"
FT                   /id="PRO_0000204111"
FT   DNA_BIND        335..415
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          128..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         94
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P43268"
FT   MOD_RES         191
FT                   /note="Phosphoserine; by RPS6KA1 and RPS6KA5"
FT                   /evidence="ECO:0000250|UniProtKB:P50549"
FT   MOD_RES         216
FT                   /note="Phosphoserine; by RPS6KA1 and RPS6KA5"
FT                   /evidence="ECO:0000250|UniProtKB:P50549"
FT   CROSSLNK        317
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P50549"
SQ   SEQUENCE   477 AA;  55041 MW;  AA211595324CF7B8 CRC64;
     MDGFYDQQVP YVVTNSQRGR NCTEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE
     AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSELG SACSQEQPFK FSYGEKCLYN
     VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNTAHTPK PDRAFPAHLP PSQSIPDSTY
     PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHTT
     MVGGAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ
     FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG
     MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA
     LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMTYM PEGGCCNPHP YNEGYVY
//