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P41164

- ETV1_MOUSE

UniProt

P41164 - ETV1_MOUSE

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Protein

ETS translocation variant 1

Gene

Etv1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi335 – 41581ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. axon guidance Source: MGI
  2. mechanosensory behavior Source: MGI
  3. muscle organ development Source: MGI
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 1
Alternative name(s):
Ets-related protein 81
Gene namesi
Name:Etv1
Synonyms:Er81, Etsrp81
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:99254. Etv1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477ETS translocation variant 1PRO_0000204111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei191 – 1911Phosphoserine; by RPS6KA1 and RPS6KA5By similarity
Modified residuei216 – 2161Phosphoserine; by RPS6KA1 and RPS6KA5By similarity

Post-translational modificationi

Sumoylated.By similarity
Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP41164.

PTM databases

PhosphoSiteiP41164.

Expressioni

Tissue specificityi

Abundant in kidney. Moderate levels seen in the heart, brain, lung, embryo and lower levels seen in spleen, intestine, testis and thymus.

Gene expression databases

BgeeiP41164.
CleanExiMM_ETV1.
ExpressionAtlasiP41164. baseline and differential.
GenevestigatoriP41164.

Interactioni

Protein-protein interaction databases

DIPiDIP-60465N.

Structurei

3D structure databases

ProteinModelPortaliP41164.
SMRiP41164. Positions 334-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258471.
HOGENOMiHOG000230986.
HOVERGENiHBG000231.
InParanoidiP41164.
KOiK09431.
OMAiQDSSYPM.
PhylomeDBiP41164.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P41164-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGFYDQQVP YVVTNSQRGR NCTEKPTNVR KRKFINRDLA HDSEELFQDL
60 70 80 90 100
SQLQETWLAE AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSELG
110 120 130 140 150
SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH
160 170 180 190 200
ASPNTAHTPK PDRAFPAHLP PSQSIPDSTY PMDHRFRRQL SEPCNSFPPL
210 220 230 240 250
PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHTT MVGGAASQSF
260 270 280 290 300
PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ
310 320 330 340 350
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN
360 370 380 390 400
SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG
410 420 430 440 450
IMQKVAGERY VYKFVCDPEA LFSMAFPDNQ RPLLKTDMER HINEEDTVPL
460 470
SHFDESMTYM PEGGCCNPHP YNEGYVY
Length:477
Mass (Da):55,041
Last modified:February 1, 1995 - v1
Checksum:iAA211595324CF7B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10426 mRNA. Translation: AAA20075.1.
BC005645 mRNA. Translation: AAH05645.1.
CCDSiCCDS49053.1.
PIRiB46396.
RefSeqiNP_031986.1. NM_007960.4.
XP_006515028.1. XM_006514965.1.
UniGeneiMm.4866.

Genome annotation databases

EnsembliENSMUST00000095767; ENSMUSP00000093442; ENSMUSG00000004151.
ENSMUST00000162563; ENSMUSP00000125157; ENSMUSG00000004151.
GeneIDi14009.
KEGGimmu:14009.
UCSCiuc007nkp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10426 mRNA. Translation: AAA20075.1 .
BC005645 mRNA. Translation: AAH05645.1 .
CCDSi CCDS49053.1.
PIRi B46396.
RefSeqi NP_031986.1. NM_007960.4.
XP_006515028.1. XM_006514965.1.
UniGenei Mm.4866.

3D structure databases

ProteinModelPortali P41164.
SMRi P41164. Positions 334-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60465N.

PTM databases

PhosphoSitei P41164.

Proteomic databases

PRIDEi P41164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095767 ; ENSMUSP00000093442 ; ENSMUSG00000004151 .
ENSMUST00000162563 ; ENSMUSP00000125157 ; ENSMUSG00000004151 .
GeneIDi 14009.
KEGGi mmu:14009.
UCSCi uc007nkp.2. mouse.

Organism-specific databases

CTDi 2115.
MGIi MGI:99254. Etv1.

Phylogenomic databases

eggNOGi NOG258471.
HOGENOMi HOG000230986.
HOVERGENi HBG000231.
InParanoidi P41164.
KOi K09431.
OMAi QDSSYPM.
PhylomeDBi P41164.
TreeFami TF316214.

Miscellaneous databases

ChiTaRSi ETV1. mouse.
NextBioi 284916.
PROi P41164.
SOURCEi Search...

Gene expression databases

Bgeei P41164.
CleanExi MM_ETV1.
ExpressionAtlasi P41164. baseline and differential.
Genevestigatori P41164.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins."
    Brown T.A., McKnight S.L.
    Genes Dev. 6:2502-2512(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary gland.

Entry informationi

Entry nameiETV1_MOUSE
AccessioniPrimary (citable) accession number: P41164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3