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P41164 (ETV1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ETS translocation variant 1
Alternative name(s):
Ets-related protein 81
Gene names
Name:Etv1
Synonyms:Er81, Etsrp81
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

Subcellular location

Nucleus.

Tissue specificity

Abundant in kidney. Moderate levels seen in the heart, brain, lung, embryo and lower levels seen in spleen, intestine, testis and thymus.

Post-translational modification

Sumoylated By similarity.

Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity By similarity.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477ETS translocation variant 1
PRO_0000204111

Regions

DNA binding335 – 41581ETS

Amino acid modifications

Modified residue1911Phosphoserine; by RPS6KA1 and RPS6KA5 By similarity
Modified residue2161Phosphoserine; by RPS6KA1 and RPS6KA5 By similarity

Sequences

Sequence LengthMass (Da)Tools
P41164 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: AA211595324CF7B8

FASTA47755,041
        10         20         30         40         50         60 
MDGFYDQQVP YVVTNSQRGR NCTEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE 

        70         80         90        100        110        120 
AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSELG SACSQEQPFK FSYGEKCLYN 

       130        140        150        160        170        180 
VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNTAHTPK PDRAFPAHLP PSQSIPDSTY 

       190        200        210        220        230        240 
PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHTT 

       250        260        270        280        290        300 
MVGGAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ 

       310        320        330        340        350        360 
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG 

       370        380        390        400        410        420 
MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA 

       430        440        450        460        470 
LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMTYM PEGGCCNPHP YNEGYVY 

« Hide

References

« Hide 'large scale' references
[1]"Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins."
Brown T.A., McKnight S.L.
Genes Dev. 6:2502-2512(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NMRI.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L10426 mRNA. Translation: AAA20075.1.
BC005645 mRNA. Translation: AAH05645.1.
CCDSCCDS49053.1.
PIRB46396.
RefSeqNP_031986.1. NM_007960.4.
XP_006515028.1. XM_006514965.1.
UniGeneMm.4866.

3D structure databases

ProteinModelPortalP41164.
SMRP41164. Positions 334-440.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60465N.

PTM databases

PhosphoSiteP41164.

Proteomic databases

PRIDEP41164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095767; ENSMUSP00000093442; ENSMUSG00000004151.
ENSMUST00000162563; ENSMUSP00000125157; ENSMUSG00000004151.
GeneID14009.
KEGGmmu:14009.
UCSCuc007nkp.2. mouse.

Organism-specific databases

CTD2115.
MGIMGI:99254. Etv1.

Phylogenomic databases

eggNOGNOG258471.
HOGENOMHOG000230986.
HOVERGENHBG000231.
InParanoidP41164.
KOK09431.
OMAQDSSYPM.
PhylomeDBP41164.
TreeFamTF316214.

Gene expression databases

ArrayExpressP41164.
BgeeP41164.
CleanExMM_ETV1.
GenevestigatorP41164.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
[Graphical view]
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSETV1. mouse.
NextBio284916.
PROP41164.
SOURCESearch...

Entry information

Entry nameETV1_MOUSE
AccessionPrimary (citable) accession number: P41164
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot