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P41164

- ETV1_MOUSE

UniProt

P41164 - ETV1_MOUSE

Protein

ETS translocation variant 1

Gene

Etv1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi335 – 41581ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. mechanosensory behavior Source: MGI
    3. muscle organ development Source: MGI
    4. positive regulation of transcription, DNA-templated Source: MGI
    5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    6. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS translocation variant 1
    Alternative name(s):
    Ets-related protein 81
    Gene namesi
    Name:Etv1
    Synonyms:Er81, Etsrp81
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:99254. Etv1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477ETS translocation variant 1PRO_0000204111Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei191 – 1911Phosphoserine; by RPS6KA1 and RPS6KA5By similarity
    Modified residuei216 – 2161Phosphoserine; by RPS6KA1 and RPS6KA5By similarity

    Post-translational modificationi

    Sumoylated.By similarity
    Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP41164.

    PTM databases

    PhosphoSiteiP41164.

    Expressioni

    Tissue specificityi

    Abundant in kidney. Moderate levels seen in the heart, brain, lung, embryo and lower levels seen in spleen, intestine, testis and thymus.

    Gene expression databases

    ArrayExpressiP41164.
    BgeeiP41164.
    CleanExiMM_ETV1.
    GenevestigatoriP41164.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60465N.

    Structurei

    3D structure databases

    ProteinModelPortaliP41164.
    SMRiP41164. Positions 334-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258471.
    HOGENOMiHOG000230986.
    HOVERGENiHBG000231.
    InParanoidiP41164.
    KOiK09431.
    OMAiQDSSYPM.
    PhylomeDBiP41164.
    TreeFamiTF316214.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR006715. ETS_PEA3_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF04621. ETS_PEA3_N. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P41164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGFYDQQVP YVVTNSQRGR NCTEKPTNVR KRKFINRDLA HDSEELFQDL    50
    SQLQETWLAE AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSELG 100
    SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH 150
    ASPNTAHTPK PDRAFPAHLP PSQSIPDSTY PMDHRFRRQL SEPCNSFPPL 200
    PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHTT MVGGAASQSF 250
    PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ 300
    FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN 350
    SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG 400
    IMQKVAGERY VYKFVCDPEA LFSMAFPDNQ RPLLKTDMER HINEEDTVPL 450
    SHFDESMTYM PEGGCCNPHP YNEGYVY 477
    Length:477
    Mass (Da):55,041
    Last modified:February 1, 1995 - v1
    Checksum:iAA211595324CF7B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10426 mRNA. Translation: AAA20075.1.
    BC005645 mRNA. Translation: AAH05645.1.
    CCDSiCCDS49053.1.
    PIRiB46396.
    RefSeqiNP_031986.1. NM_007960.4.
    XP_006515028.1. XM_006514965.1.
    UniGeneiMm.4866.

    Genome annotation databases

    EnsembliENSMUST00000095767; ENSMUSP00000093442; ENSMUSG00000004151.
    ENSMUST00000162563; ENSMUSP00000125157; ENSMUSG00000004151.
    GeneIDi14009.
    KEGGimmu:14009.
    UCSCiuc007nkp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10426 mRNA. Translation: AAA20075.1 .
    BC005645 mRNA. Translation: AAH05645.1 .
    CCDSi CCDS49053.1.
    PIRi B46396.
    RefSeqi NP_031986.1. NM_007960.4.
    XP_006515028.1. XM_006514965.1.
    UniGenei Mm.4866.

    3D structure databases

    ProteinModelPortali P41164.
    SMRi P41164. Positions 334-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60465N.

    PTM databases

    PhosphoSitei P41164.

    Proteomic databases

    PRIDEi P41164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095767 ; ENSMUSP00000093442 ; ENSMUSG00000004151 .
    ENSMUST00000162563 ; ENSMUSP00000125157 ; ENSMUSG00000004151 .
    GeneIDi 14009.
    KEGGi mmu:14009.
    UCSCi uc007nkp.2. mouse.

    Organism-specific databases

    CTDi 2115.
    MGIi MGI:99254. Etv1.

    Phylogenomic databases

    eggNOGi NOG258471.
    HOGENOMi HOG000230986.
    HOVERGENi HBG000231.
    InParanoidi P41164.
    KOi K09431.
    OMAi QDSSYPM.
    PhylomeDBi P41164.
    TreeFami TF316214.

    Miscellaneous databases

    ChiTaRSi ETV1. mouse.
    NextBioi 284916.
    PROi P41164.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P41164.
    Bgeei P41164.
    CleanExi MM_ETV1.
    Genevestigatori P41164.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR006715. ETS_PEA3_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF04621. ETS_PEA3_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins."
      Brown T.A., McKnight S.L.
      Genes Dev. 6:2502-2512(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NMRI.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiETV1_MOUSE
    AccessioniPrimary (citable) accession number: P41164
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3